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21. 发明申请

WO2019010470A1 SEGMENTATION OF MEDICAL IMAGES 审中-公开
公开(公告)号：WO2019010470A1
公开(公告)日：2019-01-10
申请号：PCT/US2018/041168
申请日：2018-07-07
申请人： UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC.
发明人： EL-BAZ, Ayman, S. , SOLIMAN, Ahmed , EL-MELEGY, Moumen , EL-GHAR, Mohamed, Abou
IPC分类号： G06T7/143 , G16H30/00
CPC分类号： G06T7/143 , G06T7/149 , G06T2207/20084 , G06T2207/20121 , G06T2207/20124 , G06T2207/30004 , G16H30/40 , G16H50/70
摘要： Methods for segmenting medical images from different modalities include integrating a plurality of types of quantitative image descriptors with a deep 3D convolutional neural network. The descriptors include: (i) a Gibbs energy for a prelearned 7th-order Markov-Gibbs random field (MGRF) model of visual appearance, (ii) an adaptive shape prior model, and (iii) a first-order appearance model of the original volume to be segmented. The neural network fuses the computed descriptors to obtain the final voxel-wise probabilities of the goal regions.

22. 发明申请

WO2018148541A1 ACTINOHIVIN VARIANT POLYPEPTIDES AND RELATED METHODS 审中-公开
公开(公告)号：WO2018148541A1
公开(公告)日：2018-08-16
申请号：PCT/US2018/017617
申请日：2018-02-09
申请人： UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC.
发明人： MATOBA, Nobuyuki
IPC分类号： A61K38/00 , A61P31/12 , C07K14/00 , C07K19/00 , C12N15/09
CPC分类号： A61P31/12 , A61K38/00 , C07K14/00 , C07K14/36 , C07K19/00
摘要： Polypeptides are provided that include an actinohivin variant polypeptide. The actinohivin variant polypeptide can be operably connected to an antibody fragment, such as a fragment crystallizable (Fc) region of immunoglobulin (Ig) G. Nucleic acid sequences, expression vectors, and transformed plant cells useful for producing the polypeptides are also provided. Further provided are methods for treating a viral infection or a cancer in a subject and include the step of administering the actinohivin variant polypeptide to the subject.

23. 发明申请

WO2018089495A1 ENCAPSULATION OF PHOSPHODIESTERASE INHIBITORS TO TREAT ALCOHOLIC LIVER DISEASE 审中-公开
标题翻译：磷酸二酯酶抑制剂包裹治疗酒精性肝病的研究
公开(公告)号：WO2018089495A1
公开(公告)日：2018-05-17
申请号：PCT/US2017/060642
申请日：2017-11-08
申请人： UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC.
发明人： MALDONADO, Claudio , MCCLAIN, Craig , BARVE, Shirish S. , GOBEJISHVILI, Leila , BAUER, Philip
IPC分类号： A61K9/127 , A61K31/70 , A61P1/16
摘要： Provided herein are compositions for treating liver inflammation. The compositions include a biologically active phosphodiesterase 4 (PDE4) inhibitor and a liposome, the liposome encapsulating the PDE4 inhibitor. The liposome may be anionic and include both neutrally charged and negatively charged phospholipids. Encapsulation of the PDE4 inhibitor in the liposome facilitates targeted delivery to the liver while limiting access to the central nervous system.
摘要翻译：本文提供了用于治疗肝脏炎症的组合物。该组合物包含生物活性磷酸二酯酶4（PDE4）抑制剂和脂质体，该脂质体包封PDE4抑制剂。脂质体可以是阴离子的并且包括中性带电和带负电荷的磷脂。封装脂质体中的PDE4抑制剂促进靶向递送至肝脏，同时限制进入中枢神经系统。

24. 发明申请

WO2018071806A1 EXOSOMAL BIOMARKERS FOR DIAGNOSIS AND PROGNOSIS OF CANCER AND RELATED METHODS 审中-公开
标题翻译：用于诊断和预测癌症的外来生物标记物及相关方法
公开(公告)号：WO2018071806A1
公开(公告)日：2018-04-19
申请号：PCT/US2017/056570
申请日：2017-10-13
申请人： UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC.
发明人： ZHANG, Huang-Ge
IPC分类号： C07H21/02 , C12N15/09 , G01N30/00 , G01N33/50 , G01N33/53
摘要： Methods for diagnosing a cancer in a subject are provided in which a biological sample is provided from a subject including one or more exosomes. The exosomes are isolated from the biological sample and are used to identify a type and/or amount of one or more tumor suppressor miRNAs encapsulated by the exosomes. A measurable difference in the type and/or amount of the tumor suppressor miRNAs as compared to control levels allows for a diagnosis of cancer in the subject. Methods of selecting or modifying a treatment and methods for determining whether to initiate or continue prophylaxis or treatment for a cancer based on the exosomal miRNAs is further provided.
摘要翻译：提供了用于诊断受试者中癌症的方法，其中从包括一种或多种外泌体的受试者提供生物样品。将外泌体从生物样品中分离出来并用于鉴定由外泌体包封的一种或多种肿瘤抑制剂miRNA的类型和/或量。与对照水平相比，肿瘤抑制剂miRNA的类型和/或量的可测量的差异允许对受试者中的癌症进行诊断。进一步提供了选择或修饰治疗的方法和基于外泌体miRNA确定是否启动或继续预防或治疗癌症的方法。

25. 发明申请

WO2018067851A1 BACTERIAL AMYLOID INDUCED PROTEINOPATHIES AND TREATMENTS THEREFOR 审中-公开
标题翻译：细菌性淀粉样蛋白引起的蛋白病及其治疗
公开(公告)号：WO2018067851A1
公开(公告)日：2018-04-12
申请号：PCT/US2017/055394
申请日：2017-10-05
申请人： UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC.
发明人： FRIEDLAND, Robert
IPC分类号： A23L1/29 , A61K35/74 , A61P25/00 , A61P25/14 , A61P25/16 , A61P25/28
摘要： Methods of preventing, inhibiting and/or decreasing protein deposits of a human amyloid protein and/or neuroinflammation in the central nervous system by reducing an amount of exposure to a pathogenic bacterial amyloid in the gastrointestinal tract are disclosed. Also disclosed are methods of preventing, inhibiting and/or treating a proteinopathy by reducing an amount of exposure to a pathogenic bacterial amyloid in the gastrointestinal tract.
摘要翻译：通过减少在胃肠道中暴露于病原性细菌淀粉样蛋白的量来预防，抑制和/或减少中枢神经系统中人淀粉样蛋白蛋白质沉积和/或神经炎症的方法。还公开了通过减少在胃肠道中暴露于致病细菌淀粉样蛋白的量来预防，抑制和/或治疗蛋白病的方法。

26. 发明申请

WO2018026958A1 TARGETED NANODROPLET EMULSIONS FOR TREATING CANCER 审中-公开
标题翻译：靶向纳米颗粒乳剂治疗癌症
公开(公告)号：WO2018026958A1
公开(公告)日：2018-02-08
申请号：PCT/US2017/045169
申请日：2017-08-02
申请人： THE UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC.
发明人： MALIK, Mohammad, Tariq , KOPECHEK, Jonathan, A. , BATES, Paula
IPC分类号： A61K47/54 , A61K47/69 , A61P35/00
摘要： A micelle, comprises a first phospholipid, a second phospholipid, a targeting agent, conjugated to the first phospholipid, a perfluorocarbon, and a therapeutically active compound. The first phospholipid and the second phospholipid form a shell enclosing the perfluorocarbon and the therapeutically active compound. The targeting agent comprises an anti-nucleolin agent, and the therapeutically active compound comprises a chemotherapeutic agent and/or a cytotoxic agent. An emulsion may be formed, comprising a plurality of the micelles, and continuous aqueous phase. A pharmaceutical composition for treating cancer may be prepared, comprising the emulsion, and a pharmaceutically acceptable carrier. A method of treating cancer includes administering an effective amount of the pharmaceutical composition to a patient in need thereof.
摘要翻译：胶束包含第一磷脂，第二磷脂，与第一磷脂缀合的靶向剂，全氟化碳和治疗活性化合物。第一种磷脂和第二种磷脂形成包封全氟化碳和治疗活性化合物的壳。靶向剂包含抗核素剂，并且治疗活性化合物包含化学治疗剂和/或细胞毒性剂。可形成包含多个胶束和连续水相的乳液。可以制备用于治疗癌症的药物组合物，其包含乳剂和药学上可接受的载体。治疗癌症的方法包括给有此需要的患者施用有效量的药物组合物。

27. 发明申请

WO2018009892A1 ISOMOTIVE DIELECTROPHORESIS FOR DIELECTRIC ANALYSIS OF PARTICLE SUB-POPULATIONS 审中-公开
标题翻译：用于粒子亚群的介电分析的等离子体电泳
公开(公告)号：WO2018009892A1
公开(公告)日：2018-01-11
申请号：PCT/US2017/041238
申请日：2017-07-07
申请人： UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC
发明人： WILLIAMS, Stuart J.
IPC分类号： B03C5/00 , B03C5/02
摘要： Provided herein are a methods of analyzing particles and isomotive dielectrophoresis devices, and methods of forming dielectrophoresis devices. The method of analyzing particles includes providing an isomotive dielectrophoresis device; positioning a sample within the device, the sample including at least one particle; applying an electric field to the device, the electric field inducing a constant dielectrophoresis force on the at least one particle of the sample; and monitoring a translation of the at least one particle. One isomotive dielectrophoresis device includes a first electrode having a first surface geometry; a second electrode having a second surface geometry; and an electrically insulating material at least partially surrounding the first electrode and the second electrode.
摘要翻译：本文提供了分析颗粒和流体介电泳装置的方法以及形成介电泳装置的方法。分析颗粒的方法包括提供一个驱动式介电电泳装置; 将样品定位在所述装置内，所述样品包括至少一个颗粒; 向器件施加电场，电场在样品的至少一个颗粒上引起恒定的介电泳力; 并监测至少一个粒子的平移。一种汽车介电电泳装置包括具有第一表面几何形状的第一电极; 具有第二表面几何形状的第二电极; 以及至少部分围绕第一电极和第二电极的电绝缘材料。

28. 发明申请

WO2017152073A1 METHODS AND COMPOSITIONS FOR EX VIVO EXPANSION OF VERY SMALL EMBRYONIC-LIKE STEM CELLS (VSELS) 审中-公开
标题翻译：用于EXVIVO扩增非常小的胚胎样干细胞（VSELS）的方法和组合物
公开(公告)号：WO2017152073A1
公开(公告)日：2017-09-08
申请号：PCT/US2017/020696
申请日：2017-03-03
申请人： UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC.
发明人： RATAJCZAK, Mariusz Z , RATAJCZAK, Janina , KUCIA, Magdalena , MILLER, Donald
IPC分类号： C12N5/0735 , A61K35/12
摘要： Methods for ex vivo expansion of very small embryonic like stem cells in the absence of feeder cells are provided. In some embodiments the methods include providing a plurality of VSELs; and growing the VSELs in a culture medium that includes a histone deacetylase inhibitor, luteinizing hormone, follicle-stimulating hormone, and optionally transforming growth factor beta in an amount that is sufficient to overcome quiescence of the VSELs. Also provided are feeder cell-free cell cultures, ex vivo expanded VSELs, pharmaceutical compositions that include the disclosed ex vivo expanded VSELs, methods for overcoming quiescence in VSELs, methods for re-establishing imprinting in VSELs, method for treating injuries to tissues in subjects, methods for repopulating cell types in subjects, methods for bone marrow transplantation, methods for treating radiation exposure in subjects, and methods that relate to regenerative medicine.
摘要翻译：提供了在不存在饲养细胞的情况下体外扩增非常小的胚胎样干细胞的方法。在一些实施例中，该方法包括提供多个VSEL; 以及在包含组蛋白脱乙酰酶抑制剂，黄体生成素，促卵泡激素和任选转化生长因子β的培养基中生长VSEL，其量足以克服VSEL的静止。还提供了无饲养细胞的细胞培养物，离体扩增的VSEL，包括公开的离体扩增VSEL的药物组合物，用于克服VSEL中的静止的方法，用于在VSEL中重建印记的方法，用于治疗受试者组织的损伤的方法，用于在受试者中重建细胞类型的方法，用于骨髓移植的方法，用于治疗受试者中的辐射暴露的方法以及涉及再生医学的方法。

29. 发明申请

WO2017087018A1 AUTOMATED METHODS FOR THE OBJECTIVE QUANTIFICATION OF RETINAL CHARACTERISTICS BY RETINAL REGION AND DIAGNOSIS OF RETINAL PATHOLOGY 审中-公开
标题翻译：自动化方法对视网膜病变患者的视网膜特征进行客观量化并对视网膜病变进行诊断
公开(公告)号：WO2017087018A1
公开(公告)日：2017-05-26
申请号：PCT/US2016/020280
申请日：2016-03-01
申请人： UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC.
发明人： SCHAAL, Shlomit , EL-BAZ, Ayman , HARJRASOULIHA, Amir, Reza
IPC分类号： A61B3/12 , A61B3/14 , G06K9/46
CPC分类号： G06T7/0012 , G06T7/12 , G06T7/143 , G06T7/149 , G06T7/168 , G06T2207/10101 , G06T2207/20064 , G06T2207/20121 , G06T2207/20124 , G06T2207/30041
摘要： Automated and objective methods for quantifying a retinal characteristic from a retinal Optometric Coherence Tomography retinal image, and methods for detecting occult ocular pathology, diagnosing ocular pathology, reducing age-bias in OCT image analysis, and monitoring efficacy ocular/retinal disease therapies based on the quantification method are disclosed.
摘要翻译：自动和客观的方法从视网膜光学相干层析成像视网膜图像定量视网膜特征，以及检测隐性眼病理学，诊断眼病理学，减少OCT图像分析中的年龄偏倚和监测疗效披露了基于定量方法的眼/视网膜疾病疗法。

30. 发明申请

WO2017079734A1 LOCAL AND REGIONAL ANESTHESIA AND ANALGESIA 审中-公开
标题翻译：局部和区域性麻醉及镇痛
公开(公告)号：WO2017079734A1
公开(公告)日：2017-05-11
申请号：PCT/US2016/060802
申请日：2016-11-07
申请人： UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC.
发明人： PETRUSKA, Jeffrey, C. , TRENT, John, O.
IPC分类号： A61K31/4164 , A61P25/00
CPC分类号： A61K31/4164
摘要： Methods and pharmaceutical compositions are provided, which make use of compounds disclosed herein, including (I). The methods and compositions are useful for producing local or regional anesthesia or analgesia in nerve tissue of a subject.
摘要翻译：提供了利用本文公开的化合物（包括（I））的方法和药物组合物。该方法和组合物可用于在受试者的神经组织中产生局部或局部麻醉或镇痛。

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