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21. 发明申请

WO2007140008A2 INSULATIVE COMPOSITE MATERIALS INCLUDING A COATED, WATER-RESISTANT PAPER LAYER 审中-公开
标题翻译：绝缘复合材料，包括涂层，耐水纸层
公开(公告)号：WO2007140008A2
公开(公告)日：2007-12-06
申请号：PCT/US2007/012636
申请日：2007-05-29
申请人： DOW REICHHOLD SPECIALTY LATEX, LLC , BAKER, Lee
发明人： BAKER, Lee
IPC分类号： B32B29/02
CPC分类号： B32B27/10 , B32B29/06
摘要： The present invention provides a composite insulation material. The material includes a layer of an insulation, such as foam or fiberglass, and a paper layer. The paper layer is coated with a moisture vapor barrier, using a coating composition that includes a resin latex and a component having a crystalline platelet structure. Suitable resin latexes include poly(meth)acrylates, carboxylated or non-carboxylated butadiene-acrylonitrile, polystyrene, styrene-acrylonitrile, styrene-acrylonitrile-butadiene, styrene acrylates, styrene-butadiene, carboxylated styrene butadiene, polyvinyl chloride, polyvinyl acetate, waterborne polyurethanes, vinyl acrylics, polyvinylidene chloride, ethyl vinyl chloride, vinyl acetate- ethylene copolymers, and copolymers, terpolymers, and blends thereof. A suspending agent for the crystalline platelet component can be present, and is typically a hydrophilic polymer. The coating compositions can include wax, or can be essentially devoid of wax. A hydrophobic agent other than wax can optionally be added. The crystalline platelet structure can be unmodified, or modified to increase its hydrophobicity. The composite material can also be in the form of a foil/scrim/Kraft paper laminate, which can be combined with a layer of insulation if desired. The insulation materials can be used, for example, to insulate pipes and ductwork, or other aspects of buildings.
摘要翻译：本发明提供一种复合绝缘材料。该材料包括绝缘层，例如泡沫或玻璃纤维，以及纸层。使用包含树脂胶乳和具有结晶血小板结构的组分的涂料组合物，涂覆有水分阻挡层的纸层。合适的树脂胶乳包括聚（甲基）丙烯酸酯，羧化或非羧化丁二烯 - 丙烯腈，聚苯乙烯，苯乙烯 - 丙烯腈，苯乙烯 - 丙烯腈 - 丁二烯，苯乙烯丙烯酸酯，苯乙烯 - 丁二烯，羧化苯乙烯丁二烯，聚氯乙烯，聚乙酸乙烯酯，水性聚氨酯，乙烯基丙烯酸类，聚偏二氯乙烯，乙基氯乙烯，乙酸乙烯酯 - 乙烯共聚物，和共聚物，三元共聚物及其共混物。可以存在结晶性血小板成分的悬浮剂，通常为亲水性聚合物。涂料组合物可以包括蜡，或者可以基本上不含蜡。可以任选地加入除蜡以外的疏水剂。结晶血小板结构可以是未改性的或改性的以增加其疏水性。复合材料也可以是箔/稀松布/牛皮纸层压板的形式，如果需要，其可与绝缘层组合。绝缘材料可用于例如绝缘管道和管道系统或建筑物的其他方面。

22. 发明申请

WO2007056262A3 POLYMER COMPOSITIONS HAVING NOVEL CURE SYSTEMS AND METHOD OF MAKING ARTICLES WITH SAME 审中-公开
公开(公告)号：WO2007056262A3
公开(公告)日：2007-05-18
申请号：PCT/US2006/043157
申请日：2006-11-03
申请人： DOW REICHHOLD SPECIALTY LATEX, LLC , SUDDABY, Kevin, Grant
发明人： SUDDABY, Kevin, Grant
IPC分类号： C08F136/00
摘要： The present invention provides a polymer composition capable of being cured or crosslinked in the absence of conventional sulfur and accelerator cure systems. The polymer is formed from olefinically unsaturated monomers and includes at least one conjugated diene monomer. Such polymer includes additional functionality provided by a monomer which may crosslink via enamine formation, condensation with aldehydes, Michael addition, alkylation with alkyl halides, reaction with diisocyanates, or reaction with melamines. By these same mechanisms, the polymer may additionally or alternatively be reacted with a substrate, such as a fiber, to bind the polymer to the substrate. Further, the polymer may be reacted with a molecule, such as a plasticizer, dye, indicator, surface modifier, or antimicrobial moiety in order to bind the molecule to the polymer. Methods of making articles of manufacture that comprise the polymer compositions of the invention are also disclosed.

23. 发明申请

WO2007047848A2 COMPOSITE LEATHER MATERIAL 审中-公开
标题翻译：复合皮革材料
公开(公告)号：WO2007047848A2
公开(公告)日：2007-04-26
申请号：PCT/US2006/040902
申请日：2006-10-19
申请人： DOW REICHHOLD SPECIALTY LATEX, LLC , SUSTAINABLE SOLUTIONS, INC. (SSI) , COULSON, Nancy, Susan , KILNSLEY, Homan, B. , NUNN, Joy, K.
发明人： COULSON, Nancy, Susan , KILNSLEY, Homan, B. , NUNN, Joy, K.
IPC分类号： B32B3/12
CPC分类号： B32B9/02 , B32B3/30 , B32B5/02 , B32B5/22 , B32B25/10 , B32B25/12 , B32B2262/062 , B32B2262/08 , B32B2307/102 , B32B2307/538 , B32B2307/546 , B32B2307/554 , B32B2437/00 , B32B2509/00 , B32B2601/00 , C08J5/045 , C08J2321/02 , C08J2333/06 , C08L1/02 , C08L9/00 , C08L89/06 , C08L91/00 , C08L97/02 , C08L2205/16 , C08L2205/18 , C08L2205/20 , C09D101/02 , C09D189/06 , C09D197/02 , Y10T442/647 , Y10T442/696 , Y10T442/699 , C08L2666/02
摘要： Engineered leather substrates, methods of making the substrates, engineered leather composites including the substrates, and articles of manufacture which include the engineered leather substrates or composites are disclosed. The substrate includes leather, non-leather fibers, a binding agent and one or more additional components such as cushioning agents, softeners, processing aids, and colorants. A composite material can be formed including the substrate and one or more additional layers, such as top coat layers, reinforcing layers, and cushioning layers. The substrate and or the composite can be chemically or mechanically embossed. The leather used to form the engineered leather substrate can be derived from post- industrial and/or post-consumer materials. The non-leather fibers can be organic or inorganic, and the composition can also include inorganic fillers, such as calcium carbonate, and clays. The cushioning agents can include polymeric microbubbles, foam, rubber particles, and other low density cushioning agents. The binding agents can be synthetic or natural, such as synthetic latex, natural latex, PVA, and starch.
摘要翻译：公开了工程皮革基材，制造基材的方法，包括基材的工程革复合材料和包括工程皮革基材或复合材料的制品。基材包括皮革，非皮革纤维，粘合剂和一种或多种另外的组分如缓冲剂，软化剂，加工助剂和着色剂。可以形成复合材料，其包括基底和一个或多个附加层，例如顶涂层，增强层和缓冲层。基底和/或复合材料可以化学或机械压花。用于形成工程皮革基材的皮革可以来自后工业和/或消费后材料。非皮革纤维可以是有机或无机的，组合物也可以包括无机填料，如碳酸钙和粘土。缓冲剂可以包括聚合物微泡，泡沫，橡胶颗粒和其它低密度缓冲剂。粘合剂可以是合成的或天然的，例如合成胶乳，天然胶乳，PVA和淀粉。

24. 发明申请

WO2007014061A2 COATED TABLES WITH ZERO-ORDER OR NEAR ZERO-ORDER RELEASE KINETICS 审中-公开
标题翻译：带有零订单或零零排放动态的涂层表
公开(公告)号：WO2007014061A2
公开(公告)日：2007-02-01
申请号：PCT/US2006/028447
申请日：2006-07-21
申请人： METRICS, INC. , GOLD, Thomas, B. , WOODAL, Patrick, Brian
发明人： GOLD, Thomas, B. , WOODAL, Patrick, Brian
IPC分类号： A61K9/20
CPC分类号： A61K9/2031 , A61K9/2866
摘要： Tablets for the controlled release of an active ingredient in a zero-order or near zero-order fashion are provided. The tablet includes a core and a coating. The core includes at least one active pharmaceutical agent and a polyethylene oxide with a molecular weight of between about 1,000,000 and 10,000,000, preferably between about 4,000,000 and 8,000,000. The core material is optionally, but preferably, coated with a cellulosic material. The active pharmaceutical agent can be hydrophilic, hydrophobic, or amphiphilic. When the active pharmaceutical agent is a hydrophilic agent, it is preferred that the coating is a relatively hydrophobic cellulose, such as ethylcellulose or propylcellulose. However, if the tablet is uncoated, it can provide a near-zero-order release rate rather than a zero-order release rate. When the active pharmaceutical agent is a hydrophobic or amphiphilic agent, the hydrophilic polymeric carrier is the same as in the first embodiment, the coating is a relatively more hydrophilic cellulose. The release rate for the active pharmaceutical agent can be controlled by adjusting the thickness of the coating, and, optionally, by adjusting the concentration of the polymeric excipients, as well as certain non-polymeric excipients which may optionally be present. An advantage of using relatively high molecular weight polyethylene oxide is that the release is pH independent, unlike where ionic polymers such as polyacrylic acids are used. Further, active pharmaceutical agents including functional groups that might react with such polymers can be used without an adverse reaction between the active agent and the polymer.
摘要翻译：提供以零级或接近零级方式控制释放活性成分的片剂。片剂包括芯和涂层。核心包括至少一种活性药剂和分子量为约1,000,000至10,000,000，优选约4,000,000至8,000,000的聚环氧乙烷。核心材料是任选的，但优选地涂覆有纤维素材料。活性药剂可以是亲水的，疏水的或两亲的。当活性药剂是亲水剂时，优选涂层是相对疏水的纤维素，例如乙基纤维素或丙基纤维素。然而，如果平板电脑是未涂覆的，则它可以提供接近零级的释放速率而不是零级释放速率。当活性药剂是疏水性或两亲性剂时，亲水性聚合物载体与第一实施方案相同，涂层是相对较亲水的纤维素。活性药剂的释放速率可以通过调节涂层的厚度和任选地通过调节聚合物赋形剂的浓度以及可任选存在的某些非聚合物赋形剂来控制。使用相对高分子量的聚环氧乙烷的优点在于，与使用离子聚合物如聚丙烯酸不同，其释放是不依赖于pH的。此外，可以使用包括可能与这种聚合物反应的官能团的活性药剂，而不会在活性剂和聚合物之间产生不良反应。

25. 发明申请

WO2004092182A1 FRAGRANCE COMPOSITIONS COMPRISING BENZO[4,5]THIENO[3,2-B]PYRAN-2-ONE 审中-公开
标题翻译：包含苯并[4,5]噻吩并[3,2-B]吡啶-2-酮的组合物
公开(公告)号：WO2004092182A1
公开(公告)日：2004-10-28
申请号：PCT/US2004/010829
申请日：2004-04-08
申请人： FLEXITRAL, INC. , TURIN, Luca
发明人： TURIN, Luca
IPC分类号： C07D495/04
CPC分类号： C07D495/04 , C11B9/0076 , C11B9/008
摘要： The present case discloses compositions of benzo[4,5]thieno[3,2-b]pyran-2-one which are employed as aroma chemicals.
摘要翻译：本发明公开了作为芳香化学物质使用的苯并[4,5]噻吩并[3,2-b]吡喃-2-酮的组合物。

26. 发明申请

WO2004005293A3 N-ARYL DIAZASPIRACYCLIC COMPOUNDS AND METHODS OF PREPARATION AND USE THEREOF 审中-公开
公开(公告)号：WO2004005293A3
公开(公告)日：2004-01-15
申请号：PCT/US2003/020524
申请日：2003-06-27
申请人： TARGACEPT, INC. , BHATTI, Balwinder, S. , MILLER, Craig, H. , SCHMIDT, Jeffrey, D.
发明人： BHATTI, Balwinder, S. , MILLER, Craig, H. , SCHMIDT, Jeffrey, D.
IPC分类号： C07D487/10
摘要： Compounds, pharmaceutical compositions including the compounds, and methods of preparation and use thereof are disclosed. The compounds are N-aryldiazaspirocyclic compounds, bridged analogs of N-heteroaryl diazaspirocyclic compounds, or prodrugs or metabolites of these compounds. The aryl group can be a five or six-membered heterocyclic ring (heteroaryl). The compounds and compositions can be used to treat and/or prevent a wide variety of conditions or disorders, particularly those disorders characterized by dysfunction of nicotinic choligernic neurotransmission, including disorders involving neuromodulation of neurotransmitter release, such as dopamine release. CNS disorders, which are characterized by an alteration in normal neurotransmitter release, are another example of disorders that can be treated and/or prevented. The compounds and compositions can also be used to alleviate pain. The compounds can: ( I ) alter the number of nicotinic cholinergic receptors of the brain of the patient, ( ii ) exhibit neuroprotective effects and ( iii ) when employed in effective amounts, not result in appreciable adverse side effects (e.g. side effects such as significant increases in blood pressure and heart rate, significant negative effects upon the gastrointestinal tract, and significant effects upon skeletal muscle).

27. 发明申请

WO2003053902A1 IMPROVED AROMACHEMICALS 审中-公开
标题翻译：改进的文化
公开(公告)号：WO2003053902A1
公开(公告)日：2003-07-03
申请号：PCT/US2002/022120
申请日：2002-07-12
申请人： FLEXITRAL, INC. , TURIN, Luca
发明人： TURIN, Luca
IPC分类号： C07C47/225
CPC分类号： C11B9/003 , A23L27/20 , A23L27/203 , A23L27/2052 , C07C45/69 , C07C47/11 , C07C47/21 , C07C47/225 , C07C47/293 , C07C47/34 , C07C47/45 , C11B9/0076 , C11D3/50
摘要： Improved aromachemical derivatives, and fragrances and flavorings including the derivatives, that have a longer useful shelf life than the aromachemicals from which they can be derived, are disclosed. In particular, the derivatives maintain the fragrance characteristics of the aromachemicals, while lowering the allergic properties, increasing the stability, and/or increasing the odor intensity. Also disclosed are methods of making the derivatives, and articles of manufacture including the derivatives. In one embodiment, the derivatives are prepared by replacing one or more double bonds in citral with a thioether, cyclopropyl, oxirane, or thiirane group. The cyclopropane ring can be unsubstituted, or substituted with one or two lower alkyl, preferably methyl groups. The alkyl groups can optionally be substituted, for example, with electron donating groups, electron with drawing groups, groups which increase the hydrophilicity or hydrophobocity, and the like. In another embodiment, the derivatives are prepared by replacing the aldehyde group in the essential oil with a nitrile, methyl ether or acetal group. The acetal groups can provide the compounds with a long lasting flavor or fragrance, where the acetals slowly hydrolyze to provide the aldehyde group in the parent essential oil. In some embodiments, both the aldehyde and at least one of the double bond functional groups are both derivatized as described herein. Examples of suitable articles of manufacture include candles, air fresheners, perfumes, disinfectant compositions, hypochlorite (bleach) compositions, beverages such as beer and soda, denture cleanser tablets and flavored orally-delivered products such as lozenges, candies, and the like.
摘要翻译：公开了改进的芳香化合物衍生物，以及包括衍生物的香料和调味剂，其具有比可衍生的芳族化合物更长的有效保质期。特别地，衍生物保持芳香化学物质的香味特性，同时降低过敏性能，增加稳定性和/或增加气味强度。还公开了制备衍生物的方法和包括衍生物的制品。在一个实施方案中，通过用硫醚，环丙基，环氧乙烷或硫杂环戊烷基取代柠檬醛中的一个或多个双键来制备衍生物。环丙烷环可以是未取代的，或被一个或两个低级烷基，优选甲基取代。烷基可以任选地被取代，例如具有给电子基团，具有拉伸基团的电子，增加亲水性或疏水性的基团等。在另一个实施方案中，通过用腈，甲基醚或缩醛基代替精油中的醛基来制备衍生物。缩醛基团可以为化合物提供持久的风味或香料，其中缩醛缓慢水解以在母体精油中提供醛基。在一些实施方案中，醛和至少一个双键官能团都如本文所述被衍生化。合适的制造方法的实例包括蜡烛，空气清新剂，香料，消毒剂组合物，次氯酸盐（漂白剂）组合物，饮料如啤酒和苏打，义齿清洁剂片剂和调味的口服递送产品如锭剂，糖果等。

28. 发明申请

WO2022251663A2 NOVEL UNIVERSAL ANTI-RNA VIRUS AGENTS 审中-公开
公开(公告)号：WO2022251663A2
公开(公告)日：2022-12-01
申请号：PCT/US2022/031381
申请日：2022-05-27
申请人： EMORY UNIVERSITY
发明人： SCHINAZI, Raymond F. , AMBLARD, Franck
IPC分类号： A61K31/7052 , A61K31/33 , A61K31/34 , C07H19/04 , A61K31/00 , A61K45/00 , A61P31/14 , C07B59/00 , C07H19/00
摘要： Deuterated and/or methylated N4-hydroxycytidine (NHC) analogs, with deuteration at one or both of the 2'- and 3'-positions on the ribo-sugar moiety and/or methylation of the 3'- positions on the ribo-sugar moiety, pharmaceutical compositions comprising one or more of these compounds, and, optionally, at least one additional therapeutic agent, and methods of treating or preventing infections caused by RNA viruses, curing an infection by an RNA virus, or reducing the biological activity of an RNA virus, are disclosed. Representative RNA viruses include, but are not limited to, Coronaviridae, such as MERSr-CoV, SARS-CoV-1, SARSCoV- 2, HCoV-OC43, HCoV-229E, HCoV-NL63, and HCoV-HKU1, Picornaviridae, Hepeviridae, Noroviruses, Zika, Dengue, Mayaro, Influenza A and B, Parainfluenza, HCV, Rinovirus, tick-borne viruses, Ebola, Lassa, RSV, adenoviruses, enteroviruses, metapneumoviruses, Eastern, Western, and Venezuelan Equine Encephalitis (EEE, WEE and VEE, respectively), and Chikungunya fever (CHIK).

29. 发明申请

WO2022094435A1 MODULATORS OF ORPHAN NUCLEAR RECEPTORS FOR TREATING PANCREATITIS, GLIOBLASTOMA, SARCOPENIA AND STROKE 审中-公开
公开(公告)号：WO2022094435A1
公开(公告)日：2022-05-05
申请号：PCT/US2021/057628
申请日：2021-11-01
申请人： EMORY UNIVERSITY , HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTD.
发明人： SCHINAZI, Raymond F. , COX, Bryan , GALUN, Eithan , AMBLARD, Franck , PATEL, Dharmesh
IPC分类号： A61K31/5513 , A61K31/551 , A61K31/55 , A61P3/06 , A61P35/00
摘要： Compounds, compositions and methods for modulating retinoic acid receptor-like orphan receptors (ROR) so as to increase FGF21 levels, and treating and preventing disorders associated with FGF21, such as pancreatitis, sarcopenia, stroke, and traumatic brain injury, and to increase miR-122 levels, and treating and preventing disorders such as glioblastoma.

30. 发明申请

WO2019177993A1 ABDOMINAL HERNIA SIMULATION MODEL FOR SURGICAL TRAINING 审中-公开
公开(公告)号：WO2019177993A1
公开(公告)日：2019-09-19
申请号：PCT/US2019/021657
申请日：2019-03-11
申请人： ALEXANDER, John , GRUBBS, W., Andrew , EMERSON, Kaity, Yu , MOORE, Morgan, Dominice , DEW, Megan, Harrison , DREW, Samuel, David
发明人： ALEXANDER, John , GRUBBS, W., Andrew , EMERSON, Kaity, Yu , MOORE, Morgan, Dominice , DEW, Megan, Harrison , DREW, Samuel, David
IPC分类号： G09B23/32 , G09B23/34 , G09B23/30 , G09B23/28
摘要： A surgeon training apparatus includes a cassette, which includes biological tissue repurposed into a form consistent with the anatomical configuration of abdominal hernias, affixed into an anatomically correct silicon framework which replicates the abdominal anatomy. The framework positions the cassette in an anatomically correct position within the abdominal cavity, enabling surgeons to train using a properly positioned representation of the target anatomy, thus requiring the surgeon to properly use surgical tools to correct the pathologic condition caused by the hernia. The cassette is formed by applying biologic tissue to a specially designed "plate," which affixes the tissue block into the anatomic framework, and is adapted for connection to a grounding device so the surgeon can use cautery during the simulated hernia repair. The cassette can be positioned inside a manikin, and can be used to train surgeons to repair human hernias using multiple techniques, including robot assisted and laparoscopic methods.

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