专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

21. 发明申请

WO2007092720A2 ANALOGUE NEL DE LA VITAMINE D ET METHODES D'UTILISATION ASSOCIEES 审中-公开
标题翻译： ANALOGUE NEL DE LA VITAMINE D ET方法D'利用相关
公开(公告)号：WO2007092720A2
公开(公告)日：2007-08-16
申请号：PCT/US2007061402
申请日：2007-01-31
申请人： WISCONSIN ALUMNI RES FOUND , DELUCA HECTOR F , CHIELLINI GRAZIA , GRZYWACZ PAWEL , PLUM LORI A , CLAGETT-DAME MARGARET
发明人： DELUCA HECTOR F , CHIELLINI GRAZIA , GRZYWACZ PAWEL , PLUM LORI A , CLAGETT-DAME MARGARET
CPC分类号： C07C401/00 , C07F7/1856 , Y02P20/55
摘要： L'invention concerne des composés de formule (IA) ou (IB), dans laquelle X 1 , X 2 et X 3 sont indépendamment sélectionnés dans le groupe constitué par H ou des groupes de protection hydroxy; et R 1 est choisi parmi des groupes alkyle à chaîne droite ou ramifiée comportant entre 1 et 8 atomes de carbone, des groupes alcényle à chaîne droite ou ramifiée comportant entre 2 et 8 atomes de carbone, des groupes alkyle substitués par hydroxy à chaîne droite ou ramifiée comportant entre 1 et 8 atomes de carbone, des groupes alcényle substitués par hydroxy à chaîne droite ou ramifiée comportant entre 2 et 8 atomes de carbone. Ces composés sont utilisés dans la préparation de compositions pharmaceutiques et sont utiles pour le traitement de diverses affections biologiques.
摘要翻译：发明协调组织（IA）ou（IB），dans laquelle X 1，X 2和X 3等独立发言人保护羟基; et R＆lt; 1＆gt; est choisi parmi des groupes alkyleàchaînedroite ouramifiéecomportant entre 1 et 8 atomes de carbone，des groupesalcényleàchaînedroite ouramifiéecomportant entre 2 et 8 atomes de carbone，des groupes alkyle 取代基对羟基àchaînedroite ouramifiéecomportant entre 1 et 8 atomes de carbone，des groupesalcénylesubstituteéspar hydroxyàchaînedroite ouramifiéecomportant entre 2 et 8 atomes de carbone。 Cescomposéssontutilisésdans lapréparationde composition pharmaceuticaliques et sont utiles pour le traitement de diverses affections biologiques。

22. 发明申请

WO2006057902A3 2ALPHA-METHYL-19-NOR-1ALPHA-HYDROXY-HOMOPREGNACALCIFEROL AND ITS USES 审中-公开
标题翻译： 2ALPHA-METHYL-19-NOR-1ALPHA-HYDROXY-HOMOPREGNACALCIFEROL及其用途
公开(公告)号：WO2006057902A3
公开(公告)日：2006-07-13
申请号：PCT/US2005041821
申请日：2005-11-18
申请人： WISCONSIN ALUMNI RES FOUND , DELUCA HECTOR F , SICINSKI RAFAL R , PLUM LORI A , CLAGETT-DAME MARGARET
发明人： DELUCA HECTOR F , SICINSKI RAFAL R , PLUM LORI A , CLAGETT-DAME MARGARET
IPC分类号： C07C401/00 , A61K31/59 , A61P11/06 , A61P17/06 , A61P29/00 , A61P35/00 , A61P37/00
CPC分类号： C07C401/00
摘要： This invention discloses 2a-methyl-19-nor-vitamin D analogs, and specifically 2a-methyl-19-nor-1a-hydroxy-homopregnacalciferol and pharmaceutical uses therefor. This compound exhibits pronounced activity in arresting the proliferation of undifferentiated cells and inducing their differentiation to the monocyte thus evidencing use as an anti-cancer agent and for the treatment of skin diseases such as psoriasis as well as skin conditions such as wrinkles, slack skin, dry skin and insufficient sebum secretion. This compound also has little, if any, calcemic activity and therefore may be used to treat autoimmune disorders or inflammatory diseases in humans as well as renal osteodystrophy. This compound may also be used for the treatment or prevention of obesity.
摘要翻译：本发明公开了2a-甲基-19-去甲 - 维生素D类似物，特别是2a-甲基-19-去甲-1α-羟基 - 高炔丙醇缩水甾醇及其药物用途。该化合物在阻止未分化细胞的增殖和诱导其向单核细胞的分化方面表现出明显的活性，因此证明其用作抗癌剂并用于治疗皮肤疾病如牛皮癣以及皮肤病如皱纹，皮肤松弛，皮肤干燥，皮脂分泌不足。该化合物如果有钙化活性也很少，因此可用于治疗人的自身免疫性疾病或炎性疾病以及肾性骨营养不良。该化合物也可用于治疗或预防肥胖症。

23. 发明申请

WO2010006135A3 2-METHYLENE-(17Z)-17(20)-DEHYDRO-19,21-DINOR-VITAMIN D ANALOGS 审中-公开
标题翻译： 2-甲基 - （17Z）-17（20）-DEHYDRO-19,21-维生素D类似物
公开(公告)号：WO2010006135A3
公开(公告)日：2010-04-15
申请号：PCT/US2009050060
申请日：2009-07-09
申请人： WISCONSIN ALUMNI RES FOUND , DELUCA HECTOR F , TADI BULLI PADMAJA , PLUM LORI A , CLAGETT-DAME MARGARET
发明人： DELUCA HECTOR F , TADI BULLI PADMAJA , PLUM LORI A , CLAGETT-DAME MARGARET
IPC分类号： C07C401/00 , A61K31/593 , A61P3/04 , A61P17/00 , A61P17/06 , A61P29/00 , A61P35/00 , A61P37/02
CPC分类号： C07C401/00 , C07C2601/14 , C07C2602/24
摘要： This invention discloses 2-methylene-(17Z)-17(20)-dehydro-19,21 -dinor-vitamin D analogs, and specifically 2-methylene-(17Z)-17(20)-dehydro-19,21-dinor-1a,25-dihydroxyvitamin D3, and pharmaceutical uses therefor. This compound exhibits relatively high transcription activity as well as pronounced activity in arresting the proliferation of undifferentiated cells and inducing their differentiation to the monocyte thus evidencing use as an anti-cancer agent and for the treatment of skin diseases such as psoriasis as well as skin conditions such as wrinkles, slack skin, dry skin and insufficient sebum secretion. This compound also has significant calcemic activity in vivo having about the same bone calcium mobilization activity and intestinal calcium transport activity as the native hormone 1a,25-dihydroxyvitamin D3, and therefore may be used to treat autoimmune disorders or inflammatory diseases in humans as well as renal osteodystrophy. This compound may also be used for the treatment or prevention of obesity.
摘要翻译：本发明公开了2-亚甲基 - （17Z）-17（20） - 脱氢-19,21-维生素D类似物，特别是2-亚甲基 - （17Z）-17（20） - 脱氢-19,21-二 -1a，25-二羟基维生素D 3及其药物用途。该化合物显示相对较高的转录活性以及阻止未分化细胞增殖并诱导其分化为单核细胞的明显活性，从而证明其用作抗癌剂并用于治疗皮肤疾病如牛皮癣以及皮肤病症如皱纹，皮肤松弛，皮肤干燥和皮脂分泌不足。该化合物在体内也具有显着的钙活性，其具有与天然激素1a，25-二羟基维生素D 3大致相同的骨钙动员活性和肠钙转运活性，因此可用于治疗人体中的自身免疫性疾病或炎性疾病以及肾性骨营养不良。该化合物也可用于治疗或预防肥胖症。

24. 发明申请

WO2009111695A1 METHODS OF INCREASING EPIDERMAL SKIN THICKNESS BY TOPICAL ADMINISTRATION OF A 19-NOR CONTAINING VITAMIN D COMPOUND 审中-公开
标题翻译：通过19-NOR含维生素D化合物的局部给药增加皮肤厚度的方法
公开(公告)号：WO2009111695A1
公开(公告)日：2009-09-11
申请号：PCT/US2009036323
申请日：2009-03-06
申请人： WISCONSIN ALUMNI RES FOUND , DELUCA HECTOR F , CLAGETT-DAME MARGARET , PLUM LORI A , NIEVES NIRCA J , AHRENS JAMIE
发明人： DELUCA HECTOR F , CLAGETT-DAME MARGARET , PLUM LORI A , NIEVES NIRCA J , AHRENS JAMIE
IPC分类号： A61K31/59 , A61P17/00
CPC分类号： A61K31/59
摘要： Methods of increasing the thickness of the epidermal layer in the skin of a human comprising topically administering a therapeutically effective dose of an active pharmaceutical ingredient comprising a vitamin D analog including 2-methylene-l 9-nor- 20(S)-I a-hydroxy-bishomopregnacalciferol, 19-nor-26,27-dimethylene-20(S)-2-methylene- la,25-dihydroxyvitamin D3, 2-methylene-19-nor-(24R)-la,25-dihydroxyvitamin D2, 2- methylene- 1 a,25-dihydroxy-( 17E)- 17(20)-dehydro- 19-nor- vitamin D3, 2-methylene- (20R,25S)- 19,26-dinor- 1 a,25-dihydroxyvitamin D3, 2-methylene-l 8, 19-dinor-(20S)- 1 a,25- dihydroxyvitamin D3, 2-methylene-l 9-nor- la-hydroxy-pregnacalciferol, la-hydroxy-2- methylene- 19-nor-homopregnacalciferol, (20R)- 1 a-hydroxy-2-methylene- 19-nor- bishomopregnacalciferol, 2-methylene-(20S)-19-nor-la-hydroxy-trishomopregnacalciferol, 2-methylene-(20R)-23,23 -difluoro- 1 a-hydroxy- 19-nor-bishomopregnacalciferol, 2- methylene-(20S)-23,23 -difluoro- 1 a-hydroxy- 19-nor-bishomopregnancalciferol, 2- (3'hydroxypropyl-l',2'-idene)-19,23,24-trinor-(20S)-la-hydroxyvitamin D3, or 13,13- dimethyl-cfe.s-C,D analog of (20S)-2-methylene-la,25-dihydroxy-l 9-nor- vitamin D3, and pharmaceutical topical formulations and topical dosage forms thereof using a pharmaceutically suitable carrier vehicle.
摘要翻译：增加人皮肤中表皮层厚度的方法，包括局部施用治疗有效剂量的活性药物成分，其包含维生素D类似物，包括2-亚甲基-9-去甲基（S）-Ia- 羟基 - 双代孕代孕甾醇，19-降-26,27-二亚甲基-20（S）-2-亚甲基-1a，25-二羟基维生素D3，2-亚甲基-19-去甲 - （24R）-la，25-二羟基维生素D2,2 - 二甲基-1a，25-二羟基 - （17E）-17（20） - 脱氢-19-去甲维生素D3，2-亚甲基 - （20R，25S） - 19,26-二烯-17α-二羟基维生素 D3，2-亚甲基-18,19-二烯 - （20S）-1a，25-二羟基维生素D 3，2-亚甲基-9-去甲酰基 - 羟基 - 孕代孕甾醇，1α-羟基-2-亚甲基-19- （20R）-1α-羟基-2-亚甲基-19-去甲基 - 二钙孕甾胆钙醇，2-亚甲基 - （20S）-19-去甲酰基 - 羟基 - 三孕代孕代胆甾醇，2-亚甲基 - （20R）-23 ，23-二氟-1α-羟基-19-去氧胆钙孕激素，2-亚甲基 - （20S）-23,23-二氟-11α-羟基-19-去甲基二孕（3'羟基丙基-1'，2'-亚苯基）-19,23,24-三硝基 - （20S）-la-羟基维生素D3或13,13-二甲基-cfe.sC，D类似物（ 20S）-2-亚甲基-1a，25-二羟基-9-去甲维生素D3，以及使用药学上合适的载体载体的药物局部制剂及其局部剂型。

25. 发明申请

WO2009086438A3 2-METHYLENE-(20S,25R)-19,26-DINOR-VITAMIN D ANALOGS 审中-公开
标题翻译： 2-甲基 - （20S，25R）-19,26-丁酮 - 维生素D类似物
公开(公告)号：WO2009086438A3
公开(公告)日：2009-08-27
申请号：PCT/US2008088273
申请日：2008-12-24
申请人： WISCONSIN ALUMNI RES FOUND , DELUCA HECTOR F , CLAGETT-DAME MARGARET , PLUM LORI A , CHIELLINI GRAZIA , GRZYWACZ PAWEL
发明人： DELUCA HECTOR F , CLAGETT-DAME MARGARET , PLUM LORI A , CHIELLINI GRAZIA , GRZYWACZ PAWEL
IPC分类号： C07D401/00 , A61K31/593 , A61P3/14 , A61P17/06 , A61P19/02 , A61P35/02 , A61P37/06
CPC分类号： C07C401/00
摘要： This invention discloses 2-methylene-(20S,25R)-19,26-dinor- vitamin D analogs, and specifically 2-methylene-(20S,25R)-19,26-dinor-la,25- dihydroxyvitamin D3, and pharmaceutical uses therefor. This compound exhibits pronounced activity in arresting the proliferation of undifferentiated cells and inducing their differentiation to the monocyte thus evidencing use as an anti-cancer agent and for the treatment of skin diseases such as psoriasis as well as skin conditions such as wrinkles, slack skin, dry skin and insufficient serum secretion. This compound also has little, if any, calcemic activity and therefore may be used to treat autoimmune disorders or inflammatory diseases in humans as well as renal osteodystrophy. This compound may also be used for the treatment or prevention of obesity.
摘要翻译：本发明公开了2-亚甲基 - （20S，25R）-19,26-二 - 维生素D类似物，特别是2-亚甲基 - （20S，25R）-19,26-二炔-1,25-二羟基维生素D 3和药物为此使用。该化合物在阻止未分化细胞的增殖和诱导其向单核细胞的分化方面表现出明显的活性，因此证明其用作抗癌剂并用于治疗皮肤疾病如牛皮癣以及皮肤病如皱纹，皮肤松弛，皮肤干燥，血清分泌不足。该化合物如果有钙化活性也很少，因此可用于治疗人的自身免疫性疾病或炎性疾病以及肾性骨营养不良。该化合物也可用于治疗或预防肥胖症。

26. 发明申请

WO2007092721A8 VITAMIN D ANALOG: RAK, METHODS AND USES THEREOF 审中-公开
标题翻译：维生素D类似物：RAK，其方法和用途
公开(公告)号：WO2007092721A8
公开(公告)日：2008-10-09
申请号：PCT/US2007061404
申请日：2007-01-31
申请人： WISCONSIN ALUMNI RES FOUND , DELUCA HECTOR F , CHIELLINI GRAZIA , GRZYWACZ PAWEL , PLUM LORI A , CLAGETT-DAME MARGARET
发明人： DELUCA HECTOR F , CHIELLINI GRAZIA , GRZYWACZ PAWEL , PLUM LORI A , CLAGETT-DAME MARGARET
IPC分类号： C07C401/00 , A61K31/59 , A61P13/12 , A61P17/06 , A61P19/00 , A61P35/00
CPC分类号： C07C401/00 , A61K8/67 , A61Q19/08 , C07F7/1856 , Y02P20/55
摘要： Compounds of formula (IA) or (IB) are provided where X 1 , X 2 and X 3 are independently selected from H or hydroxy protecting groups and R 1 is selected from straight or branched chain alkyl groups having from 1 to 8 carbon atoms; straight or branched chain alkenyl groups having from 2 to 8 carbon atoms; straight or branched chain hydroxy-substituted alkyl groups having from 1 to 8 carbon atoms; straight and branched chain hydroxy-substituted alkenyl groups having from 2 to 8 carbon atoms. Such compounds are used in preparing pharmaceutical compositions and are useful in treating a variety of biological conditions.
摘要翻译：提供式（IA）或（IB）化合物，其中X 1，X 2和X 3独立地选自H或羟基保护基基团和R 1选自具有1至8个碳原子的直链或支链烷基; 具有2-8个碳原子的直链或支链烯基; 具有1至8个碳原子的直链或支链羟基取代的烷基; 具有2-8个碳原子的直链和支链羟基取代的烯基。这些化合物用于制备药物组合物，并且可用于治疗各种生物学条件。

27. 发明申请

WO2008026078A3 19-NOR-VITAMIN D ANALOGS WITH 1,2,OR 3,2 HETEROCYCLIC RING 审中-公开
标题翻译：具有1,2或3,2个杂环环的19-维生素D模拟物
公开(公告)号：WO2008026078A3
公开(公告)日：2008-07-31
申请号：PCT/IB2007003641
申请日：2007-04-06
申请人： WISCONSIN ALUMNI RES FOUND , DELUCA HECTOR F , SICINSKI RAFAL R , GLEBOCKA AGNIESZKA , PLUM LORI A , CLAGETT-DAME MARGARET
发明人： DELUCA HECTOR F , SICINSKI RAFAL R , GLEBOCKA AGNIESZKA , PLUM LORI A , CLAGETT-DAME MARGARET
IPC分类号： C07D311/74 , A61K31/352 , A61P3/04
CPC分类号： C07D311/74
摘要： 19-nor-vitamin D analogs having an additional heterocyclic ring connecting the 3ß-oxygen and carbon-2 or the 1a-oxygen and carbon-2 of the A-ring of the analog, and pharmaceutical uses therefore, are described. These compounds exhibit significant activity in mobilization of bone, making them therapeutic agents for the treatment or prophylaxis of osteoporosis, osteomalacia, osteopenia, renal osteodystrophy and hypoparathyroidism.
摘要翻译：描述了具有连接类似物的A-ring的3β-氧和碳-2或1a-氧和碳-2的附加杂环的19-维生素D类似物，以及药用。这些化合物在骨骼运动中表现出显着的活性，使其成为治疗或预防骨质疏松症，骨软化症，骨质减少症，肾性骨营养不良和甲状旁腺功能低下的治疗剂。

28. 发明申请

WO2006057884A2 2a-METHYL AND 2ß-METHYL ANALOGS OF 19,26,27-TRINOR-(20S)-1a-HYDROXYVITAMIN D3 AND THEIR USES 审中-公开
标题翻译： 19,26,27-三氢 - （20S）-1a-羟基维生素D3的2-甲基和2-甲基类似物及其用途
公开(公告)号：WO2006057884A2
公开(公告)日：2006-06-01
申请号：PCT/US2005041669
申请日：2005-11-18
申请人： WISCONSIN ALUMNI RES FOUND , DELUCA HECTOR F , PLUM LORI A , GRZYWACZ PAWEL K , CLAGETT-DAME MARGARET
发明人： DELUCA HECTOR F , PLUM LORI A , GRZYWACZ PAWEL K , CLAGETT-DAME MARGARET
IPC分类号： C07C401/00 , A61K31/59 , A61P11/06 , A61P17/06 , A61P29/00 , A61P35/00 , A61P37/00
CPC分类号： C07C401/00 , C07F7/1856
摘要： This invention discloses 2a-methyl and 2ß-methyl analogs of 19,26,27-trinor (20S)-la-hydroxyvitamin D 3 and pharmaceutical uses therefor. These compounds exhibit pronounced activity in arresting the proliferation of undifferentiated cells and inducing their differentiation to the monocyte thus evidencing use as an anti-cancer agent and for the treatment of skin diseases such as psoriasis as well as skin conditions such as wrinkles, slack skin, dry skin and insufficient sebum secretion. These compounds also have little, if any, calcemic activity and therefore may be used to treat autoimmune disorders or inflammatory diseases in humans as well as renal osteodystrophy. These compounds may also be used for the treatment or prevention of obesity.
摘要翻译：本发明公开了19,26,27-三硝基（20S）-la-羟基维生素D 3 N的2a-甲基和2β-甲基类似物及其药物用途。这些化合物在阻止未分化细胞的增殖和诱导其分化为单核细胞方面表现出显着的活性，从而证明其用作抗癌剂并用于治疗皮肤疾病如牛皮癣以及皮肤病症如皱纹，松弛皮肤，皮肤干燥，皮脂分泌不足。这些化合物也具有很少（如果有的话）钙活性，因此可用于治疗人类的自身免疫性疾病或炎性疾病以及肾性骨营养不良。这些化合物也可用于治疗或预防肥胖症。

29. 发明申请

WO2011119610A3 (20S)-2-METHYLENE-19-NOR-22-DIMETHYL-1a,25- DIHYDROXYVITAMIN D3 AND (20R)-2-METHYLENE-19-NOR-22- DIMETHYL-1a,25-HYDROXYVITAMIN D3 审中-公开
标题翻译：（20S）-2-甲基-19-异-22-二甲基-1a，25-二羟基维生素D3和（20R）-2-甲基-19-异-22-二甲基-1,1,25-羟基维生素D3
公开(公告)号：WO2011119610A3
公开(公告)日：2012-11-29
申请号：PCT/US2011029432
申请日：2011-03-22
申请人： WISCONSIN ALUMNI RES FOUND , DELUCA HECTOR F , FLORES AGNIESZKA , GRZYWACZ PAWEL , PLUM LORI A , CLAGETT-DAME MARGARET
发明人： DELUCA HECTOR F , FLORES AGNIESZKA , GRZYWACZ PAWEL , PLUM LORI A , CLAGETT-DAME MARGARET
IPC分类号： C07C401/00 , A61K31/59 , A61P17/06 , A61P19/08 , A61P37/00 , C07F7/18
CPC分类号： C07F7/1856 , C07C401/00 , C07C2601/14 , C07C2602/24 , Y02P20/55
摘要： Compounds of formula I are provided where X1, X2 and X3 are independently selected from H or hydroxy protecting groups. Such compounds may be used in preparing pharmaceutical compositions and are useful in treating a variety of biological conditions.
摘要翻译：提供式I化合物，其中X 1，X 2和X 3独立地选自H或羟基保护基。这样的化合物可用于制备药物组合物，并且可用于治疗各种生物学条件。

30. 发明申请

WO2010006129A3 2-METHYLENE-(22E)-25-(1-METHYLENE-HEXYL)-26,27-CYCLO-22-DEHYDRO-19-NOR-VITAMIN D ANALOGS 审中-公开
标题翻译： 2-甲基 - （22E）-25-（1-甲基 - 异丙基）-26,27-环-22-脱氢-19-异维生素D类似物
公开(公告)号：WO2010006129A3
公开(公告)日：2010-04-29
申请号：PCT/US2009050054
申请日：2009-07-09
申请人： WISCONSIN ALUMNI RES FOUND , DELUCA HECTOR F , RAFAL BARYCKI , PLUM LORI A , CLAGETT-DAME MARGARET
发明人： DELUCA HECTOR F , RAFAL BARYCKI , PLUM LORI A , CLAGETT-DAME MARGARET
IPC分类号： C07C401/00 , A61K31/593 , A61P3/04 , A61P17/00 , A61P17/06 , A61P29/00 , A61P37/02
CPC分类号： C07C401/00 , C07C2601/02
摘要： This invention discloses 2-methylene-(22E)-25-(l-methylene-hexyl)-26,27- cyclo-22-dehydro-19-nor-vitamin D analogs, and specifically 2-methylene-(22E)-25- ( 1 -methylene-hexyl)-26,27-cyclo-22-dehydro- 19-nor- 1 a,24(R)-dihydroxyvitamin D3, and pharmaceutical uses therefor. This compound exhibits relatively high transcription activity as well as pronounced activity in arresting the proliferation of undifferentiated cells and inducing their differentiation to the monocyte thus evidencing use as an anti¬ cancer agent and for the treatment of skin diseases such as psoriasis as well as skin conditions such as wrinkles, slack skin, dry skin and insufficient sebum secretion. This compound also shows lower activity in vivo on bone calcium mobilization and intestinal calcium transport activity compared to the native hormone la,25- dihydroxyvitamin D3, and therefore may be used to treat autoimmune disorders or inflammatory diseases in humans as well as renal osteodystrophy. This compound may also be used for the treatment or prevention of obesity.
摘要翻译：本发明公开了2-亚甲基 - （22E）-25-（1-亚甲基 - 己基）-26,27-环22-脱氢-19-去甲维生素D类似物，特别是2-亚甲基 - （22E）-25 - （1-亚甲基 - 己基）-26,27-环-22-脱氢-19-去甲-1,4（R） - 二羟基维生素D3及其药物用途。该化合物显示相对较高的转录活性以及阻止未分化细胞增殖并诱导其分化为单核细胞的显着活性，从而证明其用作抗癌剂并用于治疗皮肤疾病如牛皮癣以及皮肤病症如皱纹，皮肤松弛，皮肤干燥和皮脂分泌不足。与天然激素la，25-二羟基维生素D 3相比，该化合物在骨钙动员和肠钙运输活性方面的活性也较低，因此可用于治疗人类的自身免疫性疾病或炎性疾病以及肾性骨营养不良。该化合物也可用于治疗或预防肥胖症。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式