专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

21. 发明申请

WO2006001771A1 SEPARATION MATRIX AND METHOD OF PURIFICATION 审中-公开
标题翻译：分离矩阵和纯化方法
公开(公告)号：WO2006001771A1
公开(公告)日：2006-01-05
申请号：PCT/SE2005/001002
申请日：2005-06-22
申请人： AMERSHAM BIOSCIENCES AB , MALOISEL, Jean-Luc , JOHANSSON, Bo-Lennart , GLAD, Gunnar , NORRMAN, Nils
发明人： MALOISEL, Jean-Luc , JOHANSSON, Bo-Lennart , GLAD, Gunnar , NORRMAN, Nils
IPC分类号： G01N30/48
CPC分类号： B01J20/3212 , B01D15/426 , B01J20/286 , B01J20/289 , B01J20/3219 , B01J20/3251
摘要： The present invention relates to a separation matrix comprised of a porous support to which ligands have been immobilised, wherein said ligands comprise at least one sulphonamide and the R group of the sulphonyl comprises an aromatic group. The nitrogen of the sulphonamide may be a secondary or tertiary amine. The invention also relates to a chromatography column that contains the described separation matrix, as well as to a method of isolating immunoglobulin-like compounds by adsorption to the separation matrix.
摘要翻译：本发明涉及由已经固定有配体的多孔载体组成的分离基质，其中所述配体包含至少一个磺酰胺，并且磺酰基的R基包括芳族基团。磺酰胺的氮可以是仲胺或叔胺。本发明还涉及含有所述分离基质的色谱柱，以及通过吸附到分离基质上分离免疫球蛋白样化合物的方法。

22. 发明申请

WO2005121165A1 PROCESS FOR PROTEIN ISOLATION 审中-公开
标题翻译：蛋白质分离过程
公开(公告)号：WO2005121165A1
公开(公告)日：2005-12-22
申请号：PCT/AU2005/000796
申请日：2005-06-06
申请人： AVT PLASMA LIMITED , LIHME, Allan
发明人： LIHME, Allan
IPC分类号： C07K1/14
CPC分类号： B01J20/28011 , B01D15/3804 , B01D15/426 , B01J20/28004 , B01J20/286 , B01J20/289 , B01J20/3242 , C07K14/745 , C07K14/75 , C07K14/755 , C07K14/765 , C07K14/78 , C07K14/81
摘要： In one aspect, the present invention is directed to a process for isolating proteins from a solution comprising proteins, wherein the solution is selected from the group consisting of: crude bood plasma, blood serum, cryosupernatant derived from plasma, fractionated human plasma, cryoprecipitate derived from plasma and recombinant broths. The process involves providing a solid separation medium having the formula: M-S-L wherein M is a matrix backbone, S is an optional spacer arm, and L is a ligand which is mercaptonicotinic acid, contacting the solid separation medium with the solution comprising the proteins, such that at least one of the proteins becomes reversibly bound bound to said solid separation medium. At least one elution step is then performed to selectively elute at least one protein fraction from the solid separation medium. In another aspect, the present invention is directed to a process for isolating Factor VIII and/or Factor IX.
摘要翻译：一方面，本发明涉及从包含蛋白质的溶液中分离蛋白质的方法，其中所述溶液选自：粗制血浆，血清，源自血浆的冷冻上清液，分级人血浆，衍生的冷沉淀物来自血浆和重组肉汤。该方法包括提供具有下式的固体分离介质：MSL其中M是基质骨架，S是可选的间隔臂，L是一种配位体，它是巯基烟酸，使固体分离介质与包含蛋白质的溶液接触，至少一种蛋白质变得可结合结合到所述固体分离介质上。然后进行至少一个洗脱步骤以从固体分离介质中选择性洗脱至少一种蛋白质级分。另一方面，本发明涉及分离因子VIII和/或因子IX的方法。

23. 发明申请

WO2005061543A1 PURIFICATION OF IMMUNOGLOBULINS 审中-公开
标题翻译：免疫球蛋白的纯化
公开(公告)号：WO2005061543A1
公开(公告)日：2005-07-07
申请号：PCT/SE2004/002007
申请日：2004-12-21
申请人： AMERSHAM BIOSCIENCES AB , GLAD, Gunnar , JOHANSSON, Bo-Lennart , MALOISEL, Jean-Luc , NORRMAN, Nils
发明人： GLAD, Gunnar , JOHANSSON, Bo-Lennart , MALOISEL, Jean-Luc , NORRMAN, Nils
IPC分类号： C07K16/06
CPC分类号： B01J20/262 , B01J20/267 , B01J20/28019 , B01J20/28023 , B01J20/28033 , B01J20/28042 , B01J20/286 , B01J20/289 , B01J20/3092 , B01J20/3208 , B01J20/3212 , B01J20/3219 , B01J20/3246 , B01J20/3248 , B01J20/3251 , B01J20/3255 , B01J20/3272 , B01J20/3285 , B01J2220/54 , B01J2220/58 , C07K16/065 , Y10T428/249963
摘要： The present invention relates to a separation matrix comprised of a porous support to which ligands have been immobilised, wherein said ligands comprise at least one aliphatic sulphonamide. The nitrogen of the sulphonamide may be a secondary or tertiary amine. The invention also relates to a chromatography column that contains the described separation matrix, as well as to a method of isolating immunoglobulin-like compounds by adsorption to a separation matrix that comprises aliphatic sulphonamide ligands.
摘要翻译：本发明涉及由已经固定有配体的多孔载体组成的分离基质，其中所述配体包含至少一种脂族磺酰胺。磺酰胺的氮可以是仲胺或叔胺。本发明还涉及含有所述分离基质的色谱柱，以及通过吸附到包含脂族磺酰胺配体的分离基质上分离免疫球蛋白样化合物的方法。

24. 发明申请

WO2005018803A1 IMMOBILIZATION MATRIX FOR PEPTIDES AND PROTEINS 审中-公开
标题翻译：肽和蛋白质的固定化矩阵
公开(公告)号：WO2005018803A1
公开(公告)日：2005-03-03
申请号：PCT/GB2004/003549
申请日：2004-08-18
申请人： WIVENHOE TECHNOLOGY LTD , CHERNUKHIN, Igor , KLENOVA, Elena
发明人： CHERNUKHIN, Igor , KLENOVA, Elena
IPC分类号： B01J20/32
CPC分类号： G01N33/545 , B01D15/3804 , B01J20/261 , B01J20/2803 , B01J20/28033 , B01J20/28085 , B01J20/286 , B01J20/289 , B01J20/3042 , B01J20/3071 , B01J20/3085 , B01J20/3092 , B01J20/321 , B01J20/3217 , B01J20/3219 , B01J20/3248 , B01J20/3251 , B01J20/3255 , B01J20/3274 , B01J2220/54 , B01J2220/58 , B01J2220/62 , B01J2220/64 , B01J2220/66 , C07K16/18 , C07K17/08
摘要： The invention relates to sintered thermoplastic polymer matrices and to the uses of such matrices for the immobilization of peptides and proteins. Preferably, the polymer used is polyethylene.
摘要翻译：本发明涉及烧结热塑性聚合物基质和这种基质用于固定肽和蛋白质的用途。优选使用的聚合物是聚乙烯。

25. 发明申请

WO2004065566A2 ALKYL-LINKED NUCLEOTIDE COMPOSITIONS 审中-公开
标题翻译：烷基连接的核苷酸组合物
公开(公告)号：WO2004065566A2
公开(公告)日：2004-08-05
申请号：PCT/US2004/001745
申请日：2004-01-22
申请人： SERENEX, INC. , HARDEMAN, Klass, P. , HALL, Steven, E. , WARE, Roy, W. , HINKLEY, Lindsay, A. , JENKS, Matthew, G.
发明人： HARDEMAN, Klass, P. , HALL, Steven, E. , WARE, Roy, W. , HINKLEY, Lindsay, A. , JENKS, Matthew, G.
IPC分类号： C12N
CPC分类号： B01D15/3819 , B01J20/289 , C07H21/04
摘要： Alkyl-linked nucleotide compositions and nucleotide affinity media comprising an alkyl-linked nucleotide are provided. The linker is generally a hydrophobic linker that can be a 3, 4, 5, 6, 7, 8, 9, 10, or a longer carbon chain. Also included in the invention are methods for synthesis of an alkyl-linked nucleotide, nucleotide affinity media and methods of use thereof for affinity chromatography and screening methods.
摘要翻译：提供了烷基连接的核苷酸组合物和包含烷基连接的核苷酸的核苷酸亲和介质。接头通常是疏水性接头，其可以是3,4,5,6,7,8,9,10或更长的碳链。本发明还包括用于合成烷基连接的核苷酸，核苷酸亲和介质的方法以及其用于亲和色谱和筛选方法的方法。

26. 发明申请

WO02055026A2 PERFLUORO SULFONYL HALIDES AND RELATED SPECIES AS POLYMER SUPPORT MODIFIERS 审中-公开
标题翻译：全氟磺酰卤及相关物种作为聚合物载体改性剂
公开(公告)号：WO02055026A2
公开(公告)日：2002-07-18
申请号：PCT/US2002/000839
申请日：2002-01-11
IPC分类号： G01N33/543 , B01J19/00 , B01J20/289 , B01J20/32 , B01J31/10 , B01J31/22 , B01J31/24 , C07B61/00 , C07C15/24 , C07C43/20 , C07C49/76 , C07C49/782 , C07C49/786 , C07C49/807 , C07C49/84 , C07C233/07 , C07C255/54 , C07C309/24 , C07C309/82 , C07C309/83 , C07C309/84 , C07F7/08 , C40B50/14 , C40B60/14 , A61K
CPC分类号： C40B50/14 , B01J19/0046 , B01J20/289 , B01J20/3204 , B01J20/321 , B01J20/3212 , B01J20/3219 , B01J20/3251 , B01J20/3257 , B01J31/10 , B01J31/1658 , B01J31/2208 , B01J31/2409 , B01J2219/00283 , B01J2219/00454 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00626 , B01J2219/00637 , B01J2219/00641 , B01J2219/0072 , B01J2219/00738 , B01J2231/4211 , B01J2231/4255 , B01J2231/4261 , B01J2231/4266 , B01J2531/824 , C07B2200/11 , C07C309/10 , C07C309/24 , C07C309/82 , C07C309/84 , C07F7/0834 , C40B60/14 , C40B80/00 , C40B99/00
摘要： Activated Supports, support-bound activators, strongly acidic supports, and silylating supports are provided; the activated support having the formula (I) wherein L is a linking group component; X is F, CL, OH, and trisubstituted silyloxy; and the shaded circle represents a solid or semi-solid support. Methods of using the activated supports in solid phase organic synthesis are also provided.
摘要翻译：本发明涉及活化的载体，与载体结合的促进剂，强酸性载体和甲硅烷基化载体。活化的载体具有式（I），其中L是连接基团的元素; X是F，CL，OH和三取代的甲硅烷氧基; 阴影圆表示固体或半固体支持物。本发明进一步涉及在固相有机合成中使用活化介质的方法。

27. 发明申请

WO1995029702A1 TEXAPHYRIN SOLID-SUPPORTS AND DEVICES 审中-公开
标题翻译： TEXAPHYRIN固体支持和设备
公开(公告)号：WO1995029702A1
公开(公告)日：1995-11-09
申请号：PCT/US1995005421
申请日：1995-04-28
申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM , PHARMACYCLICS, INC.
发明人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM , PHARMACYCLICS, INC. , SESSLER, Jonathan, L. , IVERSON, Brent, L. , KRAL, Vladimir , THOMAS, Richard, E. , SMITH, Daniel, A. , MAGDA, Darren
IPC分类号： A61K47/48
CPC分类号： B01J20/3219 , A61K41/0076 , A61K47/546 , A61K47/6903 , A61K47/6923 , A61K49/18 , A61L27/40 , A61L29/12 , A61L31/12 , B01J20/223 , B01J20/289 , B01J20/29 , B01J20/3204 , B01J20/321 , B01J20/3212 , B01J20/3265 , B01J31/1658 , B01J31/1815 , B01J2220/4825 , B01J2220/54 , B01J2220/58 , B01J2220/62 , B01J2220/84 , B01J2531/025 , B01J2531/36 , B01J2531/37 , B01J2531/38 , C07F5/00 , C12N15/101
摘要： The present invention provides various novel matrix-supported texaphyrins in which a polymeric or solid matrix is covalently modified by the addition of one or more texaphyrins or texaphyrin derivatives. Described are methods of making various polymer-supported texaphyrins, including texaphyrin chromatographic supports, and devices such as catheters, as may be used, for example, in the separation of neutral and anionic species and in applications concerning phosphate ester hydrolysis, other catalytic schemes, MRI, and PDT.
摘要翻译：本发明提供了各种新型的基质支持的泰克萨克逊，其中聚合物或固体基质通过加入一种或多种泰克萨菲瑞或泰克萨菲瑞衍生物共价修饰。描述了制备各种聚合物支持的泰克萨菲瑞，包括泰克萨菲林色谱载体和诸如导管的装置的方法，例如可用于分离中性和阴离子物质以及在磷酸酯水解，其它催化方案中的应用， MRI和PDT。

28. 发明申请

WO1986002654A1 SULPHURYL CHLORIDE/POLYAMIDE DERIVATIVES 审中-公开
标题翻译：氯化锂/聚酰胺衍生物
公开(公告)号：WO1986002654A1
公开(公告)日：1986-05-09
申请号：PCT/AU1985000260
申请日：1985-10-29
申请人： MEMTEC LIMITED , FORD, Douglas, Lyons
发明人： MEMTEC LIMITED
IPC分类号： C08G69/48
CPC分类号： B01J20/289 , B01J20/262 , B01J20/265 , C07K17/08 , C08G69/48 , C12N11/08 , G01N33/54353
摘要： Aliphatic polyamides are reacted on their surfaces with sulphuryl chloride, either neat or in solution in paraffins or cycloparaffins to give reactive intermediate which may convert into a support capable of reaction with antibodies or enzymes by providing covalent chemical links to which the antibodies or enzymes may be bound.
摘要翻译：脂肪族聚酰胺在其表面上与硫酰氯反应，纯的或在石蜡或环烷烃中的溶液中，以产生反应性中间体，其可以通过提供与抗体或酶可能相互作用的共价化学连接而转化成能够与抗体或酶反应的载体界。

29. 发明申请

WO2016115101A1 CHROMATOGRAPHIC MATERIAL HAVING IMPROVED PH STABILITY, METHOD FOR PREPARATION THEREOF AND USES THEREOF 审中-公开
标题翻译：具有改善PH稳定性的色谱材料，其制备方法及其用途
公开(公告)号：WO2016115101A1
公开(公告)日：2016-07-21
申请号：PCT/US2016/012998
申请日：2016-01-12
申请人： DIONEX CORPORATION
发明人： LIU, Xiaodong , CUI, Xiao , SUN, Xuefei
IPC分类号： B01J20/287 , B01J20/32 , B01D15/08
CPC分类号： B01J20/287 , B01D15/20 , B01D15/325 , B01J20/289 , B01J20/3078 , B01J20/3092 , B01J20/3204 , B01J20/3217 , B01J20/3272 , B01J20/328 , B01J2220/44 , B01J2220/52 , B01J2220/54 , B01J2220/58 , C07D493/04 , C07H1/06 , C07H15/224 , C07H15/23 , C07H15/232 , C07H15/234 , C07H15/238 , C08G77/392
摘要： A chromatographic material including a substrate having a surface and having a polymeric layer covalently bound to the surface; the polymeric layer comprising polymer molecules covalently attached to the surface of the substrate, each polymer molecule being attached to the surface via multiple siloxane bonds and each polymer molecule being connected to one or more functionalizing compounds that each comprise a functional group, wherein the polymeric layer is formed by covalently attaching polymer molecules to the surface of the substrate via multiple siloxane bonds, each polymer molecule containing multiple first reactive groups, and reacting the first reactive groups of the attached polymer molecules with at least one functionalizing compound that comprises a second reactive group that is reactive with the first reactive groups and that further comprises a functional group. Preferred conditions of reacting the polymer with the substrate include elevated temperature and reduced pressure.
摘要翻译：一种色谱材料，其包括具有表面并具有共价结合到所述表面的聚合物层的基底; 所述聚合物层包含共价连接到所述基底的表面的聚合物分子，每个聚合物分子经由多个硅氧烷键连接到所述表面，并且每个聚合物分子与一个或多个各自包含官能团的官能化化合物连接，其中所述聚合物层通过多个硅氧烷键将聚合物分子共价连接到基材的表面上，每个聚合物分子含有多个第一反应性基团，并使连接的聚合物分子的第一反应性基团与至少一种包含第二反应性基团的官能化化合物反应形成其与第一反应性基团反应并且还包含官能团。使聚合物与基材反应的优选条件包括提高温度和减压。

30. 发明申请

WO2016011427A1 HIGH EFFICIENCY, ULTRA-STABLE, BONDED HYDROPHILIC INTERACTION CHROMATOGRAPHY (HILIC) MATRIX ON SUPERFICIALLY POROUS PARTICLES (SPPS) 审中-公开
标题翻译：高效率，超稳定，结合的亲水相互作用色谱（HILIC）基质在超孔隙颗粒（SPPS）上的应用
公开(公告)号：WO2016011427A1
公开(公告)日：2016-01-21
申请号：PCT/US2015041028
申请日：2015-07-17
申请人： AZYP LLC
发明人： ARMSTRONG DANIEL W , BREITBACH ZACHARY S
IPC分类号： B01J20/288
CPC分类号： B01D15/305 , B01J20/103 , B01J20/22 , B01J20/24 , B01J20/28004 , B01J20/28061 , B01J20/28078 , B01J20/28083 , B01J20/283 , B01J20/288 , B01J20/289 , B01J20/29 , B01J20/3204 , B01J20/3217 , B01J20/3219 , B01J20/3263 , B01J20/3285 , B01J20/3293 , B01J2220/46 , B01J2220/54
摘要： The present invention relates to superficially porous particles (SPPs), also called core-shell, porous shell or fused core particles, which are state-of-the-art support materials used in the production of HPLC columns. Hydrolytically stable, highly selective superficially porous particle (SPP) hydrophilic interaction liquid chromatographic (HILIC) stationary phases having higher efficiencies and shorter retention times than analogous stationary phases on fully porous particles (FPP) is provided.
摘要翻译：本发明涉及表面多孔颗粒（SPPs），也称为核 - 壳，多孔壳或熔核颗粒，它们是用于HPLC柱生产的最先进的载体材料。提供了水解稳定的高选择性表面多孔颗粒（SPP）亲水相互作用液相色谱（HILIC）固定相，其具有比完全多孔颗粒（FPP）上的类似固定相更高的效率和更短的保留时间。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式