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21. 发明申请

WO2007027537A1 APPARATUS AND METHOD FOR TESTING AN IMPLANTABLE MEDICAL DEVICE AND SENSING PARAMETER SETTINGS 审中-公开
标题翻译：用于测试可植入医疗装置和感测参数设置的装置和方法
公开(公告)号：WO2007027537A1
公开(公告)日：2007-03-08
申请号：PCT/US2006/033327
申请日：2006-08-25
申请人： MEDTRONIC, INC. , CAO, Jian , GILLBERG, Jeffrey M.
发明人： CAO, Jian , GILLBERG, Jeffrey M.
IPC分类号： A61N1/372 , A61N1/37
CPC分类号： A61N1/37247 , A61N1/371
摘要： In an apparatus and a method for use in setting a sensing parameter of an implantable medical device (IMD) of a patient, cardiac data corresponding to a cardiac episode experienced by the patient is obtained from a sensing electrode associated with the IMD. At the time the cardiac data is obtained, the IMD is operated at a first setting of the sensing parameter. Based upon this cardiac data, a simulation is performed of cardiac event identification if the IMD were operated at a different setting of the sensing parameter. The simulated cardiac event identification performance of the IMD is then reported.
摘要翻译：在用于设置患者的可植入医疗装置（IMD）的感测参数的装置和方法中，从与IMD相关联的感测电极获得与患者经历的心脏发作相对应的心脏数据。在获得心脏数据时，在感测参数的第一设定下操作IMD。基于该心脏数据，如果IMD在感测参数的不同设置下操作，则进行心脏事件识别的模拟。然后报告IMD的模拟心脏事件识别性能。

22. 发明申请

WO2023007281A1 FILTER-BASED ARRHYTHMIA DETECTION 审中-公开
公开(公告)号：WO2023007281A1
公开(公告)日：2023-02-02
申请号：PCT/IB2022/056285
申请日：2022-07-07
申请人： MEDTRONIC, INC.
发明人： CHENG, Ya_Jian , WARMAN, Eduardo N. , GILLBERG, Jeffrey M. , KADROLKAR, Abhijit , SARKAR, Shantanu , OUSDIGIAN, Kevin T.
IPC分类号： A61B5/346 , G16H50/20 , A61B5/00
摘要： This disclosure is directed to a medical system and technique for a filter-based approach to arrhythmia detection. In one example, the medical system comprises one or more sensors configured to sense physiological parameter(s); sensing circuitry configured to generate patient data based on the sensed physiological parameter(s), the patient data comprising signal data to represent cardiac activity of the patient; and processing circuitry configured to: detect a cardiac arrhythmia for the patient based on a classification of the signal data in accordance with a machine learning model, wherein the machine learning model comprises filter(s) for at least one portion of the signal data, wherein the at least one filter corresponds to a feature set that maps to the cardiac activity represented by the portion(s) of the signal data; and generate for display output data indicative of a positive detection of the cardiac arrhythmia.

23. 发明申请

WO2021071713A1 SYSTEMS, METHODS, AND DEVICES FOR DETERMINING CARDIAC CONDITION 审中-公开
公开(公告)号：WO2021071713A1
公开(公告)日：2021-04-15
申请号：PCT/US2020/053472
申请日：2020-09-30
申请人： MEDTRONIC, INC.
发明人： GHOSH, Subham , GILLBERG, Jeffrey M.
IPC分类号： A61B5/00 , A61B5/04 , A61N1/37 , A61B5/0408
摘要： Systems, methods, and devices are described herein for evaluation of patients cardiac condition based on monitored electrical activity from a plurality of external electrodes. Various information such as electrical heterogeneity information may be generated based on the monitored electrical activity, which may be further analyzed to evaluate the patients cardiac condition. The systems, methods, and devices may provide an indication of whether the patient may benefit from cardiac therapy based on the evaluation of the patients cardiac condition.

24. 发明申请

WO2013162782A1 HEART SOUND -BASED PACING VECTOR SELECTION SYSTEM 审中-公开
标题翻译：心音放大矢量选择系统
公开(公告)号：WO2013162782A1
公开(公告)日：2013-10-31
申请号：PCT/US2013/032879
申请日：2013-03-19
申请人： MEDTRONIC, INC.
发明人： ZHANG, Xusheng , GILLBERG, Jeffrey M.
IPC分类号： A61N1/365 , A61N1/368
CPC分类号： A61N1/36578 , A61N1/3686
摘要： A system for generating a pacing vector selection table is configured to sense a heart sound signal and to represent sounds generated by the heart of the patient. A processor is configured to control the sequential selection (204) of pacing electrode vectors from electrodes positioned along a heart chamber. The processor is configured to receive (208) the heart sound signal, determine ((210), (212), (214), (216), (218), (220)) a plurality of different pacing responses using the heart sound signal for each of the pacing electrode vectors and generate (224) a pacing vector selection table listing the plurality of different pacing responses for each of the plurality of pacing electrode vectors.
摘要翻译：用于生成起搏矢量选择表的系统被配置为感测心音信号并且表示由患者心脏产生的声音。处理器被配置为控制来自沿心室的电极的起搏电极向量的顺序选择（204）。处理器被配置为接收（208）心音信号，使用心音响应（（210），（212），（214），（216），（218），（220））多个不同的起搏响应信号，并且生成（224）列出多个起搏电极矢量中的每一个的多个不同的起搏响应的起搏矢量选择表。

25. 发明申请

WO2022026998A1 ECG BELT SYSTEMS TO INTEROPERATE WITH IMDS 审中-公开
公开(公告)号：WO2022026998A1
公开(公告)日：2022-02-03
申请号：PCT/US2021/070964
申请日：2021-07-27
申请人： MEDTRONIC, INC.
发明人： KLEPFER, Ruth N. , JUSTEN, Manfred , GHOSH, Subham , GILLBERG, Jeffrey M. , FISCHER, Trent M. , SCHOTZKO, Elizabeth A.
IPC分类号： A61B5/024 , A61B5/0245 , A61B5/282 , A61B5/352 , A61B5/36 , A61B5/366 , A61B5/00 , A61N1/365 , A61B5/33
摘要： An electrode apparatus includes a portable amplifier and a plurality of external electrodes to be disposed proximate a patient's skin. A portable computing apparatus is operably coupled to the electrode apparatus. The portable computing apparatus is configured to monitor electrical activity from tissue of a patient using the plurality of external electrodes to generate a plurality of electrical signals over time. The portable computing apparatus is configured to perform at least one of optimizing at least one parameter of the of the implantable pacing device based on the plurality of electrical signals and determining cardiac synchrony based on the plurality of electrical signals.

26. 发明申请

WO2020191136A1 T-WAVE MORPHOLOGY ANALYSIS FOR PATHOLOGICAL EVENT DETECTION 审中-公开
公开(公告)号：WO2020191136A1
公开(公告)日：2020-09-24
申请号：PCT/US2020/023523
申请日：2020-03-19
申请人： MEDTRONIC, INC.
发明人： PIKULENKO, Inna A. , BERG, Gary L. , GILLBERG, Jeffrey M.
IPC分类号： A61B5/0452 , A61B5/00
摘要： A medical device senses cardiac electrical signals including T-waves attendant to ventricular myocardial repolarizations and detects a T-wave template condition associated with non-pathological changes in T-wave morphology. The device generates a T-wave template from T-waves sensed by the sensing circuit during the T-wave template condition. After generating the T-wave template, the device acquires a T-wave signal from the cardiac electrical signal and compares the acquired T-wave signal to the T-wave template. The device detects a pathological event in response to the acquired T-wave signal not matching the T-wave template.

27. 发明申请

WO2019183507A1 AV SYNCHRONOUS VFA CARDIAC THERAPY 审中-公开
公开(公告)号：WO2019183507A1
公开(公告)日：2019-09-26
申请号：PCT/US2019/023636
申请日：2019-03-22
申请人： MEDTRONIC, INC.
发明人： YANG, Zhongping , ANDERSON, Thomas, A. , COLIN, Brian, P. , CLEMENS, William J. , GHOSH, Subham , GILLBERG, Jeffrey M. , VERBEEK, Maurice T.I. , CAMPS, Toine , KORNET, Lilian , STEGEMANN, Berthold , RUTTEN, Jean
IPC分类号： A61N1/05 , A61N1/372 , A61N1/375 , A61N1/362 , A61N1/368
摘要： VfA cardiac therapy uses an implantable medical device or system. The implantable medical device includes a tissue-piercing electrode implanted in the basal and/or septal region of the left ventricular myocardium of the patient's heart from the triangle of Koch region of the right atrium through the right atrial endocardium and central fibrous body. The device may include a right atrial electrode, a right atrial motion detector, or both. The device may be implanted completely within the patient's heart or may use one or more leads to implant electrodes in the patient's heart. The device may be used to provide cardiac therapy, including single or multiple chamber pacing, atrioventricular synchronous pacing, asynchronous pacing, triggered pacing, cardiac resynchronization pacing, or tachycardia-related therapy. A separate medical device may be used to provide some functionality for cardiac therapy, such as sensing, pacing, or shock therapy.

28. 发明申请

WO2017023393A1 IDENTIFYING AMBIGUOUS CARDIAC SIGNALS FOR ELECTROPHYSIOLOGIC MAPPING 审中-公开
标题翻译：鉴定用于电生理映射的AMBIGUOUS CARDIAC信号
公开(公告)号：WO2017023393A1
公开(公告)日：2017-02-09
申请号：PCT/US2016/032376
申请日：2016-05-13
申请人： MEDTRONIC, INC.
发明人： DU, Juan , GHOSH, Subham , GILLBERG, Jeffrey M.
IPC分类号： A61B5/0456 , A61N1/365
CPC分类号： A61B5/04012 , A61B5/04085 , A61B5/0456 , A61B5/6823 , A61B5/7221 , A61B5/7239 , A61B5/7435 , A61N1/36507
摘要： A system and associated method is disclosed that comprises an electrode apparatus comprising a plurality of electrodes configured to be located proximate tissue of a patient. A display apparatus comprises a graphical user interface is configured to present information to a user. A computing apparatus coupled to the electrode apparatus and display apparatus, is configured to determine whether a signal acquired from a channel associated with an electrode from the plurality of electrodes is ambiguous. The computing apparatus calculates a first derivative of the signal, determine a first minimum from the first derivative, determine a second minimum from the second derivative and a second index within a window, calculate a ratio of the first and second derivatives, calculate a difference between a first and second index. The display apparatus displays whether the signal is ambiguous.
摘要翻译：公开了一种包括电极装置的系统和相关方法，所述电极装置包括被配置为位于患者的组织附近的多个电极。显示装置包括图形用户界面，其被配置为向用户呈现信息。耦合到电极装置和显示装置的计算装置被配置为确定从与多个电极中的电极相关联的通道获取的信号是否是不明确的。计算装置计算信号的一阶导数，从一阶导数确定第一最小值，从二阶导数确定第二最小值，并在窗口内确定第二索引，计算第一和第二导数的比率，计算第一和第二导数之间的差值第一和第二个索引。显示装置显示信号是否模糊。

29. 发明申请

WO2022026155A1 CARDIAC CONDUCTION SYSTEM EVALUATION 审中-公开
公开(公告)号：WO2022026155A1
公开(公告)日：2022-02-03
申请号：PCT/US2021/040994
申请日：2021-07-09
申请人： MEDTRONIC, INC.
发明人： KLEPFER, Ruth N. , JUSTEN, Manfred , GHOSH, Subham , GILLBERG, Jeffrey M.
IPC分类号： A61B5/28 , A61B5/349 , A61B5/367 , A61B5/00
摘要： Systems, interfaces, and methods are described herein related to the evaluation of a patient's cardiac conduction system and evaluation of cardiac conduction system pacing therapy being delivered to the patient's cardiac conduction system. Evaluation of the patient's cardiac conduction system may utilize a plurality of breakthrough maps to determine where a cardiac conduction system block may be located. Evaluation of cardiac conduction system pacing therapy may utilize various electrical heterogeneity information monitored before and during delivery of cardiac conduction system pacing therapy.

30. 发明申请

WO2020205091A1 SYSTEMS, METHODS, AND DEVICES FOR ADAPTIVE CARDIAC THERAPY 审中-公开
公开(公告)号：WO2020205091A1
公开(公告)日：2020-10-08
申请号：PCT/US2020/019574
申请日：2020-02-25
申请人： MEDTRONIC, INC.
发明人： GHOSH, Subham , SAMBELASHVILI, Aleksandre T. , GILLBERG, Jeffrey M. , JUSTEN, Manfred , FARRELL, Sean R.
IPC分类号： A61B5/04 , A61N1/04 , A61N1/08 , A61N1/37 , A61B5/0408 , A61N1/362
摘要： Systems, methods, and devices are described herein for evaluation, adjustment, and delivery of adaptive cardiac therapy. The systems, methods, and devices may utilize electrical heterogeneity information to determine and/or select one or more pacing settings and pacing type or configurations for a plurality of different heart rates. The adaptive cardiac therapy may deliver cardiac therapy at selected pacing settings such as, for example, A-V and/or V-V intervals, according to a presently measured heart rate and switch between left ventricular-only or biventricular cardiac pacing therapy also according to the presently measured heart rate.

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