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21. 发明申请

WO1989011083A1 A FLOWMETER 审中-公开
标题翻译：流量计
公开(公告)号：WO1989011083A1
公开(公告)日：1989-11-16
申请号：PCT/DK1988000225
申请日：1988-12-29
申请人： NIELSEN, Paul, Verner
IPC分类号： G01F01/68
CPC分类号： G01F1/684 , A61B5/028 , G01F1/6847 , G01F1/6888 , G01F1/696 , G01P5/10
摘要： A flowmeter comprising a thermocouple and a current source for causing a temperature difference between the two junctions (24, 25) of the thermocouple. The thermocouple is connected to the current source (37) through a switch (36), a control input on the switch (36) being connected to a control device (35), also controlling a measuring circuit (34), which on its input port receives a signal representing the e.m.f. of the thermocouple (24, 25) during the periods of time where the current from the current source (37) to the thermocouple (24, 25) has been interrupted by the switch (36). The current source (37) and the hot and the cold junction of said thermocouple (24, 25) all are connectable in series by the control device (35) through the same two conductors (21, 22) also connected to the measuring circuit (33, 34).
摘要翻译：一种包括热电偶和电流源的流量计，用于引起热电偶的两个结（24,25）之间的温度差。热电偶通过开关（36）连接到电流源（37），开关（36）上的控制输入端连接到控制装置（35），也控制测量电路（34），其在其输入端端口接收到表示emf的信号在从电流源（37）到热电偶（24,25）的电流已经被开关（36）中断的时间段期间，热电偶（24,25）的位置。电流源（37）以及所述热电偶（24,25）的热连接点和冷端都可以由控制装置（35）通过同样连接到测量电路的两个导体（21,22）串联连接 33，34）。

22. 发明申请

WO1988006424A1 APPARATUS FOR MEASURING DATA OF LIVING BODY 审中-公开
标题翻译：用于测量生命体数据的装置
公开(公告)号：WO1988006424A1
公开(公告)日：1988-09-07
申请号：PCT/JP1988000235
申请日：1988-03-03
申请人： TERUMO KABUSHIKI KAISHA , SEKII, Shigekazu , IKEDA, Makoto , TSUCHIDA, Kouji
发明人： TERUMO KABUSHIKI KAISHA
IPC分类号： A61B05/00
CPC分类号： G01R1/073 , A61B5/00 , A61B5/028 , G16H40/63
摘要： An apparatus for measuring data of a living body by contacting a probe to the living body or by inserting it in the living body. The apparatus comprises a living body data detecting circuit for electrically detecting data of a living body and a living body data processing circuit for digitally processing the detected data of the living body. The signals are exchanged between the living body data detecting circuit and the living body data processing circuit under an electrically insulated condition. Preferably, there are provided a first power source circuit which supplies electric power to the living body data detecting circuit only and a second power source circuit, which supplies electric power to the first power source circuit, and the electric power is supplied from the second power source circuit to the first power source circuit under the electrically insulated condition. Preferably, furthermore, the electric bias quantity applied to the detector element in the probe is compared with the bias quantity that is fed back through the detector element, in order to detect the presence of any leakage current in the living body. More preferably, an electric quantity of an element for correcting electric charateristics of the detector element in the probe is read prior to measuring the data of a living body, in order to make sure the presence of probe connection and the type thereof.

23. 发明申请

WO2017069755A1 THERMODILUTION INJECTATE MEASUREMENT AND CONTROL 审中-公开
标题翻译：热阻注射测量和控制
公开(公告)号：WO2017069755A1
公开(公告)日：2017-04-27
申请号：PCT/US2015/056765
申请日：2015-10-21
申请人： EDWARDS LIFESCIENCES CORPORATION
发明人： SIEMONS, Alexander, H. , LIU, Wei-Jiun
IPC分类号： A61B5/028 , A61B5/00
CPC分类号： A61B5/028 , A61B5/029 , A61B5/0295 , A61B5/6852 , A61B5/7275 , A61B5/742
摘要： Apparatus and methods for the measurement, control, or both, of thermodilution injectate flow for calculation of transpulmonary thermodilution parameters. An injectate delivery system includes a syringe for holding an injectate and a conduit configured at one end to be connected to a catheter. A flow measurement device is interposed in the conduit to generate a signal for determining the flow rate of the fluid from the syringe to the catheter. A processor receives the signal from the flow measurement device and calculates the injectate volume to be used as input for calculating a transpulmonary thermodilution parameter such as cardiac output. A GUI is provided to direct a user on whether the injection rate is too fast or too slow. Rather than measuring or calculating flow rate, a system may include a constant flow valve to provide a constant flow rate from the syringe.
摘要翻译：用于计算经肺热稀释参数的热稀释注射液流量的测量，控制或两者的设备和方法。注射物输送系统包括用于保持注射物的注射器和一端构造成与导管连接的导管。流量测量装置插入导管中以产生用于确定从注射器到导管的流体流量的信号。处理器接收来自流量测量装置的信号并且计算将用作输入的注射物体积，用于计算诸如心输出量的经肺热稀释参数。提供GUI以指导用户注射速度是太快还是太慢。系统可以包括恒定流量阀以提供来自注射器的恒定流速，而不是测量或计算流量。

24. 发明申请

WO2014153202A4 APPARATUS AND METHODS FOR COMPUTING CARDIAC OUTPUT OF A LIVING SUBJECT VIA APPLANATION TONOMETRY 审中-公开
标题翻译：用于计算生活物质的心脏输出的装置和方法
公开(公告)号：WO2014153202A4
公开(公告)日：2014-12-11
申请号：PCT/US2014029580
申请日：2014-03-14
申请人： TENSYS MEDICAL INC , HIGH DIM GMBH
发明人： GOEDJE OLIVER , BOHN MATTHIAS , HUNZIKER PATRICK , MOROZOV OLEKSII , FRIEDRICH FELIX
IPC分类号： A61B5/021
CPC分类号： A61B5/7278 , A61B3/165 , A61B5/02 , A61B5/021 , A61B5/02108 , A61B5/024 , A61B5/028 , A61B5/029 , A61B5/0452 , A61B5/742 , A61B8/02 , A61B8/06 , A61B8/065 , A61B8/12 , A61B8/4416 , A61B8/481 , A61B8/488
摘要： Apparatus and methods for calculating cardiac output (CO) of a living subject using applanation tonometry measurements. In one embodiment, the apparatus and methods build a nonlinear mathematical model to correlate physiologic source data vectors to target CO values. The source data vectors include one or more measurable or derivable parameters such as: systolic and diastolic pressure, pulse pressure, beat-to-beat interval, mean arterial pressure, maximal slope of the pressure rise during systole, the area under systolic part of the pulse pressure wave, gender (male or female), age, height and weight. The target CO values are acquired using various methods, across a plurality of individuals. Multidimensional nonlinear optimization is then used to find a mathematical model which transforms the source data to the target CO data. The model is then applied to an individual by acquiring physiologic data for the individual and applying the model to the collected data.
摘要翻译：使用压平眼压测量法计算活体的心输出量（CO）的装置和方法。在一个实施例中，装置和方法构建非线性数学模型以将生理源数据向量与目标CO值相关联。源数据矢量包括一个或多个可测量或可推导的参数，例如：收缩压和舒张压，脉搏压，搏动间隔，平均动脉压，收缩压升高的最大斜率，收缩期部分的面积脉压波，性别（男性或女性），年龄，身高和体重。使用各种方法在多个个体中获取目标CO值。然后使用多维非线性优化来找到将源数据转换为目标CO数据的数学模型。然后通过获取个体的生理数据并将模型应用于收集的数据，将该模型应用于个体。

25. 发明申请

WO2013085908A1 METHODS AND SYSTEMS FOR PHOTOACOUSTIC MONITORING USING INDICATOR DILUTION 审中-公开
标题翻译：使用指示剂稀释的光电监测的方法和系统
公开(公告)号：WO2013085908A1
公开(公告)日：2013-06-13
申请号：PCT/US2012/067773
申请日：2012-12-04
申请人： COVIDIEN LP
发明人： LI, Youzhi , CHEN, Bo , WOOD, Lockett , BORG, Ulf
IPC分类号： A61B5/028 , A61B5/029 , A61B5/1455
CPC分类号： A61B5/0095 , A61B5/02028 , A61B5/0205 , A61B5/0261 , A61B5/0275 , A61B5/028 , A61B5/029 , A61B5/14546 , A61B5/1455 , A61B2560/0223
摘要： A patient monitoring system may provide photoacoustic sensing based on an indicator dilution to determine one or more physiological parameters of a subject. The system may detect an acoustic pressure signal, which may include one or more thermo-dilution responses, one or more hemo-dilution responses, or a combination thereof. For example, a thermo-dilution indicator and/or a hemo-dilution indicator may be used to determine one or more hemodynamic parameters. In a further example, an isotonic indicator and a hypertonic indicator may be used to determine one or more hemodynamic parameters of the subject.
摘要翻译：患者监测系统可以基于指示剂稀释提供光声感测以确定受试者的一个或多个生理参数。该系统可以检测声压信号，其可以包括一个或多个热稀释响应，一个或多个血稀释响应或其组合。例如，可以使用热稀释指示剂和/或血稀释指示剂来确定一个或多个血液动力学参数。在另一个实例中，等渗指示剂和高渗指示剂可用于确定受试者的一个或多个血液动力学参数。

26. 发明申请

WO2013085905A1 METHODS AND SYSTEMS FOR PHOTOACOUSTIC MONITORING USING INDICATOR DILUTION 审中-公开
标题翻译：使用指示剂稀释进行光声监测的方法和系统
公开(公告)号：WO2013085905A1
公开(公告)日：2013-06-13
申请号：PCT/US2012/067770
申请日：2012-12-04
申请人： COVIDIEN LP
发明人： LI, Youzhi , CHEN, Bo , WOOD, Lockett , BORG, Ulf
IPC分类号： A61B5/1455 , A61B5/026 , A61B5/028
CPC分类号： A61B5/0095 , A61B5/02028 , A61B5/0205 , A61B5/0261 , A61B5/0275 , A61B5/028 , A61B5/029 , A61B5/14546 , A61B5/1455 , A61B2560/0223
摘要： A patient monitoring system may provide photoacoustic sensing based on an indicator dilution to determine one or more physiological parameters of a subject. The system may detect an acoustic pressure signal, which may include one or more thermo-dilution responses, one or more hemo-dilution responses, or a combination thereof. For example, a thermo-dilution indicator and/or a hemo-dilution indicator may be used to determine one or more hemodynamic parameters. In a further example, an isotonic indicator and a hypertonic indicator may be used to determine one or more hemodynamic parameters of the subject.
摘要翻译：患者监测系统可以基于指示剂稀释来提供光声传感以确定对象的一个或多个生理参数。该系统可以检测声压信号，其可以包括一个或多个热稀释响应，一个或多个血液稀释响应或其组合。例如，可以使用热稀释指示器和/或血液稀释指示器来确定一个或多个血液动力学参数。在进一步的例子中，等渗指示剂和高渗指示剂可以用于确定受试者的一种或多种血液动力学参数。

27. 发明申请

WO2011097568A2 DEVICES, SYSTEMS, AND METHODS FOR MEASURING PARALLEL TISSUE CONDUCTANCE, LUMINAL CROSS-SECTIONAL AREAS, FLUID VELOCITY, AND/OR DETERMINING PLAQUE VULNERABILITY USING TEMPERATURE 审中-公开
标题翻译：用于测量平行组织结构，红外交叉区域，流体速度和/或确定使用温度的液体脆性的装置，系统和方法
公开(公告)号：WO2011097568A2
公开(公告)日：2011-08-11
申请号：PCT/US2011/023911
申请日：2011-02-07
申请人： DTHERAPEUTICS, LLC , KASSAB, Ghassan, S.
发明人： KASSAB, Ghassan, S.
IPC分类号： G01K5/22
CPC分类号： G01K13/002 , A61B5/02007 , A61B5/028 , A61B5/0538 , A61B5/6853
摘要： Devices, systems, and methods for measuring parallel tissue conductance, luminal cross-sectional areas, fluid velocity, and/or determining plaque vulnerability using temperature. In at least one embodiment of a method to obtain parallel tissue conductance, the method comprises the steps of inserting at least part of a detection device into a luminal organ, applying current thereto, obtaining a native temperature measurement, injecting a solution of a known conductivity into the luminal organ, detecting a temperature change indicative of the fluid within the luminal organ, measuring an output conductance, and calculating a parallel tissue conductance based upon the output conductance and the conductivity of the injected solution.
摘要翻译：用于测量平行组织电导，腔内横截面积，流体速度和/或使用温度确定斑块脆弱性的装置，系统和方法。在获得平行组织电导的方法的至少一个实施例中，该方法包括以下步骤：将至少部分检测装置插入管腔器官，向其施加电流，获得天然温度测量值，注入已知电导率的溶液检测指示管腔器官内的流体的温度变化，测量输出电导，以及基于注射溶液的输出电导和电导率计算平行组织电导。

28. 发明申请

WO2010026148A1 OPTISCHER MESS-KATHETER ZUR THERMODILUTIONS-MESSUNG UND PULSKONTURANALYSE 审中-公开
标题翻译：光学测量导管中的热稀释测量和脉冲轮廓分析
公开(公告)号：WO2010026148A1
公开(公告)日：2010-03-11
申请号：PCT/EP2009/061314
申请日：2009-09-02
申请人： PULSION MEDICAL SYSTEMS AG , BOHN, Matthias , GÖDJE, Oliver , HERZ, Robert , JOEKEN, Stephan , VEECK, Marcus
发明人： BOHN, Matthias , GÖDJE, Oliver , HERZ, Robert , JOEKEN, Stephan , VEECK, Marcus
IPC分类号： A61B5/026 , A61B5/028 , A61B5/0215
CPC分类号： A61B5/02154 , A61B5/0261 , A61B5/028
摘要： Die Erfindung betrifft eine Kathetervorrichtung mit integrieter Faseroptik, insbesondere zum Einsatz in der Thermodilutionsmessung und der Pulskonturanalyse. Dabei weist die Vorrichtung einen arteriellen Katheter (2) mit einem bestimmungsgemäß intravasalen und einem bestimmungsgemäß extravasalen Teil sowie eine optische Sensoreinheit zur kombinierten Druck- und Temperaturmessung an einem Messort am distalen Ende des bestimmungsgemäß intravasalen Teils oder in der Nähe des distalen Endes bestimmungsgemäß intravasalen Teils des Katheters (2) auf. Die optische Sensoreinheit weist einen faseroptischen Leiter (11) auf, welcher vom Messort zu einem proximalen Port verläuft.
摘要翻译：本发明涉及一种导管装置与集成光纤，特别是用于热稀释和脉冲轮廓分析的用途。在这种情况下，该设备包括动脉导管（2），其具有用于以期望的血管内部分的远端或远端附近的测定部位的组合的压力和温度测量预期的血管内和预期的血管外部和光传感器部意图的血管内部分导管（2）。光学传感器单元包括从所述测量的位置到近端端口延伸的纤维光学导体（11）。

29. 发明申请

WO2009146918A3 DEVICE FOR DETERMINING THE BLOOD VOLUME AND/OR BLOOD VOLUMETRIC FLOW AND METHOD FOR OPERATING THE SAME 审中-公开
标题翻译：一种用于确定用于操作该血容量和/或血液的流速和方法
公开(公告)号：WO2009146918A3
公开(公告)日：2010-02-04
申请号：PCT/EP2009004019
申请日：2009-06-04
申请人： IPRM INTELLECTUAL PROPERTY RIG , PFEIFFER ULRICH , KNOLL REINHOLD
发明人： PFEIFFER ULRICH , KNOLL REINHOLD
IPC分类号： A61B5/028
CPC分类号： A61B5/028 , A61B5/029 , A61M1/36 , A61M1/3607 , A61M2205/3331 , A61M2205/3368
摘要： The invention relates to a device (1) for determining the blood volume and/or blood volumetric flow of a circulation section, comprising a fluid storage unit (2) for storing a measuring fluid (3), an injection device for the injection of the measuring fluid into the circulatory system, at least one pump device (5) disposed between the fluid storage unit and the injection device, means for determining at least one property of the measuring fluid before injection into the circulatory system, further means for determining the respective properties in the circulatory system downstream of the injection site, and an analysis device for calculating the blood volume or volumetric flow as a function of the properties determined. The invention further relates to such a device having means for conditioning the measuring fluid. The invention provides that the measuring fluid can be supplied from the fluid storage unit to a second pump device (9) by means of a first pump device (5), and from the second pump device to the catheter. The invention further provides that the measuring fluid can be supplied to the catheter (11) at a first volumetric flow provided by the first pump device, said first volumetric flow able to be temporarily, in particular regularly, superimposed by a second volumetric flow provided by the second pump device, and/or that the means for conditioning the measuring fluid act upon at least one pump device. The invention also relates to a method for operating such devices.
摘要翻译：本发明涉及一种装置（1），用于确定的血液和/或具有一个液体储存器（2）的循环部分的血流量的体积，用于存储测量液体（3），用于注入液体的喷射装置，以在血流中来测定，的液体储存器和之间的至少一个注射装置，其设置泵装置（5），用于确定所述测量流体之前注射到血液循环，其它装置中的至少一个属性，用于确定在注射部位的血流下游的相应的属性，并根据特定的属性血容量或-volumenstrom的计算的评估装置，本发明还涉及一种具有用于调节所述测量液体这样的装置。根据本发明，它提供了从液体储存器中的测量液体通过第一泵送装置的装置（5）的第二泵压装置（9），并且可以从第二泵装置供给至导管。还可以预期的是与来自第一泵供给的测量液体是指所述第一体积流至导管（11）可以被馈送到由第二泵送装置，第二体积流量提供的一个服务，暂时重叠，特别是周期性地和/或该装置用于调节所述测量液体作用于至少一个泵送装置。本发明还涉及一种用于操作这样的装置的方法。

30. 发明申请

WO2008139347A1 SENSOR PROBE FOR MEASURING A PHYSICAL PROPERTY INSIDE A BODILY LUMEN 审中-公开
标题翻译：用于测量身体内的物理性质的传感器探针
公开(公告)号：WO2008139347A1
公开(公告)日：2008-11-20
申请号：PCT/IB2008/051637
申请日：2008-04-28
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , DEKKER, Ronald , SUIJVER, Jan, F. , HAARTSEN, Jacob, R.
发明人： DEKKER, Ronald , SUIJVER, Jan, F. , HAARTSEN, Jacob, R.
IPC分类号： A61B5/0215 , A61B5/027 , A61B5/028 , A61M25/00
CPC分类号： A61B5/027 , A61B5/0215 , A61B5/028 , A61M2025/0002
摘要： A sensor probe (100) for measuring a physical propertyinside a bodily lumen. The sensor probe (100) comprises a catheter (1) having a hollow distalend (2) and a flexible monolithic integrated circuit foil (3), which comprises a sensor, wherein the flexible foil (3) is provided in and is extendable from the hollow distal end (2) ofthe catheter (1). This enables the measurement of, for example, a blood flow5 and/or pressureinside an artery as well as in a small and/ordif f icult to reach locations, such as an aneurysm (12).
摘要翻译：用于测量身体内部物理特性的传感器探针（100）。传感器探针（100）包括具有中空的远端（2）和柔性单片集成电路箔（3）的导管（1），其包括传感器，其中柔性箔（3）设置在可从导管（1）的中空末端（2）。这使得能够测量例如动脉血流5和/或压力，以及在小和/或难以到达诸如动脉瘤（12）的位置。

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