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21. 发明申请

WO2009019450A1 REACTION VESSEL COMPRISING ELECTRICALLY CONDUCTING POLYMER AS A HEATING ELEMENT 审中-公开
标题翻译：包含电导体聚合物作为加热元件的反应容器
公开(公告)号：WO2009019450A1
公开(公告)日：2009-02-12
申请号：PCT/GB2008/002627
申请日：2008-08-01
申请人： ENIGMA DIAGNOSTICS LIMITED , JONES, Ross, Peter , WILLIAMSON, Roger, James , GREGORY, Richard, George , GUTSELL, Graham , LEE, Martin, Alan , SQUIRRELL, David, James
发明人： JONES, Ross, Peter , WILLIAMSON, Roger, James , GREGORY, Richard, George , GUTSELL, Graham , LEE, Martin, Alan , SQUIRRELL, David, James
IPC分类号： B01L3/00 , B01L7/00 , B01J19/00 , G01N21/03
CPC分类号： B01L7/52 , B01L3/50851 , B01L2300/0858 , B01L2300/0887 , B01L2300/16 , B01L2300/1827 , B01L2300/1883 , G01N21/0332
摘要： A reaction vessel for conducting a chemical or biochemical reaction, such as a polymerase chain reaction wherein electrically conducting polymer is arranged to act as a heating element. The profile of the electrically conductive polymer differs in different regions of the vessel so as to control thermal gradients. The profile of the electrically conductive polymer may be arranged to either increase or reduce the thermal gradient. Reaction systems comprising combinations of vessels of the invention and apparatus for heating them, as well as particular reactions vessels are also described and claimed.
摘要翻译：用于进行化学或生物化学反应的反应容器，例如聚合酶链式反应，其中导电聚合物被设置为充当加热元件。导电聚合物的轮廓在容器的不同区域不同，以便控制热梯度。可以将导电聚合物的轮廓布置成增加或减少热梯度。还描述和要求保护包括本发明的容器和用于加热它们的装置的组合的反应系统以及特定的反应容器。

22. 发明申请

WO2008151832A1 OPTICALLY ACCESSIBLE COVER 审中-公开
标题翻译：光接触盖
公开(公告)号：WO2008151832A1
公开(公告)日：2008-12-18
申请号：PCT/EP2008/004796
申请日：2008-06-13
申请人： EPPENDORF AG , KROLL, Cordula , USCHKUREIT, Thomas
发明人： KROLL, Cordula , USCHKUREIT, Thomas
IPC分类号： B01L3/00 , G01N21/03
CPC分类号： G01N21/253 , B01L3/50853 , B01L2200/141 , B01L2200/142 , B01L2300/046 , B01L2300/0654 , B01L2300/0829 , B01L2300/1822 , B01L2300/1827 , B01L2300/1838 , B01L2300/1861 , G01N21/0332 , G01N21/6428 , G01N21/6452 , G01N2021/0325 , G01N2021/158
摘要： The present invention relates to a means for covering and to a device for performing processes and/or reactions involving at least one sample, which are conducted in a temperature-controlled environment and which require optical access to at least one sample. For the purposes of the present invention, "op tical access" is to be understood as the capability of electromagnetic radiation, comprising or consisting of radiation in the visible part of the electromagnetic spectrum, preferably from 400 nm to 800 nm, to interact with at least one sample and/or to emanate from the at least one sample without complete attenuation by means of passing through a means for covering. While the present invention is exemplarily discussed in the context of thermal cyclers, and in particular in the context of quantitative polymerase chain reaction (qPCR) and real time PCR, respectively, the means for covering and device of the invention are not restricted to this specific application but rather relate to all applications known to the person skilled in the art in which some kind of sample(s)/mixture(s) need(s) to be handled at a certain temperature and the requirement needs to be fulfilled that radiation, preferably radiation in the visible part of the electromagnetic spectrum, is capable of emanating from and/or interacting with said sample.
摘要翻译：本发明涉及用于覆盖和用于执行涉及至少一个样品的过程和/或反应的装置的装置，其在温度受控的环境中进行，并且需要光学进入至少一个样品。为了本发明的目的，

23. 发明申请

WO2008091626A1 APPARATUS FOR HIGH THROUGHPUT CHEMICAL REACTIONS 审中-公开
标题翻译：高通量化学反应装置
公开(公告)号：WO2008091626A1
公开(公告)日：2008-07-31
申请号：PCT/US2008/000860
申请日：2008-01-22
申请人： WAFERGEN, INC. , JOSEPH, Victor , HUDA, Amjad , SHIVJI, Alnoor
发明人： JOSEPH, Victor , HUDA, Amjad , SHIVJI, Alnoor
IPC分类号： C08F2/01 , B01J19/08
CPC分类号： C12Q1/686 , B01L7/525 , B01L7/5255 , B01L7/54 , B01L2200/10 , B01L2200/147 , B01L2300/0654 , B01L2300/0819 , B01L2300/0829 , B01L2300/0893 , B01L2300/1805 , B01L2300/1827 , B01L2300/1844 , B01L2300/1894 , G01N21/0332 , G01N21/253
摘要： Apparatus, systems, chips, and methods of performing a large number of simultaneous chemical reactions are provided herein. The chips of the invention comprise addressable units that can be addressed according to the temperature of the reaction to be run. The subject apparatus, systems, and chips are particularly suited for performing polymerase chain reactions on thousands of nucleic acid sequences, up to and including sequences of an entire genome of an organism of interest.
摘要翻译：本文提供了进行大量同时化学反应的装置，系统，芯片和方法。本发明的芯片包括可根据要运行的反应温度来寻址的寻址单元。主题装置，系统和芯片特别适用于在数千个核酸序列上进行聚合酶链反应，直到并包括感兴趣的生物体的整个基因组的序列。

24. 发明申请

WO2007002182A9 IMPROVED SYSTEMS AND METHODS FOR CHIRAL DETECTION AND ANALYSIS 审中-公开
标题翻译：改进的系统和手段检测和分析方法
公开(公告)号：WO2007002182A9
公开(公告)日：2008-01-17
申请号：PCT/US2006024123
申请日：2006-06-21
申请人： STHENO CORP , GIBBS PHILLIP R , WADE JOHN
发明人： GIBBS PHILLIP R , WADE JOHN
IPC分类号： G01N21/21 , G01J4/04 , G01M11/04 , G01N21/05
CPC分类号： G01M11/04 , G01J1/44 , G01J1/46 , G01N21/0332 , G01N21/05 , G01N21/1717 , G01N21/21 , G01N2021/0346 , G01N2021/1727
摘要： Relating to chiral detection systems, various improvements are disclosed including an improved apparatus for detecting a chiral property of a sample. It has a rugged and stable optical rail that operates as a heat sink to the systems' elements and comprises a captive guide structure (300) of heat conductive material having an elevated top platform (302) and a dove tailed lip (305) on the sides. The elevated top platform (302) has a substantial width in comparison to a height of the elevated top platform (302). The apparatus further includes a wide base portion (304) of heat conductive material supportive of the captive guide structure (300). The base (304) has a width that is at least twice the width of the elevated top platform (302) and a substantial thickness relative to the captive guide structure (300). Multiple system elements can be securely mounted on the captive guide structure (300) with some elements being in thermal contact with the elevated top platform (302).
摘要翻译：关于手性检测系统，公开了各种改进，包括用于检测样品的手性性质的改进的装置。它具有坚固且稳定的光学导轨，其作为系统元件的散热器而工作，并且包括导热材料的捕获引导结构（300），其具有升高的顶部平台（302）和在其上的鸽子尾部唇缘（305）两侧。升高的顶部平台（302）与升高的顶部平台（302）的高度相比具有相当大的宽度。所述设备还包括支撑所述捕获引导结构（300）的导热材料的宽基部（304）。基座（304）的宽度至少是升高的顶部平台（302）的宽度的两倍，并且相对于捕获引导结构（300）具有相当大的厚度。多个系统元件可以牢固地安装在固定引导结构（300）上，其中一些元件与升高的顶部平台（302）热接触。

25. 发明申请

WO2008002563A2 HEATED COVER METHODS AND TECHNOLOGY 审中-公开
标题翻译：加热覆盖方法和技术
公开(公告)号：WO2008002563A2
公开(公告)日：2008-01-03
申请号：PCT/US2007014811
申请日：2007-06-26
申请人： APPLERA CORP , HIRANO KIRK M , BABCOKE JASON E , CARRILLO ALBERT L , HAGA DOUWE D , KAO PIN , KINNEY PATRICK D , NURSE JAMES C
发明人： HIRANO KIRK M , BABCOKE JASON E , CARRILLO ALBERT L , HAGA DOUWE D , KAO PIN , KINNEY PATRICK D , NURSE JAMES C
IPC分类号： H05B3/20
CPC分类号： B01L7/52 , B01L3/50851 , B01L3/50853 , B01L3/50857 , B01L7/00 , B01L2200/0605 , B01L2200/0642 , B01L2300/0654 , B01L2300/0829 , B01L2300/1816 , B01L2300/1838 , B01L2300/1861 , B01L2300/1872 , F28F13/00 , F28F2013/001 , G01N21/0332 , G01N21/6452 , G01N2201/062 , H05B3/84 , H05B6/02 , H05B6/105
摘要： A heating apparatus comprising a support base and a microplate having a first surface and an opposing second surface. The microplate is positioned adjacent the support base and comprises a plurality of wells formed in the first surface thereof. Each of the plurality of wells is sized to receive an assay therein. A sapphire crystalline transparent window is positioned adjacent the microplate opposing the support base. A heating device heats the transparent window in response to a control system.
摘要翻译：一种加热设备，包括支撑基座和具有第一表面和相对的第二表面的微孔板。微孔板位于支撑底座附近并且包括在其第一表面中形成的多个阱。多个孔中的每一个的大小适于在其中接受测定。蓝宝石结晶透明窗口位于与支撑基座相对的微孔板附近。加热装置响应于控制系统加热透明窗口。

26. 发明申请

WO2007106306A2 REFERENCE MICROPLATES AND METHODS FOR MAKING AND USING THE REFERENCE MICROPLATES 审中-公开
标题翻译：参考微量元素和制备和使用参考微量的方法
公开(公告)号：WO2007106306A2
公开(公告)日：2007-09-20
申请号：PCT/US2007004537
申请日：2007-02-20
申请人： CORNING INC , PASTEL DAVID A , PIECH GARRETT A , SHEDD GORDON M , SHELTON BRETT C , ZAINUL MOHAMED A
发明人： PASTEL DAVID A , PIECH GARRETT A , SHEDD GORDON M , SHELTON BRETT C , ZAINUL MOHAMED A
IPC分类号： G01N21/25 , B01L3/00 , G01N21/27
CPC分类号： G01N21/0332 , B01L3/5085 , B01L3/50851 , B01L2200/148 , B01L2300/0636 , B01L2300/0654 , B01L2300/0829 , B01L2300/168 , B01L2300/1827 , G01N21/253 , G01N21/274 , G01N21/278 , G01N21/31 , G01N35/00594 , G01N35/028 , G01N2001/2893 , G01N2021/0325
摘要： A reference microplate is described herein which can be used to help calibrate and troubleshoot an optical interrogation system. In one embodiment, the reference microplate has a frame with an array of wells each of which contains an optical biosensor and each optical biosensor is at least partially coated with a substance (e.g., elastomer, optical epoxy). In another embodiment, the reference microplate in addition to having its optical biosensors at least partially covered with a substance (e.g., elastomer, optical epoxy) also has a controllable heating device attached thereto which is used to heat the optical biosensors.
摘要翻译：本文描述了参考微孔板，其可用于帮助校准和诊断光学询问系统。在一个实施方案中，参考微量培养板具有一个具有孔阵列的框架，每个孔包含光学生物传感器，并且每个光学生物传感器至少部分涂覆有物质（例如弹性体，光学环氧树脂）。在另一个实施方案中，参考微板除了使其光学生物传感器至少部分被物质（例如弹性体，光学环氧树脂）覆盖之外，还具有连接到其上的可控加热装置，其用于加热光学生物传感器。

27. 发明申请

WO2005119209A3 SYSTEM AND METHOD FOR ANALYZING MICROBIAL GROWTH 审中-公开
标题翻译：用于分析微生物生长的系统和方法
公开(公告)号：WO2005119209A3
公开(公告)日：2007-02-08
申请号：PCT/US2005019826
申请日：2005-06-03
申请人： RISING PETER E , REMMER JOHN
发明人： RISING PETER E , REMMER JOHN
IPC分类号： G01N21/00 , B32B5/02 , B32B27/04 , B32B27/12 , G01N21/03 , G01N21/27 , G01N21/31 , G01N21/59 , G01N21/78
CPC分类号： G01N21/3151 , G01N21/0332 , G01N21/78 , G01N2021/0328 , G01N2021/3155 , G01N2021/786 , G01N2201/0627
摘要： A liquid testing system includes a first well (201) for receiving a sample to be tested, a first light (301), having a first wavelength, for illuminating the first well, and a second light (302), having a second wavelength, for illuminating the first well. The liquid testing system further includes a light control (403), coupled to the first light and the second light, for selecting one of die first light or the second light to illuminate the first well, a light detector (404) receiving light passing into the first well, and a processor (401), coupled to the light control (403) and the light detector (404), for determining a light characteristic of the sample over time.
摘要翻译：液体测试系统包括用于接收待测试样品的第一阱（201），具有用于照射第一阱的第一波长的第一光（301）和具有第二波长的第二光（302）用于照亮第一口井。液体检测系统还包括耦合到第一光和第二光的光控制（403），用于选择管芯第一光或第二光中的一个以照亮第一阱;光检测器（404），其接收通过第一阱以及耦合到光控制（403）和光检测器（404）的处理器（401），用于随时间确定样品的光特性。

28. 发明申请

WO2007005076A1 VALVE CONTROL SYSTEM FOR A ROTATING MULTIPLEX FLUORESCENCE DETECTION DEVICE 审中-公开
标题翻译：用于旋转多通道荧光检测装置的阀控制系统
公开(公告)号：WO2007005076A1
公开(公告)日：2007-01-11
申请号：PCT/US2006/010750
申请日：2006-03-24
申请人： 3M INNOVATIVE PROPERTIES COMPANY
发明人： BEDINGHAM, William , LUDOWISE, Peter D., , ROBOLE, Barry W.,
IPC分类号： G01N21/64 , G01N35/00
CPC分类号： F16K99/003 , B01L3/502715 , B01L3/502738 , B01L2200/025 , B01L2300/021 , B01L2300/0806 , B01L2400/0409 , B01L2400/0677 , F16K99/0001 , F16K99/004 , F16K2099/0084 , G01N21/0332 , G01N21/07 , G01N21/359 , G01N21/6428 , G01N21/6452 , G01N35/00069 , G01N35/1097 , G01N2021/0325 , G01N2021/6421 , G01N2021/6441 , G01N2035/00267 , G01N2035/00415 , G01N2035/0474 , G01N2201/0407 , G01N2201/0415 , G01N2201/0612 , G01N2201/062 , G01N2201/0833 , Y10T436/11 , Y10T436/111666
摘要： Techniques are described for the detection of multiple target species in real-time PCR (polymerase chain reaction). For example, a system comprises a data acquisition device and a detection device coupled to the data acquisition device. The detection device includes a rotating disk having a plurality of process chambers having a plurality of species that emit fluorescent light at different wavelengths. The device further includes a plurality of removable optical modules that are optically configured to excite the species and capture fluorescent light emitted by the species at different wavelengths. A fiber optic bundle coupled to the plurality of removable optical modules conveys the fluorescent light from the optical modules to a single detector. In addition, the device may control the flow of fluid in the disk by locating and selectively opening valves separating chambers by heating the valves with a laser.
摘要翻译：描述了用于在实时PCR（聚合酶链式反应）中检测多种靶物种的技术。例如，系统包括数据采集装置和耦合到数据采集装置的检测装置。检测装置包括具有多个处理室的旋转盘，该多个处理室具有发射不同波长的荧光的多种物质。该装置还包括多个可移除的光学模块，其被光学配置为激发物种并捕获由不同波长的物质发射的荧光。耦合到多个可移除光学模块的光纤束将来自光学模块的荧光传送到单个检测器。此外，该装置可以通过利用激光加热阀来定位和选择性地打开阀分离腔来控制盘中的流体流动。

29. 发明申请

WO2006086547A2 AUTOMATED BIOLOGICAL INDICATOR INCUBATOR 审中-公开
标题翻译：自动生物指示器
公开(公告)号：WO2006086547A2
公开(公告)日：2006-08-17
申请号：PCT/US2006/004565
申请日：2006-02-09
申请人： ALLEGIANCE CORPORATION , STECKLEIN, Gregory, O , HARRIS, Matthew , PREY, John, E., Jr , KROBEL, Karl, J
发明人： STECKLEIN, Gregory, O , HARRIS, Matthew , PREY, John, E., Jr , KROBEL, Karl, J
IPC分类号： C12M3/00
CPC分类号： B01L7/00 , A61L2/28 , B01L3/5082 , B01L2200/147 , B01L2300/0654 , C12M37/06 , G01N21/0332 , G01N21/272 , G01N21/274 , G01N21/78 , G01N2035/00356 , G01N2201/12707 , G01N2201/12723
摘要： A system and method of automated incubating and reading of biological indicators is disclosed. In one embodiment, the automated biological indicator incubator is configured to control the temperature of incubation test wells to a desired temperature range suitable for use with a biological indicator, control the incubation period, and detect a change in the biological indicator colored media providing an indication of growth or lack of growth. In other embodiments, the automated biological indicator incubator is self-calibrating, and provides a communication interface to an external device, such as a computer. The communication interface is suitable for use to collect and analyze data associated with the biological indicator during the incubator period, and for making a determination of growth or lack of growth and success of the sterilization process as well as a permanent document of the monitoring of the sterilization process.
摘要翻译：公开了一种生物指示器的自动化孵化和阅读的系统和方法。在一个实施方案中，自动化生物指示剂培养箱被配置为将培养试验孔的温度控制到适合于与生物指示剂一起使用的期望温度范围，控制孵育期，并且检测生物指示剂着色介质的变化，提供指示的增长或缺乏增长。在其他实施例中，自动生物指示器孵化器是自校准的，并且提供到诸如计算机的外部设备的通信接口。通信接口适用于收集和分析孵化器期间与生物指标相关的数据，并确定灭菌过程的增长或缺乏增长和成功，以及永久性文件的监测灭菌过程。

30. 发明申请

WO2006085911A2 LOW THERMAL MASS FLUOROMETER 审中-公开
标题翻译：低热质量FLUOROMETER
公开(公告)号：WO2006085911A2
公开(公告)日：2006-08-17
申请号：PCT/US2005019584
申请日：2005-06-03
申请人： UNIV SOUTH FLORIDA , FARMER ANDREW , FRIES DAVID P , FLANERY BILL
发明人： FARMER ANDREW , FRIES DAVID P , FLANERY BILL
IPC分类号： G01J1/58 , G01N21/03 , G01N21/64
CPC分类号： G01N21/645 , G01N21/0332 , G01N2201/0221
摘要： The present invention provides core technologies necessary for a portable, low cost, thermal- regulating LED-based handheld fluorometer. The regulated fluorometer is based on al low thermal mass infrared heater, and an orthogonal geometry LED based filter fluorometer. Power is supplied through an external power supply and data is collected in real-time through standard serial interfaces of personal computers or personal digital assistants. Thermal regulation is automatically maintained using temperature sensor feedback control. Optical excitation relies on LED light source(s) and optical detection is through an adjustable integrating photodetector. Such a handheld system can allow applications requiring temperature sensitive photometric measurements for real time analyte detection to be performed in the field.
摘要翻译：本发明提供了便携式，低成本，热调节LED手持式荧光计所需的核心技术。受控的荧光计基于低热质红外线加热器和基于正交几何结构的基于LED的过滤荧光计。电源通过外部电源供电，数据通过个人电脑或个人数字助理的标准串行接口实时采集。温度传感器反馈控制自动保持温度调节。光学激励依赖于LED光源，而光学检测则通过可调整的积分光电探测器。这种手持式系统可以允许在现场进行实时分析物检测的需要温度敏感的光度测量的应用。

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