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21. 发明申请

WO2005019214A1 NOVEL ANTIMICROBIAL ARYLOXAZOLIDINONE COMPOUNDS 审中-公开
标题翻译：新型抗微生物ARYLOXAZOLIDINONE化合物
公开(公告)号：WO2005019214A1
公开(公告)日：2005-03-03
申请号：PCT/IB2004/002669
申请日：2004-08-13
申请人： WARNER-LAMBERT COMPANY LLC , GORDEEV, Mikhail , WANG, Qiang
发明人： GORDEEV, Mikhail , WANG, Qiang
IPC分类号： C07D413/10
CPC分类号： C07D263/20 , C07D263/10 , C07D413/10 , C07D413/14
摘要： Compounds of formula (I) and methods for their preparation are disclosed. Further disclosed are methods of making biologically active compounds of formula (I) as well as pharmaceutically acceptable compositions comprising compounds of formula (I). Compounds of formula (I) as disclosed herein can be used in a variety of applications including use as antibacterial agents. They are especially active against aerobic Gram-negative organisms. The compounds have the following structure: or a pharmaceutically acceptable salt thereof wherein: “---”is a bond or is absent; A is a structure selected from the group consisting of i, ii, iii, and iv wherein “---” is a bond or is absent and “~~~” indicated points of attachment; and the other variables are defined in the description
摘要翻译：公开了式（I）化合物及其制备方法。还公开了制备式（I）的生物活性化合物以及包含式（I）化合物的药学上可接受的组合物的方法。本文公开的式（I）化合物可用于多种应用，包括用作抗菌剂。他们对有氧革兰氏阴性生物特别活跃。所述化合物具有以下结构：或其药学上可接受的盐，其中：“---”是键或不存在; A是选自i，ii，iii和iv的结构，其中“---”是键或不存在，“~~”表示附着点; 其他变量在说明书中定义

22. 发明申请

WO2023065106A1 SYSTEMS AND METHODS FOR MANAGING, TRACKING, AND INSERTING CONTENT 审中-公开
公开(公告)号：WO2023065106A1
公开(公告)日：2023-04-27
申请号：PCT/CN2021/124645
申请日：2021-10-19
申请人： JIANG, Linlin , ZHANG, Xue , WANG, Qiang , CAO, Yu , ZHANG, Qi , COMCAST CABLE COMMUNICATIONS, LLC
发明人： JIANG, Linlin , ZHANG, Xue , WANG, Qiang , CAO, Yu , ZHANG, Qi
IPC分类号： H04L12/00
摘要： Systems, apparatuses, and methods are described for message classification and management. A message may indicate a request for placement of a content item, such as an advertisement or advertisement campaign, into one or more content streams. A message ID associated with the message may be converted to a bit vector to compare to one or more filter data sets. The comparison of the bit vector to the filter data sets may determine whether the message may correspond to a previous message, such as a previous advertisement or advertisement campaign. The message may be classified as a new message or an update message.

23. 发明申请

WO2010083505A1 METHOD OF TREATING CANCER USING A SURVIVIN INHIBITOR 审中-公开
标题翻译：使用SURVIVIN抑制剂治疗癌症的方法
公开(公告)号：WO2010083505A1
公开(公告)日：2010-07-22
申请号：PCT/US2010/021365
申请日：2010-01-19
申请人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA , BEREZOV, Alan , WANG, Qiang , MURALI, Ramachandran , GREENE, Mark, I.
发明人： BEREZOV, Alan , WANG, Qiang , MURALI, Ramachandran , GREENE, Mark, I.
IPC分类号： A01N43/40
CPC分类号： A61K31/404 , A61K31/352 , A61K31/4704
摘要： Disclosed herein are methods of treating cancer by administering to a patient a small molecule inhibitor of Survivin. Also disclosed herein are methods of inhibiting Survivin dimerization in a patient by administering a compound of formula (I), (II), (III), or (IV). Methods of inducing cell cycle arrest in cancer cells, comprising G2/M stage arrest, in a patient by administering a compound of formula (I), (II), (III), or (IV) are also disclosed. Further disclosed herein are methods of inducing apoptosis in cancer cells in a patient by administering a compound of formula (I), (II), (III), or (IV).
摘要翻译：本文公开了通过向患者施用存活蛋白的小分子抑制剂来治疗癌症的方法。本文还公开了通过施用式（I），（II），（III）或（IV）的化合物来抑制患者存活素二聚化的方法。还公开了通过施用式（I），（II），（III）或（IV）化合物在患者体内诱导细胞周期停滞的方法，包括G2 / M期骤停。本文进一步公开的是通过施用式（I），（II），（III）或（IV）的化合物在患者体内诱导癌细胞凋亡的方法。

24. 发明申请

WO2010023632A1 TRIBOCHARGE TEST FIXTURE 审中-公开
标题翻译： TRIBOCHARGE测试仪器
公开(公告)号：WO2010023632A1
公开(公告)日：2010-03-04
申请号：PCT/IB2009/053742
申请日：2009-08-26
申请人： SABIC INNOVATIVE PLASTICS IP B.V. , HUANG, Xin , HU, Jun , WANG, Qiang
发明人： HUANG, Xin , HU, Jun , WANG, Qiang
IPC分类号： G01N27/60 , G01N33/44
CPC分类号： G01N27/60 , G01N33/442
摘要： A fixture can include a test fixture that holds an object whose electrostatic charge characteristics are to be measured, means for moving a piece of rubbing material into contact with the object, and means for rubbing a surface of the object. A method for measuring the electrostatic charge characteristics of an object using a test fixture can include: placing the object in the test fixture, moving a piece of rubbing material into contact with the object and rubbing a surface of the object with the piece of rubbing material for a period of time. The rubbing causes an electrostatic charge to be built up on the surface of the object. The electrostatic charge characteristics of the object can be measured and the measured electrostatic charge characteristics of the object can be displayed.
摘要翻译：固定装置可以包括固定要测量其静电荷特性的物体的测试夹具，用于将一块摩擦材料移动到与物体接触的装置，以及用于摩擦物体表面的装置。使用测试夹具测量物体的静电电荷特性的方法可以包括：将物体放置在测试夹具中，使一块摩擦材料与物体接触并用该摩擦材料摩擦物体的表面一段时间。摩擦会导致在物体表面上形成静电电荷。可以测量物体的静电电荷特性，并且可以显示物体的测量的静电电荷特性。

25. 发明申请

WO2009011934A1 METHOD AND APPARATUS FOR TOMOGRAPHIC IMAGING OF ABSOLUTE OPTICAL ABSORPTION COEFFICIENT IN TURBID MEDIA USING COMBINED PHOTOACOUSTIC AND DIFFUSING LIGHT MEASUREMENTS 审中-公开
标题翻译：使用组合光电和扩散光测量的涡轮介质中绝对光学吸收系数的图像成像的方法和装置
公开(公告)号：WO2009011934A1
公开(公告)日：2009-01-22
申请号：PCT/US2008/055894
申请日：2008-03-05
申请人： UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. , JIANG, Huabei , YUAN, Zhen , WANG, Qiang , YIN, Lu , ZHANG, Qizhi
发明人： JIANG, Huabei , YUAN, Zhen , WANG, Qiang , YIN, Lu , ZHANG, Qizhi
IPC分类号： A61B5/00 , G06T11/00
CPC分类号： A61B5/0073 , A61B5/0095 , A61B5/4528
摘要： Embodiments of the invention pertain to methods for imaging a light absorption coefficient distribution. Embodiments of the subject method can be implemented without knowing the strength of incident light in advance and without requiring careful calibrations in the non-scattering medium. Embodiments of the method can combine conventional photoacoustic tomography (PAT) with diffusing light measurements coupled with an optimization procedure based on the photon diffusion equation. Images of absorbing targets as small as 0.5mm in diameter embedded in a 50mm diameter background medium can be quantitatively recovered. Small targets with various optical contrast levels relative to the background can be detected well. Embodiments of the subject reconstruction method can include first obtaining the map of absorbed optical energy density. Embodiments can obtain the map of absorbed optical energy density through a model-based reconstruction algorithm that is based on a finite element solution to the photoacoustic wave equation in frequency domain subject to the radiation or absorbing boundary conditions (BCs). The distribution of optical fluence can then be obtained. Embodiments can obtain the distribution of optical fluence using the photon diffusion equation based optimization procedure. The distribution of optical absorption coefficient can then be recovered from the distribution of optical fluence and the absorbed energy density.
摘要翻译：本发明的实施例涉及用于对光吸收系数分布进行成像的方法。可以在不知道入射光的强度并且不需要在非散射介质中仔细校准的情况下实现本方法的实施例。该方法的实施例可以将传统的光声层析成像（PAT）与基于光子扩散方程的优化过程耦合的扩散光测量结合起来。可以定量地回收直径为50mm的背景介质中直径小于0.5mm的吸收目标图像。可以很好地检测到具有相对于背景的各种光学对比度水平的小目标。被摄体重建方法的实施例可以包括首先获得吸收的光能密度的图。实施例可以通过基于模型的重建算法获得吸收的光能密度的图，该算法基于经受辐射或吸收边界条件（BC）的频域中的光声波方程的有限元解。然后可以获得光能的分布。实施例可以使用基于光子扩散方程的优化程序获得光能的分布。光吸收系数的分布可以从光能的分布和吸收的能量密度中恢复。

26. 发明申请

WO2007051062A2 SUBSTITUTED DIHYDROPYRIDINES AND METHODS OF USE 审中-公开
标题翻译：取代的二氢吡啶类和使用方法
公开(公告)号：WO2007051062A2
公开(公告)日：2007-05-03
申请号：PCT/US2006/042502
申请日：2006-10-30
申请人： CHEMOCENTRYX, INC. , HURT, Clarence, Ray , PENNELL, Andrew,M., K. , WRIGHT, John, Jessen , WANG, Qiang , LELETI, Manmohan, Reddy , THOMAS, William, D. , LI, Yandong , DRAGOLI, Dean, R.
发明人： HURT, Clarence, Ray , PENNELL, Andrew,M., K. , WRIGHT, John, Jessen , WANG, Qiang , LELETI, Manmohan, Reddy , THOMAS, William, D. , LI, Yandong , DRAGOLI, Dean, R.
IPC分类号： A61K31/519 , A61K31/4745 , A61K31/4741 , C07D491/02 , C07D487/02 , C07D471/02
CPC分类号： C07D217/22 , C07D217/26 , C07D401/04 , C07D405/04 , C07D405/14 , C07D413/04 , C07D417/04 , C07D471/04 , C07D491/04
摘要： Compounds are provided that are modulators of the C5a receptor. The compounds are substituted dihydropyridines and are useful in pharmaceutical compositions, methods for the treatment of diseases and disorders involving the pathologic activtation of C5a receptors.
摘要翻译：提供了作为C5a受体调节剂的化合物。化合物是取代的二氢吡啶并且可用于药物组合物，用于治疗涉及C5a受体的病理活化的疾病和病症的方法。

27. 发明申请

WO2005057326A2 FRAMEWORK TO ENABLE INTEGRATION OF ANTI-SPAM TECHNOLOGIES 审中-公开
标题翻译：使防垃圾邮件技术整合的框架
公开(公告)号：WO2005057326A2
公开(公告)日：2005-06-23
申请号：PCT/US2004/024164
申请日：2004-07-26
申请人： MICROSOFT CORPORATION , MCMILLAN, Bruce, A. , WALLACE, Andrew, J. , KOORLAND, Neil, K. , WANG, Qiang , ATWELL, Simon, P. , NEELY, Samuel, J.
发明人： MCMILLAN, Bruce, A. , WALLACE, Andrew, J. , KOORLAND, Neil, K. , WANG, Qiang , ATWELL, Simon, P. , NEELY, Samuel, J.
IPC分类号： G06F
CPC分类号： H04L51/12 , G06Q10/00
摘要： A method that enables multiple spam detection solutions to be deployed in a manageable and rational manner to determine if a message is spam is presented. A framework invokes anti-spam filters to analyze the message and return confidence levels of whether a message is spam. The framework evaluates the highest confidence level against a set of defined thresholds. If the highest confidence level is greater than the highest threshold set by the administrator, the action specified for the highest threshold is taken. The highest confidence level is also compared against all thresholds and the action associated with the nearest threshold that has been exceeded is taken.
摘要翻译：
介绍一种方法，可以以可管理和合理的方式部署多个垃圾邮件检测解决方案，以确定邮件是否为垃圾邮件。框架调用反垃圾邮件过滤器来分析邮件并返回邮件是否为垃圾邮件的置信度。该框架根据一组定义的阈值评估最高置信水平。如果最高置信度大于管理员设置的最高阈值，则采取为最高阈值指定的操作。还将最高置信水平与所有阈值进行比较，并采取与已经超过的最近阈值相关的动作。

28. 发明申请

WO2005019432A2 A NOVEL GENE AND PROTEIN ASSOCIATED WITH ANGIOGENESIS AND ENDOTHELIAL APOPTOSIS 审中-公开
标题翻译：一种新的与血管生成和内皮细胞凋亡相关的基因和蛋白
公开(公告)号：WO2005019432A2
公开(公告)日：2005-03-03
申请号：PCT/US2004/027324
申请日：2004-08-20
申请人： CLEVELAND CLINIC FOUNDATION INNOVATIONS , WANG, Qiang , TIAN, Xiaoli , KADABA, Rajkumar
发明人： WANG, Qiang , TIAN, Xiaoli , KADABA, Rajkumar
IPC分类号： C12N
CPC分类号： C07K14/515
摘要： This invention provides isolated nucleic acid and amino acid sequences encoding VG5Q, a novel angiogenic growth factor protein with pro-angiogenic activity, a forkhead-associated domain, a G-patch domain; characteristic subcellular localization in an in vitro Matrigel model of angiogenesis: towards the cell periphery in early stages of tubulogenesis, between cells in newly formed endothelial tubes, and no nuclear staining after 24 hours; is expressed in endothelial cells; is secreted during angiogenesis; and interacts with TWEAK. The invention also provides for expression vectors containing nucleic acid sequences encoding VG5Q protein, and host cells containing one or more expression vectors for the recombinant expression of VG5Q. The invention also provides for methods of using VG5Q for the diagnosis and treatment of angiogenesis-mediated diseases or disorders.
摘要翻译：本发明提供了编码VG5Q的分离的核酸和氨基酸序列，VG5Q是具有促血管生成活性的新型血管生成生长因子蛋白，叉头相关结构域，G-结合结构域; 在血管生成的体外基质胶模型中的特征性亚细胞定位：在血管发生的早期阶段，在新形成的内皮细胞中的细胞之间，在24小时后没有核染色; 在内皮细胞中表达; 在血管生成期间分泌; 并与TWEAK交互。本发明还提供了含有编码VG5Q蛋白的核酸序列的表达载体和含有用于重组表达VG5Q的一种或多种表达载体的宿主细胞。本发明还提供了使用VG5Q诊断和治疗血管生成介导的疾病或病症的方法。

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