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11. 发明申请

WO2018217946A1 COMPOUNDS, COMPOSITIONS AND METHODS 审中-公开
公开(公告)号：WO2018217946A1
公开(公告)日：2018-11-29
申请号：PCT/US2018/034222
申请日：2018-05-23
申请人： DENALI THERAPEUTICS INC.
发明人： ESTRADA, Anthony A. , FENG, Jianwen A. , SWEENEY, Zachary K. , DE VICENTE FIDALGO, Javier
IPC分类号： A61K31/506 , C07D403/02 , C07D403/12
摘要： The present disclosure relates generally to LRRK2 inhibitors, or a pharmaceutically acceptable salt, deuterated analog, prodrug, tautomer, stereoisomer, or mixture of stereoisomers thereof, and methods of making and using thereof.

12. 发明申请

WO2017156179A1 3-PHOSPHOGLYCERATE DEHYDROGENASE INHIBITORS AND USES THEREOF 审中-公开
公开(公告)号：WO2017156179A1
公开(公告)日：2017-09-14
申请号：PCT/US2017/021436
申请日：2017-03-08
申请人： RAZE THERAPEUTICS, INC.
发明人： MAINOLFI, Nello
IPC分类号： A61K31/395 , A61K31/397 , A61K31/497 , C07D237/20 , C07D403/02 , C07D403/12
摘要： The present invention provides compounds, compositions thereof, and methods of using the same.

13. 发明申请

WO2017156177A1 3-PHOSPHOGLYCERATE DEHYDROGENASE INHIBITORS AND USES THEREOF 审中-公开
公开(公告)号：WO2017156177A1
公开(公告)日：2017-09-14
申请号：PCT/US2017/021434
申请日：2017-03-08
申请人： RAZE THERAPEUTICS, INC.
发明人： MAINOLFI, Nello , MOYER, Mikel P.
IPC分类号： A61K31/395 , A61K31/397 , A61K31/497 , C07D237/20 , C07D403/02 , C07D403/12
摘要： The present invention provides compounds, compositions thereof, and methods of using the same.

14. 发明申请

WO2017120417A1 TREATMENTS AND PREVENTION OF OPIOID NEONATAL ABSTINENCE SYNDROME 审中-公开
标题翻译：阿片类新生儿废物综合症的治疗与预防
公开(公告)号：WO2017120417A1
公开(公告)日：2017-07-13
申请号：PCT/US2017/012452
申请日：2017-01-06
申请人： OHIO STATE INNOVATION FOUNDATION
发明人： SADEE, Wolfgang , OBERDICK, John
IPC分类号： A61P25/36 , A61K31/485 , C07D403/02
CPC分类号： A61K31/485 , A61K31/4178 , A61K45/06 , A61K2300/00
摘要： Disclosed is a method for reducing or preventing fetal opioid dependence in a drug dependent or opioid tolerant pregnant subject. The method involves administering to the pregnant subject a composition comprising an opioid antagonist in an amount effective to reduce or prevent fetal opioid dependence, wherein the opioid antagonist a) is orally available or delivered systemically and reaches the circulation of the pregnant subject, b) is substantially excluded from the subject's brain by the blood brain barrier, and c) penetrates the placenta and enters the fetal brain. The method also includes administering the opioid antagonist to the neonate in increasing amounts to facilitate weaning the neonate from continued opioid maintenance.
摘要翻译：公开了用于降低或预防药物依赖或阿片样物质耐受性怀孕受试者中胎儿阿片样物质依赖性的方法。所述方法包括向所述怀孕受试者施用包含阿片样物质拮抗剂的组合物，所述阿片样物质拮抗剂的量有效减少或预防胎儿阿片样物质依赖，其中所述阿片样物质拮抗剂a）口服使用或全身递送并到达所述怀孕受试者的循环，b）基本上被血脑屏障从受试者的大脑排除，并且c）穿透胎盘并进入胎儿大脑。该方法还包括以增加的量向新生儿施用阿片样物质拮抗剂，以促进新生儿断续连续维持阿片类药物。

15. 发明申请

WO2017087257A1 AMIDO-SUBSTITUTED PYRIDOTRIAZINE DERIVATIVES USEFUL AS HIV INTEGRASE INHIBITORS 审中-公开
标题翻译：酰胺取代的吡啶并三嗪衍生物可用作HIV整合酶抑制剂
公开(公告)号：WO2017087257A1
公开(公告)日：2017-05-26
申请号：PCT/US2016/061456
申请日：2016-11-11
申请人： MERCK SHARP & DOHME CORP. , GRAHAM, Thomas, H. , YU, Tao , WADDELL, Sherman, T. , MCCAULEY, John, A. , STAMFORD, Andrew , LIU, Wensheng , GROBLER, Jay, A. , XU, Libo
发明人： GRAHAM, Thomas, H. , YU, Tao , WADDELL, Sherman, T. , MCCAULEY, John, A. , STAMFORD, Andrew , LIU, Wensheng , GROBLER, Jay, A. , XU, Libo
IPC分类号： A61K31/53 , A61K31/495 , A61K31/4985 , C07D295/00 , C07D401/02 , C07D403/02
CPC分类号： A61K45/06 , C07D295/00 , C07D401/02 , C07D403/02 , C07F9/6561
摘要： The present invention relates to Amido-Substituted Pyridotriazine Derivatives of Formula (I): (I) and pharmaceutically acceptable salts thereof, wherein B, X, Y, R, R 1, R 2 and R 10 are as defined herein. The present invention also relates to compositions comprising at least one Amido-Substituted Pyridotriazine Derivative, and methods of using the Amido-Substituted Pyridotriazine Derivatives for treating or preventing HIV infection in a subject.
摘要翻译：本发明涉及式（I）的酰胺基取代的吡啶并三嗪衍生物：其中B，X，Y，R，R 1， R 2和R 10如本文所定义。本发明还涉及包含至少一种酰胺取代的吡啶并三嗪衍生物的组合物，以及使用该酰胺取代的吡啶并三嗪衍生物治疗或预防受试者中的HIV感染的方法。

16. 发明申请

WO2016153776A1 METHODS AND COMPOSITIONS FOR ENHANCING PLANT HEALTH AND/OR TOLERANCE TO STRESS 审中-公开
标题翻译：用于增强植物健康和/或耐受力的方法和组合物
公开(公告)号：WO2016153776A1
公开(公告)日：2016-09-29
申请号：PCT/US2016/021293
申请日：2016-03-08
申请人： DOW AGROSCIENCES LLC
发明人： CORREA DA SILVA, Olavo , MATHIESON, Todd , SLEUGH, Byron B. , STUHR, Garrick W. , HOPKINS, Bradley , RUSHTON, Mary E.
IPC分类号： A01N43/54 , A01N43/56 , C07D403/02 , C07D403/04
CPC分类号： A01N43/56 , C07D401/04 , A01N43/22 , A01N43/54 , A01N47/40
摘要： This invention is based on the discovery of compositions and methods which can greatly enhance plant health and/or tolerance to stress. The methods provided herein can be performed in a compositional mixture, or a simultaneous or sequential application with one or more compounds of Compound A and Compound B as provided herein. In one embodiment, the stress is associated with vegetable transplants from a green house/nursery into an open field. In another embodiment, the stress is associated with heat, cold, and/or drought.
摘要翻译：本发明是基于可以大大提高植物健康和/或胁迫耐受性的组合物和方法的发现。本文提供的方法可以在组合物混合物中进行，或者与本文提供的一种或多种化合物A和化合物B的化合物同时或顺序施用。在一个实施方案中，压力与从温室/苗圃到开放场的植物移植有关。在另一个实施方案中，应力与热，冷和/或干旱有关。

17. 发明申请

WO2016078738A1 MATERIALS FOR ORGANIC ELECTROLUMINESCENT DEVICES 审中-公开
标题翻译：有机电致发光器件材料
公开(公告)号：WO2016078738A1
公开(公告)日：2016-05-26
申请号：PCT/EP2015/002112
申请日：2015-10-23
申请人： MERCK PATENT GMBH
发明人： MUJICA-FERNAUD, Teresa , MONTENEGRO, Elvira , PFISTER, Jochen
IPC分类号： C07C211/54 , C07D219/14 , C07D403/02 , C07C211/61 , C07D407/02 , C07D409/02 , C07C217/92 , C07D209/86 , C07D307/91 , H01L51/00
CPC分类号： H01L51/0032 , C07C211/54 , C07C211/61 , C07C217/92 , C07C2603/18 , C07C2603/94 , C07D209/86 , C07D219/14 , C07D307/91 , C07D333/76 , H01L51/0052 , H01L51/0059 , H01L51/006 , H01L51/0061 , H01L51/0072 , H01L51/0073 , H01L51/0074 , H01L51/5056 , H01L51/5088 , H01L51/5096 , Y02E10/549
摘要： The present invention relates to compounds of the formula (1) which are suitable for use in electronic devices, in particular organic electroluminescent devices, and to electronic devices which comprise these compounds.
摘要翻译：本发明涉及适用于电子器件，特别是有机电致发光器件的式（1）化合物以及包含这些化合物的电子器件。

18. 发明申请

WO2016033436A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN 审中-公开
标题翻译：用于成像蛋白质的探针
公开(公告)号：WO2016033436A1
公开(公告)日：2016-03-03
申请号：PCT/US2015/047396
申请日：2015-08-28
申请人： CHDI FOUNDATION, INC. , DOMINGUEZ, Celia , WITYAK, John , BARD, Jonathan , BROWN, Christopher, John , KRÜLLE, Thomas, Martin , CLARK-FREW, Daniel , HAYES, Sarah , SCHAERTL, Sabine , HERRMANN, Frank , GRIMM, Steffen, Kaspar , KAHMANN, Jan, Dirk , SCHEICH, Christoph
发明人： DOMINGUEZ, Celia , WITYAK, John , BARD, Jonathan , BROWN, Christopher, John , KRÜLLE, Thomas, Martin , CLARK-FREW, Daniel , HAYES, Sarah , SCHAERTL, Sabine , HERRMANN, Frank , GRIMM, Steffen, Kaspar , KAHMANN, Jan, Dirk , SCHEICH, Christoph
IPC分类号： C07D403/02
CPC分类号： A61K51/0455 , C07B2200/05 , C07D401/04 , C07D401/14 , C07D403/04 , C07D487/04 , C07D513/04 , C07D513/14
摘要： Provided are imaging agents comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof, and methods of their use.
摘要翻译：提供了包含式I化合物或其药学上可接受的盐的成像剂及其使用方法。

19. 发明申请

WO2015198046A1 1,3-SUBSTITUTED 2-AMINOINDOLE DERIVATIVES AND ANALOGUES USEFUL IN THE TREATMENT OR PREVENTION OF DIABETES MELLITUS, OBESITY AND INFLAMMATORY BOWEL DISEASE 审中-公开
标题翻译： 1,3-取代的2-氨基嘌呤衍生物和用于治疗或预防糖尿病，肥胖和炎症性皮肤病的类似物
公开(公告)号：WO2015198046A1
公开(公告)日：2015-12-30
申请号：PCT/GB2015/051841
申请日：2015-06-24
申请人： TAKEDA PHARMACEUTICAL COMPANY LIMITED , TAKEDA CAMBRIDGE LTD
发明人： DAVENPORT, Richard , DUNN, Jonathan , FARNABY, William , HANNAH, Duncan , HARRISON, David , WRIGHT, Susanne
IPC分类号： C07D401/02 , C07D403/02 , A61K31/437 , A61K31/4985 , A61P1/04 , A61P3/04 , A61P3/10
CPC分类号： C07D487/04 , A61K31/437 , A61K31/4985 , A61K31/5025 , A61K31/519 , A61K31/5377 , A61K31/541 , A61K31/55 , C07D401/02 , C07D403/02 , C07D471/04 , C07D519/00
摘要： The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein Q, X 4 , X 5 , X 6 , X 7 , R 1 , R 2 , R 3 and R 8 are as defined in the specification, processes for the preparation of such compounds, pharmaceutical compositions containing them and the use of such compounds in therapy.
摘要翻译：本发明提供式（I）化合物及其药学上可接受的盐，其中Q，X4，X5，X6，X7，R1，R2，R3和R8如本说明书中所定义，制备这些化合物的方法，药物含有它们的组合物和这些化合物在治疗中的用途。

20. 发明申请

WO2015130547A8 BIS-CYCLIC GUANIDINE COMPOUND COMPOSITIONS, METHODS OF USE AND TREATMENT THEREOF 审中-公开
标题翻译：双周期化合物化合物组合物，其使用方法及其处理方法
公开(公告)号：WO2015130547A8
公开(公告)日：2015-10-29
申请号：PCT/US2015016609
申请日：2015-02-19
申请人： UNIV SOUTH FLORIDA , TOREY PINES INST FOR MOLECULAR STUDIES
发明人： SHAW LINDSEY NEIL , FLEEMAN RENEE MARIE , HOUGHTEN RICHARD ALLEN , GIULIANOTTI MARCELLO ANGELO , SANTOS RADLEIGH G , NEFZI ADEL
IPC分类号： C07D247/02 , C07D403/02 , C07D403/06
CPC分类号： A61K31/4178 , A01N43/50 , C07D233/46
摘要： The present disclosure provides compositions including a bis-cyclic guanidine compound, pharmaceutical compositions including a bis-cyclic guanidine compound, methods of treatment of a condition {e.g., bacterial infection) or disease, methods of treatment using compositions or pharmaceutical compositions, and the like.
摘要翻译：本公开提供了包含双环胍化合物，包含双环胍化合物的药物组合物，治疗病症（例如细菌感染）或疾病的方法，使用组合物或药物组合物的治疗方法等的组合物。

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