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21. 发明申请

WO2007038571A3 PROLYL HYDROXYLASE ANTAGONISTS 审中-公开
标题翻译：丙氨酸羟化酶拮抗剂
公开(公告)号：WO2007038571A3
公开(公告)日：2007-10-11
申请号：PCT/US2006037611
申请日：2006-09-26
申请人： SMITHKLINE BEECHAM CORP , CHAI DEPING , COLON MARIELA , DUFFY KEVIN J , FITCH DUKE M , TEDESCO ROSANNA , ZIMMERMAN MICHAEL N
发明人： CHAI DEPING , COLON MARIELA , DUFFY KEVIN J , FITCH DUKE M , TEDESCO ROSANNA , ZIMMERMAN MICHAEL N
IPC分类号： A01N43/42 , A61K31/47 , A61K31/497
CPC分类号： C07D215/56 , C07D401/06 , C07D413/06 , C07D417/06 , C07D491/056
摘要： This invention relates to certain 2-[(quinolin-3-yl)carbonyl]aminoacetic acid derivatives of formula (I), where the various groups are defined herein, and which are useful in treating anemia.
摘要翻译：本发明涉及式（I）的某些2 - [（喹啉-3-基）羰基]氨基乙酸衍生物，其中各种基团在本文中定义，并且其可用于治疗贫血。

22. 发明申请

WO2006135712A3 (5Z)-5-(6-QUINOXALINYLMETHYLIDENE)-2-[(2,6-DICHLOROPHENYL)AMINO]-1,3-THIAZOL-4(5H)-ONE 审中-公开
标题翻译：（5Z）-5-（6- QUINOXALINYLMETHYLIDENE）-2 - [（2,6-二氯苯基）氨基] -1,3-噻唑-4（5H） - 酮
公开(公告)号：WO2006135712A3
公开(公告)日：2007-06-28
申请号：PCT/US2006022385
申请日：2006-06-08
申请人： SMITHKLINE BEECHAM CORP , DUFFY KEVIN J , FITCH DUKE M , NORTON BETH A
发明人： DUFFY KEVIN J , FITCH DUKE M , NORTON BETH A
IPC分类号： C07D217/00 , A01N43/42 , A61K31/47 , C07D277/04
CPC分类号： C07D417/06
摘要： Invented is the compound (5Z)-5-(6-quinoxalinylmethylidene)-2-[(2,6-dichlorophenyl)amino]-1,3-thiazol-4(5H)-one, and/or pharmaceutically acceptable salts, hydrates, solvates and pro-drugs thereof. Also invented are pharmaceutical compositions containing this compound, methods of preparing this compound and pharmaceutically acceptable salts, hydrates, solvates and pro-drugs thereof. Also invented are methods of using this compound as an inhibitor of hYAK3 proteins.
摘要翻译：本发明是化合物（5Z）-5-（6-喹喔啉基亚甲基）-2 - [（2,6-二氯苯基）氨基] -1,3-噻唑-4（5H） - 酮，和/或其药学上可接受的盐，水合物，溶剂化物和其前体药物。还发明了含有该化合物的药物组合物，制备该化合物的方法及其药学上可接受的盐，水合物，溶剂化物和其前体药物。还发明了使用该化合物作为hYAK3蛋白的抑制剂的方法。

23. 发明申请

WO2007038331A2 NOVEL CHEMICAL COMPOUNDS 审中-公开
标题翻译：新化学化合物
公开(公告)号：WO2007038331A2
公开(公告)日：2007-04-05
申请号：PCT/US2006037090
申请日：2006-09-22
申请人： SMITHKLINE BEECHAM CORP , DUFFY KEVIN J , FITCH DUKE M , TEDESCO ROSANNA , ZIMMERMAN MICHAEL N
发明人： DUFFY KEVIN J , FITCH DUKE M , TEDESCO ROSANNA , ZIMMERMAN MICHAEL N
IPC分类号： A61K39/00
CPC分类号： C07D417/06 , C07D487/04
摘要： This invention relates to newly identified compounds for inhibiting hYAK3 proteins and methods for treating diseases associated with the imbalance or inappropriate activity of hYAK3 proteins.
摘要翻译：本发明涉及新鉴定的用于抑制hYAK3蛋白的化合物和治疗与hYAK3蛋白失衡或不适当活性有关的疾病的方法。

24. 发明申请

WO2004052313A2 ANTI-INFECTIVES 审中-公开
标题翻译：抗感染药
公开(公告)号：WO2004052313A2
公开(公告)日：2004-06-24
申请号：PCT/US2003/039983
申请日：2003-12-11
申请人： SMITHKLINE BEECHAM CORPORATION , CHAI, Deping , DUFFY, Kevin, J. , FITCH, Duke, M. , SHAW, Antony, N. , TEDESCO, Rosanna , WIGGALL, Kenneth, J. , ZIMMERMAN, Michael, N.
发明人： CHAI, Deping , DUFFY, Kevin, J. , FITCH, Duke, M. , SHAW, Antony, N. , TEDESCO, Rosanna , WIGGALL, Kenneth, J. , ZIMMERMAN, Michael, N.
IPC分类号： A61K
CPC分类号： C07D417/14 , C07D417/04
摘要： Compounds useful as HCV anti-infectives having the formula (I) wherein the formula variables are as defined herein, are disclosed. Also disclosed are methods of making and using the same.
摘要翻译：公开了可用作具有式（I）的HCV抗感染药的化合物，其中式变量如本文所定义。还公开了制造和使用它们的方法。

25. 发明申请

WO2004052312A2 ANTI-INFECTIVES 审中-公开
标题翻译：抗感染药
公开(公告)号：WO2004052312A2
公开(公告)日：2004-06-24
申请号：PCT/US2003/039982
申请日：2003-12-11
申请人： SMITHKLINE BEECHAM CORPORATION , CHAI, Deping , DUFFY, Kevin, J. , FITCH, Duke, M. , SHAW, Antony, N. , TEDESCO, Rosanna , WIGGALL, Kenneth, J. , ZIMMERMAN, Michael, N.
发明人： CHAI, Deping , DUFFY, Kevin, J. , FITCH, Duke, M. , SHAW, Antony, N. , TEDESCO, Rosanna , WIGGALL, Kenneth, J. , ZIMMERMAN, Michael, N.
IPC分类号： A61K
CPC分类号： C07D417/04
摘要： Compounds useful as HCV anti-infectives are disclosed. Also disclosed are methods of making and using the same.
摘要翻译：公开了可用作HCV抗感染剂的化合物。还公开了制造和使用它们的方法。

26. 发明申请

WO2012061557A3 CHEMICAL COMPOUNDS 审中-公开
标题翻译：化学化合物
公开(公告)号：WO2012061557A3
公开(公告)日：2013-11-14
申请号：PCT/US2011059067
申请日：2011-11-03
申请人： GLAXOSMITHKLINE IP NO 2 LTD , CHAI DEPING , COLON MARIELA , DODSON CHRISTOPHER , DUFFY KEVIN J , SHAW ANTONY NICHOLAS
发明人： CHAI DEPING , COLON MARIELA , DODSON CHRISTOPHER , DUFFY KEVIN J , SHAW ANTONY NICHOLAS
IPC分类号： C07D401/00
CPC分类号： A61K31/506 , A61K31/4706 , A61K31/4709 , A61K31/496 , A61K31/513 , A61K31/517 , A61K31/69 , A61K45/06 , C07D215/44 , C07D215/54 , C07D401/04 , C07D401/10 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D407/14 , C07D413/04 , C07D413/10 , C07D413/14 , C07D471/04 , C07F5/025
摘要： The invention is directed to substituted quinoline derivatives. Specifically, the invention is directed to compounds according to Formula I: wherein, R1, R3; R4; ANC R5 are defined herein. The compounds of the invention are inhibitors of lactate dehydrogenase A and can be useful in the treatment of cancer and diseases associated with tumor cell metabolism, such as cancer, and more specifically cancers of the breast, colon, prostate and lung. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting lactate dehydrogenase A activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.
摘要翻译：本发明涉及取代的喹啉衍生物。具体地，本发明涉及式I化合物：其中R1，R3， R4; ANC R5在本文中定义。本发明的化合物是乳酸脱氢酶A的抑制剂，并且可用于治疗与肿瘤细胞代谢相关的癌症和疾病，例如癌症，更具体地说，涉及乳腺癌，结肠癌，前列腺癌和肺癌。因此，本发明进一步涉及包含本发明化合物的药物组合物。本发明还涉及抑制乳酸脱氢酶A活性的方法以及使用本发明化合物或包含本发明化合物的药物组合物治疗与之相关的疾病。

27. 发明申请

WO2008150837A1 METHODS OF TREATMENT 审中-公开
标题翻译：治疗方法
公开(公告)号：WO2008150837A1
公开(公告)日：2008-12-11
申请号：PCT/US2008/065038
申请日：2008-05-29
申请人： SMITHKLINE BEECHAM CORPORATION , DUFFY, Kevin, J. , ERICKSON-MILLER, Connie, Lynn , KIKKAWA, Hideo , MARONEY, Anna, Coco
发明人： DUFFY, Kevin, J. , ERICKSON-MILLER, Connie, Lynn , KIKKAWA, Hideo , MARONEY, Anna, Coco
IPC分类号： A61K31/497
CPC分类号： A61K31/497
摘要： This invention relates to a method of treating a disease state selected from: Alzheimer's disease, Down's syndrome, mental retardation, memory defects, memory loss, pancreatic cancer, bone resorption disease, osteoporosis, sickle cell anemia, chronic kidney disease, diabetes, depression, and subsets of depression including: alcoholism, anxiety, obsessive compulsive disorder, panic disorder, chronic pain, obesity, senile dementia, migraine, bulimia, anorexia, social phobia, pre-menstrual syndrome (PMS), adolescent depression, trichotillomania, dysthymia and substance abuse, in a mammal in need thereof, including a human, which comprises administering to such mammal a therapeutically effective amount of a selected substituted thiazol compound. The invention also relates to a method of enhancing cognition in a mammal in need thereof which comprises administering to such mammal a therapeutically effective amount of a selected substituted thiazol compound.
摘要翻译：本发明涉及治疗选自以下的疾病状态的方法：阿尔茨海默氏病，唐氏综合征，智力迟钝，记忆缺陷，记忆丧失，胰腺癌，骨吸收疾病，骨质疏松症，镰状细胞性贫血，慢性肾脏病，糖尿病，抑郁症，抑郁症，包括酗酒，焦虑，强迫症，恐慌症，慢性疼痛，肥胖症，老年痴呆症，偏头痛，贪食症，厌食症，社交恐惧症，月经前期综合征（PMS），青春期抑郁症，头发性躁狂症，精神郁闷和物质在有需要的哺乳动物中包括人，其包括向所述哺乳动物施用治疗有效量的选择的取代的噻唑化合物。本发明还涉及增强需要的哺乳动物的认知的方法，该方法包括向所述哺乳动物施用治疗有效量的选择的取代的噻唑化合物。

28. 发明申请

WO2008089051A1 N-SUBSTITUTED GLYCINE DERIVATIVES: PROLYL HYDROXYLASE INHIBITORS 审中-公开
标题翻译： N-取代的甘氨酸衍生物：丙基羟基酶抑制剂
公开(公告)号：WO2008089051A1
公开(公告)日：2008-07-24
申请号：PCT/US2008/050831
申请日：2008-01-11
申请人： SMITHKLINE BEECHAM CORPORATION , SHAW, Antony, N. , DUFFY, Kevin, J. , TEDESCO, Rosanna , WIGGALL, Kenneth
发明人： SHAW, Antony, N. , DUFFY, Kevin, J. , TEDESCO, Rosanna , WIGGALL, Kenneth
IPC分类号： A01N43/54 , A61K31/505
CPC分类号： C07D239/557
摘要： The invention described herein relates to certain pyrimidinedione N-substituted glycine derivatives of formula (I) which are antagonists of HIF prolyl hydroxylases and are useful for treating diseases benefiting from the inhibition of this enzyme, anemia being one example.
摘要翻译：本文描述的本发明涉及作为HIF脯氨酰羟化酶的拮抗剂的式（I）的某些嘧啶二酮N-取代的甘氨酸衍生物，并且可用于治疗受益于该酶的抑制的疾病，贫血是一个示例。

29. 发明申请

WO2007150011A3 PROLYL HYDROXYLASE INHIBITORS 审中-公开
公开(公告)号：WO2007150011A3
公开(公告)日：2007-12-27
申请号：PCT/US2007/071854
申请日：2007-06-22
申请人： SMITHKLINE BEECHAM CORPORATION , DUFFY, Kevin, J. , FITCH, Duke, M. , JIN, Jian , LIU, Ronggang , SHAW, Antony, N. , WIGGALL, Kenneth
发明人： DUFFY, Kevin, J. , FITCH, Duke, M. , JIN, Jian , LIU, Ronggang , SHAW, Antony, N. , WIGGALL, Kenneth
IPC分类号： A61K31/47 , A61K31/495 , C07D487/08
摘要： The invention described herein relates to certain pyrimidinetrione N-substituted glycine derivatives of formula (I), (I) which are antagonists of HIF prolyl hydroxylases and are useful for treating diseases benefiting from the inhibition of this enzyme, anemia being one example.

30. 发明申请

WO2004052312A3 ANTI-INFECTIVES 审中-公开
标题翻译：抗感染药
公开(公告)号：WO2004052312A3
公开(公告)日：2007-08-02
申请号：PCT/US0339982
申请日：2003-12-11
申请人： SMITHKLINE BEECHAM CORP , CHAI DEPING , DUFFY KEVIN J , FITCH DUKE M , SHAW ANTONY N , TEDESCO ROSANNA , WIGGALL KENNETH J , ZIMMERMAN MICHAEL N
发明人： CHAI DEPING , DUFFY KEVIN J , FITCH DUKE M , SHAW ANTONY N , TEDESCO ROSANNA , WIGGALL KENNETH J , ZIMMERMAN MICHAEL N
IPC分类号： C07D417/04 , A61K31/549 , A61P31/12
CPC分类号： C07D417/04
摘要： Compounds useful as HCV anti-infectives are disclosed. Also disclosed are methods of making and using the same.
摘要翻译：公开了可用作HCV抗感染剂的化合物。还公开了制造和使用它们的方法。

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