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21. 发明申请

WO2009137689A3 DELIVERY OF NUCLEIC ACID COMPLEXES FROM PARTICLES 审中-公开
公开(公告)号：WO2009137689A3
公开(公告)日：2009-11-12
申请号：PCT/US2009/043158
申请日：2009-05-07
申请人： SURMODICS, INC. , SLAGER, Joram
发明人： SLAGER, Joram
IPC分类号： A61K9/16 , A61K48/00
摘要： Embodiments of the invention include particles with nucleic acid complexes, medical devices including the same and related methods. In an embodiment, the invention can include a method of making a medical device. The method can include contacting nucleic acids with cationic carrier agents to form nucleic acid complexes, adsorbing the nucleic acid complexes to porous particles to form nucleic acid complex containing particles, mixing the nucleic acid complex containing particles with a polymer solution to form a coating mixture, and applying the coating mixture to a substrate. In an embodiment, the method can include contacting nucleic acids with cationic carrier agents to form nucleic acid complexes, combining the nucleic acid complexes with a material to form nucleic acid complex containing particles in situ, mixing the nucleic acid complex particles with a polymer solution to form a coating mixture, and applying the coating mixture to a substrate. In an embodiment, the invention can include an implantable medical device including a substrate, an elution control matrix disposed on the substrate; a plurality of particles disposed within the elution control matrix, and a plurality of nucleic acid complexes disposed within the particles, the nucleic acid complexes comprising a nucleic acid and a cationic carrier agent. Other embodiments are included herein.

22. 发明申请

WO2009005718A8 POLYPEPTIDE MICROPARTICLES HAVING SUSTAINED RELEASE CHARACTERISTICS, METHODS AND USES 审中-公开
公开(公告)号：WO2009005718A8
公开(公告)日：2009-01-08
申请号：PCT/US2008/008011
申请日：2008-06-27
申请人： SURMODICS, INC. , SLAGER, Joram , NEW, Michael, D. , WALL, John, V. , BURKSTRAND, Michael, J. , REED, Pamela, J.
发明人： SLAGER, Joram , NEW, Michael, D. , WALL, John, V. , BURKSTRAND, Michael, J.
IPC分类号： A61K9/50 , A61K38/00
摘要： The invention provides polypeptide microparticles having control release features, particular methods for the preparation of such microparticles, and drug delivery systems that include polypeptide microparticles.

23. 发明申请

WO2008042748A2 POLYELECTROLYTE MEDIA FOR BIOACTIVE AGENT DELIVERY 审中-公开
标题翻译：用于生物交换剂的聚电解质介质
公开(公告)号：WO2008042748A2
公开(公告)日：2008-04-10
申请号：PCT/US2007/079835
申请日：2007-09-28
申请人： SURMODICS, INC. , LOCKWOOD, Nathan, A. , SLAGER, Joram , WALL, John, V. , DUQUETTE, Peter, H.
发明人： LOCKWOOD, Nathan, A. , SLAGER, Joram , WALL, John, V. , DUQUETTE, Peter, H.
IPC分类号： A61L31/04 , A61L31/14 , A61L31/16
CPC分类号： A61L31/16 , A61L31/145 , A61L2300/606 , C08J7/047 , C08L25/18 , C09D105/08 , C09D105/10 , C09D125/18 , C09D139/02 , C09D189/00 , C08L2666/04
摘要： The invention provides polyelectrolyte hydrogels, blends, and multilayers for the controlled release of bioactive agents from implantable medical devices coated with or containing such media.
摘要翻译：本发明提供了聚电解质水凝胶，共混物和多层，用于由可涂覆或含有这种介质的可植入医疗装置控制释放生物活性剂。

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