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11. 发明申请

WO2005034728A3 COLON CLEANSING COMPOSITION AND METHOD 审中-公开
标题翻译： COLON CLEANSING组合物和方法
公开(公告)号：WO2005034728A3
公开(公告)日：2005-10-27
申请号：PCT/US2004028215
申请日：2004-08-31
申请人： ABBOUD SEMAAN
发明人： ABBOUD SEMAAN
IPC分类号： A61K31/165 , A61K31/4402 , A61K33/00 , A61K33/42 , A61K45/06 , A61K31/435 , A61K31/66 , A61K33/14 , A61P1/10
CPC分类号： A61K33/00 , A61K31/166 , A61K31/4402 , A61K33/42 , A61K45/06 , Y10S514/867 , Y10S514/872 , Y10S514/892 , A61K2300/00
摘要： A composition and method for cleansing a colon prior to endoscopic procedure. More particularly, a combination of bisacodyl, metoclopramide, sodium, and/or a phosphorus containing composition administered in sequential doses for preparing a colon prior to colonoscopy.
摘要翻译：在内窥镜手术前清洗结肠的组合物和方法。更具体地，在结肠镜检查之前，以连续剂量施用的比索酸，甲氧氯普胺，钠和/或含磷组合物的组合用于制备结肠。

12. 发明申请

WO2005034728A2 COLON CLEANSING COMPOSITION AND METHOD 审中-公开
标题翻译： COLON清洁组合物和方法
公开(公告)号：WO2005034728A2
公开(公告)日：2005-04-21
申请号：PCT/US2004/028215
申请日：2004-08-31
申请人： ABBOUD, Semaan
发明人： ABBOUD, Semaan
IPC分类号： A61B
CPC分类号： A61K33/00 , A61K31/166 , A61K31/4402 , A61K33/42 , A61K45/06 , Y10S514/867 , Y10S514/872 , Y10S514/892 , A61K2300/00
摘要： A composition and method for cleansing a colon prior to endoscopic procedure. More particularly, a combination of bisacodyl, metoclopramide, sodium, and/or a phosphorus containing composition administered in sequential doses for preparing a colon prior to colonoscopy.
摘要翻译：在内窥镜手术之前用于清洗结肠的组合物和方法。更特别地，在结肠镜检查之前，以连续剂量施用比沙可啶，甲氧氯普胺，钠和/或含磷组合物的组合用于制备结肠。

13. 发明申请

WO0027363A9 AEROSOLS COMPRISING NANOPARTICLE DRUGS 审中-公开
标题翻译：包含纳米颗粒药物的气溶胶
公开(公告)号：WO0027363A9
公开(公告)日：2000-11-30
申请号：PCT/US9926799
申请日：1999-11-12
申请人： NANOSYSTEMS
发明人： BOSCH H WILLIAM , OSTRANDER KEVIN D , COOPER EUGENE R
IPC分类号： A61J3/02 , A61K9/00 , A61K9/12 , A61K9/14 , A61K9/16 , A61K9/19 , A61K31/573 , A61K38/00 , A61K45/00 , A61M15/00 , A61P9/00 , A61P11/00 , A61P11/06 , A61P25/00 , A61P29/00 , A61P31/06 , A61P31/10 , A61P35/00 , A61P37/06 , A61K9/72
CPC分类号： A61K9/0078 , A61K9/0075 , A61K9/008 , A61K9/146 , A61K9/1694 , A61K9/19 , Y10S514/826 , Y10S514/851 , Y10S514/872
摘要： The invention discloses aqueous dispersions of nanoparticulate aerosol formulations, dry powder nanoparticulate aerosol formulation, propellant-based aerosol formulations, methods of using the formulations in aerosol delivery devices, and methods of making such formulations. The nanoparticles of the aqueous dispersions or dry powder formulations comprise insoluble drug particles having a surface modifier on the surface thereof.
摘要翻译：本发明公开了纳米颗粒气雾剂配方的水分散体，干粉纳米颗粒气溶胶配制剂，基于推进剂的气雾剂配方，在气溶胶递送装置中使用制剂的方法，以及制备这些制剂的方法。含水分散体或干粉配方的纳米颗粒包含在其表面上具有表面改性剂的不溶性药物颗粒。

14. 发明申请

WO0027363B1 AEROSOLS COMPRISING NANOPARTICLE DRUGS 审中-公开
标题翻译：包含纳米颗粒药物的气雾剂
公开(公告)号：WO0027363B1
公开(公告)日：2000-07-13
申请号：PCT/US9926799
申请日：1999-11-12
申请人： NANOSYSTEMS
发明人： BOSCH H WILLIAM , OSTRANDER KEVIN D , COOPER EUGENE R
IPC分类号： A61J3/02 , A61K9/00 , A61K9/12 , A61K9/14 , A61K9/16 , A61K9/19 , A61K31/573 , A61K38/00 , A61K45/00 , A61M15/00 , A61P9/00 , A61P11/00 , A61P11/06 , A61P25/00 , A61P29/00 , A61P31/06 , A61P31/10 , A61P35/00 , A61P37/06 , A61K9/72
CPC分类号： A61K9/0078 , A61K9/0075 , A61K9/008 , A61K9/146 , A61K9/1694 , A61K9/19 , Y10S514/826 , Y10S514/851 , Y10S514/872
摘要： The invention discloses aqueous dispersions of nanoparticulate aerosol formulations, dry powder nanoparticulate aerosol formulation, propellant-based aerosol formulations, methods of using the formulations in aerosol delivery devices, and methods of making such formulations. The nanoparticles of the aqueous dispersions or dry powder formulations comprise insoluble drug particles having a surface modifier on the surface thereof.
摘要翻译：本发明公开了纳米微粒气雾剂制剂，干粉纳米微粒气雾剂制剂，基于推进剂的气雾剂制剂，在气雾剂递送装置中使用该制剂的方法以及制备这种制剂的方法。水分散体或干粉制剂的纳米颗粒包含在其表面上具有表面改性剂的不溶性药物颗粒。

15. 发明申请

WO1994027966A1 PROCESS FOR PREPARING AND RESOLVING 2-PHENYL-3-AMINOPIPERIDINE 审中-公开
标题翻译：制备和分解2-苯基-3-氨基哌啶的方法
公开(公告)号：WO1994027966A1
公开(公告)日：1994-12-08
申请号：PCT/IB1994000059
申请日：1994-04-06
申请人： PFIZER INC. , SNYDER, William, M. , WATSON, Harry, A., Jr. , WILCOX, Glenn, E.
发明人： PFIZER INC.
IPC分类号： C07D211/56
CPC分类号： C07D211/56 , Y10S514/872
摘要： The present invention relates to a novel process for preparing and resolving 3-amino-2-phenylpiperidine and for synthesizing from the enantiomers of such compound certain pharmaceutically active substituted 2-phenyl-3-benzylaminopiperidines. The substituted 2-phenyl-3-benzylaminopiperidines that can be prepared by the processes of this invention are substance P receptor antagonists and are useful in the treatment and prevention of inflammatory and central nervous system disorders, as well as several other disorders.
摘要翻译：本发明涉及一种用于制备和分解3-氨基-2-苯基哌啶的新方法，并用于从该化合物的对映异构体合成某些药学活性的取代的2-苯基-3-苄基氨基哌啶。可以通过本发明的方法制备的取代的2-苯基-3-苄基氨基哌啶是物质P受体拮抗剂，可用于治疗和预防炎性和中枢神经系统疾病以及其它几种疾病。

16. 发明申请

WO1993025555A1 DERIVATIVES OF IMIDAZO [5,1-C][1, 4]BENZOXAZIN-1-ONE AS 5 HT3 ANTAGONISTS 审中-公开
标题翻译：咪唑并[5,1-C] [1,4]苯并恶嗪-1-酮作为5 HT3拮抗剂的衍生物
公开(公告)号：WO1993025555A1
公开(公告)日：1993-12-23
申请号：PCT/EP1993001498
申请日：1993-06-14
申请人： FARMITALIA CARLO ERBA S.R.L.
发明人： FARMITALIA CARLO ERBA S.R.L. , VARASI, Mario , HEIDEMPERGHER, Franco , ARRIGONI, Claudio , CACCIA, Carla
IPC分类号： C07D491/04
CPC分类号： C07D519/00 , Y10S514/872
摘要： The invention provides derivatives of 2,3,3a,4-tetrahydro-2-azabicyclo alkyl-1H-imidazo [5,1-C][1,4]benzoxazin-1-one of general formula (I), in which inter alia R3 represents (a) or (b) wherein n is an integer or 1 or 2 and R8 is hydrogen, C1-C6 alkyl unsubstituted or substituted by phenyl, C2-C4 alkenyl, C2-C4 alkynyl, formyl or C2-C6 alkanoyl; and the pharmaceutically acceptable salts thereof, which are useful in the treatment of CNS disorders, gut motility disorders, emesis and migraine, as cognition activators, anti-drug addiction agents and analgesics.
摘要翻译：本发明提供通式（I）的2,3,3a，4-四氢-2-氮杂二环烷基-1H-咪唑并[5,1-C] [1,4]苯并恶嗪-1-酮的衍生物，其中其中R 3表示（a）或（b），其中n是整数或1或2，并且R 8是氢，未被取代或被苯基，C 2 -C 4烯基，C 2 -C 4炔基，甲酰基或C 2 -C 6烷酰基取代的C 1 -C 6烷基 ; 可用于治疗CNS疾病，肠蠕动障碍，呕吐和偏头痛的药学上可接受的盐，作为认知激活剂，抗药成瘾剂和镇痛药。

17. 发明申请

WO1993000074A1 METHOD AND COMPOSITIONS FOR TREATING EMESIS, NAUSEA AND OTHER DISORDERS USING OPTICALLY PURE R(+) ONDANSETRON 审中-公开
标题翻译：使用光学纯度R（+）ONDANSETRON治疗EMESIS，NAUSEA和其他疾病的方法和组合物
公开(公告)号：WO1993000074A1
公开(公告)日：1993-01-07
申请号：PCT/US1992005376
申请日：1992-06-25
申请人： SEPRACOR, INC.
发明人： SEPRACOR, INC. , YOUNG, James, W.
IPC分类号： A61K09/48
CPC分类号： A61K31/4178 , A61K31/415 , Y10S514/872
摘要： Methods and compositions are disclosed utilizing the optically pure R(+) isomer of ondansetron. This compound is a potent drug for the treatment of nausea and vomiting associated with chemotherapy and radiation therapy, while avoiding the concomitant liability of adverse effects associated with the racemic mixture of ondansetron. The R(+) isomer of ondansetron is also useful for the treatment of behavioral disorders such as mood anxiety and schizophrenia, and such other conditions as may be related to R(+) ondansetron's activity as a competitive antagonist of serotonin receptor subtype 5-HT3 such as disorders of gastrointestinal motility, depression, migraine, and as an aid for alcohol withdrawal, nicotine withdrawal, and drug (benzodiazepine et al.) withdrawal, without the concomitant liability of adverse effects associated with the racemic mixture of ondansetron. Furthermore, the R(+) isomer of ondansetron is also useful for the treatment of cognitive disorders such as dementia or age-associated memory impairment, while avoiding the concomitant liability of adverse effects associated with the racemic mixture of ondansetron.
摘要翻译：公开了使用昂丹司琼的光学纯的R（+）异构体的方法和组合物。该化合物是用于治疗与化疗和放射治疗相关的恶心和呕吐的有效药物，同时避免与昂丹司琼外消旋混合物相关的副作用的伴随责任。昂丹司琼的R（+）异构体也可用于治疗诸如情绪焦虑和精神分裂症等行为障碍，以及可能与R（+）昂丹司琼活性作为5-羟色胺受体亚型5-HT3的竞争性拮抗剂相关的其他条件例如消化道运动障碍，抑郁症，偏头痛，以及用于酒精戒断，尼古丁戒断和药物（苯并二氮杂类等）撤离的辅助，而不伴随昂丹司琼外消旋混合物的不良反应。此外，昂丹司琼的R（+）异构体也可用于治疗诸如痴呆或年龄相关记忆障碍的认知障碍，同时避免与昂丹司琼外消旋混合物相关的副作用的伴随责任。

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