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21. 发明申请

WO2010138791A1 ANTIVIRAL COMPOUNDS COMPOSED OF THREE LINKED ARYL MOIETIES TO TREAT DISEASES SUCH AS HEPATITIS C 审中-公开
标题翻译：由三个连接的ARYL MOIETIES组成的抗病毒化合物治疗疾病如HEPATITIS C
公开(公告)号：WO2010138791A1
公开(公告)日：2010-12-02
申请号：PCT/US2010/036523
申请日：2010-05-28
申请人： SCHERING CORPORATION , ZENG, Qingbei , CHEN, Kevin, X. , ANILKUMAR, Gopinadhan, N. , ROSENBLUM, Stuart, B. , KOZLOWSKI, Joseph, A. , NJOROGE, F., George
发明人： ZENG, Qingbei , CHEN, Kevin, X. , ANILKUMAR, Gopinadhan, N. , ROSENBLUM, Stuart, B. , KOZLOWSKI, Joseph, A. , NJOROGE, F., George
IPC分类号： C07D403/14 , A61P31/12 , A61K31/4184
CPC分类号： C07D403/14
摘要： The present invention relates to novel Linked Tricyclic Aryl Compounds, compositions comprising at least one Linked Tricyclic Compound, and methods of using Linked Tricyclic Aryl Compounds for treating or preventing HCV infection in a patient. in one aspect, the present invention provides Compounds of Formula (I): and pharmaceutically acceptable salts thereof, wherein: Non-limiting examples of the Compounds of Formula (II) include compound 56
摘要翻译：本发明涉及新的连接三环芳基化合物，包含至少一种连接的三环化合物的组合物，以及使用连接的三环芳基化合物治疗或预防患者HCV感染的方法。一方面，本发明提供式（I）的化合物及其药学上可接受的盐，其中：式（II）化合物的非限制性实例包括化合物56

22. 发明申请

WO2010132538A1 FUSED TRICYCLIC ARYL COMPOUNDS USEFUL FOR THE TREATMENT OF VIRAL DISEASES 审中-公开
标题翻译：用于治疗病毒性疾病的融合的三酰甘油化合物
公开(公告)号：WO2010132538A1
公开(公告)日：2010-11-18
申请号：PCT/US2010/034498
申请日：2010-05-12
申请人： SCHERING CORPORATION , ROSENBLUM, Stuart, B. , CHEN, Kevin, X. , KOZLOWSKI, Joseph, A. , NJOROGE, F., George , COBURN, Craig, A.
发明人： ROSENBLUM, Stuart, B. , CHEN, Kevin, X. , KOZLOWSKI, Joseph, A. , NJOROGE, F., George , COBURN, Craig, A.
IPC分类号： C07D403/04 , C07D403/14 , C07D471/04 , C07D487/04 , C07D491/044 , C07D493/04 , A61P31/12 , A61K31/4178 , A61K31/437 , A61K31/55
CPC分类号： C07D403/14 , C07C403/04 , C07D403/04 , C07D471/04 , C07D487/04 , C07D491/044 , C07D493/04
摘要： The present invention relates to novel Fused Tricyclic Aryl Compounds, compositions comprising at least one Fused Tricyclic Aryl Compound, and methods of using the Fused Tricyclic Aryl Compounds for treating or preventing HCV infection in a patient.
摘要翻译：本发明涉及新的熔融三环芳基化合物，包含至少一种稠合三环芳基化合物的组合物，以及使用稠合三环芳基化合物治疗或预防患者HCV感染的方法。

23. 发明申请

WO2008136815A3 5, 6-RING ANNULATED INDOLE DERIVATIVES AND USE THEREOF 审中-公开
标题翻译： 5，6环结构的吲哚衍生物及其用途
公开(公告)号：WO2008136815A3
公开(公告)日：2009-05-22
申请号：PCT/US2007025757
申请日：2007-12-17
申请人： SCHERING CORP , BENNETT FRANK , VENKATRAMAN SRIKANTH , NJOROGE F GEORGE , CHEN KEVIN X , SHIH NENG-YANG , ROSENBLUM STUART B , KOZLOWSKI JOSEPH A
发明人： BENNETT FRANK , VENKATRAMAN SRIKANTH , NJOROGE F GEORGE , CHEN KEVIN X , SHIH NENG-YANG , ROSENBLUM STUART B , KOZLOWSKI JOSEPH A
IPC分类号： C07D401/04 , A61K31/437 , A61K31/4375 , A61K31/4439 , A61K31/444 , A61K31/4709 , A61K31/517 , A61K31/519 , A61P31/12 , C07D471/04 , C07D491/04 , C07D513/04
CPC分类号： C07D513/04 , C07D401/04 , C07D471/04 , C07D491/04
摘要： The present invention relates to 5,6-ring annulated indole derivatives of the formula (I), compositions comprising at least one 5,6-ring annulated indole derivatives, and methods of using the 5,6-ring annulated indole derivatives for treating or preventing a viral infection or a virus-related disorder in a patient.
摘要翻译：本发明涉及式（I）的5,6环环状吲哚衍生物，包含至少一种5,6环环状吲哚衍生物的组合物，以及使用5,6环环状吲哚衍生物用于治疗或预防患者的病毒感染或病毒相关疾病。

24. 发明申请

WO2009032125A1 2,3-SUBSTITUTED AZAINDOLE DERIVATIVES FOR TREATING VIRAL INFECTIONS 审中-公开
标题翻译：用于治疗病毒感染的2,3-取代的AZAINDOLE衍生物
公开(公告)号：WO2009032125A1
公开(公告)日：2009-03-12
申请号：PCT/US2008/010149
申请日：2008-08-27
申请人： SCHERING CORPORATION , ANILKUMAR, Gopinadhan, N. , ROSENBLUM, Stuart, B. , VENKATRAMAN, Srikanth , NJOROGE, F., George , KOZLOWSKI, Joseph, A.
发明人： ANILKUMAR, Gopinadhan, N. , ROSENBLUM, Stuart, B. , VENKATRAMAN, Srikanth , NJOROGE, F., George , KOZLOWSKI, Joseph, A.
IPC分类号： C07D471/04 , A61K31/437 , A61P31/12
CPC分类号： C07D471/04
摘要： The present invention relates to 2,3-Substituted Azaindole Derivatives, compositions comprising at least one 2,3-Substituted Azaindole Derivatives, and methods of using the 2,3-Substituted Azaindole Derivatives for treating or preventing a viral infection or a virus-related disorder in a patient.
摘要翻译：本发明涉及2,3-取代的Azaindole衍生物，包含至少一种2,3-取代的Azaindole衍生物的组合物，以及使用2,3-取代的Azaindole衍生物治疗或预防病毒感染或病毒相关的方法病人无序。

25. 发明申请

WO2009032123A2 TETRACYCLIC INDOLE DERIVATIVES AND METHODS OF USE THEREOF 审中-公开
标题翻译：四取代吲哚衍生物及其使用方法
公开(公告)号：WO2009032123A2
公开(公告)日：2009-03-12
申请号：PCT/US2008/010147
申请日：2008-08-27
申请人： SCHERING CORPORATION , BENNETT, Frank , ZENG, Qingbei , VENKATRAMAN, Srikanth , SANNIGRAHI, Mousumi , CHEN, Kevin, X. , ANILKUMAR, Gopinadhan, N. , ROSENBLUM, Stuart, B. , KOZLOWSKI, Joseph, A. , NJOROGE, F., George
发明人： BENNETT, Frank , ZENG, Qingbei , VENKATRAMAN, Srikanth , SANNIGRAHI, Mousumi , CHEN, Kevin, X. , ANILKUMAR, Gopinadhan, N. , ROSENBLUM, Stuart, B. , KOZLOWSKI, Joseph, A. , NJOROGE, F., George
IPC分类号： C07D491/052 , C07D498/04 , A61K31/436
CPC分类号： C07D498/04 , C07D491/052
摘要： The present invention relates to Tetracyclic Indole Derivatives, compositions comprising at least one Tetracyclic Indole Derivative, and methods of using the Tetracyclic Indole Derivatives for treating or preventing a viral infection or a virus-related disorder in a patient.
摘要翻译：本发明涉及四环吲哚衍生物，包含至少一种四环吲哚衍生物的组合物，以及使用四环吲哚衍生物治疗或预防患者病毒感染或病毒相关病症的方法。

26. 发明申请

WO2008082488A1 4, 5-RING ANNULATED INDOLE DERIVATIVES FOR TREATING OR PREVENTING OF HCV AND RELATED VIRAL INFECTIONS 审中-公开
标题翻译： 4，用于治疗或预防HCV和相关病毒感染的5环结合吲哚类衍生物
公开(公告)号：WO2008082488A1
公开(公告)日：2008-07-10
申请号：PCT/US2007/025765
申请日：2007-12-17
申请人： SCHERING CORPORATION , ANILKUMAR, Gopinadhan, N. , JIANG, Yueheng , ROSENBLUM, Stuart, B. , VENKATRAMAN, Srikanth , VELAZQUEZ, Francisco , SHIH, Neng-yang , NJOROGE, F., George , KOZLOWSKI, Joseph, A.
发明人： ANILKUMAR, Gopinadhan, N. , JIANG, Yueheng , ROSENBLUM, Stuart, B. , VENKATRAMAN, Srikanth , VELAZQUEZ, Francisco , SHIH, Neng-yang , NJOROGE, F., George , KOZLOWSKI, Joseph, A.
IPC分类号： C07D209/60 , C07D401/06 , C07D401/14 , C07D403/06 , C07D471/04 , C07D491/04 , A61K31/407 , A61P31/12
CPC分类号： C07D209/60 , C07D401/06 , C07D401/14 , C07D403/06 , C07D471/04 , C07D491/04
摘要： The present invention relates to 4, 5 - ring annulated indole derivatives of formula ( I ), compositions comprising at leas t one 4, 5 - ring annulated indole derivatives, and methods of using the 4, 5 - ring annulated ^ndole derivatives for treating or preventing a viral inf ection or a virus - related disorder in a patient, (I) wherein ring Z of formula (I), is cyclohexyl, cyclohexenyl, 6-membered heterocycloalkyl, 6- membered heterocycloalkenyl, 6-membered aryl or 6-membered heteroaryl, wherein R 1 , R 2 , R 3 , R 6 . R 7 and R 10 are as described herein.
摘要翻译：本发明涉及式（I）的四环环状吲哚衍生物，包含四氢环环吲哚衍生物的组合物，以及使用4,5环环状衍生物用于治疗或预防患者中的病毒感染或病毒相关疾病，（I）其中式（I）的环Z为环己基，环己烯基，6-元杂环烷基，6-元杂环烯基，6-元芳基或6- 其中R 1，R 2，R 3，R 6，R 6， R＆lt; 7＆gt;和＆lt; 10＆gt;如本文所述。

27. 发明申请

WO2008082484A1 4,5-RING ANNULATED INDOLE DERIVATIVES FOR TREATING OR PREVENTING OF HCV AND RELATED VIRAL INFECTIONS 审中-公开
标题翻译：用于治疗或预防HCV和相关病毒感染的4,5环结构吲哚类衍生物
公开(公告)号：WO2008082484A1
公开(公告)日：2008-07-10
申请号：PCT/US2007/025754
申请日：2007-12-17
申请人： SCHERING CORPORATION , CHEN, Kevin, X. , VENKATRAMAN, Srikanth , NJOROGE, F., George , ROSENBLUM, Stuart, B. , LESBURG, Charles, A. , DUCA, Jose, S. , SHIH, Neng-Yang , VELAZQUEZ, Francisco , ANILKUMAR, Gopinadhan, N. , ZENG, Qingbei , KOZLOWSKI, Joseph, A.
发明人： CHEN, Kevin, X. , VENKATRAMAN, Srikanth , NJOROGE, F., George , ROSENBLUM, Stuart, B. , LESBURG, Charles, A. , DUCA, Jose, S. , SHIH, Neng-Yang , VELAZQUEZ, Francisco , ANILKUMAR, Gopinadhan, N. , ZENG, Qingbei , KOZLOWSKI, Joseph, A.
IPC分类号： C07D209/60 , C07D401/06 , C07D401/14 , C07D403/06 , C07D471/04 , C07D491/04 , A61K31/407 , A61P31/12 , C07D401/04 , C07D487/04 , C07D495/04 , C07D513/04
CPC分类号： C07D491/04 , C07D401/04 , C07D487/04 , C07D495/04 , C07D513/04
摘要： The present invention relates to 4,5-ring annulated indole derivatives, compositions comprising at least one 4,5-ring annulated indole derivatives, and methods of using the 4,5-ring annulated indole derivatives for treating or preventing a viral infection or a virus-related disorder in a patient. Wherein ring Z, of formula (I), is a cyclopentyl, cyclopentenyl, 5-membered heterocycloalkyl, 5-membered heterocycloalkenyl or 5-membered heteroaryl ring.
摘要翻译：本发明涉及4,5-环环状吲哚衍生物，包含至少一个4,5-环环状吲哚衍生物的组合物，以及使用4,5-环环状吲哚衍生物治疗或预防病毒感染或患者病毒相关疾病。其中式（I）的Z环是环戊基，环戊烯基，5元杂环烷基，5元杂环烯基或5元杂芳基环。

28. 发明申请

WO2007001975A8 PIPERIDINE DERIVATIVES USEFUL AS HISTAMINE H3 ANTAGONISTS 审中-公开
标题翻译：哌嗪衍生物作为组胺H3拮抗剂有用
公开(公告)号：WO2007001975A8
公开(公告)日：2008-01-24
申请号：PCT/US2006023800
申请日：2006-06-19
申请人： SCHERING CORP , ASLANIAN ROBERT G , BERLIN MICHAEL Y , BOYCE CHRISTOPHER W , CHAO JIANHUA , DE LERA RUIZ MANUEL , MANGIARACINA PIETRO , MCCORMICK KEVIN D , MUTAHI MWANGI W , ROSENBLUM STUART B , SHIH NENG-YANG , SOLOMON DANIEL M , TOM WING C , VACCARO HENRY A , ZHENG JUNYING , ZHU XIAOHONG
发明人： ASLANIAN ROBERT G , BERLIN MICHAEL Y , BOYCE CHRISTOPHER W , CHAO JIANHUA , DE LERA RUIZ MANUEL , MANGIARACINA PIETRO , MCCORMICK KEVIN D , MUTAHI MWANGI W , ROSENBLUM STUART B , SHIH NENG-YANG , SOLOMON DANIEL M , TOM WING C , VACCARO HENRY A , ZHENG JUNYING , ZHU XIAOHONG
IPC分类号： C07D401/12 , A61P3/04 , A61P29/00 , A61P37/00 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D471/04
CPC分类号： C07D295/185 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , Y02P20/582
摘要： Disclosed are novel compounds of the formula (I) or a pharmaceutically acceptable salt thereof, wherein: M 1 and M 3 are CH or N; M 2 is CH, CF or N; Y is -C(=O)-, -C(=S)-, -(CH 2 ) q -, -C(=NOR 7 )- or -SO 1-2 -; Z is a bond or optionally substituted alkylene or alkenylene; R 1 is H, or alkyl, cycloalkyl, aryl, heteroaryl, heterocycloalkyl, all optionally substituted, or a group of the formula (II) where ring A is a heteroaryl ring; R 2 is optionally substituted alkyl, alkenyl, aryl, heteroaryl, cycloalkyl or heterocycloalkyl; R 3 is H, -C(O)NH 2 , or alkyl, aryl, cycloalkyl, heterocycloalkyl or heteroaryl, all optionally substituted; and the remaining variables are as defined in the specification; compositions and methods of treating allergy-induced airway responses, congestion, obesity, metabolic syndrome, alcoholic fatty liver disease, hepatic steatosis, nonalcoholic steatohepatitis, cirrhosis, hepatacellular carcinoma and cognition deficit disorders using said compounds, alone or in combination with other agents.
摘要翻译：公开了式（I）的新化合物或其药学上可接受的盐，其中：M 1和M 3是CH或N; M 2是CH，CF或N; Y是-C（= O） - ， - C（= S） - ， - （CH 2 CH 2）q - ， - / SO 2 - ） - 或-SO 2 1-2。 Z是键或任选取代的亚烷基或亚烯基; R 1是H或烷基，环烷基，芳基，杂芳基，杂环烷基，全部任意取代，或其中环A是杂芳基环的式（II）基团; R 2是任选取代的烷基，烯基，芳基，杂芳基，环烷基或杂环烷基; R 3是H，-C（O）NH 2或烷基，芳基，环烷基，杂环烷基或杂芳基，全部任选被取代; 剩余的变量如规范中所定义; 使用所述化合物单独或与其它试剂组合治疗过敏引起的气道反应，充血，肥胖，代谢综合征，酒精性脂肪肝疾病，肝脂肪变性，非酒精性脂肪性肝炎，肝硬化，肝细胞癌和认知缺陷障碍的组合物和方法。

29. 发明申请

WO2007047202A1 SUBSTITUTED HETEROCYCLIC COMPOUNDS WITH CXCR3 ANTAGONIST ACTIVITY 审中-公开
标题翻译：具有CXCR3拮抗剂活性的取代的杂环化合物
公开(公告)号：WO2007047202A1
公开(公告)日：2007-04-26
申请号：PCT/US2006/039404
申请日：2006-10-10
申请人： SCHERING CORPORATION , KIM, Seong, Heon , SHANKAR, Bandarpalle, B. , KOZLOWSKI, Joseph, A. , ROSENBLUM, Stuart, B. , SHIH, Neng-Yang
发明人： KIM, Seong, Heon , SHANKAR, Bandarpalle, B. , KOZLOWSKI, Joseph, A. , ROSENBLUM, Stuart, B. , SHIH, Neng-Yang
IPC分类号： C07D401/14 , C07D413/14 , A61K31/497 , A61P29/00
CPC分类号： C07D401/14 , C07D401/08 , C07D413/14
摘要： The present application discloses a compound, or enantiomers, stereoisomers, rotamers, tautomers, racemates or prodrug of said compound, or pharmaceutically acceptable salts, solvates or esters of said compound, or of said prodrug, said compound having the general structure shown in Formula (1) , or a pharmaceutically acceptable salt, solvate or ester thereof, wherein the various moieties are defined herein. Also disclosed is a method of treating chemokine mediated diseases, such as, palliative therapy, curative therapy, prophylactic therapy of certain diseases and conditions such as inflammatory diseases (non-limiting example(s) include, psoriasis), autoimmune diseases (non-limiting example(s) include, rheumatoid arthritis, multiple sclerosis), graft rejection (non-limiting example(s) include, allograft rejection, xenograft rejection), infectious diseases (e.g , tuberculoid leprosy), fixed drug eruptions, cutaneous delayed-type hypersensitivity responses, type I diabetes, viral meningitis and tumors using a compound of Formula (1).
摘要翻译：本申请公开了所述化合物或所述前体药物的所述化合物或其药学上可接受的盐，溶剂合物或酯的化合物或对映体，立体异构体，旋转异构体，互变异构体，前体药物，所述化合物具有式 1）或其药学上可接受的盐，溶剂合物或酯，其中各种部分在本文中定义。还公开了治疗趋化因子介导的疾病的方法，例如姑息治疗，疗效治疗，某些疾病和疾病如炎性疾病的预防性治疗（非限制性实例，牛皮癣），自身免疫性疾病（非限制性的例如，类风湿性关节炎，多发性硬化症），移植排斥反应（非限制性实例包括，同种异体移植排斥反应，异种移植物排斥），感染性疾病（例如结核性麻风病），固定药物爆发，皮肤迟发型超敏反应应答，I型糖尿病，病毒性脑膜炎和使用式（1）的化合物的肿瘤。

30. 发明申请

WO2006088837A2 HETEROCYCLIC SUBSTITUTED PIPERAZINES WITH CXCR3 ANTAGONIST ACTIVITY 审中-公开
标题翻译：具有CXCR3拮抗剂活性的杂环取代的哌啶
公开(公告)号：WO2006088837A2
公开(公告)日：2006-08-24
申请号：PCT/US2006005123
申请日：2006-02-14
申请人： SCHERING CORP , PHARMACOPEIA DRUG DISCOVERY , KIM SEONG HEON , ANILKUMAR GOPINADHAN N , WONG MICHAEL K C , ZENG QINGBEI , ROSENBLUM STUART B , KOZLOWSKI JOSEPH A , SHAO YUEFEI , MC GUINNESS BRIAN F , HOBBS DOUGLAS W
发明人： KIM SEONG HEON , ANILKUMAR GOPINADHAN N , WONG MICHAEL K C , ZENG QINGBEI , ROSENBLUM STUART B , KOZLOWSKI JOSEPH A , SHAO YUEFEI , MC GUINNESS BRIAN F , HOBBS DOUGLAS W
IPC分类号： C07D401/14 , A61K31/445 , A61K31/495 , C07D413/14 , C07D417/14
CPC分类号： C07D401/12 , C07D401/14 , C07D413/14 , C07D417/14
摘要： The present application discloses a compound, or enantiomers, stereoisomers, rotamers, tautomers, racemates or prodrug of said compound, or pharmaceutically acceptable salts, solvates or esters of said compound, or of said prodrug, said compound having the general structure shown in Formula 1 or a pharmaceutically acceptable salt, solvate or ester thereof, wherein the various moieties are defined herein. Also disclosed is a method of treating chemokine mediated diseases, such as, palliative therapy, curative therapy, prophylactic therapy of certain diseases and conditions such as inflammatory diseases (non limiting example(s) include, psoriasis), autoimmune diseases (non limiting example(s) include, rheumatoid arthritis, multiple sclerosis), graft rejection (non limiting example(s) include, allograft rejection, xenograft rejection), infectious diseases (e.g , tuberculoid leprosy), fixed drug eruptions, cutaneous delayed type hypersensitivity responses, ophthalmic inflammation, type I diabetes, viral meningitis and tumors using a compound of Formula 1.
摘要翻译：本申请公开了所述化合物或所述前体药物的所述化合物或其药学上可接受的盐，溶剂合物或酯的化合物或对映异构体，立体异构体，旋转异构体，互变异构体或前药，所述化合物具有式1所示的一般结构或其药学上可接受的盐，溶剂合物或酯，其中各种部分在本文中定义。还公开了治疗趋化因子介导的疾病的方法，例如姑息治疗，治疗疗法，某些疾病和疾病如炎性疾病的预防性治疗（非限制性实例，包括牛皮癣），自身免疫疾病（非限制性实例（传染性疾病（例如，结核性麻风病），固定药物爆发，皮肤迟发型超敏反应，眼部炎症反应（例如，类风湿性关节炎，多发性硬化症），移植物排斥反应（非限制性实例，同种异体移植排斥反应，，I型糖尿病，病毒性脑膜炎和使用式1的化合物的肿瘤。

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