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31. 发明申请

WO2020028230A3 PATTERNED SURFACES WITH SUCTION 审中-公开
公开(公告)号：WO2020028230A3
公开(公告)日：2020-02-06
申请号：PCT/US2019/043879
申请日：2019-07-29
申请人： BVW HOLDING AG
发明人： BLUECHER, Lukas , MILBOCKER, Michael
IPC分类号： C09J9/00 , C09J7/00
摘要： A microstructured pressure- sensitive surface (102) is described comprising a Wenzel-Cassie hydrophilic- hydrophobic zone structure and capillary action with improved peel strength. The capillary action is enhanced by the Wenzel-Cassie zone creation, and the barrier energy to disruption of the Wenzel-Cassie zone is increased by the capillary action. The micro-structured surfaces of the present invention create water zones of exclusion, where entropic effects reinforce Wenzel-Cassie zone stability, creating a suction effect that conforms the micro structure surface to a target surface.

32. 发明申请

WO2020028223A1 BILIARY STENT 审中-公开
公开(公告)号：WO2020028223A1
公开(公告)日：2020-02-06
申请号：PCT/US2019/043869
申请日：2019-07-29
申请人： BVW HOLDING AG
发明人： BLUECHER, Lukas , MILBOCKER, Michael
IPC分类号： A61F2/00
摘要： The present disclosure provides an endoprosthesis where a preferably polymeric coating has a number of surface features such as protrusions or textures that are arranged in a micropattern. The endoprosthesis optionally has an expanded state and a contracted state, and in some cases includes a stent (200) with a polymeric coating (206) attached to an outer surface of the stent. The stent may have an inner surface defining a lumen, an outer surface, and a stent thickness defined between the inner surface and outer surface. The stent may comprise a plurality of surface textures extending from the stent surfaces, wherein the textures are arranged in a macropattern.

33. 发明申请

WO2019067963A1 DEVICE FOR DYNAMIC FLUID PINNING 审中-公开
公开(公告)号：WO2019067963A1
公开(公告)日：2019-04-04
申请号：PCT/US2018/053522
申请日：2018-09-28
申请人： BVW HOLDING AG , MILBOCKER, Michael
发明人： MILBOCKER, Michael , BLUECHER, Lukas
IPC分类号： B32B3/30 , B32B27/08 , B81B1/00
摘要： The present disclosure provides microstructured hydrophobic surfaces and devices for gripping wet deformable surfaces. The surfaces and devices disclosed herein utilize a split contact Wenzel-Cassie mechanism to develop multi-level Wenzel-Cassie structures. The Wenzel-Cassie structures are separated with a spatial period corresponding to at least one wrinkle eigenmode of a wet deformable surface to which the microstructure or device is designed to contact, allowing grip of the deformable surface without slippage. Microstructures of the present invention are specifically designed to prevent the formation of Shallamach waves when a shear force is applied to a deformable surface. The multi-level Wenzel-Cassie states of the present disclosure develop temporally, and accordingly are characterized by hierarchical fluid pinning, both in the instance of slippage, and more importantly in the instance of localization.

34. 发明申请

WO2013043998A3 SURGICAL BARRIER POSSESSING CLINICALLY IMPORTANT ABSORPTION CHARACTERISTICS 审中-公开
标题翻译：手术障碍临床重要吸收特征
公开(公告)号：WO2013043998A3
公开(公告)日：2013-12-12
申请号：PCT/US2012056523
申请日：2012-09-21
申请人： BVW HOLDING AG , WIESE HINRICH , TESSMAR JOERG , KESSLER MARTINA , BLUECHER LUKAS , MILBOCKER MICHAEL
发明人： WIESE HINRICH , TESSMAR JOERG , KESSLER MARTINA , BLUECHER LUKAS , MILBOCKER MICHAEL
IPC分类号： A61L31/06 , A61K31/765 , A61K31/77 , A61L31/14 , C08G18/40 , C08G18/42 , C08G18/48 , C08G63/06 , C08G63/66 , C08G65/26
CPC分类号： C08G63/06 , A61L31/06 , A61L31/10 , A61L31/14 , A61L31/148 , A61L31/16 , A61L2300/604 , B32B3/02 , B32B3/266 , B32B27/08 , B32B38/04 , C08G18/3203 , C08G18/3234 , C08G18/4018 , C08G18/4266 , C08G18/4277 , C08G18/428 , C08G18/44 , C08G18/48 , C08G18/4833 , C08G18/4854 , C08G18/4887 , C08G18/73 , C08G18/755 , C08G63/66 , C08G63/664 , C08G65/2603 , C08G2230/00 , C08G2261/126 , C08L71/02 , C08L2205/05 , Y10T428/239 , Y10T428/24331 , Y10T428/31554 , C08L75/04 , C08L67/00
摘要： The present disclosure provides copolymers useful in medical devices. For example, the disclosure provides copolymers comprising the polymerization product ester block, ether blocks and diisocyanates. In certain embodiments, the disclosure provides a medical copolymer for implantation comprising ester blocks and ether blocks, wherein: the ester blocks comprise a negative free energy transfer and the ether blocks comprise a positive free energy transfer, the ether and ester blocks are less than 1/10 the length of said copolymer, and, the blocks are distributed such that no domain of contiguous blocks possessing the same polarity of free energy transfer are less than 1/3 of the molecular weight of the copolymer. The disclosure further provides methods of making the aforementioned polymers, and medical devices comprising the polymers.
摘要翻译：本公开提供了可用于医疗装置的共聚物。例如，本公开提供了包含聚合产物酯嵌段，醚嵌段和二异氰酸酯的共聚物。在某些实施方案中，本公开提供了用于植入的医用共聚物，其包含酯嵌段和醚嵌段，其中：酯嵌段包含负自由能转移，并且所述醚嵌段包含正的自由能转移，所述醚和酯嵌段小于1 所述共聚物的长度为10，并且所述嵌段被分布成使得不具有相同极性的自由能转移的连续嵌段的区域小于共聚物分子量的1/3。本公开进一步提供了制备上述聚合物的方法和包含聚合物的医疗装置。

35. 发明申请

WO2013112378A2 IMPLANTABLE SUPERHYDROPHOBIC SURFACES 审中-公开
标题翻译：可植入超级表面
公开(公告)号：WO2013112378A2
公开(公告)日：2013-08-01
申请号：PCT/US2013/022214
申请日：2013-01-18
申请人： BVW HOLDING AG , BLUECHER, Lukas , MILBOCKER, Michael
发明人： BLUECHER, Lukas , MILBOCKER, Michael
IPC分类号： A61F2/02
CPC分类号： A61L27/34 , A61F2/0077 , A61L27/50 , A61L27/54
摘要： Bio-adhesive textured surfaces are described which allow implants to be localized within a living body. Hierarchical levels of texture on an implantable medical device, some capable of establishing a Wenzel state and others a Cassie state, are employed to interface with living structures to provide resistance to device migration. Since a gaseous state is traditionally required to establish a Cassie or Wenzel state, and gases do not remain long in living tissue, described are tissue/device interactions analogous to the above states with the component normally represented by a gas replaced by a bodily constituent, wherein separation of tissue constituents develops and an analogous Cassie, Wenzel or Cassie-Wenzel state evolves.
摘要翻译：描述了生物粘合剂纹理表面，其允许植入物定位在活体内。采用可植入式医疗装置上的层次水平的纹理，一些能够建立Wenzel状态和其他Cassie状态的纹理层与生物结构接口以提供对器件迁移的抵抗力。由于传统上需要气态以建立Cassie或Wenzel状态，并且气体在生物体组织中不会保持长时间，所描述的是类似于上述状态的组织/器件相互作用，其中组分通常由被身体成分取代的气体代表，其中组织成分的分离发展，并且类似的Cassie，Wenzel或Cassie-Wenzel状态发展。

36. 发明申请

WO2013043998A2 SURGICAL BARRIER POSSESSING CLINICALLY IMPORTANT ABSORPTION CHARACTERISTICS 审中-公开
标题翻译：手术屏障具有临床重要的吸收特性
公开(公告)号：WO2013043998A2
公开(公告)日：2013-03-28
申请号：PCT/US2012/056523
申请日：2012-09-21
申请人： BVW HOLDING AG , WIESE, Hinrich , TESSMAR, Joerg , KESSLER, Martina , BLUECHER, Lukas , MILBOCKER, Michael
发明人： WIESE, Hinrich , TESSMAR, Joerg , KESSLER, Martina , BLUECHER, Lukas , MILBOCKER, Michael
IPC分类号： A61L31/06
CPC分类号： C08G63/06 , A61L31/06 , A61L31/10 , A61L31/14 , A61L31/148 , A61L31/16 , A61L2300/604 , B32B3/02 , B32B3/266 , B32B27/08 , B32B38/04 , C08G18/3203 , C08G18/3234 , C08G18/4018 , C08G18/4266 , C08G18/4277 , C08G18/428 , C08G18/44 , C08G18/48 , C08G18/4833 , C08G18/4854 , C08G18/4887 , C08G18/73 , C08G18/755 , C08G63/66 , C08G63/664 , C08G65/2603 , C08G2230/00 , C08G2261/126 , C08L71/02 , C08L2205/05 , Y10T428/239 , Y10T428/24331 , Y10T428/31554 , C08L75/04 , C08L67/00
摘要： The present disclosure provides copolymers useful in medical devices. For example, the disclosure provides copolymers comprising the polymerization product ester block, ether blocks and diisocyanates. In certain embodiments, the disclosure provides a medical copolymer for implantation comprising ester blocks and ether blocks, wherein: the ester blocks comprise a negative free energy transfer and the ether blocks comprise a positive free energy transfer, the ether and ester blocks are less than 1/10 the length of said copolymer, and, the blocks are distributed such that no domain of contiguous blocks possessing the same polarity of free energy transfer are less than 1/3 of the molecular weight of the copolymer. The disclosure further provides methods of making the aforementioned polymers, and medical devices comprising the polymers.
摘要翻译：本公开提供可用于医疗装置中的共聚物。例如，本公开提供了包含聚合产物酯嵌段，醚嵌段和二异氰酸酯的共聚物。在某些实施方案中，本公开内容提供了用于植入的医用共聚物，其包含酯嵌段和醚嵌段，其中：酯嵌段包含负自由能转移并且醚嵌段包含正自由能转移，醚和酯嵌段小于1 / 10是所述共聚物的长度，并且嵌段是分布的，使得不具有相同极性的自由能转移的连续嵌段的区域小于共聚物的分子量的1/3。本公开进一步提供了制造上述聚合物的方法和包含该聚合物的医疗装置。

37. 发明申请

WO2012177825A1 MEDICAL DEVICE COMPRISING BOSWELLIC ACID 审中-公开
标题翻译：包含硼酸的医疗装置
公开(公告)号：WO2012177825A1
公开(公告)日：2012-12-27
申请号：PCT/US2012/043462
申请日：2012-06-21
申请人： BVW HOLDING AG , MILBOCKER, Michael, T. , BLUECHER, Lukas, Von
发明人： MILBOCKER, Michael, T. , BLUECHER, Lukas, Von
IPC分类号： A61K36/324
CPC分类号： A61K31/785 , A61K31/19 , A61K36/324 , A61L29/16 , A61L31/041 , A61L31/16 , A61L2300/30 , C08G18/348 , C08G18/771 , C08L67/04 , C08L75/04
摘要： A medical composition and. devices made from the composition for the delivery of extracts obtained from Boswellia genus, similar compounds synthetically derived,, and in particular derivatives of triterpenes is disclosed. The medical device may be implantable, or alternatively a device which contacts the interior of a mammalian body. The medical device may be comprised, of or present an absorbable component containing Boswellia derivatives, or an eluting component. When administered into a particular body site, the Boswellia component may be released substantially and immediately, released slowly, or not released, into the body and residing actively on the medical device surface.
摘要翻译：医学成分和。公开了由用于递送从乳香属属获得的提取物的组合物制备的装置，合成衍生的类似化合物，特别是三萜烯的衍生物。医疗装置可以是可植入的，或者可以是接触哺乳动物体内部的装置。医疗装置可以包含或存在含有乳香脂衍生物的可吸收组分或洗脱组分。当施用于特定身体部位时，可以基本上立即释放乳香组织部分，缓慢释放或不释放到体内并主动地存在于医疗装置表面上。

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