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21. 发明申请

WO2021188163A1 NUTRITIONAL HEALTH SUPPLEMENTS 审中-公开
公开(公告)号：WO2021188163A1
公开(公告)日：2021-09-23
申请号：PCT/US2020/061750
申请日：2020-11-23
申请人： MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
发明人： DODICK, David, W.
IPC分类号： A23L33/10 , A23L33/15 , A23L33/12 , A23L33/16 , A23L33/175
摘要： A nutritional health supplement is provided for the brain. In one exemplary embodiment, a nutritional health supplement comprises a first neuroprotective agent having antioxidant, anti-inflammatory, anti-apoptic, anti-autophagic, and anti-cerebral edema properties, and having calcium-induced apoptotic signaling-inhibiting properties; a second neuroprotective agent having glutamate-mediated excitotoxicity-mitigating and calcium influx-mitigating properties and having antioxidant and blood-brain barrier protecting properties; a third neuroprotective agent that is a precursor for glutathione synthesis and has calcium influx-mitigating and anti-oxidative stress mediating properties and that augments the first neuroprotective agent's calcium-induced apoptotic signaling-inhibiting properties and anti-cerebral edema properties and the second neuroprotective agent's antioxidant properties; a NAD+ precursor that augments the first neuroprotective agent's anti-apoptotic properties, the second neuroprotective agent's glutamate-mediated excitotoxicity-mitigating and blood-brain barrier protecting properties, and the third neuroprotective agent's calcium influx-mitigating and anti-oxidative stress mediating properties. The second neuroprotective agent augments the third neuroprotective agent's calcium influx-reducing property.

22. 发明申请

WO2021113242A1 MODEL-BASED NYQUIST GHOST CORRECTION FOR REVERSE READOUT ECHO PLANAR IMAGING 审中-公开
公开(公告)号：WO2021113242A1
公开(公告)日：2021-06-10
申请号：PCT/US2020/062712
申请日：2020-12-01
申请人： MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
发明人： TRZASKO, Joshua D. , YARACH, Uten , BERNSTEIN, Matthew A. , IN, Myung-Ho , SUI, Yi
IPC分类号： G01R33/565 , G01R33/561
摘要： Nyquist ghost artifacts in echo planar imaging ("EPI") are mitigated, reduced, or otherwise eliminated by implementing robust Nyquist ghost correction ("NGC") directly from two reversed readout EPI acquisitions. As one advantage, these techniques do not require explicit reference scanning. A model-based process is used for directly estimating statistically optimal NGC coefficients from multi-channel k-space data.

23. 发明申请

WO2021062396A1 FUNCTIONAL ULTRASOUND IMAGING FOR SPINAL CORD STIMULATION ELECTRODE GUIDANCE AND STIMULATION PARAMETER OPTIMIZATION 审中-公开
公开(公告)号：WO2021062396A1
公开(公告)日：2021-04-01
申请号：PCT/US2020/053140
申请日：2020-09-28
申请人： MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
发明人： ISLAM, Riazul , LAVROV, Igor A. , CHEN, Shigao , SONG, Pengfei
IPC分类号： A61N1/36 , A61B8/00 , G01S15/89
摘要： Functional ultrasound imaging ("fUS") is used to facilitate the placement of electrodes for spinal cord stimulation and to optimize and update stimulation parameters for spinal cord stimulation devices.

24. 发明申请

WO2021034710A2 CHIMERIC VESICULOVIRUSES AND METHODS OF USE 审中-公开
公开(公告)号：WO2021034710A2
公开(公告)日：2021-02-25
申请号：PCT/US2020/046503
申请日：2020-08-14
申请人： MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
发明人： BORAD, Mitesh, J. , NAGALO, Bolni, M.
IPC分类号： A61K48/00 , A61K39/12 , C12N7/00 , C12N15/86 , C12Q1/70 , C12N15/00
摘要： The disclosure provides methods and materials for treating cancer. Specifically, the disclosure provides a chimeric vesiculovirus comprising: (a) a first genomic fragment of a first vesiculovirus species; and (b) a second genomic fragment of a second vesiculovirus species different from said first vesiculovirus species; wherein the vesiculovirus species comprising vesicular stomatitis viruses (VSVs) and morreton Virus (MorV). Further disclosed are methods of using chimeric vesiculoviruses as oncolytic agents for treating cancer.

25. 发明申请

WO2021021922A1 COMPOUNDS AND METHODS FOR TREATING FIBROTIC PATHOLOGIES 审中-公开
公开(公告)号：WO2021021922A1
公开(公告)日：2021-02-04
申请号：PCT/US2020/044054
申请日：2020-07-29
申请人： MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
发明人： TSCHUMPERLIN, Daniel J. , HAAK, Andrew J.
IPC分类号： A61K31/454 , A61P35/00 , C07D401/12
摘要： The present application provides methods for treating or preventing diseases and conditions associated with tissue fibrosis.

26. 发明申请

WO2021021402A1 MUSCLE LENGTH MEASUREMENT 审中-公开
公开(公告)号：WO2021021402A1
公开(公告)日：2021-02-04
申请号：PCT/US2020/041136
申请日：2020-07-08
申请人： MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
发明人： HOOKE, Alexander W. , SANCHEZ-SOTELO, Joaquin , ELHASSAN, Bassem T.
IPC分类号： A61F2/00
摘要： Operative lengths of muscles can be determined. For example, this document describes techniques for measuring operating muscle lengths of the infraspinatus, teres minor, and subscapularis through the internal-external rotation range of motion before and after implantation of RSA components. In some embodiments, the techniques described herein can be advantageously used as a part of preoperative surgical planning. Such pre-surgical planning can help to select optimal prosthetic implants, ensure fewer surgical complications, and attain better patient outcomes.

27. 发明申请

WO2020257248A1 PREVOTELLA PREPARATIONS AND TREATING CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD) AND OTHER LUNG CONDITIONS 审中-公开
公开(公告)号：WO2020257248A1
公开(公告)日：2020-12-24
申请号：PCT/US2020/038084
申请日：2020-06-17
申请人： MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
发明人： TANEJA, Veena
IPC分类号： A61P9/00 , A61P13/12 , A61P17/06 , A61P19/02 , A61P29/00 , A61P37/02
摘要： This document provides methods and materials related to the treatment of a lung condition, such as chronic obstructive pulmonary disease (COPD), using a composition containing live Prevotella (e.g., P. histicola and/or P. melaninogenica ), dead (or killed) Prevotella (e.g., P. histicola and/or P. melaninogenica ), components of Prevotella (e.g., P. histicola and/or P. melaninogenica ), vesicles (e.g., OMVs) of Prevotella (e.g., P. histicola and/or P. melaninogenica ), or a combination thereof. For example, methods and materials for using a composition containing live Prevotella (e.g., P. histicola and/or P. melaninogenica ), dead (or killed) Prevotella (e.g., P. histicola and/or P. melaninogenica ), components of Prevotella (e.g., P. histicola and/or P. melaninogenica ), vesicles (e.g., OMVs) of Prevotella (e.g., P. histicola and/or P. melaninogenica ), or a combination thereof to treat a lung condition, such as COPD, are provided.

28. 发明申请

WO2020252463A1 SUPER-RESOLUTION MICROVESSEL IMAGING USING SEPARATED SUBSETS OF ULTRASOUND DATA 审中-公开
公开(公告)号：WO2020252463A1
公开(公告)日：2020-12-17
申请号：PCT/US2020/037763
申请日：2020-06-15
申请人： MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
发明人： TRZASKO, Joshua D. , CHEN, Shigao , SONG, Pengfei , HUANG, Chengwu , MANDUCA, Armando , LOWERISON, Matthew
IPC分类号： A61B8/08 , G01S7/52
摘要： Super-resolution ultrasound imaging of microvessels in a subject is described. Ultrasound data are acquired from a region-of-interest in a subject who has been administered a microbubble contrast agent. The ultrasound data are acquired while the microbubbles are moving through, or otherwise present in, the region-of-interest. Microbubble signals are isolated from the ultrasound data and are separated into subsets of data based on properties of the microbubbles, such as spatial-temporal hemodynamics. By localizing, tracking, and accumulating the microbubbles in each subset of data, super-resolution images of the microvessels can be generated for each subset, such that each of these images represents a sparse subset of microbubble signals. These images are combined to generate a super-resolution microvessel image.

29. 发明申请

WO2020247125A1 DEVICES AND METHODS FOR TREATING TINNITUS USING ELECTRICAL STIMULATION 审中-公开
公开(公告)号：WO2020247125A1
公开(公告)日：2020-12-10
申请号：PCT/US2020/031020
申请日：2020-05-01
申请人： MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
发明人： CARLSON, Matthew L.
IPC分类号： A61N1/02
摘要： Electrical stimulation devices can be used to treat tinnitus. For example, tinnitus can be treated using implantable electrodes and stimulation devices for delivering electrical stimulation to a patient's cochlear region, such as the cochlear promontory. Intraosseous cochlear promontory electrode(s), endosteal electrode(s), subendosteal electrode(s), or short intracochlear electrode(s) (or a combination thereof), connected to a cochlear implant receiver/stimulator device, can provide a successful model for long-term treatment of tinnitus in a large number of patients. In some cases, patients can simply turn on the tinnitus implant when experiencing troublesome tinnitus and gain instant relief.

30. 发明申请

WO2020236890A1 TREATING CHRONIC LIVER DISEASE 审中-公开
公开(公告)号：WO2020236890A1
公开(公告)日：2020-11-26
申请号：PCT/US2020/033726
申请日：2020-05-20
申请人： MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH , IBRAHIM, Samar H.
发明人： IBRAHIM, Samar H.
IPC分类号： A61K31/52 , A61K31/522 , A61P1/16 , A61P3/04 , A61P3/10 , A61P9/12 , A61P29/00
摘要： This document provides methods and materials involved in treating chronic liver disease (e.g., non-alcoholic fatty liver disease such as nonalcoholic steatohepatitis (NASH)). For example, methods and materials for using one or more inhibitors of an integrin β1 (ITGβ1) polypeptide, one or more inhibitors of an integrin α9 polypeptide (ITGα9), and/or one or more inhibitors of a vascular cell adhesion molecule 1 (VCAM-1) polypeptide to treat a mammal having chronic liver disease are provided.

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