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    • 23. 发明申请
    • FOAMED POLYURETHANE POLYMERS FOR THE REGENERATION OF CONNECTIVE TISSUE
    • 用于再生连接组织的泡沫聚氨酯聚合物
    • WO2015162523A1
    • 2015-10-29
    • PCT/IB2015/052737
    • 2015-04-15
    • FONDAZIONE FILARETE PER LE BIOSCIENZE E L'INNOVAZIONE
    • GERGES, IriniMARTELLO, FedericoTAMPLENIZZA, MargheritaTOCCHIO, Alessandro
    • C08G18/08A61L27/18A61L31/06A61L26/00
    • C08J9/08A61L27/12A61L27/18A61L27/56C08G18/0847C08G18/0852C08G18/14C08G18/163C08G18/165C08G18/4081C08G18/6677C08G18/73C08G2101/00C08G2230/00C08J9/0066C08J2203/02C08J2205/06C08J2205/10C08J2207/10C08J2375/08C08K3/32C08K2003/325C08L75/04
    • The present invention relates to a method of synthesis and the use of foamed, cross-linked polyurethane polymers, as a three-dimensional support called a "scaffold" for cell cultures in vitro and for in vivo implantation for the regeneration of connective tissues such as adipose tissue, osteochondral tissue and bone tissue. In particular, the invention relates to a method of preparing polymers or foamed polyurethane co polymers, having improved hydrophilia, which involves the use of two types of catalyst, one for the cross- linking reaction and one for the foaming reaction and the use of at least one polar aprotic high-boiling solvent. Said method comprises the following steps in sequence : a) providing a solution of a polyol or a mixture of polyols in a solvent or mixture of solvents; b) heating the solution in step a) to a temperature higher than the softening temperature of the polymer precursors; c) optionally adding an organic or inorganic filler material; d) adding to the mixture in step c) an aliphatic poly-isocyanate or a mixture of poly-aliphatic isocyanates; e) adding to the mixture in step (d) ) a porogenic additive; f) adding to the mixture in step e) simultaneously a cross-linking catalyst of polyols with poly-isocyanates and a foaming catalyst to form a foamed polyurethane polymer or co-polymer; g) isolating the foamed polyurethane polymer or co-polymer produced in step f ).
    • 本发明涉及一种合成和使用发泡的交联聚氨酯聚合物的方法,作为体外用于细胞培养物的体外植入的称为“支架”的三维支架,用于再结合组织如 脂肪组织,骨软骨组织和骨组织。 特别地,本发明涉及一种制备聚合物或发泡聚氨酯共聚物的方法,其具有改进的亲水性,其涉及使用两种类型的催化剂,一种用于交联反应,一种用于发泡反应,以及使用 至少一种极性非质子高沸点溶剂。 所述方法包括以下步骤:a)在溶剂或溶剂混合物中提供多元醇或多元醇混合物的溶液; b)将步骤a)中的溶液加热到高于聚合物前体的软化温度的温度; c)任选地加入有机或无机填料; d)在步骤c)中向混合物中加入脂族聚异氰酸酯或多脂族异氰酸酯的混合物; e)在步骤(d)中向混合物中加入致孔剂; f)在步骤e)中向混合物中加入多元醇与聚异氰酸酯的交联催化剂和发泡催化剂以形成发泡聚氨酯聚合物或共聚物; g)分离步骤f)中产生的泡沫聚氨酯聚合物或共聚物。