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21. 发明申请

WO2022018040A2 SARS-COV-2 PROTEINS, ANTI-SARS-COV-2 ANTIBODIES, AND METHODS OF USING THE SAME 审中-公开
公开(公告)号：WO2022018040A2
公开(公告)日：2022-01-27
申请号：PCT/EP2021/070176
申请日：2021-07-19
申请人： ASTRAZENECA UK LIMITED
发明人： HUGHES, Glen , MARCH, Ruth, E. , ESSER, Mark , MCTAMNEY, II, Patrick , LOO, Yueh-Ming , VARKEY, Reena, M. , DU, Qun , STEINHARDT, James , RAJAN, Saravanan
IPC分类号： C07K16/10 , G01N2469/20 , G01N33/56983
摘要： The present disclosure provides SARS-CoV-2 spike proteins and trimers containing such spike proteins. The present disclosure also provides antibodies and antigen-binding fragments thereof that specifically bind to the spike protein of SARS-CoV-2. The proteins, trimers, and antibodies can be used, for example, to detect anti-SARS-CoV-2 antibodies in sample obtained from a subject.

22. 发明申请

WO2021250467A2 DETECTION OF ANTIBODIES TO SARS-COV-2 审中-公开
公开(公告)号：WO2021250467A2
公开(公告)日：2021-12-16
申请号：PCT/IB2021/000395
申请日：2021-06-08
申请人： IDEXX LABORATORIES, INC.
发明人： BUCH, Jesse, Stephen , BOUCHER, Joshua, Michael , LIU, Jiayou , MORIN, Trevor, Justin , KRAH, Eugene, Regis, III
IPC分类号： C07K16/10 , A61K39/215 , A61K47/68 , G01N33/50 , G01N2333/165 , G01N2469/20 , G01N33/56983
摘要： The disclosure is directed to methods and apparatus for the detecting, diagnosis of infection with SARS-CoV-2. The disclosure includes methods for detecting a current or former SARS-CoV-2 infection in an animal, methods for diagnosing and treating an animal infected with SARS-CoV-2. in various aspects, the disclosure is directed to the detection of a nucleocapsid polypeptide of SARS-CoV-2 in a sample from an animal, the detection of a portion of a spike polypeptide of SARS-CoV-2 in a sample from and animal, or detection of both a portion of a spike polypeptide of SARS-CoV-2 and a portion of a nucleocapsid polypeptide of SARS-CoV-2 in a sample from an animal.

23. 发明申请

WO2021245139A8 NOVEL CORONAVIRUS TESTING 审中-公开
公开(公告)号：WO2021245139A8
公开(公告)日：2021-12-09
申请号：PCT/EP2021/064797
申请日：2021-06-02
申请人： OLISA CARE S.À R.L.
发明人： LAN, Jixian , YANG, Guanghua , ZHUANG, Qiang
IPC分类号： G01N33/543 , G01N33/569 , G01N33/68 , G01N2333/165 , G01N2469/20 , G01N33/54388 , G01N33/56983 , G01N33/686
摘要： The invention proposes a testing device and method for detecting infection with or immunity to SARS-Cov-2 of a subject, the method comprising the following steps: (i) contacting a urine sample from the subject with an application area of a testing device comprising a urine sorption material defining a sequence of said application area, a conjugate area and a testing area, the areas being in direct or indirect capillary flow communication with each other, (ii) allowing the urine sample to flow by capillarity from said application area to said conjugate area, said conjugate area comprising a testing conjugate movably held therein, wherein said testing conjugate comprises or consists of a polypeptide having an amino acid sequence that shares sequence identity of at least 90 %, preferably at least 95 %, with a SARS-CoV-2 protein or fragment thereof, coupled to a first colored marker, (iii) allowing the urine sample to continue to flow by capillarity to the testing area, said testing area comprising a testing sub-area with immobilized anti-human IgA antibodies, and (iv) determining infection with or immunity SARS-CoV-2 of the subject by visually inspecting the testing sub-area of the testing area for a color build-up, wherein the presence of a color build-up is indicative of said infection with or immunity to SARS-CoV-2.

24. 发明申请

WO2021244629A1 检测SARS-CoV-2病毒中和抗体的免疫层析装置及其应用审中-公开
公开(公告)号：WO2021244629A1
公开(公告)日：2021-12-09
申请号：PCT/CN2021/098272
申请日：2021-06-04
申请人：南京金斯瑞生物科技有限公司
发明人：覃喜建 , 虎慧珍
IPC分类号： G01N33/68 , G01N2333/165 , G01N2469/20 , G01N33/54313 , G01N33/54346 , G01N33/558 , G01N33/56983
摘要：涉及抗体检测领域，具体涉及检测SARS-CoV-2病毒中和抗体的免疫层析装置及其应用，进一步包括SARS-CoV-2病毒中和抗体的免疫层析装置的制备和使用方法。所述冠状病毒中和抗体的免疫检测装置，包括冠状病毒的刺突蛋白部分、特异性结合所述冠状病毒刺突蛋白部分的ACE2蛋白或其功能片段以及固相支持物，在所述固相支持物上检测待测样品对所述冠状病毒刺突蛋白部分与ACE2蛋白或其功能片段结合的影响，判断样品中是否存在冠状病毒中和抗体。免疫层析检测装置，如检测试纸特异、敏感、快捷、简便，易在生产实践中推广应用。

25. 发明申请

WO2021231498A2 DETECTION ASSAY FOR ANTI-SARS-COV-2 ANTIBODIES 审中-公开
公开(公告)号：WO2021231498A2
公开(公告)日：2021-11-18
申请号：PCT/US2021/031871
申请日：2021-05-11
申请人： CHAN ZUCKERBERG BIOHUB, INC. , THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： WELLS, James A. , ELLEDGE, Susanna , ZHOU, Xin
IPC分类号： C12Q1/04 , C12Q1/37 , G01N21/64 , G01N33/533 , C07K14/005 , C07K2319/00 , C07K2319/30 , C07K2319/60 , C12N2770/20022 , C12N9/485 , C12Q1/66 , C12Y304/17023 , G01N2333/165 , G01N2469/20 , G01N2470/10 , G01N33/56983 , G01N33/6854
摘要： Protein biosensors and methods of using these sensors to detect anti-SARS-CoV-2 patient antibodies (Abs) in a solution-based, rapid, and quantitative COVID-19 serological assay are provided. In certain aspects, the sensors each comprise a first fusion protein that comprises a first SARS-CoV-2 viral protein and a first peptide fragment of a split reporter protein, and a second fusion protein that comprises a second fusion protein that comprises a second SARS-CoV-2 viral protein domain and a second peptide fragment of the split reporter protein. Only if the test sample comprise SARS-CoV- antibodies, the first and second peptide fragments associate to produce an enzymatically active reporter protein.

26. 发明申请

WO2021211332A2 METHODS AND KITS FOR DETECTING OR DETERMINING AN AMOUNT OF AN ANTI-Β-CORONAVIRUS ANTIBODY IN A SAMPLE 审中-公开
公开(公告)号：WO2021211332A2
公开(公告)日：2021-10-21
申请号：PCT/US2021/026149
申请日：2021-04-07
申请人： ABBOTT LABORATORIES
发明人： MUERHOFF, A. Scott , PROSTKO, John C. , RODGERS, Mary A. , CLOHERTY, Gavin A. , STEWART, James L.
IPC分类号： G01N33/68 , G01N33/50 , G01N2333/165 , G01N2469/20 , G01N2800/52 , G01N2800/56 , G01N33/56983
摘要： Disclosed herein are methods, kits, systems, algorithms and improvements for detecting the presence of or determining an amount, quantity, concentration and/or level of an antibody against at least one type of β-coronavirus, such as, for example, an antibody against SARS-CoV or SARS-CoV-2, in one or more samples obtained from a subject. In some aspects, the methods, kits and systems relate to detecting the presence of or determining an amount, quantity, concentration and/or level of at least one type of anti-β-coronavirus antibody, such as an IgG and/or IgM antibody, in one or more samples obtained from a subject. The methods, kits systems, algorithms and improvements can also be used to monitor a subject's response and/or treatment to a β-coronavirus, determine whether or not a subject will develop or experience a cytokine storm, predict outcome in a subject, determine whether a subject can be administered a vaccine for a β-coronavirus, monitoring antibody response in individuals that have received a β-coronavirus vaccine (such as a SARS-CoV-2 vaccine), and/or determine the immune status of a subject.

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