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21. 发明申请

WO2003051029A3 POSITION LOCATION USING_DIGITAL TV SIGNALS 审中-公开
公开(公告)号：WO2003051029A3
公开(公告)日：2003-06-19
申请号：PCT/US2002/036022
申请日：2002-11-08
申请人： ROSUM CORPORATION , SPILKER, James, J., Jr. , RABINOWITZ, Matthew
发明人： SPILKER, James, J., Jr. , RABINOWITZ, Matthew
IPC分类号： G01S13/00
摘要： A method, apparatus, and computer-readable media for determining the position of a user terminal (102) comprises receiving at the user terminal (102) a digital television (DTV) broadcast signal from a DTV transmitter (106A, 106B ..., 106N) ), wherein the DTV signal comprises an Integrated Services Digital Broadcasting - Terrestrial (ISDB-T) signal; determining a pseudo-range between the user terminal (102) and the DTV transmitter (106A, 106B,..., 106N) based on a known component in the broadcast DTV signal; and determining a position of the user terminal (102) based on the pseudo-range and a location of the DTV transmitter (106A, 106B,..., 106N).

22. 发明申请

WO2013052557A3 METHODS FOR PREIMPLANTATION GENETIC DIAGNOSIS BY SEQUENCING 审中-公开
标题翻译：通过测序进行预先植入遗传诊断的方法
公开(公告)号：WO2013052557A3
公开(公告)日：2013-06-20
申请号：PCT/US2012058578
申请日：2012-10-03
申请人： NATERA INC , RABINOWITZ MATTHEW , HILL MATTHEW , ZIMMERMANN BERNHARD , BANER JOHAN , RYAN ALLISON , GEMELOS GEORGE
发明人： RABINOWITZ MATTHEW , HILL MATTHEW , ZIMMERMANN BERNHARD , BANER JOHAN , RYAN ALLISON , GEMELOS GEORGE
IPC分类号： C12Q1/68 , G06F19/20
CPC分类号： C12Q1/6858 , C12Q1/6883 , C12Q2600/156 , G06F19/18 , C12Q2535/122 , C12Q2545/114
摘要： The present disclosure provides methods for determining the ploidy status of an embryo at a chromosome from a sample of DNA from an embryo. The ploidy state is determined by sequencing the DNA from one or more cells biopsied from the embryo, and analyzing the relative amounts of each allele at a plurality of polymorphic loci on the chromosome. In an embodiment, the ploidy state is determined by comparing the observed allele ratios to the expected allele ratios for different ploidy states. In an embodiment, the DNA is selectively amplified at a plurality of polymorphic loci by targeted sequencing. In an embodiment, the mixed sample of DNA may be preferentially enriched at a plurality of polymorphic loci in a way that minimizes the allelic bias.
摘要翻译：本公开提供了用于从来自胚胎的DNA样品确定染色体中胚胎倍性状态的方法。倍性状态通过对来自胚胎活检的一个或多个细胞的DNA测序并分析染色体上多个多态性基因座处每个等位基因的相对量来确定。在一个实施方案中，通过将观察到的等位基因比率与不同倍性状态的预期等位基因比率进行比较来确定倍性状态。在一个实施方案中，通过靶向测序在多个多态性基因座选择性扩增DNA。在一个实施方案中，DNA的混合样品可以以使等位基因偏倚最小化的方式在多个多态性基因座上优先富集。

23. 发明申请

WO2013052557A2 METHODS FOR PREIMPLANTATION GENETIC DIAGNOSIS BY SEQUENCING 审中-公开
标题翻译：通过序列预测遗传学诊断的方法
公开(公告)号：WO2013052557A2
公开(公告)日：2013-04-11
申请号：PCT/US2012/058578
申请日：2012-10-03
申请人： NATERA, INC. , RABINOWITZ, Matthew , HILL, Matthew , ZIMMERMANN, Bernhard , BANER, Johan , RYAN, Allison , GEMELOS, George
发明人： RABINOWITZ, Matthew , HILL, Matthew , ZIMMERMANN, Bernhard , BANER, Johan , RYAN, Allison , GEMELOS, George
IPC分类号： C12Q1/68 , G06F19/24 , G06F19/20
CPC分类号： C12Q1/6858 , C12Q1/6883 , C12Q2600/156 , G06F19/18 , C12Q2535/122 , C12Q2545/114
摘要： The present disclosure provides methods for determining the ploidy status of an embryo at a chromosome from a sample of DNA from an embryo. The ploidy state is determined by sequencing the DNA from one or more cells biopsied from the embryo, and analyzing the relative amounts of each allele at a plurality of polymorphic loci on the chromosome. In an embodiment, the ploidy state is determined by comparing the observed allele ratios to the expected allele ratios for different ploidy states. In an embodiment, the DNA is selectively amplified at a plurality of polymorphic loci by targeted sequencing. In an embodiment, the mixed sample of DNA may be preferentially enriched at a plurality of polymorphic loci in a way that minimizes the allelic bias.
摘要翻译：本公开提供了用于从胚胎的DNA样品测定染色体上胚胎的倍性状态的方法。倍性状态通过对来自胚胎活检的一个或多个细胞的DNA进行测序，并分析染色体上多个多态性位点处的每个等位基因的相对量来确定。在一个实施方案中，通过将观察到的等位基因比率与不同倍性状态的预期等位基因比率进行比较来确定倍性状态。在一个实施方案中，通过靶向测序在多个多态位点选择性扩增DNA。在一个实施方案中，DNA的混合样品可以以使等位基因偏倚最小化的方式优先富集在多个多态位点。

24. 发明申请

WO2009149104A3 TIME, FREQUENCY, AND LOCATION DETERMINATION FOR FEMTOCELLS 审中-公开
标题翻译：时间，频率和位置确定FEMTOCELLS
公开(公告)号：WO2009149104A3
公开(公告)日：2010-03-25
申请号：PCT/US2009046002
申请日：2009-06-02
申请人： ROSUM CORP , DO JU-YONG , OPSHAUG GUTTORM , SPILKER JAMES J , RABINOWITZ MATTHEW
发明人： DO JU-YONG , OPSHAUG GUTTORM , SPILKER JAMES J , RABINOWITZ MATTHEW
IPC分类号： G01S3/02
CPC分类号： H04W64/00 , H04W64/003 , H04W84/045
摘要： Apparatus having corresponding methods and tangible computer-readable media comprise: a measurement module adapted to generate measurements of a wireless television signal received by the apparatus and measurements of a wireless satellite positioning signal received by the apparatus; a location module adapted to determine a location of the apparatus based on the measurements of the wireless television signal and the measurements of the wireless satellite positioning signal; and a time module adapted to provide a clock control signal for the apparatus based on at least one of the measurements of the wireless television signal, and the measurements of the wireless satellite positioning signal.
摘要翻译：具有相应方法和有形计算机可读介质的装置包括：测量模块，其适于产生由所述装置接收的无线电视信号的测量值和由所述装置接收的无线卫星定位信号的测量值; 位置模块，适于基于无线电视信号的测量结果和无线卫星定位信号的测量来确定设备的位置; 以及时间模块，其适于基于所述无线电视信号的所述测量的至少一个以及所述无线卫星定位信号的测量来为所述装置提供时钟控制信号。

25. 发明申请

WO2003043323A1 USING DIGITAL TELEVISION BROADCAST SIGNALS TO PROVIDE GPS AIDING INFORMATION 审中-公开
标题翻译：使用数字电视广播信号提供GPS辅助信息
公开(公告)号：WO2003043323A1
公开(公告)日：2003-05-22
申请号：PCT/US2002/036221
申请日：2002-11-12
申请人： ROSUM CORPORATION , RABINOWITZ, Matthew , SPILKER, James, J., Jr. , OMURA, Jimmy, K. , PIERCE, Matthew, D.
发明人： RABINOWITZ, Matthew , SPILKER, James, J., Jr. , OMURA, Jimmy, K. , PIERCE, Matthew, D.
IPC分类号： H04N7/12
CPC分类号： G01S5/0036 , G01S5/0054 , G01S5/0081 , G01S5/02 , G01S5/021 , G01S5/0215 , G01S5/0221 , G01S5/14 , G01S5/145 , G01S19/05 , G01S19/09 , G01S19/10 , G01S19/254 , G01S19/256 , G01S19/258 , G01S19/46 , H04N21/235 , H04N21/435 , H04N21/8126
摘要： A method, apparatus, and computer-readable media (fig.15) for providing satellite positioning system aiding information to a satellite positioning system receiver (1502) configured to determine th eposition of the satellite positioning system receiver using the satellite positioning system aiding information (1522) and th epropagation time of a signal transmitted by a satellite in the satellite positioning system comprises providing the satellite positioning system aiding information (1522) ; providing a digital television signal (1506) comprising a plurality of frames, each frame comprising a plurality of data segments; encoding the satellite positioning system aiding information as codewords; replacing data segments within the digital television signal with the codewords; and transmitting the digital television signal; wherein the satellite positioning system receiver receives the digital television signal and recovers the satellite positioning system aiding information.
摘要翻译：一种用于向卫星定位系统接收机（1502）提供卫星定位系统辅助信息的方法，装置和计算机可读介质（图15），其被配置为使用卫星定位系统辅助信息来确定卫星定位系统接收机的定位（ 1522）和由卫星在卫星定位系统中发射的信号的传播时间包括提供卫星定位系统辅助信息（1522）; 提供包括多个帧的数字电视信号（1506），每个帧包括多个数据段; 将卫星定位系统辅助信息编码为码字; 用码字代替数字电视信号内的数据段; 并发送数字电视信号; 其中卫星定位系统接收机接收数字电视信号并恢复卫星定位系统辅助信息。

26. 发明申请

WO2013130848A1 INFORMATICS ENHANCED ANALYSIS OF FETAL SAMPLES SUBJECT TO MATERNAL CONTAMINATION 审中-公开
标题翻译：信息增强分析场效应物质污染
公开(公告)号：WO2013130848A1
公开(公告)日：2013-09-06
申请号：PCT/US2013/028378
申请日：2013-02-28
申请人： NATERA, INC. , RABINOWITZ, Matthew , BANER, Johan , GEMELOS, George , HILL, Matthew, M. , SIGURJONSSON, Styrmir
发明人： RABINOWITZ, Matthew , BANER, Johan , GEMELOS, George , HILL, Matthew, M. , SIGURJONSSON, Styrmir
IPC分类号： C12Q1/68
CPC分类号： G06F19/18 , C12Q1/6827
摘要： The invention provides methods for chromosome copy number calling on genetic samples, such as fetal samples subject to contamination from maternal DNA. The present disclosure provides methods for determining the ploidy status of a chromosome in a fetus (such as a gestating fetus or a POC sample) from genotypic data measured from a mixed sample of DNA comprising DNA from both the mother of the fetus and from the fetus, and optionally from genotypic data from the mother and father. In some embodiments, the ploidy state is determined by using a joint distribution model to create a plurality of expected allele distributions for different possible fetal ploidy states given the parental genotypic data, and comparing the expected allelic distributions to the pattern of measured allelic distributions measured in the mixed sample, and choosing the ploidy state whose expected allelic distribution pattern most closely matches the observed allelic distribution pattern. The mixed sample of DNA may be preferentially enriched at a plurality of polymorphic loci in a way that minimizes the allelic bias, for example using massively multiplexed targeted PCR.
摘要翻译：本发明提供了染色体拷贝数调用基因样品的方法，例如受母体DNA污染的胎儿样品。本公开提供了从包含来自胎儿母体和胎儿的DNA的DNA的混合样品测量的基因型数据中确定胎儿（例如胎儿胎儿或POC样品）中染色体的倍性状态的方法，以及来自母亲和父亲的基因型数据。在一些实施方案中，通过使用联合分布模型来确定给定父母基因型数据的不同可能的胎儿倍性状态的多个预期等位基因分布，并将预期的等位基因分布与所测量的等位基因分布的模式进行比较来确定倍性状态混合样品，并选择其预期等位基因分布模式与观察到的等位基因分布模式最为匹配的倍性状态。 DNA的混合样品可以以使等位基因偏倚最小化的方式优先富集在多个多态性位点，例如使用大规模复用的靶向PCR。

27. 发明申请

WO2012088456A2 METHODS FOR NON-INVASIVE PRENATAL PATERNITY TESTING 审中-公开
标题翻译：非侵入性预防性试验方法
公开(公告)号：WO2012088456A2
公开(公告)日：2012-06-28
申请号：PCT/US2011/066938
申请日：2011-12-22
申请人： NATERA, INC. , RYAN, Allison , SIGURJONSSON, Styrmir , BANJEVIC, Milena , GEMELOS, George , HILL, Matthew , BANER, Johan , RABINOWITZ, Matthew , DEMKO, Zachary
发明人： RYAN, Allison , SIGURJONSSON, Styrmir , BANJEVIC, Milena , GEMELOS, George , HILL, Matthew , BANER, Johan , RABINOWITZ, Matthew , DEMKO, Zachary
IPC分类号： G06F19/00 , C07H21/04
CPC分类号： C12Q1/6869 , C12Q1/6876 , C12Q2600/156 , G06F19/14
摘要： Methods for non-invasive prenatal paternity testing are disclosed herein. The method uses genetic measurements made on plasma taken from a pregnant mother, along with genetic measurements of the alleged father, and genetic measurements of the mother, to determine whether or not the alleged father is the biological father of the fetus. This is accomplished by way of an informatics based method that can compare the genetic fingerprint of the fetal DNA found in maternal plasma to the genetic fingerprint of the alleged father.
摘要翻译：本文公开了非侵入性产前亲子鉴定的方法。该方法使用从怀孕母亲获得的血浆进行的遗传测量，以及所称父亲的遗传测量以及母亲的遗传测量，以确定所称父亲是否是胎儿的生物之父。这通过基于信息学的方法来实现，该方法可以将母体血浆中发现的胎儿DNA的遗传指纹与所称父亲的遗传指纹进行比较。

28. 发明申请

WO2007062164A3 SYSTEM AND METHOD FOR CLEANING NOISY GENETIC DATA AND USING DATA TO MAKE PREDICTIONS 审中-公开
公开(公告)号：WO2007062164A3
公开(公告)日：2007-05-31
申请号：PCT/US2006/045281
申请日：2006-11-22
申请人： GENE SECURITY NETWORK LLC , RABINOWITZ, Matthew , BANJEVIC, Milena , DEMKO, Zachary, Paul , JOHNSON, David, Scott
发明人： RABINOWITZ, Matthew , BANJEVIC, Milena , DEMKO, Zachary, Paul , JOHNSON, David, Scott
IPC分类号： G06F19/00
摘要： A system and method for determining the genetic data for one or a small set of cells, or from fragmentary DNA, where a limited quantity of genetic data is available, and also for predicting likely phenotypic outcomes using mathematical models and given genetic, phenotypic and/or clinical data of an individual, and also relevant aggregated medical data consisting of genotypic, phenotypic, and/or clinical data from germane patient subpopulations. Genetic data for the target individual is acquired and amplified using known methods, and poorly measured base pairs, missing alleles and missing regions are reconstructed using expected similarities between the target genome and the genome of genetically related subjects.

29. 发明申请

WO03042713A3 LOCATION USING GHOST CANCELLING REFERENCE TELEVISION SIGNALS 审中-公开
标题翻译：使用GHOST取消参考电视信号的位置
公开(公告)号：WO03042713A3
公开(公告)日：2003-10-16
申请号：PCT/US0235913
申请日：2002-11-08
申请人： ROSUM CORP , RABINOWITZ MATTHEW , SPILKER JAMES J JR
发明人： RABINOWITZ MATTHEW , SPILKER JAMES J JR
IPC分类号： G01S5/00 , G01S5/14 , G01S3/02
CPC分类号： G01C21/206 , G01S5/0036 , G01S5/0054 , G01S5/14
摘要： A method, apparatus, and computer-readable media for determining the position of a user terminal comprises generating a correlation reference signal based on known characteristics of a chirp-type signal present in a broadcast analog television signal; receiving, at the user terminal (102), a broadcast analog television signal comprising the chirp-type signal; and correlating the broadcast analog television signal with the correlation reference signal, thereby producing a pseudorange; and wherein the location of the user terminal is determined based on the pseudorange and a location of the transmitter of the broadcast analog television signal.
摘要翻译：用于确定用户终端的位置的方法，装置和计算机可读介质包括：基于存在于广播模拟电视信号中的啁啾型信号的已知特性产生相关参考信号; 在所述用户终端（102）处接收包括所述啁啾型信号的广播模拟电视信号; 并将广播模拟电视信号与相关参考信号相关，从而产生伪距; 并且其中，基于广播模拟电视信号的伪距和发射机的位置来确定用户终端的位置。

30. 发明申请

WO2003067869A3 USING TELEVISION SIGNALS TO PROVIDE LOCALIZED POSITION 审中-公开
公开(公告)号：WO2003067869A3
公开(公告)日：2003-08-14
申请号：PCT/US2003/002959
申请日：2003-01-31
申请人： ROSUM CORPORATION , SPILKER, James, J., Jr. , RABINOWITZ, Matthew
发明人： SPILKER, James, J., Jr. , RABINOWITZ, Matthew
IPC分类号： G01S1/08
摘要： An apparatus, method, and computer-readable media. The apparatus comprises a receiver adapted to receive a plurality of broadcast signals; a signal processor adapted to determine a position based on the received plurality of broadcast signals; a signal generator adapted to generate a ranging signal comprising a known component of a television signal; and a transmitter adapted to broadcast a signal comprising the ranging signal and a position signal comprising a description of the position.

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