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21. 发明申请

WO0228481A9 METHODS OF THERAPY FOR B-CELL MALIGNANCIES USING ANTAGONIST ANTI-CD40 ANTIBODIES 审中-公开
标题翻译：使用拮抗剂抗CD40抗体治疗B细胞恶性肿瘤的方法
公开(公告)号：WO0228481A9
公开(公告)日：2003-07-03
申请号：PCT/US0130963
申请日：2001-10-02
申请人： CHIRON CORP , CHU KETING , MASUOKA LORIANNE
发明人： CHU KETING , MASUOKA LORIANNE
IPC分类号： C12N15/09 , A61K39/395 , A61P1/04 , A61P17/06 , A61P19/02 , A61P25/00 , A61P29/00 , A61P35/00 , A61P37/00 , A61P37/02 , A61P37/06 , A61P43/00 , C07K16/18 , C07K16/28 , C07K16/30 , C12N15/13 , C12P21/08
CPC分类号： C07K16/2878 , A01K2217/05 , A61K2039/505 , C07K2317/21 , C12N2799/026
摘要： Methods of therapy for B-cell malignancies are provided. The methods comprise administering a therapeutically effective amount of an antagonist anti-CD40 antibody or antigen-binding fragment thereof to a patient in need thereof. The antagonist anti-CD40 antibody or antigen-binding fragment thereof is free of significant agonist activity when the antibody binds a CD40 antigen on a normal human B cell, exhibits antagonist activity when the antibody binds a CD40 antigen on a malignant human B cell, and can exhibit antagonist activity when the antibody binds a CD40 antigen on a normal human B cell. Antagonist activity of the anti-CD40 antibody or antigen-binding fragment thereof beneficially inhibits proliferation and/or differentiation of malignant human B cells.
摘要翻译：提供了B细胞恶性肿瘤治疗方法。所述方法包括向有需要的患者施用治疗有效量的拮抗性抗CD40抗体或其抗原结合片段。当抗体结合正常人B细胞上的CD40抗原时，拮抗性抗CD40抗体或其抗原结合片段没有显着的激动剂活性，当抗体结合恶性人B细胞上的CD40抗原时，拮抗剂抗CD40抗体或其抗原结合片段，当抗体结合正常人B细胞上的CD40抗原时，可以显示拮抗剂活性。抗CD40抗体或其抗原结合片段的拮抗作用有益地抑制恶性人B细胞的增殖和/或分化。

22. 发明申请

WO2003045978A3 ANTAGONIST ANTI-CD40 MONOCLONAL ANTIBODY THERAPY FOR MULTIPLE SCLEROSIS TREATMENT 审中-公开
公开(公告)号：WO2003045978A3
公开(公告)日：2003-06-05
申请号：PCT/US2002/038164
申请日：2002-11-26
申请人： CHIRON CORPORATION , MASUOKA, Lorianne, K. , KWAN, Min, F.
发明人： MASUOKA, Lorianne, K. , KWAN, Min, F.
IPC分类号： A61K38/19
摘要： The present invention is directed to a method for preventing or alleviating the symptons of MS by delivering to the central nervous system an interferon and an anti-CD40 antibody. Interferons include interferon-β and its muteins such as IFN-β ser17 .

23. 发明申请

WO2003028809A1 METHODS OF THERAPY FOR B-CELL MALIGNANCIES 审中-公开
标题翻译： B细胞恶性肿瘤治疗方法
公开(公告)号：WO2003028809A1
公开(公告)日：2003-04-10
申请号：PCT/US2001/030960
申请日：2001-10-02
申请人： CHIRON CORPORATION , CHU, Keting , MASUOKA, Lorianne
发明人： CHU, Keting , MASUOKA, Lorianne
IPC分类号： A61P35/00
CPC分类号： C07K16/2878
摘要： Methods of therapy for B-cell malignancies are provided. The methods comprise administering a therapeutically effective amount of an antagonist anti-CD40 antibody or antigen-binding fragment thereof to a patient in need thereof. The antagonist anti-CD40 antibody or antigen-binding fragment thereof is free of significant agonist activity when the antibody binds a CD40 antigen on a normal human B cell, exhibits antagonist activity when the antibody binds a CD40 antigen on a malignant human B cell, and can exhibit antagonist activity when the antibody binds a CD40 antigen on a normal human B cell. Antagonist activity of the anti-CD40 antibody or antigen-binding fragment thereof beneficially inhibits proliferation and/or differentiation of malignant human B cells.
摘要翻译：提供了B细胞恶性肿瘤治疗方法。所述方法包括向有需要的患者施用治疗有效量的拮抗性抗CD40抗体或其抗原结合片段。当抗体结合正常人B细胞上的CD40抗原时，拮抗性抗CD40抗体或其抗原结合片段没有显着的激动剂活性，当抗体结合恶性人B细胞上的CD40抗原时，拮抗剂抗CD40抗体或其抗原结合片段，当抗体结合正常人B细胞上的CD40抗原时，可以显示拮抗剂活性。抗CD40抗体或其抗原结合片段的拮抗作用有益地抑制恶性人B细胞的增殖和/或分化。

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