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21. 发明申请

WO2003010182A1 NOVEL DAMMARANE SAPOGENINS, THEIR USE AS ANTI-CANCER AGENTS, AND A PROCESS FOR PRODUCING SAME 审中-公开
标题翻译：新型丹麦青蒿素，其作为抗癌剂的用途及其生产方法
公开(公告)号：WO2003010182A1
公开(公告)日：2003-02-06
申请号：PCT/CA2002/001173
申请日：2002-07-24
申请人： PANAGIN PHARMACEUTICALS INC. , HUANG, Dong , QI, Dong, Feng
发明人： HUANG, Dong , QI, Dong, Feng
IPC分类号： C07J17/00
CPC分类号： C07J17/005
摘要： This invention relates to a group of novel sapogenins, their use in anti-cancer applications, and to a process for their production. More particularly, this invention pertains to a novel group of dammarane sapogenins, PAM-120, PBM-110 and PBM-100 (the dammarane sapogenin structure is specifically clean of any sugar moieties (glycons) at any position and hydroxyl at C-20) and PAN-20 and PAN-30 (the dammarane sapogenin structure has sugar moieties but is free of hydroxyl at C-20), obtained by chemical cleavage of dammarane saponins. The invention also includes a novel application of the said sapogenins for anti-cancer treatment by using them separately or together, and/or jointly with other drugs, as well as to the process of producing these novel sapogenins. Said novel dammarane sapogenins show surprising anti-cancer effect when applied, particularly against multi-drug resistant cancers.
摘要翻译：本发明涉及一组新的皂甙元，它们在抗癌应用中的用途，以及它们的制备方法。更具体地说，本发明涉及一组新的一组抗坏血酸皂苷元PAM-120，PBM-110和PBM-100（在任何位置上任何糖部分（糖）和C-20处的羟基）和PAN-20和PAN-30（dammarane sapogenin结构具有糖部分，但在C-20时不含羟基），通过化学裂解dammarane皂苷获得。本发明还包括通过分别或一起使用它们，和/或与其它药物联合使用所述皂苷元进行抗癌治疗的新应用，以及生产这些新型皂甙元的方法。所述新型的dammarane sapogenins在使用时显示出惊人的抗癌作用，特别是针对多重耐药性癌症。

22. 发明申请

WO2012058137A3 METHODS FOR DIVERSIFYING ANTIBODIES, ANTIBODIES DERIVED THEREFROM AND USES THEREOF 审中-公开
标题翻译：用于分化抗体的方法，其衍生的抗体及其用途
公开(公告)号：WO2012058137A3
公开(公告)日：2014-04-10
申请号：PCT/US2011057426
申请日：2011-10-24
申请人： MERCK SHARP & DOHME , WANG KEVIN CAILI , LI YAN , HSIEH MARK , WANG XINWEI , DONG FENG , LUO PEIZHI PETER , ZHONG PINGYU
发明人： WANG KEVIN CAILI , LI YAN , HSIEH MARK , WANG XINWEI , DONG FENG , LUO PEIZHI PETER , ZHONG PINGYU
IPC分类号： C12P21/02
CPC分类号： C12N15/1055 , C07K16/00 , C07K16/005 , C07K16/087 , C07K16/2863 , C07K16/2866 , C07K16/32 , C07K2317/21 , C07K2317/55 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92 , G01N33/6845
摘要： Disclosed are methods of introducing diversity into antibody molecules substitutions of at least one amino acid sequence in the CDR of the target antibody together with at least one amino acid in the FW region spanning the 3 amino acid adjoining the CRD on each side. The resulting diverse antibodies with variant CDRs and flanking region sequences comprising diverse amino acid sequences Libraries comprising a plurality of these polypeptides are also provided as well as methods of and compositions for generating and using these polypeptides and libraries.
摘要翻译：公开了将多样性引入到靶抗体的CDR中的至少一个氨基酸序列的取代的多样性的方法以及跨越与每个CRD相邻的3个氨基酸的FW区域中的至少一个氨基酸。所得到的具有不同CDR的多态抗体和包含不同氨基酸序列的侧翼区序列也提供了包含多个这些多肽的文库以及生成和使用这些多肽和文库的方法和组合物。

23. 发明申请

WO2006116474A3 FRICTION MATERIAL 审中-公开
标题翻译：摩擦材料
公开(公告)号：WO2006116474A3
公开(公告)日：2007-10-25
申请号：PCT/US2006015769
申请日：2006-04-25
申请人： BORGWARNER INC , LAM ROBERT C , DONG FENG
发明人： LAM ROBERT C , DONG FENG
IPC分类号： C08J5/14
CPC分类号： F16D69/026 , C08J5/04 , C08J2361/00 , D06M11/74 , D06M11/79
摘要： This friction material has a fibrous base material and preferably is a wet friction material for use in a fluid environment. The fibers have a small diameter and a high tensile modulus resulting in flexible fibers that performs well in a high temperature, high pressure fluid environment. The fibers have a diameter ranging from 1 to 20 micrometers and a tensile modulus greater than 70 Gpa. In the preferred embodiment, the small diameter fibers are small diameter carbon fibers or small diameter mineral fibers.
摘要翻译：该摩擦材料具有纤维基材，优选为用于流体环境的湿摩擦材料。纤维具有小直径和高拉伸模量，导致在高温高压流体环境中表现良好的柔性纤维。纤维的直径范围为1至20微米，拉伸模量大于70Gpa。在优选实施例中，小直径纤维是小直径碳纤维或小直径矿物纤维。

24. 发明申请

WO2007055951A1 CARBON FRICTION MATERIALS 审中-公开
标题翻译：碳摩擦材料
公开(公告)号：WO2007055951A1
公开(公告)日：2007-05-18
申请号：PCT/US2006/042342
申请日：2006-10-31
申请人： BORGWARNER INC. , DONG, Feng , LAM, Robert, C. , CHEN, Yih, Fang
发明人： DONG, Feng , LAM, Robert, C. , CHEN, Yih, Fang
IPC分类号： C08K3/04 , C08J5/14
CPC分类号： F16D69/023 , C08K3/04 , F16D69/026 , Y10T428/249921 , Y10T428/2965 , Y10T428/2969 , Y10T428/2971 , Y10T442/20 , Y10T442/30 , Y10T442/60
摘要： Sintered, carbon friction materials are made from fibrous materials that are impregnated with resins prior to sintering. Preferably, non-woven fibrous materials are impregnated with phenolic resin and sintered at 400 to 8000C. The resulting material has an open porosity above 50 percent by volume.
摘要翻译：烧结的碳摩擦材料由在烧结之前用树脂浸渍的纤维材料制成。优选地，用酚醛树脂浸渍无纺纤维材料并在400-800℃下烧结。所得材料具有高于50体积％的开放孔隙率。

25. 发明申请

WO2006116474A2 FRICTION MATERIAL 审中-公开
标题翻译：摩擦材料
公开(公告)号：WO2006116474A2
公开(公告)日：2006-11-02
申请号：PCT/US2006/015769
申请日：2006-04-25
申请人： BORGWARNER INC. , LAM, Robert, C. , DONG, Feng
发明人： LAM, Robert, C. , DONG, Feng
IPC分类号： C08J5/14
CPC分类号： F16D69/026 , C08J5/04 , C08J2361/00 , D06M11/74 , D06M11/79
摘要： This friction material has a fibrous base material and preferably is a wet friction material for use in a fluid environment. The fibers have a small diameter and a high tensile modulus resulting in flexible fibers that performs well in a high temperature, high pressure fluid environment. The fibers have a diameter ranging from 1 to 20 micrometers and a tensile modulus greater than 70 Gpa. In the preferred embodiment, the small diameter fibers are small diameter carbon fibers or small diameter mineral fibers.
摘要翻译：该摩擦材料具有纤维基材，优选为用于流体环境的湿摩擦材料。纤维具有小直径和高拉伸模量，导致在高温高压流体环境中表现良好的柔性纤维。纤维的直径范围为1至20微米，拉伸模量大于70Gpa。在优选实施例中，小直径纤维是小直径碳纤维或小直径矿物纤维。

26. 发明申请

WO2013022823A3 WET FRICTION MATERIAL 审中-公开
标题翻译：湿摩擦材料
公开(公告)号：WO2013022823A3
公开(公告)日：2013-04-25
申请号：PCT/US2012049716
申请日：2012-08-06
申请人： BORGWARNER INC , DONG FENG , LAM ROBERT C , NEWCOMB TIMOTHY P
发明人： DONG FENG , LAM ROBERT C , NEWCOMB TIMOTHY P
IPC分类号： F16D69/02
CPC分类号： F16D69/026 , F16D13/64 , F16D2200/0065 , F16D2200/0069 , F16D2200/0073 , Y10T428/25 , Y10T428/26
摘要： A wet friction material for use in a wet clutch includes a friction interfacing surface for experiencing frictional engagement with an opposed surface in the presence of a lubricant. At least a portion of the friction interfacing surface comprises fibrillated nanofibers, which define a nanofibrous web. and friction adjusting particles held by the nanofibrous web. A cured resin may adhere the fibrillated nanofibers and the friction adjusting particles to provide structural support for the friction material.
摘要翻译：用于湿式离合器的湿摩擦材料包括摩擦接合表面，用于在存在润滑剂的情况下与相对表面摩擦接合。摩擦接合表面的至少一部分包括限定纳米纤维网的原纤化纳米纤维。和由纳米纤维网保持的摩擦调节颗粒。固化的树脂可以粘附原纤化纳米纤维和摩擦调节颗粒以提供摩擦材料的结构支撑。

27. 发明申请

WO2009100318A1 1B20 PCSK9 ANTAGONISTS 审中-公开
公开(公告)号：WO2009100318A1
公开(公告)日：2009-08-13
申请号：PCT/US2009/033369
申请日：2009-02-06
申请人： MERCK & CO., INC. , CONDRA, Jon, H. , CUBBON, Rose, M. , HAMMOND, Holly, A. , MCCABE, Timothy , PANDIT, Shilpa , PETERSON, Laurence, B. , SANTORO, Joseph, C. , SITLANI, Ayesha , WOOD, Dana, D. , MACH, Henryk , YODER, Heidi , GREGORY, Sonia, M. , BLUE, Jeffrey, T. , WANG, Kevin , LUO, Peter , NAWROCKI, Denise, K. , ZHONG, Pingyu , DONG, Feng , LI, Yan
发明人： CONDRA, Jon, H. , CUBBON, Rose, M. , HAMMOND, Holly, A. , MCCABE, Timothy , PANDIT, Shilpa , PETERSON, Laurence, B. , SANTORO, Joseph, C. , SITLANI, Ayesha , WOOD, Dana, D. , MACH, Henryk , YODER, Heidi , GREGORY, Sonia, M. , BLUE, Jeffrey, T. , WANG, Kevin , LUO, Peter , NAWROCKI, Denise, K. , ZHONG, Pingyu , DONG, Feng , LI, Yan
IPC分类号： C07K16/40 , C12N9/64 , A61K39/395 , C12N15/13 , A61P3/06
CPC分类号： C07K16/40 , A61K2039/505 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C12N9/6424
摘要： Antagonists of human proprotein convertase subtilisin-kexin type 9 ('PCSK9') are disclosed. The disclosed antagonists are effective in the inhibition of PCSK9 function and, accordingly, present desirable antagonists for use in the treatment of conditions associated with PCSK9 activity. The present invention also discloses nucleic acid encoding said antagonists, vectors, host cells, and compositions comprising the antagonists. Methods of making PCSK9-specific antagonists as well as methods of using the antagonists for inhibiting or antagonizing PCSK9 function are also disclosed and form important additional aspects of the present disclosure.
摘要翻译：公开了人前体蛋白转化酶枯草杆菌蛋白酶-Kexin 9型（'PCSK9'）的拮抗剂。所公开的拮抗剂在抑制PCSK9功能方面是有效的，因此，呈现用于治疗与PCSK9活性相关的病症的所需拮抗剂。本发明还公开了编码所述拮抗剂，载体，宿主细胞和包含拮抗剂的组合物的核酸。还公开了制备PCSK9特异性拮抗剂的方法以及使用拮抗剂抑制或拮抗PCSK9功能的方法，并且形成了本公开的重要的附加方面。

28. 发明申请

WO2009055371A8 FRICTION MATERIAL COATED WITH PARTICLES AND SATURATED WITH ELASTIC RESIN 审中-公开
公开(公告)号：WO2009055371A8
公开(公告)日：2009-04-30
申请号：PCT/US2008/080617
申请日：2008-10-21
申请人： BORGWARNER INC. , CIUPAK, Brian, R. , DONG, Feng , NEWCOMB, Timothy, P.
发明人： CIUPAK, Brian, R. , DONG, Feng , NEWCOMB, Timothy, P.
IPC分类号： C09K3/14 , C08J5/14 , F16D65/02
摘要： A friction material including a plurality of fibers and a resin component binding the fibers, and wherein the resin component includes an elastic resin.

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