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21. 发明申请

WO2008028935A2 PYRIDINYL-PYRIMIDINE DERIVATIVES USEFUL AS POTASSIUM CHANNEL MODULATING AGENTS 审中-公开
标题翻译：适用于钾通道调节剂的吡啶基吡啶衍生物
公开(公告)号：WO2008028935A2
公开(公告)日：2008-03-13
申请号：PCT/EP2007/059313
申请日：2007-09-06
申请人： NeuroSearch A/S , ERIKSEN, Birgitte, L. , SØRENSEN, Ulrik, Svane , HOUGAARD, Charlotte , TEUBER, Lene , PETERS, Dan , CHRISTOPHERSEN, Palle , JOHANSEN, Tina, Holm
发明人： ERIKSEN, Birgitte, L. , SØRENSEN, Ulrik, Svane , HOUGAARD, Charlotte , TEUBER, Lene , PETERS, Dan , CHRISTOPHERSEN, Palle , JOHANSEN, Tina, Holm
IPC分类号： C07D401/04 , A61K31/506 , A61P11/00
CPC分类号： C07D401/04
摘要： This invention relates to novel pyridinyl-pyrimidine derivatives and their use as potassium channel modulating agents. Moreover the invention is directed to pharmaceutical compositions useful for the treatment or alleviation of diseases or disorders associated with the activity of potassium channels.
摘要翻译：本发明涉及新的吡啶基 - 嘧啶衍生物及其作为钾通道调节剂的用途。此外，本发明涉及可用于治疗或缓解与钾通道活性相关的疾病或病症的药物组合物。

22. 发明申请

WO2007110363A1 NOVEL GUANIDINE DERIVATIVES AND THEIR MEDICAL USE 审中-公开
标题翻译：新型胍衍生物及其医疗用途
公开(公告)号：WO2007110363A1
公开(公告)日：2007-10-04
申请号：PCT/EP2007/052747
申请日：2007-03-22
申请人： NeuroSearch A/S , SØRENSEN, Ulrik, Svane , ERIKSEN, Birgitte, L. , TEUBER, Lene , PETERS, Dan , STRØBÆK, Dorte , JOHANSEN, Tina, Holm , CHRISTOPHERSEN, Palle
发明人： SØRENSEN, Ulrik, Svane , ERIKSEN, Birgitte, L. , TEUBER, Lene , PETERS, Dan , STRØBÆK, Dorte , JOHANSEN, Tina, Holm , CHRISTOPHERSEN, Palle
IPC分类号： C07D233/46 , C07D235/30 , C07D239/14 , C07D239/84 , C07D243/04
CPC分类号： C07D233/46 , C07D235/30 , C07D239/14 , C07D239/84 , C07D243/04
摘要： This invention relates to novel guanidine derivatives useful as modulators of small-conductance calcium-activated potassium channels (SK channels). In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
摘要翻译：本发明涉及可用作小电导钙激活钾通道（SK通道）的调节剂的新型胍衍生物。在其它方面，本发明涉及这些化合物在治疗方法中的用途以及包含本发明化合物的药物组合物。

23. 发明申请

WO2007042571A1 NOVEL PYRIMIDINE-2,4-DIAMINE DERIVATIVES AND THEIR USE AS MODULATORS OF SMALL-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS 审中-公开
标题翻译：新型吡咯烷-2,4-二胺衍生物及其作为小肠钙激活钾通道的调节剂
公开(公告)号：WO2007042571A1
公开(公告)日：2007-04-19
申请号：PCT/EP2006/067387
申请日：2006-10-13
申请人： NEUROSEARCH A/S , SØRENSEN, Ulrik, Svane , ERIKSEN, Birgitte, L. , TEUBER, Lene , PETERS, Dan , STRØBÆK, Dorte , JOHANSEN, Tina, Holm , CHRISTOPHERSEN, Palle
发明人： SØRENSEN, Ulrik, Svane , ERIKSEN, Birgitte, L. , TEUBER, Lene , PETERS, Dan , STRØBÆK, Dorte , JOHANSEN, Tina, Holm , CHRISTOPHERSEN, Palle
IPC分类号： C07D239/48 , A61K31/505 , A61P25/28
CPC分类号： C07D239/48
摘要： This invention relates to novel pyrimidine-2,4-diamine derivatives useful as modulators of small-conductance calcium-activated potassium channels (SK channels). In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
摘要翻译：本发明涉及可用作小电导钙激活钾通道（SK通道）的调节剂的新型嘧啶-2,4-二胺衍生物。在其它方面，本发明涉及这些化合物在治疗方法中的用途以及包含本发明化合物的药物组合物。

24. 发明申请

WO2006136580A3 2-(PHENYLAMINO)BENZIMIDAZOLE DERIVATIVES AND THEIR USE AS MODULATORS OF SMALL-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS 审中-公开
公开(公告)号：WO2006136580A3
公开(公告)日：2006-12-28
申请号：PCT/EP2006/063405
申请日：2006-06-21
申请人： NEUROSEARCH A/S , SØRENSEN, Ulrik, Svane , TEUBER, Lene , PETERS, Dan , STRØBÆK, Dorte , JOHANSEN, Tina, Holm , NIELSEN, Karin, Sandager , CHRISTOPHERSEN, Palle
发明人： SØRENSEN, Ulrik, Svane , TEUBER, Lene , PETERS, Dan , STRØBÆK, Dorte , JOHANSEN, Tina, Holm , NIELSEN, Karin, Sandager , CHRISTOPHERSEN, Palle
IPC分类号： C07D235/30 , A61K31/4184 , A61P25/28 , A61P9/04 , A61P11/06 , A61P1/06
摘要： This invention relates to 2-(phenylamino) benzimidazole derivatives useful as modulators of small-conductance calcium-activated potassium channels (SK channels). In other aspects the invention relates to the use of these compounds in the preparation of medicaments and to pharmaceutical compositions comprising the compounds of the invention.

25. 发明申请

WO2008092942A2 PYRIDINYL-PYRAZOLE DERIVATIVES AND THEIR USE AS POTASSIUM CHANNEL MODULATORS 审中-公开
标题翻译：吡啶并吡唑衍生物及其作为钾通道调节剂的用途
公开(公告)号：WO2008092942A2
公开(公告)日：2008-08-07
申请号：PCT/EP2008/051233
申请日：2008-02-01
申请人： NeuroSearch A/S , ERIKSEN, Birgitte, L. , SØRENSEN, Ulrik, Svane , HOUGAARD, Charlotte , TEUBER, Lene , PETERS, Dan , JOHANSEN, Tina, Holm , CHRISTOPHERSEN, Palle
发明人： ERIKSEN, Birgitte, L. , SØRENSEN, Ulrik, Svane , HOUGAARD, Charlotte , TEUBER, Lene , PETERS, Dan , JOHANSEN, Tina, Holm , CHRISTOPHERSEN, Palle
IPC分类号： C07D401/04 , C07D405/14 , A61K31/4439 , A61P11/00
CPC分类号： C07D401/04 , C07D405/14
摘要： This invention relates to novel pyridinyl-pyrazole derivatives and their use as potassium channel modulating agents. Moreover the invention is directed to pharmaceutical compositions useful for the treatment or alleviation of diseases or disorders associated with the activity of potassium channels.
摘要翻译：本发明涉及新的吡啶基 - 吡唑衍生物及其作为钾通道调节剂的用途。此外，本发明涉及可用于治疗或缓解与钾通道活性相关的疾病或病症的药物组合物。

26. 发明申请

WO2008058536A1 NOVEL 4-AMINO-PYRIDINE DERIVATIVES AND THEIR USE AS POTASSIUM CHANNEL MODULATORS 审中-公开
标题翻译：新型4-氨基吡啶衍生物及其作为钾通道调节剂的用途
公开(公告)号：WO2008058536A1
公开(公告)日：2008-05-22
申请号：PCT/DK2007/000497
申请日：2007-11-13
申请人： NEUROSEARCH A/S , SØRENSEN, Ulrik, Svane , ERIKSEN, Brigitte, L. , TEUBER, Lene , PETERS, Dan , STRØBÆK, Dorte , JOHANSEN, Tina, Holm , CHRISTOPHERSEN, Palle
发明人： SØRENSEN, Ulrik, Svane , ERIKSEN, Brigitte, L. , TEUBER, Lene , PETERS, Dan , STRØBÆK, Dorte , JOHANSEN, Tina, Holm , CHRISTOPHERSEN, Palle
IPC分类号： A61K31/44 , A61K31/47 , C07D213/74 , C07D215/42 , C07D215/44 , A61P11/06 , A61P25/22 , A61P35/00
CPC分类号： C07D213/74 , C07D215/44
摘要： This invention relates to novel 4-amino-pyridine derivative useful a modulators of small-conductance calcium-activated potassium channels (SK channels). In other aspects the invention relates to the use of these compounds in method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
摘要翻译：本发明涉及用于小电导钙激活钾通道（SK通道）的调节剂的新型4-氨基 - 吡啶衍生物。在其它方面，本发明涉及这些化合物在治疗方法中的用途以及包含本发明化合物的药物组合物。

27. 发明申请

WO2007071632A2 PYRIDINYL-QUINAZOLINE DERIVATIVES AND THEIR MEDICAL USE 审中-公开
标题翻译：吡啶并喹啉衍生物及其医学用途
公开(公告)号：WO2007071632A2
公开(公告)日：2007-06-28
申请号：PCT/EP2006/069795
申请日：2006-12-18
申请人： NEUROSEARCH A/S , ERIKSEN, Birgitte, L. , SØRENSEN, Ulrik, Svane , TEUBER, Lene , PETERS, Dan , HOUGAARD, Charlotte , JOHANSEN, Tina, Holm , CHRISTOPHERSEN, Palle
发明人： ERIKSEN, Birgitte, L. , SØRENSEN, Ulrik, Svane , TEUBER, Lene , PETERS, Dan , HOUGAARD, Charlotte , JOHANSEN, Tina, Holm , CHRISTOPHERSEN, Palle
CPC分类号： C07D401/04
摘要： This invention relates to novel pyridinyl-quinazoline derivatives and their use as potassium channel modulating agents. Moreover the invention is directed to pharmaceutical compositions useful for the treatment or alleviation of diseases or disorders associated with the activity of potassium channels.
摘要翻译：本发明涉及新的吡啶基 - 喹唑啉衍生物及其作为钾通道调节剂的用途。此外，本发明涉及可用于治疗或缓解与钾通道活性相关的疾病或病症的药物组合物。

28. 发明申请

WO2007065913A1 NOVEL QUINAZOLINE-2,4-DIAMINE DERIVATIVES AND THEIR USE AS MODULATORS OF SMALL-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS 审中-公开
标题翻译：新型喹唑啉-2,4-二胺衍生物及其作为小肠钙激活钾通道调节剂的用途
公开(公告)号：WO2007065913A1
公开(公告)日：2007-06-14
申请号：PCT/EP2006/069380
申请日：2006-12-06
申请人： NEUROSEARCH A/S , SØRENSEN, Ulrik, Svane , ERIKSEN, Birgitte, L. , TEUBER, Lene , PETERS, Dan , STRØBÆK, Dorte , JOHANSEN, Tina, Holm , CHRISTOPHERSEN, Palle
发明人： SØRENSEN, Ulrik, Svane , ERIKSEN, Birgitte, L. , TEUBER, Lene , PETERS, Dan , STRØBÆK, Dorte , JOHANSEN, Tina, Holm , CHRISTOPHERSEN, Palle
IPC分类号： C07D239/95 , C07D401/04
CPC分类号： C07D239/95 , C07D401/04
摘要： Quinazoline-2,4-diamine derivatives of formula (I), pharmaceutical compositions thereof and their use for the modulation of small conductance calcium activated potassium channels (SK channels).
摘要翻译：式（I）的喹唑啉-2,4-二胺衍生物，其药物组合物及其用于调节小电导钙活化钾通道（SK通道）的用途。

29. 发明申请

WO2006100212A1 PYRAZOLYL-PYRIMIDINES AS POTASSIUM CHANNEL MODULATING AGENTS AND THEIR MEDICAL USE 审中-公开
标题翻译：作为钾通道调节剂及其医疗用途的吡唑并吡啶
公开(公告)号：WO2006100212A1
公开(公告)日：2006-09-28
申请号：PCT/EP2006/060857
申请日：2006-03-20
申请人： NEUROSEARCH A/S , ERIKSEN, Birgitte, L. , TEUBER, Lene , HOUGAARD, Charlotte , SØRENSEN, Ulrik, Svane
发明人： ERIKSEN, Birgitte, L. , TEUBER, Lene , HOUGAARD, Charlotte , SØRENSEN, Ulrik, Svane
IPC分类号： C07D403/04 , A61K31/505
CPC分类号： C07D403/04
摘要： This invention relates to novel potassium channel modulating agents of formul (I) with the definitions of R1-R4, X, Y and n according to claiml, and their use in the preparation of pharmaceutical compositions. Moreover the invention is directed to pharmaceutical compositions useful for the treatment or alleviation of diseases or disorders associated with the activity of potassiu channels, in particular respiratory diseases, epilepsy, convulsions, vascular spasms, coronary artery spasms, renal disorders, polycystic kidney disease, bladder spasms, urinary incontinence, bladder outflow obstruction, irritable bowel syndrome, gastrointestinal dysfunction, secretory diarrhoea, ischaemia, cerebral ischaemia, ischaemic heart disease, angina pectoris, coronary heart disease, traumatic brain injury, psychosis, schizophrenia, anxiety, depression, dementia, memory and attention deficits, Alzheimer's disease, dysmenorrhea, narcolepsy, Reynaud's disease, intermittent claudication, Sjorgren's syndrome, migraine, arrhythmia, hypertension, absence seizures, myotonic muscle dystrophia, xerostomi, diabetes type II, hyperinsulinemia, premature labour, baldness, cancer, immune suppression or pain.
摘要翻译：本发明涉及具有根据权利要求1的R1-R4，X，Y和n定义的配方（I）的新型钾通道调节剂及其在制备药物组合物中的用途。此外，本发明涉及可用于治疗或缓解与卡塔西丝通道，特别是呼吸系统疾病，癫痫，惊厥，血管痉挛，冠状动脉痉挛，肾功能障碍，多囊肾病，膀胱活动相关的疾病或病症的药物组合物痉挛，尿失禁，膀胱流出阻塞，肠易激综合征，胃肠功能障碍，分泌性腹泻，局部缺血，脑缺血，缺血性心脏病，心绞痛，冠心病，创伤性脑损伤，精神病，精神分裂症，焦虑，抑郁，痴呆，记忆注意缺陷，阿尔茨海默氏症，痛经，发作性睡病，雷诺病，间歇性跛行，Sjorgren综合征，偏头痛，心律失常，高血压，不存在癫痫发作，强直肌营养不良，口干燥症，II型糖尿病，高胰岛素血症，早产，秃发，癌症，免疫抑制或疼痛。

30. 发明申请

WO2008058537A1 NOVEL 2-AMINO-PYRIDINE DERIVATIVES AND THEIR USE AS POTASSIUM CHANNEL MODULATORS 审中-公开
标题翻译：新型2-氨基吡啶衍生物及其作为钾通道调节剂的用途
公开(公告)号：WO2008058537A1
公开(公告)日：2008-05-22
申请号：PCT/DK2007/000498
申请日：2007-11-13
申请人： NEUROSEARCH A/S , SØRENSEN, Ulrik, Svane , ERIKSEN, Brigitte, L. , TEUBER, Lene , PETERS, Dan , STRØBÆK, Dorte , JOHANSEN, Tina, Holm , CHRISTOPHERSEN, Palle
发明人： SØRENSEN, Ulrik, Svane , ERIKSEN, Brigitte, L. , TEUBER, Lene , PETERS, Dan , STRØBÆK, Dorte , JOHANSEN, Tina, Holm , CHRISTOPHERSEN, Palle
IPC分类号： C07D213/74 , A61K31/4402 , A61P25/00 , A61P25/28
CPC分类号： C07D213/74
摘要： This invention relates to novel 2-amino-pyridine derivative useful as modulators of small-conductance calcium-activated potassium channels (SK channels). In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
摘要翻译：本发明涉及可用作小电导钙激活钾通道（SK通道）的调节剂的新型2-氨基 - 吡啶衍生物。在其它方面，本发明涉及这些化合物在治疗方法中的用途以及包含本发明化合物的药物组合物。

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