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21. 发明申请

WO2012027481A1 COMPOUNDS FOR TREATMENT OF CANCER 审中-公开
标题翻译：用于治疗癌症的化合物
公开(公告)号：WO2012027481A1
公开(公告)日：2012-03-01
申请号：PCT/US2011048980
申请日：2011-08-24
申请人： GTX INC , UNIV TENNESSEE REASEARCH FOUNDATION , DALTON JAMES T , MILLER DUANE D , LI CHIEN-MING , AHN SUNJOO , LU YAN , WANG ZHAO , CHEN JIANJUN , LI WEI , DUKE CHARLES
发明人： DALTON JAMES T , MILLER DUANE D , LI CHIEN-MING , AHN SUNJOO , LU YAN , WANG ZHAO , CHEN JIANJUN , LI WEI , DUKE CHARLES
IPC分类号： A01N43/50 , A61K31/415
CPC分类号： A61K31/415 , C07D233/60 , C07D263/32 , C07D277/24 , C07D277/42 , C07D403/04 , C07D403/12 , C07D417/04 , C07D417/12 , C07D417/14
摘要： The present invention relates to novel compounds having anti-cancer activity, methods of making these compounds, and their use for treating cancer and drug-resistant tumors, e.g. melanoma, metastatic melanoma, drug resistant melanoma, prostate cancer and drug resistant prostate cancer.
摘要翻译：本发明涉及具有抗癌活性的新化合物，制备这些化合物的方法及其用于治疗癌症和药物抗性肿瘤的用途，例如，黑素瘤，转移性黑素瘤，耐药性黑素瘤，前列腺癌和耐药前列腺癌。

22. 发明申请

WO2010115046A2 VACCINE COMPOSITIONS AND METHODS OF USE THEREOF 审中-公开
标题翻译：疫苗组合物及其使用方法
公开(公告)号：WO2010115046A2
公开(公告)日：2010-10-07
申请号：PCT/US2010029694
申请日：2010-04-01
申请人： UNIV MIAMI , DAFTARIAN PIROUZ MOHAMMAD , SERAFINI PAOLO , LEMMON VANCE PAUL , LI WEI , KAIFER ANGEL , BLOMBERG BONNIE BETH , PEREZ VICTOR L
发明人： DAFTARIAN PIROUZ MOHAMMAD , SERAFINI PAOLO , LEMMON VANCE PAUL , LI WEI , KAIFER ANGEL , BLOMBERG BONNIE BETH , PEREZ VICTOR L
IPC分类号： A61K39/145
CPC分类号： A61K39/0011 , A61K39/12 , A61K39/145 , A61K2039/53 , A61K2039/55516 , A61K2039/55555 , A61K2039/645 , C08G83/006 , C12N2760/16022 , C12N2760/16034 , G01N2333/70539
摘要： Nanoparticle -based vaccines, compositions, kits and methods are used for the effective delivery of one or more antigens in vivo for vaccination and antibody (e.g., monoclonal antibody) production, and for the effective delivery of peptides, proteins, siRNA, RNA or DNA to PAPCs or MHC class II positive cells (e.g. tumor cells). Antigens may be, for example, DNA that results in expression of the gene of interest and induction of a robust and specific immune response to the expressed protein in a subject (e.g., mammal). Antigens may also be immunogenic peptides or polypeptides that are processed and presented. In one embodiment, a nanoparticle -based method to deliver antigens in vivo as described herein includes injection of a vaccine composed of a DNA encoding at least one antigen, or at least one antigenic peptide or polypeptide conjugated to a charged dendrimer (e.g., PADRE-derivatized dendrimer) that is also conjugated to a T helper epitope (e.g., PADRE). Negatively-charged plasmids bind naturally to a positively-charged PADRE-dendrimer, while peptide or polypeptide antigens can be chemically linked to the PADRE-dendrimer if they are not negatively-charged. Alternatively, negatively-charged dendrimers may be used. The compositions, kits, vaccines and methods described herein have both prophylactic and treatment applications, i.e., can be used as a prophylactic to prevent onset of a disease or condition in a subject, as well as to treat a subject having a disease or condition. A vaccine as described herein can be used to mount an immune response against any infectious pathogen or cancer.
摘要翻译：基于纳米颗粒的疫苗，组合物，试剂盒和方法用于体内有效递送一种或多种抗原用于疫苗接种和抗体（例如单克隆抗体）生产以及有效递送肽，蛋白质，siRNA，RNA或DNA 到PAPC或MHC II类阳性细胞（例如肿瘤细胞）。例如，抗原可以是导致感兴趣基因表达并诱导受试者（例如哺乳动物）中所表达的蛋白质的强烈和特异性免疫应答的DNA。抗原也可以是经过处理和呈递的免疫原性肽或多肽。在一个实施方案中，如本文所述的体内递送抗原的基于纳米粒子的方法包括注射由编码至少一种抗原的DNA组成的疫苗或缀合至带电荷的树状聚体的至少一种抗原性肽或多肽（例如PADRE- 衍生的树枝状聚合物），其也与T辅助表位（例如，PADRE）缀合。带负电荷的质粒自然结合带正电荷的PADRE-树状聚体，而肽或多肽抗原可以化学连接至PADRE-树状聚合物（如果它们不带负电荷的话）。或者，可以使用带负电的树枝状聚合物。本文所述的组合物，试剂盒，疫苗和方法具有预防和治疗应用，即可用作预防以预防对象中疾病或病症的发作，以及治疗患有疾病或病症的对象。如本文所述的疫苗可用于产生针对任何感染性病原体或癌症的免疫应答。

23. 发明申请

WO2009036059A2 NOVEL STAT3 PATHWAY INHIBITORS AND CANCER STEM CELL INHIBITORS 审中-公开
标题翻译：新型STAT3途径抑制剂和癌症干细胞抑制剂
公开(公告)号：WO2009036059A2
公开(公告)日：2009-03-19
申请号：PCT/US2008075848
申请日：2008-09-10
申请人： BOSTON BIOMEDICAL INC , JIANG ZHIWEI , LI CHIANG JIA , LI WEI , LEGGETT DAVID
发明人： JIANG ZHIWEI , LI CHIANG JIA , LI WEI , LEGGETT DAVID
IPC分类号： A61K31/505 , A61K31/55 , A61K38/17
CPC分类号： C07D307/92 , A61K31/38 , C07D333/74
摘要： The present invention relates to a novel naphtho class of compounds as Stat3 pathway inhibitors and as cancer stem cell inhibitors; to methods of using such compounds to treat cancer; to methods of using such compounds to treat disorders in a mammal related to aberrent Stat3 pathway activity; to pharmaceutical compositions containing such compounds.
摘要翻译：本发明涉及新的萘酚类化合物作为Stat3途径抑制剂和癌症干细胞抑制剂; 使用这些化合物治疗癌症的方法; 涉及使用这些化合物治疗哺乳动物与异常Stat3途径活性有关的疾病的方法; 含有这些化合物的药物组合物。

24. 发明申请

WO2008040015A2 3D MICRO-SCALE ENGINEERED TISSUE MODEL SYSTEMS 审中-公开
标题翻译： 3D微型工程组织模型系统
公开(公告)号：WO2008040015A2
公开(公告)日：2008-04-03
申请号：PCT/US2007079979
申请日：2007-09-28
申请人： UNIV WASHINGTON , LI WEI , WANG HAI
发明人： LI WEI , WANG HAI
IPC分类号： B01L3/00
CPC分类号： B01L3/502753 , B01L3/5025 , B01L3/5027 , B01L2200/12 , B01L2300/0681 , B01L2300/069 , B01L2300/0816 , B01L2300/0864 , C12M23/16 , C12M25/14 , C12M35/08
摘要： A polymeric chip having at least one three-dimensional porous scaffold, a microfluidic channel inlet to the porous scaffold, and a microfluidic channel outlet from the porous scaffold. In one embodiment, the polymeric chip has two three-dimensional porous scaffolds: one scaffold comprises liver cells and the other scaffold comprises cancer cells. The chip can be used as a multi-organ tissue model system.
摘要翻译：具有至少一个三维多孔支架，多孔支架的微流体通道入口和多孔支架的微流体通道出口的聚合物芯片。在一个实施方案中，聚合物芯片具有两个三维多孔支架：一个支架包含肝细胞，另一个支架包含癌细胞。该芯片可以用作多器官组织模型系统。

25. 发明申请

WO2006094445A8 CATALYST FOR OLEFIN POLYMERIZATION AND PREPARATION THEREOF AND POLYMERIZATION PROCESS 审中-公开
标题翻译：烯烃聚合催化剂及其制备方法及聚合方法
公开(公告)号：WO2006094445A8
公开(公告)日：2007-01-04
申请号：PCT/CN2006000274
申请日：2006-02-24
申请人： YINGKOU XIANGYANG CATALYST CO , UNIV DALIAN TECH , WANG LICAI , LI WEI , ZHENG GUOTONG , DONG QINGXIN , WANG JINGZHUANG , CAI SHIMIAN , GAO ZHANXIAN , LIU RIPING , WANG XIAOHUAN , ZHANG NAN
发明人： WANG LICAI , LI WEI , ZHENG GUOTONG , DONG QINGXIN , WANG JINGZHUANG , CAI SHIMIAN , GAO ZHANXIAN , LIU RIPING , WANG XIAOHUAN , ZHANG NAN
IPC分类号： C08F4/65 , B01J21/00 , B01J31/00 , B01J37/00 , C08F2/34 , C08F4/646 , C08F10/00 , C08F210/00
CPC分类号： C08F10/00 , B01J21/063 , B01J35/023 , B01J35/1019 , C08F110/06 , C08F4/6543 , C08F4/651 , C08F4/6545 , C08F2500/15 , C08F2500/18
摘要： The catalyst for olefin polymerization contains three components A, B and C. The component A is a solid catalyst containing titanium, magnesium, chlorine element and an internal electron donor, the internal electron donor consists of 1,4 aromatic diether [2,2'-dialkoxy-1,1'-biphenyl, 2,2'-dialkoxy-1,1'-binaphthalene, 10,10'-dialkoxy-9,9'-biphenanthrene] and organic acid ester or 1,3-diether[9,9-bis (methoxymethyl) fluorene, 2,2-dialkyl-1,3-dimethoxypropane]; the component B is an organoaluminum compound; the component C is external electron donor-organic silicon compound or the 1,4 aromatic diether. The catalyst has high catalytic activity, and can be adjusted in the range from 40,000 to 150,000 gPP/gCat when used in propylene polymerization. The polymer made therefrom has isotacticity of 80 to 99 percent and the molecular weight distribution can be adjusted in a wide range. The invention provides a novel method for preparing the 1,4 aromatic diether.
摘要翻译：用于烯烃聚合的催化剂包含三种组分A，B和C.组分A是含有钛，镁，氯元素和内电子给体的固体催化剂，内部电子给体由1,4芳族二醚[2,2' 二烷氧基-1,1'-联苯，2,2'-二烷氧基-1,1'-联萘，10,10'-二烷氧基-9,9'-联菲]和有机酸酯或1,3-二醚[9 ，9-双（甲氧基甲基）芴，2,2-二烷基-1,3-二甲氧基丙烷]; 组分B是有机铝化合物; 组分C是外电子给体 - 有机硅化合物或1,4-芳族二醚。该催化剂具有高催化活性，当用于丙烯聚合时可以将其调节至40,000至150,000gPP / gCat。由其制备的聚合物具有80-99％的全同立构规整度，并且可以在宽范围内调节分子量分布。本发明提供了一种制备1,4芳族二醚的新方法。

26. 发明申请

WO2013033625A2 SYSTEMS AND METHODS FOR SWITCHING A RELAY AT ZERO CROSS 审中-公开
标题翻译：用于在零交叉点切换继电器的系统和方法
公开(公告)号：WO2013033625A2
公开(公告)日：2013-03-07
申请号：PCT/US2012053509
申请日：2012-08-31
申请人： OSRAM SYLVANIA INC , LI WEI , BLISS CANYON
发明人： LI WEI , BLISS CANYON
CPC分类号： H01H9/56 , H01H47/325 , H01H2009/566
摘要： Circuitry, systems and methods that address the need to coordinate relay switching with another event, such as a zero crossing of an alternating current (AC) voltage waveform are described. In some embodiments, the systems and methods continuously or periodically calibrate the timing of control signals to a relay, such that the switching of the relay in response to some (e.g., second or subsequent) control signals occurs closer in time to a zero crossing of an AC line voltage than the switching of the relay in response to other (e.g., initial or first) control signals.
摘要翻译：描述了解决需要协调继电器切换与另一事件（例如交流（AC）电压波形的过零）的电路，系统和方法。在一些实施例中，系统和方法连续或周期性地对中继器的控制信号的定时校准，使得响应于一些（例如，第二或后续）控制信号的继电器的切换在时间上更接近于零交叉响应于其它（例如，初始或第一）控制信号的继电器的切换而言的AC线电压。

27. 发明申请

WO2011159739A3 REGISTER MAPPING TECHNIQUES FOR EFFICIENT DYNAMIC BINARY TRANSLATION 审中-公开
标题翻译：用于有效动态二进制翻译的注册映射技术
公开(公告)号：WO2011159739A3
公开(公告)日：2012-04-05
申请号：PCT/US2011040406
申请日：2011-06-14
申请人： INTEL CORP , OTTONI GUILHERME D , WANG HONG , LI WEI
发明人： OTTONI GUILHERME D , WANG HONG , LI WEI
IPC分类号： G06F9/45 , G06F9/24 , G06F9/30
CPC分类号： G06F8/441 , G06F9/45525
摘要： Generally, the present disclosure provides a system and method for mapping registers from a system with more registers to a system with fewer registers. Regions may be formed that include one or more blocks of code with relatively frequent register accesses. The most frequently accessed source registers may be mapped to target registers. Each block in the region may be bounded by a prologue and at least one epilogue. The prologue may be configured to implement register mapping and the epilogue(s) may be configured to manage program flow from a block in the region to another block in the region or to a block not in the region.
摘要翻译：通常，本公开提供了一种用于将具有更多寄存器的系统的寄存器映射到具有较少寄存器的系统的系统和方法。可以形成包括具有相对频繁的寄存器访问的一个或多个代码块的区域。最常访问的源寄存器可能被映射到目标寄存器。该区域中的每个块可以由前序和至少一个结尾界定。序言可以被配置为实现寄存器映射，并且结尾可以被配置为管理从该区域中的块到该区域中的另一块或者不在该区域中的块的程序流。

28. 发明申请

WO2010074776A3 COMPOUNDS FOR THE TREATMENT OF CANCER 审中-公开
标题翻译：治疗癌症的化合物
公开(公告)号：WO2010074776A3
公开(公告)日：2010-08-19
申请号：PCT/US2009047572
申请日：2009-06-16
申请人： UNIV TENNESSEE RES FOUNDATION , UNIV OHIO STATE RES FOUND , MILLER DUANE D , LI WEI , WANG ZHAO , LU YAN , CHEN JIANJUN , DALTON JAMES T , LI CHIEN-MING
发明人： MILLER DUANE D , LI WEI , WANG ZHAO , LU YAN , CHEN JIANJUN , DALTON JAMES T , LI CHIEN-MING
IPC分类号： A01N43/64 , A61K31/41
CPC分类号： C07D403/04 , A61K31/421 , A61K31/426
摘要： Compounds according to formula (I) are disclosed, (I), where Q is S, N, or O; X is optional, and can be O=, S=, =N-NH2, =N-OH, or -OH; Y is optional and can be -N(H)-, O, or C1 to C20 hydrocarbon; and R1 and R2 are each independently substituted or unsubstituted single-, fused- or multiple-ring aryl or (hetero)cyclic ring systems. Methods of making these compounds, pharmaceutical compositions containing the compounds, and their use, particularly for treating or preventing cancer, are also disclosed.
摘要翻译：公开了根据式（I）的化合物，（I），其中Q是S，N或O; X是可选的，并且可以是O =，S =，= N-NH 2，= N-OH或-OH; Y是任选的并且可以是-N（H） - ，O或C1至C20烃; 并且R 1和R 2各自独立地为取代或未取代的单环，稠环或多环芳基或（杂）环系。还公开了制备这些化合物的方法，含有该化合物的药物组合物及其用途，特别是用于治疗或预防癌症的用途。

29. 发明申请

WO2009129361A2 MACROCYCLIC COMPOUNDS AND METHODS OF MAKING AND USING THEREOF 审中-公开
标题翻译：大环化合物及其制备和使用方法
公开(公告)号：WO2009129361A2
公开(公告)日：2009-10-22
申请号：PCT/US2009040747
申请日：2009-04-16
申请人： UNIV UTAH RES FOUND , KECK GARY E , KRAFT MATTHEW B , TRUONG ANH P , SANCHEZ CARINA C , LI WEI , COVEL JONATHAN A , WELCH DENNIE , POUDEL YAM
发明人： KECK GARY E , KRAFT MATTHEW B , TRUONG ANH P , SANCHEZ CARINA C , LI WEI , COVEL JONATHAN A , WELCH DENNIE , POUDEL YAM
IPC分类号： C07D493/22 , A61K31/365 , A61P25/28 , A61P35/00 , C07F7/08
CPC分类号： C07D259/00 , A61K31/351 , A61K31/695 , C07D309/22 , C07D323/00 , C07D471/04 , C07D493/18 , C07D493/22 , C07F7/08 , C07F7/1876 , C07F7/1892
摘要： Described herein are tricyclic macrolactones. The macrolactones have a high binding affinity for PKC. The compounds described herein can be used in a number of therapeutic applications including cancer and Alzheimer's prevention and treatment. The compounds described herein can also treat memory loss. Also described herein are methods for producing macrolactones. The methods permit the high-yield synthesis of macrolactones in fewer steps and with a higher degree of substitution and specificity.
摘要翻译：本文描述的是三环大环内酯。该大环内酯对PKC具有高的结合亲和力。本文所述的化合物可用于许多治疗应用，包括癌症和阿尔茨海默病的预防和治疗。本文所述的化合物还可以治疗记忆丧失。本文还描述了生产羟基己内酯的方法。该方法允许以较少的步骤和更高的取代度和特异性高产率地合成大分子内酯。

30. 发明申请

WO2009072095A3 PAGE INDEXER 审中-公开
公开(公告)号：WO2009072095A3
公开(公告)日：2009-10-15
申请号：PCT/IB2008055666
申请日：2008-12-03
申请人： FRANCE TELECOM , BAJAJ RASHMI , LI WEI
发明人： BAJAJ RASHMI , LI WEI
IPC分类号： G06F17/30
CPC分类号： G06F17/30864 , G06F17/30867
摘要： The invention relates to a method to enhance the relevance of search results provided by a search engine server accessible through an operator network, said method comp rising the acts of: - collecting data related to a subscriber to said operator network, - aggregating said data to built a network profile for said subscriber, - receiving a search query from said subscriber addressed to the search engine server, - transmitting the search query to said search engine server through the network, said query being associated to at least part of the subscriber network profile, - receiving search results from the search engine server, said search results being ranked according to said at least part of the subscriber network profile.
摘要翻译：本发明涉及一种增强搜索引擎服务器提供的搜索结果的相关性的方法，所述搜索引擎服务器通过运营商网络可访问，所述方法提升以下行为： - 将与用户有关的数据收集到所述运营商网络; - 将所述数据聚合到为所述订户建立网络简档， - 从所述订户接收到寻址到搜索引擎服务器的搜索查询， - 通过网络将搜索查询发送到所述搜索引擎服务器，所述查询与至少部分订户网络简档 - 从搜索引擎服务器接收搜索结果，所述搜索结果根据所述至少部分订户网络简档进行排序。

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