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21. 发明申请

WO9013314A2 ANTIGENES OF THE ENVELOPE TRANSMEMBRANE GLYCOPROTEIN OF A HUMAN RETROVIRUS OF THE HIV-2 TYPE, AND ANTIGENS PRESENTING WITH THEM AN IMMUNOLOGICAL RELATIONSHIP 审中-公开
标题翻译： HIV-2型人类革兰氏阳性细胞转运蛋白的抗原以及与免疫荧光相关的抗原
公开(公告)号：WO9013314A2
公开(公告)日：1990-11-15
申请号：PCT/FR9000336
申请日：1990-05-11
申请人： PASTEUR INSTITUT
发明人： HOVANESSIAN ARA , REY MAIRE-ANNE , LAURENT ANNE , KRUST BERNARD , MONTAGNIER LUC
IPC分类号： G01N33/569 , A61K39/21 , A61K39/395 , A61P31/18 , C07K1/16 , C07K1/22 , C07K14/00 , C07K14/155 , C07K14/16 , C07K16/00 , C07K16/10 , C07K19/00 , C12N5/10 , C12N15/02 , C12P21/00 , C12P21/08 , C12R1/91 , C12R1/92 , G01N33/536
CPC分类号： C07K14/005 , C07K16/1063 , C12N2740/15022 , C12N2740/16122 , C12N2740/16222
摘要： The invention relates to an antigenic glycoprotein gp80 characterized by the following properties: it has a molecular weight (PM) close to 80 kDa; it is recognized by polyclonal antibodies directed against the glycoprotein gp300; it includes in association in the form a dimer to entities of the envelope transmembrane glycoprotein gp36, coded by the genome of a human retrovirus of the type HIV-2, susceptible of causing SLA or AIDS in human beings, or any glycoprotein having a molecular weight of the same order of magnitude, capable of forming an immunological complex of the type antigene-antibody, with antibodies directed against said gp80. The invention also relates to antibodies directed against said glycoprotein. It also relates to diagnostic and vaccination applications.
摘要翻译：本发明涉及具有以下性质的抗原性糖蛋白gp80：其具有接近80kDa的分子量（PM）; 由针对糖蛋白gp300的多克隆抗体识别; 或者包含跨膜糖蛋白gp36的二聚体与HIV-2型人类逆转录病毒基因组编码，其易于引起人体SLA或AIDS或任何具有分子量的糖蛋白能够形成抗原抗体类型的免疫学复合物，具有针对所述gp80的抗体的相同数量级。本发明还涉及针对所述糖蛋白的抗体。它还涉及诊断和疫苗接种应用。

22. 发明申请

WO2022143550A1 间皮素结合分子及其应用审中-公开
公开(公告)号：WO2022143550A1
公开(公告)日：2022-07-07
申请号：PCT/CN2021/141734
申请日：2021-12-27
申请人：浙江纳米抗体技术中心有限公司
发明人：李加国 , 于海翔 , 刘祥箴 , 朱伟民 , 孙艳 , 丁娜 , 钱其军
IPC分类号： C07K16/30 , C12N15/13 , G01N33/574 , G01N33/68 , C12N7/01 , A61K39/395 , A61P35/00 , C12R1/92
摘要：本发明提供一种间皮素结合分子，包含抗间皮素单域抗体，所述单域抗体的互补决定区CDR包括SEQ ID NO:1所示的CDR1、SEQ ID NO:2所示的CDR2、和SEQ ID NO:3所示的CDR3。

23. 发明申请

WO2022048061A1 一种耐高温宽裂解谱的沙门氏菌噬菌体及其组合物审中-公开
公开(公告)号：WO2022048061A1
公开(公告)日：2022-03-10
申请号：PCT/CN2020/134390
申请日：2020-12-08
申请人：菲吉乐科（南京）生物科技有限公司
发明人：黄杰 , 费文斌 , 胡怿林
IPC分类号： C12N7/00 , A61K35/76 , A61P31/04 , A01P1/00 , A01N63/40 , A23K10/18 , A23K50/75 , C12R1/92
摘要：提供了一种耐高温宽裂解谱沙门氏菌噬菌体及其组合物和应用，该沙门氏菌噬菌体为沙门氏菌噬菌体SG8P3(Salmonella pullorum phage SG8P3)，保藏编号为CCTCCNO:M2020205。

24. 发明申请

WO2019123349A1 VIRAL MEDIATED BIOLOGICAL CONTROL OF PLANT PATHOGENIC MICROORGANISMS 审中-公开
公开(公告)号：WO2019123349A1
公开(公告)日：2019-06-27
申请号：PCT/IB2018/060395
申请日：2018-12-20
申请人： THE NEW ZEALAND INSTITUTE FOR PLANT AND FOOD RESEARCH LIMITED
发明人： KHALIFA, Mahmoud Elhoseny Elhoseny Elsayed , MACDIARMID, Robin Marion
IPC分类号： C12N7/00 , A01N63/00 , C07K14/005 , C07K14/01 , C12R1/92
摘要： The present invention relates to an isolated strain of DNA mycovirus or a degenerate strain thereof, an isolated hypovirulent fungal strain or part thereof, and the use of the isolated strain of DNA mycovirus or hypovirulent fungal strain or part thereof as a biological control agent. Processes and compositions for the biological control of phytopathogenic microorganisms, particularly fungi, using the DNA mycovirus and hypovirulent fungal strain are also provided.

25. 发明申请

WO2018045029A1 PAN SOUTH AMERICAN ARENAVIRUS LIVE ATTENUATED VACCINE 审中-公开
标题翻译：潘南美洲沙门氏菌减毒活疫苗
公开(公告)号：WO2018045029A1
公开(公告)日：2018-03-08
申请号：PCT/US2017/049371
申请日：2017-08-30
申请人： THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF THE ARMY
发明人： GOLDEN, Joseph W. , HOOPER, Jay W.
IPC分类号： C12R1/92 , C07K14/08 , C12N15/86 , A61P31/14 , C12N7/01 , A61K35/76
CPC分类号： A61P31/14 , A61K35/761 , C12N7/00 , C12N2760/10021 , C12N2760/10034 , C12N2760/10062 , C12N2760/10064 , C12N2760/10071
摘要： Disclosed herein are methods of making attenuated Arenaviruses, compositions comprising the attenuated Arenaviruses, and methods of using the attenuated Arenaviruses. As disclosed herein, the attenuated Arenaviruses have a deletion of at least a portion of the intergenic region (IGR) of one or both genome segments.
摘要翻译：本文公开了制备减毒的沙粒病毒的方法，包含减毒的沙粒病毒的组合物，以及使用减毒的沙粒病毒的方法。如本文所公开的，减毒的沙粒病毒具有一个或两个基因组区段的基因间区（IGR）的至少一部分的缺失。

26. 发明申请

WO2012126367A1 适合于在原核及真核系统中表达的固氮基因岛审中-公开
公开(公告)号：WO2012126367A1
公开(公告)日：2012-09-27
申请号：PCT/CN2012/072709
申请日：2012-03-21
申请人：北京大学 , 王霞 , 杨建国 , 陈丽 , 杨云 , 王忆平
发明人：王霞 , 杨建国 , 陈丽 , 杨云 , 王忆平
IPC分类号： C12N15/79 , C12N15/63 , C12N15/31 , C12N15/113 , C12N15/33 , C12R1/92
CPC分类号： C12N15/70 , C12N15/52 , C12N15/8261 , Y02A40/146

27. 发明申请

WO2011137445A3 SALIVA POLYMERASE CHAIN REACTION ASSAY FOR CYTOMEGALOVIRUS INFECTION 审中-公开
标题翻译：用于细胞病毒感染的SALIVA聚合酶链反应测定
公开(公告)号：WO2011137445A3
公开(公告)日：2012-03-29
申请号：PCT/US2011034809
申请日：2011-05-02
申请人： UAB RESEARCH FOUNDATION , BOPPANA SURESH , NOVAK ZDENEK , ROSS SHANNON
发明人： BOPPANA SURESH , NOVAK ZDENEK , ROSS SHANNON
IPC分类号： C12Q1/70 , C12N15/38 , C12Q1/68 , C12R1/92
CPC分类号： C12Q1/705 , C12Q2600/16 , C12Q2537/143 , C12Q2531/113
摘要： Congenital cytomegalovirus (CMV) infection is an important cause of disease in infants and immune-compromised adults. Most infants infected with CMV are not promptly identified because of the absence of symptoms. It has been discovered that an assay based on the polymerase chain reaction (PCR) for testing of saliva specimens for CMV is rapid, accurate, and inexpensive. Some versions of the assay employ primers that are specific for sequences flanking the highly conserved major envelope glycoprotein B or the highly conserved immediate early 2 exon 5 genes. The assay exceeds the standard rapid culture technique in accuracy, speed, and economy. When the assay is performed on dried saliva, it loses no significant amount of accuracy, and is surprisingly much more sensitive than a PCR assay using dried blood. This assay will permit broader testing to detect and intervene in congenital CMV infection, potentially avoiding numerous cases of associated disease.
摘要翻译：先天性巨细胞病毒（CMV）感染是婴幼儿和免疫受损成年人疾病的重要原因。感染CMV的大多数婴儿由于没有症状而没有及时发现。已经发现，基于用于测试CMV唾液样本的聚合酶链反应（PCR）的测定是快速，准确和便宜的。该测定的一些版本使用对高度保守的主要包膜糖蛋白B或高度保守的即时早期2外显子5基因侧翼的序列特异性的引物。该测定超过了准确性，速度和经济性的标准快速培养技术。当在干唾液上进行测定时，其不会显着的准确度，并且令人惊奇地比使用干燥血液的PCR测定法更加敏感。该测定将允许更广泛的测试来检测和干预先天性CMV感染，可能避免许多相关疾病的病例。

28. 发明申请

WO2010143761A1 미지시료 내 감염성 미생물을 신속하게 검출하는 방법 审中-公开
标题翻译：在未知样品中快速检测感染性微生物的方法
公开(公告)号：WO2010143761A1
公开(公告)日：2010-12-16
申请号：PCT/KR2009/003168
申请日：2009-06-12
申请人： (주)바이오니아 , 윤홍란 , 박한오
发明人： 윤홍란 , 박한오
IPC分类号： C12Q1/68 , C12Q1/02 , C12R1/92 , C12R1/90
CPC分类号： C12Q1/689
摘要： 본 발명은 미지시료 중에 존재하는 감염성 미생물을 검출하는 방법에 관한 것으로서, 보다 상세하게는 실시간 중합효소연쇄반응법과 세포배양법을 이용하여 미지시료 중에 존재하는 감염성 미생물을 빠른 시간 안에 검출하는 방법에 관한 것이다. 본 발명의 검출방법을 이용하면 검출 시료 중에 감염성이 없는 미생물일지라도 그 미생물의 핵산만 존재하면 검출되는 중합효소연쇄반응법의 단점을 극복할 수 있을 뿐만 아니라 기존의 세포배양법을 이용하는 방법에 비해 감염성이 있는 미생물만 선택적으로 신속하게 검출할 수 있다. 이러한 검출방법은 수계에 존재하는 감염성 미생물을 검출할 수 있는 외에도 식수검사, 식당 위생검사 및 농축수산물 등의 식품검사에의 활용이 가능하므로 광범하게 이용될 수 있다.
摘要翻译：本发明涉及一种用于快速检测未知样品中感染性微生物的方法，更具体地涉及通过实时聚合酶链反应和细胞培养方法在短时间内检测未知样品中存在的感染性微生物的方法。本发明的检测方法可以克服即使在微生物是非传染性的情况下，即使在微生物中存在核酸的情况下也可以在检测样品中检测到微生物的实时聚合酶链式反应的缺点。此外，与常规细胞培养物相反，本发明的检测方法可以选择性且快速地检测感染性微生物。检测方法可以检测水系中的感染性微生物，广泛应用于饮用水检测，餐饮卫生检查，农业，畜牧业，渔业检验等食品检验。

29. 发明申请

WO01029244A1 NUCLEIC ACID TRANSPORTER CONTAINING POLYPEPTIDE AND RECOMBINANT VIRUS VECTOR 审中-公开
标题翻译：含有多肽和重组病毒载体的核酸运输机
公开(公告)号：WO01029244A1
公开(公告)日：2001-04-26
申请号：PCT/JP2000/007337
申请日：2000-10-20
IPC分类号： C12N15/09 , A61K35/76 , A61K47/42 , A61K48/00 , C12N15/86 , C12N15/867 , C12R1/92 , C12N15/90
CPC分类号： C12N15/86 , A61K48/00 , C12N2740/16043 , C12N2740/16045 , C12N2800/108 , C12N2810/6054 , C12N2830/42
摘要： Gene therapy is carried out by efficiently and safely transferring a nucleic acid transporter, which contains a polypeptide comprising diaminobutyric acid and/or its pharmaceutically acceptable salt and a recombinant vector (preferably together with a drug gene), and a drug gene into cells and thus enabling the expression of the drug gene at a high level in the cells.
摘要翻译：基因治疗通过将包含二氨基丁酸和/或其药学上可接受的盐的多肽和重组载体（优选与药物基因一起）的核酸转运体和药物基因有效且安全地转移到细胞中进行，因此使得能够在细胞中高水平表达药物基因。

30. 发明申请

WO01009305A2 PURINE METABOLISM GENES IN PLANTS 审中-公开
标题翻译：植物中嘌呤代谢的基因
公开(公告)号：WO01009305A2
公开(公告)日：2001-02-08
申请号：PCT/US2000/021009
申请日：2000-07-28
IPC分类号： C12N15/09 , C07K14/415 , C12N1/19 , C12N1/21 , C12N5/10 , C12N7/00 , C12N9/78 , C12N15/82 , C12Q1/68 , C12R1/92 , C12N15/00
CPC分类号： C12N15/8243 , C12N9/78
摘要： This invention relates to an isolated nucleic acid fragment encoding an AMP deaminase or adenosine deaminase, a transformed host cell comprising the nucleic acid fragment, and a transgenic plant comprising the nucleic acid fragment. The invention also relates to the construction of a chimeric gene encoding all or a substantial portion of an AMP or adenosine deaminase, and a chimeric gene comprising the isolated fragment in sense or antisense orientation. This invention further relates to a method for altering expression level of AMP deaminase or adenosine deaminase in a transformed host cell, and a method for evaluating a compound that affects the activity of an AMP deaminase or an adenosine deaminase.
摘要翻译：本发明提供了编码AMP脱氨酶或腺苷脱氨酶的分离的核酸片段，包含该核酸片段的转化的宿主细胞和包含该片段的转基因植物。本发明还涉及编码部分或全部AMP脱氨酶或腺苷脱氨酶和嵌合基因的嵌合基因，所述嵌合基因含有有义或反义方向的分离片段。另外，本发明涉及用于改变转化的宿主细胞中AMP脱氨酶或腺苷脱氨酶的表达水平的技术，以及评估具有影响AMP脱氨酶或腺苷脱氨酶的活性。

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