专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

21. 发明申请

WO2007084415A3 COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISORDERS 审中-公开
公开(公告)号：WO2007084415A3
公开(公告)日：2007-07-26
申请号：PCT/US2007/000930
申请日：2007-01-16
申请人： SCHERING CORPORATION , YU, Wensheng , TONG, Ling , CHEN, Lei , KOZLOWSKI, Joseph, A. , LAVEY, Brian, J. , SHIH, Neng-Yang , MADISON, Vincent, S. , ZHOU, Guowei , ORTH, Peter , GUO, Zhuyan , WONG, Michael, K.C. , YANG, De-Yi , KIM, Seong-Heon , SHANKAR, Bandarpalle, B. , SIDDIQUI, M., Arshad , ROSNER, Kristin, E. , DAI, Chaoyang , POPOVICI-MULLER, Janeta , GIRIJAVALLABHAN, Vinay, M. , LI, Dansu , RIZVI, Razia , MICULA, Aneta, S , FELTZ, Robert
发明人： YU, Wensheng , TONG, Ling , CHEN, Lei , KOZLOWSKI, Joseph, A. , LAVEY, Brian, J. , SHIH, Neng-Yang , MADISON, Vincent, S. , ZHOU, Guowei , ORTH, Peter , GUO, Zhuyan , WONG, Michael, K.C. , YANG, De-Yi , KIM, Seong-Heon , SHANKAR, Bandarpalle, B. , SIDDIQUI, M., Arshad , ROSNER, Kristin, E. , DAI, Chaoyang , POPOVICI-MULLER, Janeta , GIRIJAVALLABHAN, Vinay, M. , LI, Dansu , RIZVI, Razia , MICULA, Aneta, S , FELTZ, Robert
IPC分类号： C07D401/14 , C07D403/06 , A61P35/00 , A61K31/4166 , C07D471/04 , C07D473/34 , C07D473/00 , C07D491/04 , C07D495/04 , C07D417/14 , C07D413/14 , C07D405/14 , C07D403/14
摘要： This invention relates to compounds of the Formula (I) or a pharmaceutically acceptable salt, solvate, ester or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, aggrecanase, TNF- or combinations thereof.

22. 发明申请

WO2007084415A2 COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISORDERS 审中-公开
标题翻译：用于治疗炎症性疾病的化合物
公开(公告)号：WO2007084415A2
公开(公告)日：2007-07-26
申请号：PCT/US2007000930
申请日：2007-01-16
申请人： SCHERING CORP , YU WENSHENG , TONG LING , CHEN LEI , KOZLOWSKI JOSEPH A , LAVEY BRIAN J , SHIH NENG-YANG , MADISON VINCENT S , ZHOU GUOWEI , ORTH PETER , GUO ZHUYAN , WONG MICHAEL K C , YANG DE-YI , KIM SEONG-HEON , SHANKAR BANDARPALLE B , SIDDIQUI M ARSHAD , ROSNER KRISTIN E , DAI CHAOYANG , POPOVICI-MULLER JANETA , GIRIJAVALLABHAN VINAY M , LI DANSU , RIZVI RAZIA , MICULA ANETA S , FELTZ ROBERT
发明人： YU WENSHENG , TONG LING , CHEN LEI , KOZLOWSKI JOSEPH A , LAVEY BRIAN J , SHIH NENG-YANG , MADISON VINCENT S , ZHOU GUOWEI , ORTH PETER , GUO ZHUYAN , WONG MICHAEL K C , YANG DE-YI , KIM SEONG-HEON , SHANKAR BANDARPALLE B , SIDDIQUI M ARSHAD , ROSNER KRISTIN E , DAI CHAOYANG , POPOVICI-MULLER JANETA , GIRIJAVALLABHAN VINAY M , LI DANSU , RIZVI RAZIA , MICULA ANETA S , FELTZ ROBERT
CPC分类号： C07D403/06 , C07D401/14 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D473/00 , C07D473/34 , C07D487/04 , C07D491/04 , C07D495/04
摘要： This invention relates to compounds of the Formula (I) or a pharmaceutically acceptable salt, solvate, ester or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, aggrecanase, TNF- or combinations thereof.
摘要翻译：本发明涉及式（I）化合物或其药学上可接受的盐，溶剂合物，酯或异构体，其可用于治疗由MMP，ADAM，TACE，聚集蛋白聚糖酶，TNF-或其组合介导的疾病或病症。

23. 发明申请

WO2022132679A1 AMIDO-SUBSTITUTED PYRIDYL COMPOUNDS AND METHODS OF USE THEREOF FOR THE TREATMENT OF HERPESVIRUSES 审中-公开
公开(公告)号：WO2022132679A1
公开(公告)日：2022-06-23
申请号：PCT/US2021/063183
申请日：2021-12-14
申请人： MERCK SHARP & DOHME CORP. , BERGER, Richard Thaddeus, Jr. , COX, Christopher Douglas , CROWLEY, Brendan, M. , LABROLI, Marc , PLOTKIN, Michael Aaron , RAHEEM, Izzat Tiedje , SHA, Deyou , SHAW, Anthony, W. , SKUDLAREK, Jason, W. , TONG, Ling
发明人： BERGER, Richard Thaddeus, Jr. , COX, Christopher Douglas , CROWLEY, Brendan, M. , LABROLI, Marc , PLOTKIN, Michael Aaron , RAHEEM, Izzat Tiedje , SHA, Deyou , SHAW, Anthony, W. , SKUDLAREK, Jason, W. , TONG, Ling
IPC分类号： A61K31/44 , C07D213/82 , C07D401/04 , C07D413/04 , A61P31/12
摘要： The present invention relates to novel Amido-Substituted Heterocycle Compounds of Formula (I): and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, and R5 are as defined herein. The present invention also relates to compositions comprising at least one Amido-Substituted Heterocycle Compound, and methods of using the Amido-Substituted Heterocycle Compounds for treating or preventing a herpesvirus infection in a patient.

24. 发明申请

WO2022060763A2 MODIFIED IMIDAZOPYRIDINES AS GLUCOSYLCERAMIDE SYNTHASE INHIBITORS 审中-公开
公开(公告)号：WO2022060763A2
公开(公告)日：2022-03-24
申请号：PCT/US2021/050359
申请日：2021-09-15
申请人： MERCK SHARP & DOHME CORP. , FORD, Melissa, C. , FRALEY, Mark, E. , JONES, Kristen, L. G. , LOUGHRAN, H. Marie , MULHEARN, James, J. , ROECKER, Anthony, J. , SCHIRRIPA, Kathy, M. , TONG, Ling
发明人： FORD, Melissa, C. , FRALEY, Mark, E. , JONES, Kristen, L. G. , LOUGHRAN, H. Marie , MULHEARN, James, J. , ROECKER, Anthony, J. , SCHIRRIPA, Kathy, M. , TONG, Ling
IPC分类号： A61K31/4355 , A61K31/4365 , A61K31/437 , C07D471/04
摘要： The present invention relates to Compounds of Formula I: I and pharmaceutically acceptable salts or prodrug thereof. The present invention also relates to compositions comprising at least one compound of Formula I, and methods of using the compounds of Formula I for treatment or prophylaxis of lysosomal storage diseases, neurodegenerative disease, cystic disease, cancer, or a diseases or disorders associated with elevated levels of glucosylceramide (GlcCer), glucosylsphingosine (GlcSph) and/or other glucosylceramide-based glycosphingolipids (GSLs).

25. 发明申请

WO2020092102A2 3-(1H-PYRAZOL-4-YL)PYRIDINE ALLOSTERIC MODULATORS OF THE M4 MUSCARINIC ACETYLCHOLINE RECEPTOR 审中-公开
公开(公告)号：WO2020092102A2
公开(公告)日：2020-05-07
申请号：PCT/US2019/057746
申请日：2019-10-24
申请人： MERCK SHARP & DOHME CORP. , MSD R&D (CHINA) CO., LTD. , ACTON, John, J., III , EGBERTSON, Melissa , GAO, Xiaolei , HARRISON, Scott, T. , HENDERSON, Timothy, J. , LO, Michael Man-Chu , MAZZOLA, Robert, D., Jr. , MENG, Zhaoyang , MULHEARN, James , RADA, Vanessa, L. , SCHUBERT, Jeffrey, W. , SELYUTIN, Oleg, B. , TELLERS, David, M. , TONG, Ling , ZHANG, Fengqi , BAO, Jianming , LI, Chunsing
发明人： ACTON, John, J., III , EGBERTSON, Melissa , GAO, Xiaolei , HARRISON, Scott, T. , HENDERSON, Timothy, J. , LO, Michael Man-Chu , MAZZOLA, Robert, D., Jr. , MENG, Zhaoyang , MULHEARN, James , RADA, Vanessa, L. , SCHUBERT, Jeffrey, W. , SELYUTIN, Oleg, B. , TELLERS, David, M. , TONG, Ling , ZHANG, Fengqi , BAO, Jianming , LI, Chunsing
IPC分类号： A61K31/4709
摘要： The present invention is directed to cinnolinyl and quinolinyl pyrazol-4-yl-pyridine compounds which are allosteric modulators of the M4 muscarinic acetylcholine receptor. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which M4 muscarinic acetylcholine receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which M4 muscarinic acetylcholine receptors are involved.

26. 发明申请

WO2019019081A1 PANT-TYPE ABSORBENT ARTICLE 审中-公开
公开(公告)号：WO2019019081A1
公开(公告)日：2019-01-31
申请号：PCT/CN2017/094631
申请日：2017-07-27
申请人： THE PROCTER & GAMBLE COMPANY , CHENG, Chunmin , LIU, Hui , MORIMOTO, Koichi , TONG, Ling
发明人： CHENG, Chunmin , LIU, Hui , MORIMOTO, Koichi , TONG, Ling
IPC分类号： A61F13/49
摘要： An absorbent article (20) continuous in a longitudinal direction and a transverse direction, comprises a front elastic belt region (84), a back elastic belt region(86), a crotch region(30), a waist opening and two leg openings； the article (20) further comprising a center chassis (38) comprising an absorbent core (62) which extends longitudinally from the front elastic belt region (84) to the back elastic belt region (86)；the front elastic belt region (84) having a front absorbent core stiffness edge (52SE) wherein the distance from the distal edge (88) to the front absorbent core stiffness edge (52SE) defines a length L2, wherein L2 is no greater than about 77mm, wherein the front elastic belt region (84) is divided into 3 zones extending in the transverse direction and defined by its location from the distal edge (88) wherein； 0-50％of L2 is a Zone 1, 50-100％of L2 is a Zone 2, and the remainder of the front elastic belt region (84) is a Zone 3；wherein Zone 1 has a Vertical Stiffness Z1, Zone 2 has a Vertical Stiffness of Z2, and Zone 3 has a Vertical Stiffness of Z3 according to the measurements herein, and having a relationship of Z1≤Z2≤Z3；wherein the article (20) having a Stretch Circumference Force and a Full Circumference according to the measurements herein, wherein the ratio of Stretch Circumference Force to Full Circumference is less than about 0.01 (N/mm).

27. 发明申请

WO2019019079A1 PANT-TYPE WEARABLE ARTICLE 审中-公开
公开(公告)号：WO2019019079A1
公开(公告)日：2019-01-31
申请号：PCT/CN2017/094626
申请日：2017-07-27
申请人： THE PROCTER & GAMBLE COMPANY , TONG, Ling , MORIMOTO, Koichi , CHENG, Chunmin
发明人： TONG, Ling , MORIMOTO, Koichi , CHENG, Chunmin
IPC分类号： A61F13/49
摘要： A wearable article (20) continuous in a longitudinal direction and a transverse direction comprises a front elastic belt region (84), a back elastic belt region (86), a crotch region (30), a waist opening and two leg openings; the crotch region (30) extending longitudinally between the front elastic belt region (84) and the back elastic belt region (86); the front elastic belt region (84) having an area of A1, the crotch region (30) having an area of A2, the back elastic belt region (86) having an area of A3, according to the measurements herein; wherein the total of A1, A2 and A3 is less than about 1500 cm 2 , and having a relationship of A2>A3 or A2>A1; wherein the article (20) is a Size 4 baby diaper.

28. 发明申请

WO2018209629A1 ABSORBENT ARTICLE WITH BELT HAVING PROFILED ELASTICITY 审中-公开
公开(公告)号：WO2018209629A1
公开(公告)日：2018-11-22
申请号：PCT/CN2017/084805
申请日：2017-05-18
申请人： THE PROCTER & GAMBLE COMPANY , LAVON, Gary , MORIMOTO, Koichi , CHENG, Chunmin , TONG, Ling
发明人： LAVON, Gary , MORIMOTO, Koichi , CHENG, Chunmin , TONG, Ling
IPC分类号： A61F13/49 , A61F13/64
摘要： An absorbent article (20) has a front belt (60) and a rear belt (40), each comprising a central zone (64, 44) and first and second peripheral zones (43,45), the zones extending substantially in transverse direction of the absorbent article (20). The at least first belt provides improved fit in the low motion zone of a wearer while being able to adapt easily to the motion of the wearer outside the low motion zone.

29. 发明申请

WO2018032467A1 CHROMANE-SUBSTITUED TETRACYCLIC COMPOUNDS AND USES THEREOF FOR TREATMENT OF VIRAL DISEASES 审中-公开
标题翻译：色氨酸取代的四环化合物及其用于治疗病毒性疾病的用途
公开(公告)号：WO2018032467A1
公开(公告)日：2018-02-22
申请号：PCT/CN2016/095881
申请日：2016-08-18
申请人： MERCK SHARP & DOHME CORP. , YU, Wensheng , KOZLOWSKI, Joseph A. , TONG, Ling , COBURN, Craig A. , HU, Bin , ZHONG, Bin , HAO, Jinglai , WANG, Dahai
发明人： YU, Wensheng , KOZLOWSKI, Joseph A. , TONG, Ling , COBURN, Craig A. , HU, Bin , ZHONG, Bin , HAO, Jinglai , WANG, Dahai
IPC分类号： C07D498/04 , C07D487/04 , C07D471/04 , A61K31/5365 , A61K31/4985 , A61K31/437 , A61P31/14
CPC分类号： C07D498/04 , A61K31/496 , A61K31/5365 , A61K45/06 , A61P31/14
摘要： Disclosed are novel chromane-substituted tetracyclic compounds of Formula (I), and pharmaceutically acceptable salts thereof, wherein A, A', R 2 R 3 , R 4 and R 5 are as defined in the description. Also disclosed are compositions comprising a chromane-substituted tetracyclic compound, and methods of using the chromane-substituted tetracyclic compounds for treating or preventing HCV infection in a patient.
摘要翻译：公开了式（I）的新颖的苯并二氢吡喃 - 取代的四环化合物及其药学上可接受的盐，其中A，A'，R 2，R 3， R 4和R 5如说明书中所定义。还公开了包含苯并二氢吡喃取代的四环化合物的组合物，以及使用苯并二氢吡喃取代的四环化合物治疗或预防患者HCV感染的方法。

30. 发明申请

WO2016029377A1 WEARABLE ARTICLE HAVING ELASTIC BELT 审中-公开
标题翻译：具有弹性带的耐磨文章
公开(公告)号：WO2016029377A1
公开(公告)日：2016-03-03
申请号：PCT/CN2014/085258
申请日：2014-08-27
申请人： THE PROCTER & GAMBLE COMPANY , MORIMOTO, Koichi , TONG, Ling , CHENG, Chunmin
发明人： MORIMOTO, Koichi , TONG, Ling , CHENG, Chunmin
IPC分类号： A61F13/496
CPC分类号： A61F13/49011 , A61F13/496 , A61F2013/49026
摘要： A wearable article (20) comprises a main body (38) and a ring-like elastic belt (40) comprising a front belt (84) and a back belt (86). At least some of elastic bodies (96) are arranged in at least 2 sets of a concentrated array (124) defined as meeting a), b), and c) as follows: a) one concentrated array is formed by 2-4 elastic bodies; b) each elastic body within one concentrated array (124) is disposed in an inner-interval (132) between each elastic body of 2-4 mm; c) one specific concentrated array (124) disposed in an extra-interval (134) between at least one neighboring elastic body outside the specific concentrated array (124) of less than 8mm; the front and back belts (84, 86) each divided into 4 zones wherein at least 2 concentrated arrays are disposed on each of front waist zone (102), back waist zone (102), and front leg zone (108).
摘要翻译：可穿戴物品（20）包括主体（38）和包括前带（84）和后带（86）的环形弹性带（40）。至少一些弹性体（96）布置在至少2组集中的阵列（124）中，所述集合阵列（124）定义为满足a），b）和c），如下所述：a）一个集中的阵列由2-4个弹性身体; b）一个集中阵列（124）内的每个弹性体设置在2-4mm的每个弹性体之间的内部间隔（132）中; c）设置在小于8mm的特定集中阵列（124）外部的至少一个相邻弹性体之间的超间隔（134）中的一个特定集中阵列（124）前后腰带（84,86）分为4个区域，其中在前腰围区域（102），后腰围区域（102）和前腿区域（108）中的每一个上设置有至少2个集中排列。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式