专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

21. 发明申请

WO2005116236A3 METHODS FOR TREATING CANCER USING ANTI-WNT2 MONOCLONAL ANTIBODIES AND SIRNA 审中-公开
标题翻译：使用抗WNT2单克隆抗体和SIRNA治疗癌症的方法
公开(公告)号：WO2005116236A3
公开(公告)日：2006-11-09
申请号：PCT/US2005017047
申请日：2005-05-16
申请人： UNIV CALIFORNIA , YOU LIANG , BIAO HE , XU ZHIDONG , JABLONS DAVID M
发明人： YOU LIANG , BIAO HE , XU ZHIDONG , JABLONS DAVID M
IPC分类号： C12Q1/68 , C07K16/18 , C12N15/113 , C12P21/06
CPC分类号： C07K16/18 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K2317/565 , C07K2317/73 , C07K2317/75 , C12N15/113 , C12N2310/14 , A61K2300/00
摘要： This invention relates to methods of inhibiting the growth of cells, in particular cancer cells, that overexpress Wnt2. The methods comprise contacting the cell with an agent that binds to Wnt2 mRNA or Wnt2 protein, interferes with Wnt2 signaling or inhibits binding of the Wnt2 protein to another protein, such as a Frizzled receptor.
摘要翻译：本发明涉及抑制过表达Wnt2的细胞，特别是癌细胞生长的方法。所述方法包括使细胞与结合Wnt2mRNA或Wnt2蛋白的试剂接触，干扰Wnt2信号传导或抑制Wnt2蛋白与另一种蛋白质如卷曲毛发受体的结合。

22. 发明申请

WO2005112988B1 METHODS FOR TREATING AND DIAGNOSING CANCER WITH WNT INHIBITORY FACTOR-1 (WIF-1) 审中-公开
标题翻译：用Wnt抑制因子-1（WIF-1）治疗和诊断癌症的方法
公开(公告)号：WO2005112988B1
公开(公告)日：2006-09-21
申请号：PCT/US2005018133
申请日：2005-05-23
申请人： UNIV CALIFORNIA , YOU LIANG , HE BIAO , XU ZHIDONG , JABLONS DAVID M
发明人： YOU LIANG , HE BIAO , XU ZHIDONG , JABLONS DAVID M
IPC分类号： C07K14/00 , A61K38/00 , A61K38/17 , A61K38/54 , C07K14/82 , C12Q1/68 , G01N33/53
CPC分类号： A61K38/1709 , C07K14/82
摘要： This invention provides compositions, methods and kits for the diagnosis and treatment of cancers wherein Wnt Inhibitory Factor-1 (WIF-1) is underexpressed.
摘要翻译：本发明提供了用于诊断和治疗Wnt抑制因子-1（WIF-1）低表达的癌症的组合物，方法和试剂盒。

23. 发明申请

WO2006017318A2 METHODS FOR TREATING CANCER USING AGENTS THAT INHIBIT WNT16 SIGNALING 审中-公开
标题翻译：使用禁止WNT16信号的药物治疗癌症的方法
公开(公告)号：WO2006017318A2
公开(公告)日：2006-02-16
申请号：PCT/US2005024759
申请日：2005-07-11
申请人： UNIV CALIFORNIA , YOU LIANG , HE BIAO , XU ZHIDONG , JABLONS DAVID M
发明人： YOU LIANG , HE BIAO , XU ZHIDONG , JABLONS DAVID M
IPC分类号： A61K48/00
CPC分类号： A61K48/00 , A61K31/00 , A61K2039/505 , C07K16/22 , C07K16/3015 , C07K16/3023 , C07K16/3061 , C07K2317/21 , C07K2317/55 , C07K2317/73 , C07K2317/75 , C12N15/1135 , C12N2310/14
摘要： This invention relates to methods of inhibiting the growth of cells, in particular cancer cells that over express Wnt16 protein. The methods comprise contacting the cell with an agent that binds to Wnt16 mRNA or Wnt16 protein, interferes with Wnt16 signaling or inhibits binding of the Wnt16 protein to another protein, such as a Frizzled receptor.
摘要翻译：本发明涉及抑制细胞生长的方法，特别是过表达Wnt16蛋白的癌细胞的生长方法。所述方法包括使细胞与结合Wnt16mRNA或Wnt16蛋白的试剂接触，干扰Wnt16信号传导或抑制Wnt16蛋白与另一种蛋白质如卷曲毛发受体的结合。

24. 发明申请

WO2005023199A2 SOCS-3 PROMOTER METHYLATION IN CANCER 审中-公开
标题翻译： SOCS-3促性腺激素在癌症中的表达
公开(公告)号：WO2005023199A2
公开(公告)日：2005-03-17
申请号：PCT/US2004/029037
申请日：2004-09-03
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , HE, Biao , YOU, Liang , XU, Zhidong , JABLONS, David, M.
发明人： HE, Biao , YOU, Liang , XU, Zhidong , JABLONS, David, M.
IPC分类号： A61K
CPC分类号： C12Q1/6886 , C12Q1/6827 , C12Q2600/136 , C12Q2600/154 , C12Q2600/158 , G01N33/5011 , G01N33/57407 , G01N33/57415 , G01N33/57419 , G01N33/57423 , G01N2500/00 , G01N2800/52 , C12Q2523/125
摘要： This invention provides compositions and methods for the diagnosis and treatment of cancers that exhibit decreased SOCS-3 expression.
摘要翻译：本发明提供了用于诊断和治疗SOCS-3表达降低的癌症的组合物和方法。

25. 发明申请

WO2010011180A1 METHOD AND SYSTEM FOR SECURING AGAINST LEAKAGE OF SOURCE CODE 审中-公开
标题翻译：用于保护源代码泄漏的方法和系统
公开(公告)号：WO2010011180A1
公开(公告)日：2010-01-28
申请号：PCT/SG2008/000271
申请日：2008-07-25
申请人： RESOLVO SYSTEMS PTE LTD , WONG, Onn Chee , LOH, Siew Keng , YANG, Hui , WANG, You Liang
发明人： WONG, Onn Chee , LOH, Siew Keng , YANG, Hui , WANG, You Liang
IPC分类号： G06F21/00 , H04L9/00
CPC分类号： H04L63/0227 , G06F21/12 , G06F21/55 , H04L63/0245 , H04L63/1416 , Y10S707/99933
摘要： Embodiments of the invention provide a method and a system of detecting source code in a message being sent over a digital communication network to secure against unauthorized leakage of source code. The message is intercepted on a network device, placed into a memory on the network device, and divided into one or more segments, wherein each segment includes a predetermined number of lines of text from the message. For each segment, one or more syntax rules of a programming language is applied to the segment and a predetermined number of context lines of text before the segment and/or after the segment, to determine which of the syntax rules of the programming language are matched in the segment. A determination of whether the text message includes source code is provided based on the syntax rules that were matched.
摘要翻译：本发明的实施例提供了一种检测在数字通信网络中发送的消息中的源代码的方法和系统，以防止未经授权的源代码泄漏。消息在网络设备上被拦截，放置在网络设备上的存储器中，并且被划分成一个或多个段，其中每个段包括来自消息的预定数量的文本行。对于每个段，编程语言的一个或多个语法规则被应用于段和/或在段之后的段和预定数量的文本上下文行，以确定编程语言的哪个语法规则被匹配在细分。基于匹配的语法规则，确定文本消息是否包含源代码。

26. 发明申请

WO2008066569A3 HERMETIC CHAMBER WITH ELECTRICAL FEEDTHROUGHS 审中-公开
标题翻译：具有电子充电器的电磁室
公开(公告)号：WO2008066569A3
公开(公告)日：2008-10-02
申请号：PCT/US2007011612
申请日：2007-05-15
申请人： CARDIOMEMS INC , O'BRIEN DAVID , COURCIMAULT CHRISTOPHE , YOU LIANG
发明人： O'BRIEN DAVID , COURCIMAULT CHRISTOPHE , YOU LIANG
IPC分类号： G01L9/12
CPC分类号： G01L9/0042 , G01L9/0075
摘要： A pressure cavity is durable, stable, and biocompatible and configured in such a way that it constitutes pico to nanoliter-scale volume. The pressure cavity is hermetically sealed from the exterior environment while maintaining the ability to communicate with other devices. Micromachined, hermetically-sealed sensors are configured to receive power and return information through direct electrical contact with external electronics. The pressure cavity and sensor components disposed therein are hermetically sealed from the ambient in order to reduce drift and instability within the sensor. The sensor is designed for harsh and biological environments, e.g. intracorporeal implantation and in vivo use. Additionally, novel manufacturing methods are employed to construct the sensors.
摘要翻译：压力腔是耐用的，稳定的和生物相容的并且被配置成使得其构成微微至纳升级体积的量。压力腔与外部环境密封，同时保持与其他设备通信的能力。微加工的密封传感器配置为通过与外部电子设备的直接电气接触来接收电力并返回信息。设置在其中的压力腔和传感器部件与环境密封，以便减少传感器内的漂移和不稳定性。传感器设计用于苛刻和生物环境，例如体内植入和体内使用。另外，采用新颖的制造方法来构造传感器。

27. 发明申请

WO2008066569A2 HERMETIC CHAMBER WITH ELECTRICAL FEEDTHROUGHS 审中-公开
标题翻译：带电子馈线的密封室
公开(公告)号：WO2008066569A2
公开(公告)日：2008-06-05
申请号：PCT/US2007/011612
申请日：2007-05-15
申请人： CARDIOMEMS, INC. , O'BRIEN, David , COURCIMAULT, Christophe , YOU, Liang
发明人： O'BRIEN, David , COURCIMAULT, Christophe , YOU, Liang
IPC分类号： G01L9/12
CPC分类号： G01L9/0042 , G01L9/0075
摘要： A pressure cavity is durable, stable, and biocompatible and configured in such a way that it constitutes pico to nanoliter-scale volume. The pressure cavity is hermetically sealed from the exterior environment while maintaining the ability to communicate with other devices. Micromachined, hermetically-sealed sensors are configured to receive power and return information through direct electrical contact with external electronics. The pressure cavity and sensor components disposed therein are hermetically sealed from the ambient in order to reduce drift and instability within the sensor. The sensor is designed for harsh and biological environments, e.g. intracorporeal implantation and in vivo use. Additionally, novel manufacturing methods are employed to construct the sensors.
摘要翻译：压力腔是耐用的，稳定的和生物相容性的，并且以这样的方式配置，使得它构成微微至纳升级的体积。压力腔与外部环境密封，同时保持与其他设备通信的能力。微机械密封传感器配置为通过与外部电子设备的直接电接触来接收电源并返回信息。设置在其中的压力腔和传感器部件与环境气密密封以减少传感器内的漂移和不稳定性。该传感器设计用于恶劣和生物环境，例如体内植入和体内使用。此外，采用新颖的制造方法构建传感器。

28. 发明申请

WO2007061841A2 CAPACITOR ELECTRODE FORMED ON SURFACE OF INTEGRATED CIRCUIT CHIP 审中-公开
标题翻译：集成电路芯片表面形成电容器电极
公开(公告)号：WO2007061841A2
公开(公告)日：2007-05-31
申请号：PCT/US2006/044670
申请日：2006-11-17
申请人： CARDIOMEMS, INC. , O'BRIEN, David , YOU, Liang
发明人： O'BRIEN, David , YOU, Liang
IPC分类号： G01L9/12
CPC分类号： G01L9/0075
摘要： A sensor has a sensor housing defining a cavity therein. A first wall partially defining the cavity is deflectable under a physiologically relevant range of pressures. An integrated circuit chip bearing electronics is fixedly mounted within the cavity. A capacitor comprises first and second capacitor plates in generally parallel, spaced-apart relation. The first capacitor plate is physically coupled to the deflectable wall so as to move as the wall deflects, and the second capacitor plate is carried by the chip. The second capacitor plate is in electrical communication with the input pad of the chip.
摘要翻译：传感器具有在其中限定空腔的传感器外壳。部分地限定空腔的第一壁在生理学上相关的压力范围内是可偏转的。集成电路芯片轴承电子器件固定地安装在腔内。电容器包括大致平行且间隔开的关系的第一和第二电容器板。第一电容器板物理耦合到可偏转壁，以便当壁偏转时移动，并且第二电容器板由芯片承载。第二电容器板与芯片的输入焊盘电连通。

29. 发明申请

WO2006017318A3 METHODS FOR TREATING CANCER USING AGENTS THAT INHIBIT WNT16 SIGNALING 审中-公开
公开(公告)号：WO2006017318A3
公开(公告)日：2006-02-16
申请号：PCT/US2005/024759
申请日：2005-07-11
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , YOU, Liang , HE, Biao , XU, Zhidong , JABLONS, David, M.
发明人： YOU, Liang , HE, Biao , XU, Zhidong , JABLONS, David, M.
IPC分类号： A61K38/00 , A61K31/70 , C07K16/00 , C12N5/00 , C07H21/02 , C07H21/04 , C12Q1/68
摘要： This invention relates to methods of inhibiting the growth of cells, in particular cancer cells that over express Wnt16 protein. The methods comprise contacting the cell with an agent that binds to Wnt16 mRNA or Wnt16 protein, interferes with Wnt16 signaling or inhibits binding of the Wnt16 protein to another protein, such as a Frizzled receptor.

30. 发明申请

WO2004092346A2 SMALL MOLECULE INHIBITION OF A PDZ-DOMAIN INTERACTION 审中-公开
标题翻译：小分子抑制PDZ领域相互作用
公开(公告)号：WO2004092346A2
公开(公告)日：2004-10-28
申请号：PCT/US2004/011619
申请日：2004-04-15
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , GUY, Rodney, Kiplin , KUNTZ, Irwin, D. , HARESCO, Jose , FUJII, Naoaki , NOVAK, Kathleen, P. , STOKOE, David , HE, Biao , YOU, Liang , XU, Zhidong , JABLONS, David, M.
发明人： GUY, Rodney, Kiplin , KUNTZ, Irwin, D. , HARESCO, Jose , FUJII, Naoaki , NOVAK, Kathleen, P. , STOKOE, David , HE, Biao , YOU, Liang , XU, Zhidong , JABLONS, David, M.
IPC分类号： C12N
CPC分类号： C07D209/12 , C07D209/18
摘要： Novel compounds that have been found effective in inhibiting PDZ domain interactions, and particularly interactions of PDZ domains in MAGIs with the oncogenic (tumor suppressor) protein PTEN and interactions between the PDZ domain in the Dishevelled (Dvl) protein and other proteins such as the Frizzled (Fz) protein, have the general formula (I) or (II) The invention also includes combinatorial libraries, arrays and methods for screening and studying proteins using such compounds. Compounds of the invention have produced apoptosis in certain cell lines that overexpress the Dishevelled protein (Dvl); inhibiting Wnt signaling.
摘要翻译：已经发现已经发现有效抑制PDZ结构域相互作用的新型化合物，特别是MAGI中PDZ结构域与致癌（肿瘤抑制基因）蛋白PTEN的相互作用以及Dishedvelled（Dvl）蛋白质中的PDZ结构域和其它蛋白质之间的相互作用（Fz）蛋白，具有通式（I）或（II）本发明还包括用于筛选和研究使用这些化合物的蛋白质的组合文库，阵列和方法。本发明化合物在过表达蛋白质（Dv1）的某些细胞系中产生凋亡; 抑制Wnt信号。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式