专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

21. 发明申请

WO0198527A3 METHOD FOR THE HIGH-PARALLEL ANALYSIS OF POLYMORPHISMS 审中-公开
标题翻译：方法多态性的高度并行分析
公开(公告)号：WO0198527A3
公开(公告)日：2002-06-27
申请号：PCT/DE0102273
申请日：2001-06-19
申请人： EPIGENOMICS AG , BERLIN KURT , GUT IVO GLYNNE
发明人： BERLIN KURT , GUT IVO GLYNNE
IPC分类号： C12Q1/68 , G01N33/50
CPC分类号： C12Q1/6827 , C12Q1/6813 , C12Q1/6837 , C12Q2565/627 , C12Q2565/537 , C12Q2523/125 , C12Q2535/125
摘要： Disclosed is a method for the high-parallel characterisation of polymorphisms, especially SNPs. Said method can also be used for the simultaneous or separate detection of DNA methylation. First, a set of probes provided with at least one characteristic detectable identifying mark for a respective probe is connected to an addressed surface. A nucleic acid to be examined is then hybridised to these probes and the probes are extended in an allele-specific enzymatic reaction. The type and the occurrence of said allele-specific reaction determine whether the respective probe is enzymatically decomposed. Finally, the remaining allele-specific products are analysed and the existing alleles in the extracted nucleic acid samples are determined.
摘要翻译：为多态性，尤其是单核苷酸多态性，其也被用于DNA甲基化的同时或分开的检测的高度并行的表征方法被描述kann.Zuerst以配合一组探针，其设置有各自的探针检测的标记的至少一个特征，到所寻址的表面。然后杂交的核酸来进行检查，以这些探针，并且探针的等位基因特异性酶促反应延长。的性质和等位基因特异性反应的发生，以决定是否在特定的探针在以下步骤酶促降解。最近分析剩余allelespezifischen产品并使得存在于由询问核酸样品中等位基因的确定。

22. 发明申请

WO0177375A3 DIAGNOSIS OF DISEASES ASSOCIATED WITH GENE REGULATION 审中-公开
标题翻译：与基因调节有关的疾病的诊断
公开(公告)号：WO0177375A3
公开(公告)日：2002-06-27
申请号：PCT/EP0103968
申请日：2001-04-06
申请人： EPIGENOMICS AG , OLEK ALEXANDER , PIEPENBROCK CHRISTIAN , BERLIN KURT
发明人： OLEK ALEXANDER , PIEPENBROCK CHRISTIAN , BERLIN KURT
IPC分类号： G01N27/62 , A61K31/711 , A61K48/00 , A61P7/04 , A61P9/10 , A61P11/06 , A61P13/12 , A61P29/00 , A61P35/00 , B01J19/00 , C07K14/46 , C07K14/47 , C07K14/82 , C12M1/00 , C12N15/09 , C12Q1/48 , C12Q1/68 , G01N33/483 , G01N33/53 , G01N33/566 , G01N37/00 , A61K31/70 , C12N15/11 , G01N33/50
CPC分类号： C12Q1/6883 , C07K14/4703 , C07K14/82 , C12Q1/6886 , C12Q2600/154 , C12Q2600/156
摘要： The present invention relates to the chemically modified genomic sequences of genes associated with gene regulation, to oligonucleotides and/or PNA-oligomers for detecting the cytosine methylation state of genes associated with gene regulation which are directed against the sequence, as well as to a method for ascertaining genetic and/or epigenetic parameters of genes associated with gene regulation.
摘要翻译：本发明涉及与基因调节相关的基因的化学修饰的基因组序列，涉及用于检测针对该序列的与基因调节相关基因的胞嘧啶甲基化状态的寡核苷酸和/或PNA-寡聚体，以及涉及一种方法用于确定与基因调节相关的基因的遗传和/或表观遗传学参数。

23. 发明申请

WO0168912A3 DIAGNOSIS OF DISEASES ASSOCIATED WITH TUMOR SUPPRESSOR GENES AND ONCOGENES 审中-公开
标题翻译：诊断与肿瘤抑制基因和癌基因相关的疾病
公开(公告)号：WO0168912A3
公开(公告)日：2002-04-18
申请号：PCT/EP0102955
申请日：2001-03-15
申请人： EPIGENOMICS AG , OLEK ALEXANDER , PIEPENBROCK CHRISTIAN , BERLIN KURT
发明人： OLEK ALEXANDER , PIEPENBROCK CHRISTIAN , BERLIN KURT
IPC分类号： G01N27/62 , A61K31/7088 , A61K48/00 , A61P35/00 , C07K14/47 , C07K14/82 , C12M1/00 , C12N15/09 , C12Q1/68 , G01N21/78 , G01N33/15 , G01N33/50 , G01N33/53 , G01N33/566 , G01N33/58 , G01N37/00 , A61K31/70 , B01J19/00 , C12N15/11
CPC分类号： C07K14/82 , C07K14/4703 , C12Q1/6886 , C12Q2600/154
摘要： The present invention relates to the chemically modified genomic sequences of genes associated with tumor suppressor genes and oncogenes, to oligonucleotides and/or PNA-oligomers for detecting the cytosine methylation state of tumor suppressor genes and oncogenes which are directed against the sequence, as well as to a method for ascertaining genetic and/or epigenetic parameters of tumor suppressor genes and oncogenes.
摘要翻译：本发明涉及与肿瘤抑制基因和癌基因相关的基因的化学修饰的基因组序列，涉及用于检测针对该序列的肿瘤抑制基因和癌基因的胞嘧啶甲基化状态的寡核苷酸和/或PNA寡聚体，以及涉及确定肿瘤抑制基因和癌基因的遗传和/或表观遗传学参数的方法。

24. 发明申请

WO0138565A3 OLIGOMER ARRAY WITH PNA AND/OR DNA OLIGOMERS ON A SURFACE 审中-公开
标题翻译：具有PNA和/或DNA寡核苷酸的寡核苷酸阵列在表面上
公开(公告)号：WO0138565A3
公开(公告)日：2001-11-15
申请号：PCT/DE0004301
申请日：2000-11-24
申请人： EPIGENOMICS AG , BERLIN KURT
发明人： BERLIN KURT
IPC分类号： C12N15/09 , C12Q1/68
CPC分类号： C12Q1/6827 , C12Q1/6837 , C12Q2523/125
摘要： The invention relates to an oligomer array with PNA (Peptide Nucleic Acid) and/or DNA oligomers on a surface, said oligomers comprising oligomers of 6 to 20 monomers or nucleobases each. Said monomers or nucleobases comprise at least one sequence of the general formula DDCGDD or of the general formula DDTGDD or of the general formula HHCGHH or of the general formula HHCAHH, wherein H represents any of the bases adenine (A), cytosine (C) or thymine (T) and D represents any of the bases adenine (A), guanine (G) or thymine (T). The location of the oligomers on the surface is correlated with the sequence of the oligomers. The inventive oligomer arrays are used to detect cytosine methylations in genomic DNA.
摘要翻译：公开的是与PNA（肽核酸）的低聚物阵列 - 和/或DNA寡聚体的表面上，包括单体或核碱基6和20之间的低聚物，其中，所述通式或一般DDCGDD中的至少一个序列式DDTGDD或通式HHCGHH或通式HHCAHH包括wobeiH的碱基腺嘌呤（A），胞嘧啶（C）或胸腺嘧啶（T）的装置之一和D的碱基腺嘌呤（A），鸟嘌呤（G）或胸腺嘧啶的一个（T ）基团，并且其中，所述的低聚物与所述低聚物的序列的表面上的位点相关。本发明Oligomar阵列在基因组DNA用于检测甲基化胞嘧啶的。

25. 发明申请

WO0130489A3 DEVICE AND METHOD FOR HYBRIDIZING DOUBLE-STRANDED DNA SAMPLES ON OLIGOMER ARRAYS 审中-公开
标题翻译： DEVICE AND METHOD FOR杂交双链DNA样本，以低聚物阵列
公开(公告)号：WO0130489A3
公开(公告)日：2001-10-25
申请号：PCT/DE0003771
申请日：2000-10-18
申请人： EPIGENOMICS AG , BERLIN KURT
发明人： BERLIN KURT
IPC分类号： C12N15/09 , B01J19/00 , B01L7/00 , C12M1/00 , C12M1/38 , C12M1/40 , C12Q1/68 , C40B40/06 , C40B60/14
CPC分类号： B01L7/52 , B01J19/0013 , B01J2219/00054 , B01J2219/00094 , B01J2219/00103 , B01J2219/00137 , B01J2219/00353 , B01J2219/00495 , B01J2219/00529 , B01J2219/00608 , B01J2219/00659 , B01J2219/00689 , B01J2219/00722 , C40B40/06 , C40B60/14
摘要： The invention relates to a device for hybridizing double-stranded DNA samples on oligomer arrays, comprising at least one pump (4, 14), which has two conveying directions, a closed hybridization chamber (1, 11), a cooling element (2, 12) and a heating element (3, 13). The individual components are interconnected in the above order by lines (5, 15) in which liquids are conveyed.
摘要翻译：描述了用于杂交双链DNA样本，以低聚物的阵列的设备，其包括在两个方向上的至少一个促销泵（4,14），一个封闭的杂交室（1，11），冷却元件（2，12）和加热元件（3 ，13），其特征在于，在每种情况下按上述顺序彼此通过液体促销线路路径（5，15）的各个部件被连接。

26. 发明申请

WO2007009755A8 COMPOSITIONS AND METHODS FOR CANCER DIAGNOSTICS COMPRISING PAN-CANCER MARKERS 审中-公开
标题翻译：包含PAN-CANCER标记的癌症诊断的组成和方法
公开(公告)号：WO2007009755A8
公开(公告)日：2008-05-02
申请号：PCT/EP2006007067
申请日：2006-07-18
申请人： EPIGENOMICS AG , BERLIN KURT
发明人： BERLIN KURT
IPC分类号： C12Q1/68
CPC分类号： G01N33/574 , C12Q1/6881 , C12Q1/6886 , C12Q2600/154 , C12Q2600/158 , C12Q2600/16
摘要： The present invention relates to compositions and methods for cancer diagnostics, including but not limited to, so-called ,,pan cancer markers". In particular, the present invention provides methods of identifying methylation patterns in genes associated with specific cancers, and their related uses. In another aspect, the present invention provides methods of selecting and combining useful sets of pan cancer markers.
摘要翻译：本发明涉及用于癌症诊断的组合物和方法，包括但不限于所谓的泛癌标记物。特别地，本发明提供鉴定与特定癌症相关基因中的甲基化模式及其相关的方法另一方面，本发明提供了选择和组合有用的泛癌标记物的方法。

27. 发明申请

WO2007039290A2 METHODS AND NUCLEIC ACIDS FOR THE ANALYSIS OF GENE EXPRESSION ASSOCIATED WITH THE PROGNOSIS OF CELL PROLIFERATIVE DISORDERS 审中-公开
标题翻译：与细胞增殖性疾病预后相关的基因表达分析的方法和核酸
公开(公告)号：WO2007039290A2
公开(公告)日：2007-04-12
申请号：PCT/EP2006009605
申请日：2006-10-04
申请人： EPIGENOMICS AG , BERLIN KURT
发明人： BERLIN KURT
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/154
摘要： The present application provides methods and nucleic acids for providing a prognosis of cell proliferative disorders, most preferably cancer but not breast cancer.
摘要翻译：本申请提供了用于提供细胞增殖性病症预后的方法和核酸，最优选癌症而不是乳腺癌。

28. 发明申请

WO2005019477A3 METHODS AND COMPOSITIONS FOR DIFFERENTIATING TISSUES OR CELL TYPES USING EPIGENETIC MARKERS 审中-公开
标题翻译：使用染色体标记分化组织或细胞类型的方法和组合物
公开(公告)号：WO2005019477A3
公开(公告)日：2005-06-16
申请号：PCT/US2004026071
申请日：2004-08-12
申请人： EPIGENOMICS AG , LEWIN JOERN , BERLIN KURT , HILDMANN THOMAS , OLEK ALEXANDER , BECK STEPHAN , NOVIK KAREN
发明人： LEWIN JOERN , BERLIN KURT , HILDMANN THOMAS , OLEK ALEXANDER , BECK STEPHAN , NOVIK KAREN
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6881 , C12Q2600/154 , C12Q2600/16
摘要： The present invention provides, inter alia, a method for generating a genome-wide epigenomic map, comprising a correlation between methylation variable CpG positions (MVP) and genomic DNA sample types. MVP are those CpG positions that show a variable quantitative level of methylation between sample types. Particular genomic regions of interest (ROI) provide preferred marker sequences that comprise multiple, and preferably proximate MVP, and that have novel utility for distinguishing sample types. The epigenic maps have broad utility, for example, in identifying sample types, or for distinguishing between and among sample types. In a preferred embodiment the epigenomic map is based on methylation variable regions (MVP) within the major histocompatibility complex (MHC), and has utility, for example, in identifying the cell or tissue source of a genomic DNA sample, or for distinguishing one or more particular cell or tissue types among other cell or tissue types. Analysis of epigenetic characteristics of one, or of a set of nucleic acid sequences, in the context of an inventive epigenomic map, allows for the determination of an origin of the nucleic acids.
摘要翻译：本发明尤其提供了一种生成全基因组表观遗传学图谱的方法，其包括甲基化可变CpG位点（MVP）和基因组DNA样品类型之间的相关性。 MVP是显示样品类型之间甲基化可变定量水平的那些CpG位置。特定的感兴趣的基因组区域（ROI）提供优选的标记序列，其包含多个，优选接近MVP，并且具有用于区分样品类型的新颖效用。表征性地图具有广泛的用途，例如，在识别样本类型中，或用于区分样本类型和样本类型。在优选的实施方案中，表观基因组图基于主要组织相容性复合物（MHC）内的甲基化可变区（MVP），并且可用于例如鉴定基因组DNA样品的细胞或组织来源，或用于区分一个或更特定的细胞或组织类型与其他细胞或组织类型。在本发明表观遗传学图谱的背景下，一种或一组核酸序列的表观遗传学特征的分析允许确定核酸的来源。

29. 发明申请

WO0200932A3 DIAGNOSIS OF KNOWN GENETIC PARAMETERS WITHIN THE MHC 审中-公开
标题翻译：诊断中的主要遗传参数在MHC
公开(公告)号：WO0200932A3
公开(公告)日：2003-09-04
申请号：PCT/IB0101501
申请日：2001-06-29
申请人： EPIGENOMICS AG , OLEK ALEXANDER , PIEPENBROCK CHRISTIAN , BERLIN KURT
发明人： OLEK ALEXANDER , PIEPENBROCK CHRISTIAN , BERLIN KURT
IPC分类号： G01N27/62 , C07K14/47 , C07K14/82 , C12N15/09 , C12Q1/68 , G01N33/53 , G01N37/00
CPC分类号： C07K14/82 , C07K14/4703 , C12Q1/6883 , C12Q2600/154
摘要： The invention relates to nuclear acids to diagnose a set of genetic parameters in the Major Histocompatibility Complex (MHC), comprising a reversibly complimentary or identical piece of at least 20 base pairs of a chemically pre-treated genomic DNA, in addition to a set of oligomer probes (oligonucleotides and /or PNO oligomers) which are used to detect cytosine methylation substances in nucleic acids. Said probes are especially suitable for the diagnosis of genetic parameters within the MHC.
摘要翻译：本发明描述了从一组主要组织相容性复合体（MHC）内的遗传参数的用于诊断的核酸，其包含至少20个碱基对长的反转化学预处理的基因组DNA的互补或相同部分和一组低聚物探针（寡核苷酸和/或PNA寡聚体）其用于在核酸检测胞嘧啶Metylierungszustandes。这些探针是特别适合于MHC内的遗传参数的诊断。

30. 发明申请

WO0200705A3 METHOD AND NUCLEIC ACIDS FOR THE DIFFERENTIATION OF ASTROCYTOMA, OLIGOASTROCYTOMA AND OLIGODENDROGLIOMA TUMOR CELLS 审中-公开
标题翻译：方法和核酸对阿氏体，低密度脂蛋白胆固醇和低密度脂蛋白肿瘤细胞的分化
公开(公告)号：WO0200705A3
公开(公告)日：2003-08-14
申请号：PCT/EP0107539
申请日：2001-07-02
申请人： EPIGENOMICS AG , OLEK ALEXANDER , PIEPENBROCK CHRISTIAN , BERLIN KURT
发明人： OLEK ALEXANDER , PIEPENBROCK CHRISTIAN , BERLIN KURT
IPC分类号： G01N27/62 , C07K14/47 , C07K14/82 , C12M1/00 , C12M1/34 , C12N15/09 , C12Q1/68 , G01N33/53 , G01N33/58 , G01N37/00 , B01J19/00 , C07K14/48 , G01N33/483
CPC分类号： C07K14/82 , C07K14/4703 , C12Q1/6883 , C12Q1/6886 , C12Q2523/125 , C12Q2600/154 , C12Q2600/156
摘要： The present invention relates to the chemically modified nucleic acid sequences of genomic DNA, to oligonucleotides and/or PNA-oligomers for detecting the cytosine methylation state of genomic DNA, as well as to a method for ascertaining genetic and/or epigenetic parameters of genes for the characterization, classification, differentiation, grading, staging, treatment and diagnosis of oligodendrogliomas, astrocytomas and oligoastrocytomas.
摘要翻译：本发明涉及基因组DNA的化学修饰的核酸序列，用于检测基因组DNA的胞嘧啶甲基化状态的寡核苷酸和/或PNA寡聚体，以及用于确定基因组DNA的遗传和/或表观遗传参数的方法少突胶质细胞瘤，星形细胞瘤和低分子细胞瘤的表征，分类，分化，分级，分期，治疗和诊断。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式