专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

21. 发明申请

WO2008067481A1 AZA-INDOLYL COMPOUNDS AND METHODS OF USE 审中-公开
标题翻译： AZA-INDOLYL化合物及其使用方法
公开(公告)号：WO2008067481A1
公开(公告)日：2008-06-05
申请号：PCT/US2007/085962
申请日：2007-11-29
申请人： GENENTECH, INC. , GOODACRE, Simon Charles , WILLIAMS, Karen , PRICE, Stephen , DYKE, Hazel Joan , MONTANA, John Gary , STANLEY, Mark S. , BAO, Liang , LEE, Wendy
发明人： GOODACRE, Simon Charles , WILLIAMS, Karen , PRICE, Stephen , DYKE, Hazel Joan , MONTANA, John Gary , STANLEY, Mark S. , BAO, Liang , LEE, Wendy
IPC分类号： C07D471/04 , C07D487/04 , A61K31/407 , A61P29/00 , A61P35/00
CPC分类号： C07D471/04 , C07D487/04
摘要： The invention relates to azaindolyl compounds of Formula I with anti-cancer and/or anti-inflammatory activity and more specifically to azaindolyl compounds which inhibit MEK kinase activity. The invention provides compositions and methods useful for inhibiting abnormal cell growth or treating a hyperproliferative disorder, or treating an inflammatory disease in a mammal. The invention also relates to methods of using the compounds for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, or associated pathological conditions.
摘要翻译：本发明涉及具有抗癌和/或抗炎活性的具有式I的唑烷基化合物，更具体地涉及抑制MEK激酶活性的唑烷基化合物。本发明提供了可用于抑制异常细胞生长或治疗过度增殖性疾病或治疗哺乳动物炎性疾病的组合物和方法。本发明还涉及将化合物用于体外，原位和体内诊断或治疗哺乳动物细胞或相关病理状况的方法。

22. 发明申请

WO2008024725A1 AZA-BENZOFURANYL COMPOUNDS AND METHODS OF USE 审中-公开
标题翻译： AZA-BENZOFURANYL化合物及其使用方法
公开(公告)号：WO2008024725A1
公开(公告)日：2008-02-28
申请号：PCT/US2007/076344
申请日：2007-08-20
申请人： GENENTECH, INC. , PRICE, Stephen , WILLIAMS, Karen , SAVY, Pierre Pascal , DYKE, Hazel Joan , MONTANA, John Gary , STANLEY, Mark S. , BAO, Liang
发明人： PRICE, Stephen , WILLIAMS, Karen , SAVY, Pierre Pascal , DYKE, Hazel Joan , MONTANA, John Gary , STANLEY, Mark S. , BAO, Liang
IPC分类号： C07D491/048 , A61K31/4355 , A61K31/5025 , A61K31/519 , A61P35/00 , A61P29/00
CPC分类号： C07D491/048
摘要： The invention relates to azabenzofuranyl compounds of Formula (I) with anti-cancer and/or anti-inflammatory activity and more specifically to azabenzofuranyl compounds which inhibit MEK kinase activity. The invention provides compositions and methods useful for inhibiting abnormal cell growth or treating a hyperproliferative disorder, or treating an inflammatory disease in a mammal. The invention also relates to methods of using the compounds for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, or associated pathological conditions.
摘要翻译：本发明涉及具有抗癌和/或抗炎活性的式（I）的氮杂苯并呋喃基化合物，更具体地涉及抑制MEK激酶活性的氮杂苯并呋喃基化合物。本发明提供了可用于抑制异常细胞生长或治疗过度增殖性疾病或治疗哺乳动物炎性疾病的组合物和方法。本发明还涉及将化合物用于体外，原位和体内诊断或治疗哺乳动物细胞或相关病理状况的方法。

23. 发明申请

WO2008024724A1 AZA-BENZOTHIOPHENYL COMPOUNDS AND METHODS OF USE 审中-公开
标题翻译： AZA-BENZOTHOPHENYL化合物及其使用方法
公开(公告)号：WO2008024724A1
公开(公告)日：2008-02-28
申请号：PCT/US2007/076340
申请日：2007-08-20
申请人： GENENTECH, INC. , PRICE, Stephen , WILLIAMS, Karen , SAVY, Pascal Pierre , DYKE, Hazel Joan , MONTANA, John Gary , STANLEY, Mark S. , BAO, Liang
发明人： PRICE, Stephen , WILLIAMS, Karen , SAVY, Pascal Pierre , DYKE, Hazel Joan , MONTANA, John Gary , STANLEY, Mark S. , BAO, Liang
IPC分类号： C07D495/04 , A61K31/4743 , A61P35/00 , A61P29/00
CPC分类号： C07D495/04
摘要： The invention relates to azabenzothiophenyl compounds of Formula (I) with anti-cancer and/or anti-inflammatory activity and more specifically to azabenzothiophenyl compounds which inhibit MEK kinase activity. The invention provides compositions and methods useful for inhibiting abnormal cell growth or treating a hyperproliferative disorder, or treating an inflammatory disease in a mammal. The invention also relates to methods of using the compounds for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, or associated pathological conditions.
摘要翻译：本发明涉及具有抗癌和/或抗炎活性的式（I）的氮杂苯并噻吩基化合物，更具体地涉及抑制MEK激酶活性的氮杂苯并噻吩基化合物。本发明提供了可用于抑制异常细胞生长或治疗过度增殖性疾病或治疗哺乳动物炎性疾病的组合物和方法。本发明还涉及将化合物用于体外，原位和体内诊断或治疗哺乳动物细胞或相关病理状况的方法。

24. 发明申请

WO2007115409A1 COMPOSITIONS AND METHODS FOR MODULATING GATED ION CHANNELS 审中-公开
标题翻译：用于调节门控离子通道的组合物和方法
公开(公告)号：WO2007115409A1
公开(公告)日：2007-10-18
申请号：PCT/CA2007/000595
申请日：2007-04-10
申请人： PAINCEPTOR PHARMA CORPORATION , VOHRA, Rahul , GAN, Zhonghong , PRICE, Stephen , DYKE, Hazel, Joan
发明人： VOHRA, Rahul , GAN, Zhonghong , PRICE, Stephen , DYKE, Hazel, Joan
IPC分类号： C07D471/04 , A61K31/437
CPC分类号： C07D471/04 , C07D209/40
摘要： Indole derivatives according to formula (I), (II) or (III) wherein R 1 is a hydrogen atom, an alkyl or alkoxy group and X-Y together with their adjacent carbon atoms form a six membered ring involving a nitrogen heteroatom or not. These compounds and their pharmaceutically acceptable salts are used for modulating gated ion channels in order to treat pain, inflammatory disorders, neurological disorders, or diseases associated with the genitourinary or gastrointestinal systems.
摘要翻译：根据式（I），（II）或（III）的吲哚衍生物其中R 1是氢原子，烷基或烷氧基和XY以及它们的相邻碳原子形成六元环，涉及或不包含氮杂原子。这些化合物及其药学上可接受的盐用于调节门控离子通道以治疗与泌尿生殖系统或胃肠系统相关的疼痛，炎性疾病，神经系统疾病或疾病。

25. 发明申请

WO2004113312A1 HYDROXAMATE SULFONAMIDES AS CD23 SHEDDING INHIBITORS 审中-公开
标题翻译：羟基磺酸盐作为CD23洗涤抑制剂
公开(公告)号：WO2004113312A1
公开(公告)日：2004-12-29
申请号：PCT/GB2004/002638
申请日：2004-06-18
申请人： CELLTECH R & D LIMITED , OWEN, David Alan , WATSON, Robert John , ALLEN, Daniel Rees , SHARPE, Andrew , DYKE, Hazel Joan
发明人： OWEN, David Alan , WATSON, Robert John , ALLEN, Daniel Rees , SHARPE, Andrew , DYKE, Hazel Joan
IPC分类号： C07D295/22
CPC分类号： C07D295/26 , C07D211/56 , C07D309/14
摘要： A class of piperazine and related heterocyclic derivatives, substituted at the 4-position by a substituted aryl or heteroaryl moiety, and at the 1-position by an ethylsulfonyl group which in turn is substituted at the 2-position by a hydroxamic acid moiety and also by a range of alternative substituents, being potent inhibitors of CD23 shedding, are useful in the treatment and/or prevention of allergic, inflammatory and neoplastic diseases.
摘要翻译：一类哌嗪和相关的杂环衍生物，其在4-位被取代的芳基或杂芳基部分取代，在1-位被乙基磺酰基取代，乙基磺酰基又被异羟肟酸部分在2位上取代，通过一系列替代取代基，作为CD23脱落的有效抑制剂，可用于治疗和/或预防过敏性，炎性和肿瘤性疾病。

26. 发明申请

WO2004113298A1 HYDROXAMATE SULFONAMIDES AS CD23 SHEDDING INHIBITORS 审中-公开
标题翻译：羟基磺酸盐作为CD23洗涤抑制剂
公开(公告)号：WO2004113298A1
公开(公告)日：2004-12-29
申请号：PCT/GB2004/002646
申请日：2004-06-18
申请人： CELLTECH R & D LIMITED , OWEN, David Alan , WATSON, Robert John , ALLEN, Daniel Rees , SHARPE, Andrew , DYKE, Hazel Joan
发明人： OWEN, David Alan , WATSON, Robert John , ALLEN, Daniel Rees , SHARPE, Andrew , DYKE, Hazel Joan
IPC分类号： C07D211/96
CPC分类号： C07D211/96
摘要： A class of piperidine and related heterocyclic derivatives, C-substituted by a substituted aryl or heteroaryl moiety, and N-substituted by an ethylsulfonyl group which in turn is substituted at the 2-position by a hydroxamic acid moiety and also by a range of alternative substituents, being potent inhibitors of CD23 shedding, are useful in the treatment and/or prevention of allergic, inflammatory and neoplastic diseases.
摘要翻译：一类哌啶和相关的杂环衍生物，被取代的芳基或杂芳基部分C取代，并被乙基磺酰基取代，其又被异羟肟酸部分在2位上被取代，并且还被一系列替代物作为CD23脱落的有效抑制剂的取代基可用于治疗和/或预防过敏性，炎性和肿瘤性疾病。

27. 发明申请

WO2004022554A1 QUINAZOLINONE DERIVATIVES 审中-公开
标题翻译：喹诺酮衍生物
公开(公告)号：WO2004022554A1
公开(公告)日：2004-03-18
申请号：PCT/GB2003/003878
申请日：2003-09-05
申请人： CELLTECH R & D LIMITED , HAUGHAN, Alan, Findlay , BUCKLEY, George, Martin , DAVIES, Natasha , DYKE, Hazel, Joan , HANNAH, Duncan, Robert , MORGAN, Trevor , RICHARD, Marianna, Dilani , SHARPE, Andrew , WILLIAMS, Sophie, Caroline
发明人： HAUGHAN, Alan, Findlay , BUCKLEY, George, Martin , DAVIES, Natasha , DYKE, Hazel, Joan , HANNAH, Duncan, Robert , MORGAN, Trevor , RICHARD, Marianna, Dilani , SHARPE, Andrew , WILLIAMS, Sophie, Caroline
IPC分类号： C07D413/04
CPC分类号： C07D413/04 , C07D239/70 , C07D471/10 , C07D487/10 , C07D491/10
摘要： A compound of formula (1), wherein: X is an oxygen or sulfur atom; R 1 is an aliphatic, cycloaliphatic or cycloalkyl-alkyl- group; R 2 is an optionally substituted heteroaromatic group or a -CN group; R 3 is a group -(Alk 1 ) m L 1 (AIk 2 ) n R 4 in which m and n, which may be the same or different, is each zero or the integer 1, Alk 1 and AIk 2 , which may be the same or different, is each an optionally substituted aliphatic or heteroaliphatic chain, L 1 is a covalent bond or a linker atom or group and R 4 is a hydrogen atom or an optionally substituted cycloaliphatic, heterocycloaliphatic, aromatic or heteroaromatic group; A is an optionally substituted cycloaliphatic or heterocycloaliphatic group optionally fused to an optionally substituted aryl or heteroaryl group; R 5 , which may be attached to any available C or N atom present in the cycloaliphatic or heterocycloaliphatic, or where fused, aryl or heteroaryl group, is a group -(AIk 3 ) t L 2 (AIk 4 ) v R 6 in which t and v, which may be the same or different, is each zero or the integer 1, Alk 3 and AIk 4 , which may be the same or different, is each an optionally substituted aliphatic or heteroaliphatic chain, L 2 is a covalent bond or a linker atom or group and R 6 is a hydrogen or halogen atom or a -CN group or an optionally substituted cycloaliphatic, heterocycloaliphatic, aromatic or heteroaromatic group; and the salts, solvates, hydrates, tautomers, isomers or N-oxides thereof. The compounds of the present invention are potent inhibitors of IMPDH.
摘要翻译：式（1）的化合物，其中：X是氧或硫原子; R 1是脂族，脂环族或环烷基 - 烷基; R 2是任选取代的杂芳基或-CN基; R 3是基团 - （Alk 1）mL -1（Alk 2）n R 4，其中m和n可以相同或不同，分别为零或整数1， Alk 1和Alk 2可以相同或不同，各自为任选取代的脂族或杂脂族链，L 1为共价键或连接原子或基团，R 4为氢原子或任选取代的脂环族，杂脂族，芳族或杂芳族基团; A是任选地与任选取代的芳基或杂芳基稠合的任选取代的脂环族或杂环脂族基; R 5可以连接在存在于脂环族或杂环脂族基中的任何可用的C或N原子上，或者其中稠合的，芳基或杂芳基是基团 - （Alk 3）tL 2（Alk <4） >）vR <6>其中可以相同或不同的t和v各自为零或整数1，Alk 3和Alk 4可以相同或不同，各自为任选地取代的脂族或杂脂族链，L 2是共价键或连接原子或基团，R 6是氢或卤素原子或-CN基团或任选取代的脂环族，杂脂族，芳族或杂芳族基团; 及其盐，溶剂合物，水合物，互变异构体，异构体或N-氧化物。本发明的化合物是IMPDH的有效抑制剂。

28. 发明申请

WO2004013130A1 SUBSTITUTED THIENYL-HYDROXAMIC ACIDS AS HISTONE DEACETYLASE INHIBITORS 审中-公开
标题翻译：作为脱乙酰壳多糖酶抑制剂的取代的三羟甲基
公开(公告)号：WO2004013130A1
公开(公告)日：2004-02-12
申请号：PCT/GB2003/003168
申请日：2003-07-24
申请人： ARGENTA DISCOVERY LIMITED , ARCHER, Janet, Ann , BORDOGNA, Walter , BULL, Richard, James , CLARK, David, Edward , DYKE, Hazel, Joan , GILL, Matthew, Iain, Andrew , HARRIS, Neil, Victor , VAN DEN HEUVEL, Marco , PRICE, Stephen
发明人： ARCHER, Janet, Ann , BORDOGNA, Walter , BULL, Richard, James , CLARK, David, Edward , DYKE, Hazel, Joan , GILL, Matthew, Iain, Andrew , HARRIS, Neil, Victor , VAN DEN HEUVEL, Marco , PRICE, Stephen
IPC分类号： C07D409/04
CPC分类号： C07D409/04 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/14
摘要： A compound of formula (I): which can be used in the treatment of diseases associated with histone deacetylase enzymatic activity.
摘要翻译：式（I）化合物：其可用于治疗与组蛋白脱乙酰酶酶活性相关的疾病。

29. 发明申请

WO1997044036A1 QUINOLINE CARBOXAMIDES AS TNF INHIBITORS AND AS PDE-IV INHIBITORS 审中-公开
标题翻译：喹啉羧酰胺作为TNF抑制剂和PDE-IV抑制剂
公开(公告)号：WO1997044036A1
公开(公告)日：1997-11-27
申请号：PCT/GB1997001359
申请日：1997-05-20
申请人： CHIROSCIENCE LIMITED , DYKE, Hazel, Joan , MONTANA, John, Gary , LOWE, Christopher , KENDALL, Hannah, Jayne , SABIN, Verity, Margaret
发明人： CHIROSCIENCE LIMITED
IPC分类号： A61K31/47
CPC分类号： C07D401/12 , A61K45/06 , C07D215/48 , C07D401/14 , C07D417/12
摘要： A compound of general formula (i), wherein X is CO or CS; R is H, halogen or alkyl; R1 represents OH, alkoxy optionally substituted with one or more halogens, or thioalkyl; R2, R3 and R4 are the same or different and are each H, R7, OR11, COR7, C(=NOR7)R7, alkyl-C(=NOR7)R7, halogen CF3, alkyl-C(=NOH)R7, C(=NOH)R7, CN, CO2H, CO2R11, CONH2, CONHR7, CON(R7)2, NR9R10 or CONR12R13 where NR12R13 is a heterocyclic ring optionally substituted with one or more R15; R5 represents H, arylalkyl, heteroarylalkyl, heterocycloalkyl, S(O)mR11 or alkyl optionally substituted with one or more substituents chosen from hydroxy, alkoxy, CO2R8, SO2NR12R13, CONR12R13, CN, carbonyl oxygen, NR9R10, COR11 and S(O)nR11; R6 represents aryl, heteroaryl, heterocyclo, arylalkyl, heteroarylalkyl or heterocycloalkyl; in R5 and/or R6, the aryl/heteroaryl/heterocyclo portion is optionally substituted with one or more substituents alkyl-R14 or R14. The compounds can be used to treat disease states, for example disease states associated with proteins that mediate cellular activity, for example by inhibiting tumour necrosis factor and/or by inhibiting phosphodiesterase IV.
摘要翻译：通式（i）的化合物，其中X为CO或CS; R是H，卤素或烷基; R1表示OH，任选被一个或多个卤素取代的烷氧基或硫代烷基; R2，R3和R4相同或不同，分别为H，R7，OR11，COR7，C（= NOR7）R7，烷基-C（= NOR7）R7，卤素CF3，烷基-C（= NOH）R7，C （= NOH）R 7，CN，CO 2 H，CO 2 R 11，CONH 2，CONHR 7，CON（R 7）2，NR 9 R 10或CONR 12 R 13，其中NR 12 R 13是任选被一个或多个R 15取代的杂环; R 5表示H，芳基烷基，杂芳基烷基，杂环烷基，S（O）m R 11或任选被一个或多个选自羟基，烷氧基，CO 2 R 8，SO 2 NR 12 R 13，CONR 12 R 13，CN，羰基氧，NR 9 R 10，COR 11和S（O）n R 11 ; R 6表示芳基，杂芳基，杂环基，芳基烷基，杂芳基烷基或杂环烷基; 在R 5和/或R 6中，芳基/杂芳基/杂环部分任选被一个或多个烷基-R 14或R 14取代基取代。该化合物可用于治疗疾病状态，例如与介导细胞活性的蛋白质相关的疾病状态，例如通过抑制肿瘤坏死因子和/或通过抑制磷酸二酯酶IV。

30. 发明申请

WO2012154676A9 PARTIALLY SATURATED TRICYCLIC COMPOUNDS AND METHODS OF MAKING AND USING SAME 审中-公开
公开(公告)号：WO2012154676A9
公开(公告)日：2012-11-15
申请号：PCT/US2012/036789
申请日：2012-05-07
申请人： ZAFGEN INC. , CRAMP, Susan, Mary , DYKE, Hazel, Joan , PALLIN, Thomas, David , ZAHLER, Robert
发明人： CRAMP, Susan, Mary , DYKE, Hazel, Joan , PALLIN, Thomas, David , ZAHLER, Robert
IPC分类号： C07D311/94 , C07D405/02 , C07D491/048 , C07D493/04 , A61K31/352 , A61K31/335 , A61K31/4355 , A61K31/397 , A61K31/4025 , A61P3/04
摘要： The invention provides tricyclic compounds and their use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of making various tricyclic compounds are provided. The compounds are contemplated to have activity against methionyl aminopeptidase 2.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式