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21. 发明申请

WO2009105531A1 METHODS FOR CELL GENOTYPING 审中-公开
标题翻译：细胞基因分析方法
公开(公告)号：WO2009105531A1
公开(公告)日：2009-08-27
申请号：PCT/US2009/034506
申请日：2009-02-19
申请人： GENE SECURITY NETWORK, INC. , RABINOWITZ, Matthew , JOHNSON, David, S. , BANER, Johan , DEMKO, Zachary, P. , CINNIOGLU, Cengiz
发明人： RABINOWITZ, Matthew , JOHNSON, David, S. , BANER, Johan , DEMKO, Zachary, P. , CINNIOGLU, Cengiz
IPC分类号： G01N33/48 , C12Q1/68
CPC分类号： C12Q1/6876 , C12Q2600/156 , C12Q2600/16 , C12Q2600/172
摘要： Methods for cell genotyping are disclosed herein. A method for determining the genomic data of one or a small number of cells, or from fragmentary DNA, where a limited quantity of genetic data is available may include adding one or more targeted primers to a whole genome amplification of a cell, increasing the accuracy with which key alleles are measured in the context of a whole genome amplification. The genetic material from a single cell may be divided into fractions, each of which may be separately genotyped, allowing the reconstruction of the cells haplotype. The genetic material from a single cell may be divided into fractions, each of which may be separately genotyped, and the distribution of the various alleles in the different fractions may be used to determine the ploidy state of one or a plurality of chromosomes in the cell.
摘要翻译：本文公开了细胞基因分型的方法。用于确定有限数量的遗传数据可用的一个或少数细胞或来自片段DNA的基因组数据的方法可包括向细胞的全基因组扩增添加一种或多种靶向引物，增加细胞的准确度在全基因组扩增的情况下测量关键等位基因。来自单个细胞的遗传物质可以被分成各自的部分，每一个可以分开进行基因分型，允许重建细胞单元型。来自单个细胞的遗传物质可以分成各自的部分，每个可以分别进行基因分型，并且可以使用不同级分中各种等位基因的分布来确定细胞中一条或多条染色体的倍性状态。

22. 发明申请

WO2003075630A2 POSITION LOCATION USING GLOBAL POSITIONING SIGNALS AUGMENTED BY BROADCAST TELEVISION SIGNALS 审中-公开
标题翻译：使用全球定位信号的位置位置由广播电视信号
公开(公告)号：WO2003075630A2
公开(公告)日：2003-09-18
申请号：PCT/US2003/006453
申请日：2003-03-04
申请人： ROSUM CORPORATION , RABINOWITZ, Matthew , SPILKER, James, J. Jr.
发明人： RABINOWITZ, Matthew , SPILKER, James, J. Jr.
IPC分类号： G01S19/46 , G01S1/00 , G01S5/00 , G01S5/02 , G01S5/14
CPC分类号： G01S19/46 , A63F2300/205 , G01S5/0036 , G01S5/0054 , G01S5/0081 , G01S5/02 , G01S5/021 , G01S5/0215 , G01S5/0221 , G01S5/14 , G01S5/145 , G01S19/05 , G01S19/11 , G01S19/254 , G01S19/256 , G01S19/258 , H04N21/25841 , H04N21/2668 , H04N21/41422 , H04N21/615 , H04N21/8126
摘要： A method, apparatus, and computer-readable media for determining the position of a user terminal comprises receiving at the user terminal a broadcast television signal from a television signal transmitter; determining a first pseudo-range between the user terminal and the television signal transmitter based on a known component of the broadcast television signal; receiving at the user terminal a global positioning signal from a global positioning satellite; determining a second pseudo-range between the user terminal and the global positioning satellite based on the global positioning signal; and determining a position of the user terminal based on the first and second pseudo-ranges, a location of the television signal transmitter, and a location of the global positioning satellite.
摘要翻译：一种用于确定用户终端的位置的方法，装置和计算机可读介质包括：在用户终端接收来自电视信号发射机的广播电视信号; 基于所述广播电视信号的已知分量，确定所述用户终端和所述电视信号发射机之间的第一伪距; 在用户终端接收来自全球定位卫星的全球定位信号; 基于全球定位信号确定用户终端和全球定位卫星之间的第二伪距; 以及基于第一和第二伪距，电视信号发射机的位置和全球定位卫星的位置来确定用户终端的位置。

23. 发明申请

WO2013130848A1 INFORMATICS ENHANCED ANALYSIS OF FETAL SAMPLES SUBJECT TO MATERNAL CONTAMINATION 审中-公开
标题翻译：信息增强分析场效应物质污染
公开(公告)号：WO2013130848A1
公开(公告)日：2013-09-06
申请号：PCT/US2013/028378
申请日：2013-02-28
申请人： NATERA, INC. , RABINOWITZ, Matthew , BANER, Johan , GEMELOS, George , HILL, Matthew, M. , SIGURJONSSON, Styrmir
发明人： RABINOWITZ, Matthew , BANER, Johan , GEMELOS, George , HILL, Matthew, M. , SIGURJONSSON, Styrmir
IPC分类号： C12Q1/68
CPC分类号： G06F19/18 , C12Q1/6827
摘要： The invention provides methods for chromosome copy number calling on genetic samples, such as fetal samples subject to contamination from maternal DNA. The present disclosure provides methods for determining the ploidy status of a chromosome in a fetus (such as a gestating fetus or a POC sample) from genotypic data measured from a mixed sample of DNA comprising DNA from both the mother of the fetus and from the fetus, and optionally from genotypic data from the mother and father. In some embodiments, the ploidy state is determined by using a joint distribution model to create a plurality of expected allele distributions for different possible fetal ploidy states given the parental genotypic data, and comparing the expected allelic distributions to the pattern of measured allelic distributions measured in the mixed sample, and choosing the ploidy state whose expected allelic distribution pattern most closely matches the observed allelic distribution pattern. The mixed sample of DNA may be preferentially enriched at a plurality of polymorphic loci in a way that minimizes the allelic bias, for example using massively multiplexed targeted PCR.
摘要翻译：本发明提供了染色体拷贝数调用基因样品的方法，例如受母体DNA污染的胎儿样品。本公开提供了从包含来自胎儿母体和胎儿的DNA的DNA的混合样品测量的基因型数据中确定胎儿（例如胎儿胎儿或POC样品）中染色体的倍性状态的方法，以及来自母亲和父亲的基因型数据。在一些实施方案中，通过使用联合分布模型来确定给定父母基因型数据的不同可能的胎儿倍性状态的多个预期等位基因分布，并将预期的等位基因分布与所测量的等位基因分布的模式进行比较来确定倍性状态混合样品，并选择其预期等位基因分布模式与观察到的等位基因分布模式最为匹配的倍性状态。 DNA的混合样品可以以使等位基因偏倚最小化的方式优先富集在多个多态性位点，例如使用大规模复用的靶向PCR。

24. 发明申请

WO2012088456A2 METHODS FOR NON-INVASIVE PRENATAL PATERNITY TESTING 审中-公开
标题翻译：非侵入性预防性试验方法
公开(公告)号：WO2012088456A2
公开(公告)日：2012-06-28
申请号：PCT/US2011/066938
申请日：2011-12-22
申请人： NATERA, INC. , RYAN, Allison , SIGURJONSSON, Styrmir , BANJEVIC, Milena , GEMELOS, George , HILL, Matthew , BANER, Johan , RABINOWITZ, Matthew , DEMKO, Zachary
发明人： RYAN, Allison , SIGURJONSSON, Styrmir , BANJEVIC, Milena , GEMELOS, George , HILL, Matthew , BANER, Johan , RABINOWITZ, Matthew , DEMKO, Zachary
IPC分类号： G06F19/00 , C07H21/04
CPC分类号： C12Q1/6869 , C12Q1/6876 , C12Q2600/156 , G06F19/14
摘要： Methods for non-invasive prenatal paternity testing are disclosed herein. The method uses genetic measurements made on plasma taken from a pregnant mother, along with genetic measurements of the alleged father, and genetic measurements of the mother, to determine whether or not the alleged father is the biological father of the fetus. This is accomplished by way of an informatics based method that can compare the genetic fingerprint of the fetal DNA found in maternal plasma to the genetic fingerprint of the alleged father.
摘要翻译：本文公开了非侵入性产前亲子鉴定的方法。该方法使用从怀孕母亲获得的血浆进行的遗传测量，以及所称父亲的遗传测量以及母亲的遗传测量，以确定所称父亲是否是胎儿的生物之父。这通过基于信息学的方法来实现，该方法可以将母体血浆中发现的胎儿DNA的遗传指纹与所称父亲的遗传指纹进行比较。

25. 发明申请

WO2007062164A3 SYSTEM AND METHOD FOR CLEANING NOISY GENETIC DATA AND USING DATA TO MAKE PREDICTIONS 审中-公开
公开(公告)号：WO2007062164A3
公开(公告)日：2007-05-31
申请号：PCT/US2006/045281
申请日：2006-11-22
申请人： GENE SECURITY NETWORK LLC , RABINOWITZ, Matthew , BANJEVIC, Milena , DEMKO, Zachary, Paul , JOHNSON, David, Scott
发明人： RABINOWITZ, Matthew , BANJEVIC, Milena , DEMKO, Zachary, Paul , JOHNSON, David, Scott
IPC分类号： G06F19/00
摘要： A system and method for determining the genetic data for one or a small set of cells, or from fragmentary DNA, where a limited quantity of genetic data is available, and also for predicting likely phenotypic outcomes using mathematical models and given genetic, phenotypic and/or clinical data of an individual, and also relevant aggregated medical data consisting of genotypic, phenotypic, and/or clinical data from germane patient subpopulations. Genetic data for the target individual is acquired and amplified using known methods, and poorly measured base pairs, missing alleles and missing regions are reconstructed using expected similarities between the target genome and the genome of genetically related subjects.

26. 发明申请

WO2003041388A3 POSITION LOCATION AND NAVIGATION USING TELEVISION SIGNALS 审中-公开
公开(公告)号：WO2003041388A3
公开(公告)日：2003-05-15
申请号：PCT/US2002/035338
申请日：2002-11-04
申请人： ROSUM CORPORATION , PIERCE, Matthew, D. , RABINOWITZ, Matthew
发明人： PIERCE, Matthew, D. , RABINOWITZ, Matthew
IPC分类号： G01S13/00
摘要： A service depends on the location of a device (102). The device (102) location is determined using DTV signals. More specifically, the device (102) location is determined based on pseudo-ranges between the device (102) and a plurality of digital television (DTV) transmitters (106A, 106B,…106N) and the pseudo-ranges are determined based on broadcast DTV signals received by the device (102) from the DTV transmitters (106A, 106B,…106N). Examples of DTV signals include the American Television Standards Committee (ATSC) signals, the European Telecommunications Standards Institute Digital Video Broadcasting - Terrestrial (DVB-T) signals and the Japanese Integrated Service Digital Broadcasting-Terrestrial (ISDB-T) signals.

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