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21. 发明申请

WO2008140500A3 HYALURONIDASE INHIBITORS AS ANTI-CANCER AGENTS 审中-公开
标题翻译： HYALURONIDASE抑制剂作为抗癌剂
公开(公告)号：WO2008140500A3
公开(公告)日：2008-12-31
申请号：PCT/US2007025057
申请日：2007-12-07
申请人： UNIV MIAMI , LOKESHWAR VINATA B
发明人： LOKESHWAR VINATA B
IPC分类号： C12Q1/34 , C12N9/26
CPC分类号： A61K31/728
摘要： Specific inhibitors of hyaluronidase (HYA1-type hyaluronidase) are used to treat cancer, especially carcinoma and solid tumors, and/or precancerous conditions.
摘要翻译：透明质酸酶（HYA1型透明质酸酶）的特异性抑制剂用于治疗癌症，特别是癌和实体瘤，和/或癌前病症。

22. 发明申请

WO2008105790A3 ULTRASONICALLY ENHANCED FUEL CELL SYSTEMS AND METHODS OF USE 审中-公开
标题翻译：超声波增强燃料电池系统及其使用方法
公开(公告)号：WO2008105790A3
公开(公告)日：2008-12-18
申请号：PCT/US2007014502
申请日：2007-06-21
申请人： UNIV MIAMI , LIU HONGTAN , HAN JIAHUA , GE JIABIN
发明人： LIU HONGTAN , HAN JIAHUA , GE JIABIN
IPC分类号： H01L21/20
CPC分类号： H01M8/04201 , H01M8/04223 , H01M8/1009 , H01M8/1011 , Y02E60/523
摘要： A fuel cell system comprises at least one fuel source (e.g., methanol or methanol solution) In a storage tank, tubes and/or flow channels that provide the fuel to the fuel cells via tubes and/or flow channels, which are used to connect the different fuel cells and/or supply the fuel to all or some of the fuel cells, one or more ultrasonic transducers, which are set inside or are associated with the tubes and/or flow channels through which the fuel (e.g., methanol or methanol solution) is supplied to the fuel cells. The transducers can optionally be integrated with the tubes and/or flow channels of the fuel cell systems. The ultrasonic transducers are able to generate high frequency vibration, and the fuel is able to transmit the high-frequency vibration through the liquid fuel body, to increase the performance of the fuel fed fuel cell system.
摘要翻译：燃料电池系统包括至少一个燃料源（例如，甲醇或甲醇溶液）在储罐中，通过管和/或流动通道向燃料电池提供燃料的管和/或流动通道，其用于连接不同的燃料电池和/或将燃料供应到所有或一些燃料电池，一个或多个超声换能器，其设置在管和/或流动通道内部或与燃料（例如，甲醇或甲醇溶液）供应到燃料电池。传感器可以可选地与燃料电池系统的管和/或流动通道集成。超声波换能器能够产生高频振动，并且燃料能够通过液体燃料体传递高频振动，以增加燃料供给的燃料电池系统的性能。

23. 发明申请

WO2008105790A9 ULTRASONICALLY ENHANCED FUEL CELL SYSTEMS AND METHODS OF USE 审中-公开
标题翻译：超声增强燃料电池系统和使用方法
公开(公告)号：WO2008105790A9
公开(公告)日：2008-10-30
申请号：PCT/US2007014502
申请日：2007-06-21
申请人： UNIV MIAMI , LIU HONGTAN , HAN JIAHUA , GE JIABIN
发明人： LIU HONGTAN , HAN JIAHUA , GE JIABIN
IPC分类号： H01L21/20
CPC分类号： H01M8/04201 , H01M8/04223 , H01M8/1009 , H01M8/1011 , Y02E60/523
摘要： A fuel cell system comprises at least one fuel source (e.g., methanol or methanol solution) in a storage tank, tubes and/or flow channels that provide the fuel to the fuel cells via tubes and/or flow channels, which are used to connect the different fuel cells and/or supply the fuel to all or some of the fuel cells, one or more ultrasonic transducers, which are set inside or are associated with the tubes and/or flow channels through which the fuel (e.g., methanol or methanol solution) is supplied to the fuel cells. The transducers can optionally be integrated with the tubes and/or flow channels of the fuel cell systems. The ultrasonic transducers are able to generate high frequency vibration, and the fuel is able to transmit the high-frequency vibration through the liquid fuel body, to increase the performance of the fuel fed fuel cell system. The ultrasonic transducers may optionally be set inside one or more containers which are connected to the tubes and/or flow channels. A method for operating the fuel system is also provided.
摘要翻译：燃料电池系统包括在储罐中的至少一个燃料源（例如，甲醇或甲醇溶液），管和/或流动通道，其经由管和/或流动通道向燃料电池提供燃料，所述管和/或流动通道用于连接不同的燃料电池和/或将燃料供应给全部或部分燃料电池，一个或多个超声波换能器，其设置在管道和/或流动通道内部或与管道和/或流动通道相关联，燃料（例如甲醇或甲醇溶液）供应给燃料电池。换能器可以可选地与燃料电池系统的管和/或流动通道集成。超声波换能器能够产生高频振动，并且燃料能够通过液体燃料体传输高频振动，以提高燃料供给燃料电池系统的性能。超声波换能器可以可选地设置在连接到管和/或流动通道的一个或多个容器内。还提供了用于操作燃料系统的方法。

24. 发明申请

WO2007100728A3 MANNOSE DERIVATIVES FOR KILLING TUMOR CELLS 审中-公开
标题翻译：用于杀死肿瘤细胞的MANNOSE衍生物
公开(公告)号：WO2007100728A3
公开(公告)日：2008-10-09
申请号：PCT/US2007004845
申请日：2007-02-26
申请人： UNIV MIAMI , LAMPIDIS THEODORE J , KURTOGLU METIN , MATHER JOHN
发明人： LAMPIDIS THEODORE J , KURTOGLU METIN , MATHER JOHN
IPC分类号： A01N43/04 , A61K31/70
CPC分类号： A61K31/70 , A61K45/06 , A61K2300/00
摘要： A method for treating cancer by killing selected tumor cells such as human breast, non-small cell lung cancer cells, pancreatic cancer cells, osteosarcoma cancer cells, and glioblastoma cells, includes administering to a patient in need of treatment, an effective amount of at least one mannose analog such as 2-DG or 2-FM or 2-CM. The killing is believed to be due to an interference with glycosylation. A theranostic method includes determining whether a patient. cancer tumor sample comprises cells sensitive to killing to at least one mannose analog due to an interference with glycosylation.
摘要翻译：通过杀死所选择的肿瘤细胞如人乳腺癌，非小细胞肺癌细胞，胰腺癌细胞，骨肉瘤癌细胞和成胶质细胞瘤细胞来治疗癌症的方法包括向需要治疗的患者施用有效量的至少一种甘露糖类似物如2-DG或2-FM或2-CM。这种杀戮被认为是由于对糖基化的干扰。鉴别方法包括确定患者是否。癌症肿瘤样品包含由于干扰糖基化而对至少一种甘露糖类似物的杀伤敏感的细胞。

25. 发明申请

WO2008036333A3 HYPERMETHYLATION OF CD44 PROMOTER IN HEAD AND NECK SQUAMOUS CELL CARCINOMA 审中-公开
标题翻译： CD44启动子在头颈部鳞状细胞癌组织中的高甲基化
公开(公告)号：WO2008036333A3
公开(公告)日：2008-08-07
申请号：PCT/US2007020339
申请日：2007-09-19
申请人： UNIV MIAMI , FRANZMANN ELIZABETH , SINGAL RAKESH
发明人： FRANZMANN ELIZABETH , SINGAL RAKESH
IPC分类号： G01N1/00 , G01N21/00 , G01N21/75 , G01N33/48 , G01N33/566
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/154
摘要： Use of methylated CD44 promoter and a panel of biomarkers including methylated CD44 promoter for the diagnosis and prognosis of head and neck squamous cell carcinoma (HNSCC). In particular, methods and kits are provided that measure hypermethylation of CD44 promoter for the diagnosis and prognosis of HNSCC.
摘要翻译：使用甲基化的CD44启动子和一组生物标志物（包括甲基化的CD44启动子）用于头颈部鳞状细胞癌（HNSCC）的诊断和预后。具体而言，提供了测量CD44启动子的超甲基化用于HNSCC的诊断和预后的方法和试剂盒。

26. 发明申请

WO2008091598A2 CONFORMATION AND ACTIVITY OF Gß5 COMPLEXES 审中-公开
标题翻译： Gß5复合物的结构和活性
公开(公告)号：WO2008091598A2
公开(公告)日：2008-07-31
申请号：PCT/US2008000819
申请日：2008-01-23
申请人： UNIV MIAMI , SLEPAK VLADLEN , SANDIFORD SIMONE , WANG QIANG
发明人： SLEPAK VLADLEN , SANDIFORD SIMONE , WANG QIANG
IPC分类号： C40B30/04
CPC分类号： G01N33/6893 , G01N2333/726 , G01N2500/02 , G01N2800/044
摘要： The invention provides novel recombinant Gß 5 complex proteins, novel methods of identifying compounds that modulate the conformation of Gß 5 complex, novel methods of treating disorders, including neurological disorders and obesity, with modulators of Gß 5 complex activity, and a mouse model of obesity, where the expression level of Gß 5 complex is reduced by targeted deletion of one allele of a gene encoding a member of the Gß 5 complex.
摘要翻译：本发明提供了新的重组腺病毒复合蛋白，鉴定调节Gβ5复合物构象的化合物的新方法，治疗疾病（包括神经障碍和肥胖）的新方法，具有Gβ5复合物活性的调节剂和肥胖症的小鼠模型，其中通过靶基因的编码一个等位基因的一个等位基因的靶向缺失来降低Gβ5复合物的表达水平 Gß＆lt; 5＆gt; 5＆gt;复合物的成员。

27. 发明申请

WO2008088385A2 PEPTIDES THAT ENHANCE ACETYLCHOLINESTERASE EXPRESSION 审中-公开
标题翻译：肽增强乙酰胆碱酯酶表达
公开(公告)号：WO2008088385A2
公开(公告)日：2008-07-24
申请号：PCT/US2007017950
申请日：2007-08-14
申请人： UNIV MIAMI , ROTUNDO RICHARD L , RUIZ CARLOS A
发明人： ROTUNDO RICHARD L , RUIZ CARLOS A
IPC分类号： C07K7/08
CPC分类号： C12N9/18 , A61K38/00 , C07K2319/06
摘要： The present invention provides novel chimeric peptides and novel methods for treating animals including humans by administering the novel chimeric peptides. In particular, the invention is useful for enhancing endogenous acetylcholinesterase expression in individuals exposed to organophosphate compounds, such as nerve gases and pesticides.
摘要翻译：本发明提供了新的嵌合肽和通过施用新的嵌合肽来治疗包括人在内的动物的新方法。特别地，本发明可用于增强暴露于有机磷酸盐化合物如神经毒气和杀虫剂的个体中的内源性乙酰胆碱酯酶表达。

28. 发明申请

WO2005021710A3 CHIMERIC MOLECULES AND METHODS OF USE 审中-公开
标题翻译： CHIMERIC分子和使用方法
公开(公告)号：WO2005021710A3
公开(公告)日：2008-01-17
申请号：PCT/US2004017119
申请日：2004-06-02
申请人： UNIV MIAMI
发明人： SHIN SEUNG-UON , MORRISON SHERIE L , ROSENBLATT JOSEPH D
IPC分类号： C12P21/08 , A61K39/00 , C07H21/04 , C07K14/78 , C07K16/28 , C07K16/32 , C07K16/46
CPC分类号： C07K16/32 , A61K2039/505 , C07K14/78 , C07K2317/622 , C07K2319/00
摘要： Chimeric molecules comprising endostatin and all or a portion of an Ig (Ig) molecule are used to treat tumors. A chimeric molecule, including endostatin fused to an Ig domain of an anti-HER2/neu antibody exhibited longer serum half-life and stability than native endostatin. 125 I-labeled anti HER2/neu IgG3-endostatin chimeric molecule and anti-HER2/neu IgG3-endostatin was 6 fold faster than that of anti-HER2/neu IgG3 (CLss=0.374 and 0.062ml/min/kg, respectively), however, the specific tumor radiolocalization indices of anti-HER2/neu IgG3-endostatin were greater than those of anti-HER2/neu IgG3. Anti-HER2/neu IgG3-endostatin inhibited tumor growth more effectively than endostatin alone, anti-HER2/neu IgG3 antibody, or the combination of antibody and endostatin.
摘要翻译：包含内皮抑素和Ig（Ig）分子全部或部分的嵌合分子用于治疗肿瘤。融合到抗HER2 / neu抗体的Ig结构域的内含抑制素的嵌合分子比天然内皮抑素表现出更长的血清半衰期和稳定性。 125I标记的抗HER2 / neu IgG3-内皮抑制素嵌合分子和抗HER2 / neu IgG3-内皮抑制素比抗HER2 / neu IgG3快6倍（CLss = 0.374和0.062ml / min / kg），然而，抗HER2 / neu IgG3-内皮抑制素的特异性肿瘤放射性定位指数大于抗HER2 / neu IgG3的特异性肿瘤放射性定位指数。抗HER2 / neu IgG3-内皮抑制素比单独内皮抑制素，抗HER2 / neu IgG3抗体或抗体和内皮抑制素的组合更有效地抑制肿瘤生长。

29. 发明申请

WO2006059965A3 DEVICES, KITS, AND METHODS FOR PROVIDING PROTECTION TO PLANTS 审中-公开
标题翻译：用于向植物提供保护的装置，工具和方法
公开(公告)号：WO2006059965A3
公开(公告)日：2008-01-10
申请号：PCT/US2004039897
申请日：2004-11-30
申请人： UNIV MIAMI , FRANCKO DAVID A , WILSON KENNETH G , LANDRUM BARRY D
发明人： FRANCKO DAVID A , WILSON KENNETH G , LANDRUM BARRY D
IPC分类号： A01G9/20 , A01G13/02 , A01M1/18
CPC分类号： A01G13/0212
摘要： Plant Protection devices, kits, and methods of protecting plants during adverse conditions are provided. The plant protection devices can have a freestanding enclosure (11) and/or a bonnet assembly (30). The plant protection devices can provide wind protection, mulch retention, and precipitation deflection.
摘要翻译：提供植物保护装置，试剂盒和在不利条件下保护植物的方法。植物保护装置可以具有独立的外壳（11）和/或发动机盖组件（30）。植物保护装置可提供防风保护，覆盖保留和降水偏转。

30. 发明申请

WO2006020288A3 HYBRID DEVICE FOR CELL THERAPIES 审中-公开
标题翻译：用于细胞治疗的混合装置
公开(公告)号：WO2006020288A3
公开(公告)日：2007-03-15
申请号：PCT/US2005025582
申请日：2005-07-20
申请人： UNIV MIAMI , RICORDI CAMILLO
发明人： RICORDI CAMILLO
IPC分类号： A61F2/02 , C12M3/00 , C12N11/02
CPC分类号： A61M5/14244 , A61M5/14276 , A61M2202/097
摘要： A device for receiving implanted biological material includes a porous outer wall defining an inner space, a fluid manifold assembly for selectively infusing at least one immunosuppresive and growth factor media to said space, and a pump structure operatively coupled to the manifold assembly. The device may comprise an additional plunger body for being disposed in said space and so as to define a peripheral gap between the plunger and the perforated wall of the device.
摘要翻译：用于接收植入的生物材料的装置包括限定内部空间的多孔外壁，用于选择性地向所述空间注入至少一种免疫抑制和生长因子介质的流体歧管组件，以及可操作地联接到歧管组件的泵结构。该装置可以包括附加的柱塞体，用于设置在所述空间中并且限定柱塞与装置的穿孔壁之间的周边间隙。

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