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11. 发明申请

WO2011130537A2 PHARMACEUTICAL COMPOSITIONS AND METHODS FOR DIGESTING ATHEROSCLEROTIC PLAQUES 审中-公开
标题翻译：药物组合物和方法用于消化甲状腺素
公开(公告)号：WO2011130537A2
公开(公告)日：2011-10-20
申请号：PCT/US2011032530
申请日：2011-04-14
申请人： UNIV NORTHWESTERN , KIBBE MELINA R , AMEER GUILLERMO A , VARU VINIT N
发明人： KIBBE MELINA R , AMEER GUILLERMO A , VARU VINIT N
IPC分类号： A61K38/48 , A61K38/46 , A61K38/54 , A61P9/00 , A61P9/04
CPC分类号： A61K38/4886 , A61B17/2202 , A61K9/0019 , A61K31/724 , A61K38/49 , A61K38/54 , A61K45/06 , A61M25/1011 , A61M37/0092 , C12Y304/21068 , C12Y304/24003 , C12Y304/24024 , C12Y304/24035 , A61K2300/00
摘要： Disclosed are pharmaceutical compositions and methods for digesting atherosclerotic plaques in a patient in need thereof. The compositions include and the methods utilize a mixture of collagenases for digesting plaques and optionally may include or utilize additional agents such as cyclodextrins, chelating agents, and tissue plasminogen activator.
摘要翻译：公开了用于在有需要的患者中消化动脉粥样硬化斑块的药物组合物和方法。组合物包括并且方法利用胶原酶的混合物来消化斑块，并且任选地可以包括或利用另外的试剂例如环糊精，螯合剂和组织纤溶酶原激活剂。

12. 发明申请

WO2010062057A2 수정란의 착상 또는 임신 촉진용 조성물 审中-公开
标题翻译：用于促进胚胎或妊娠植入的组合物
公开(公告)号：WO2010062057A2
公开(公告)日：2010-06-03
申请号：PCT/KR2009/006419
申请日：2009-11-03
申请人： 주식회사 베네비오 , 김철호 , 강승우
发明人： 김철호 , 강승우
IPC分类号： A61K38/46 , A61P15/00
CPC分类号： A61K38/4886 , C12Y304/24035
摘要： 본 발명은 MMP-9(metalloproteinase-9)을 유효성분으로 포함하는 동물의 수정란의 착상 또는 임신 촉진용 조성물에 관한 것이다. 본 발명의 조성물은 수정란의 착상을 크게 증가시키거나 또는 임신율을 크게 증가시킨다. 하기의 실시예에서 입증된 바와 같이, 본 발명의 조성물은 약 25%의 임신율 증가 및 착상율 증가를 유도할 수 있다.
摘要翻译：本发明涉及用于促进植入胚胎或妊娠动物的组合物，其含有MMP-9（金属蛋白酶-9）作为活性成分。本发明的组合物显着增加胚胎植入率，或显着增加妊娠率。如以下实施例所证明的，本发明的组合物导致妊娠率和胚胎植入率增加了25％。

13. 发明申请

WO2019046288A1 COMPOSITIONS AND MULTIPLEX ASSAYS FOR CHARACTERIZING ACTIVE PROTEASES AND THEIR INHIBITORS 审中-公开
公开(公告)号：WO2019046288A1
公开(公告)日：2019-03-07
申请号：PCT/US2018/048321
申请日：2018-08-28
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY
发明人： AHRENS, Caroline Chopko , GRIFFITH, Linda G. , TANNENBAUM, Steven Robert , COOK, Christi Dionne , KODIHALLI, Ravindra , LAUFFENBURGER, Douglas A. , CHISWICK, Evan L. , MILLER, Miles
IPC分类号： C12Q1/37 , G01N33/543 , G01N33/573 , G01N33/58
CPC分类号： G01N33/573 , C12Q1/37 , C12Y304/24007 , C12Y304/24024 , C12Y304/24035 , G01N33/533 , G01N33/535 , G01N33/54306 , G01N33/54326 , G01N33/574 , G01N33/577 , G01N33/58 , G16B99/00 , G16C99/00
摘要： Proteases regulate a wide range of normal cellular functions where dysregulated activity is observed in various diseases. Compositions and methods use protease activity multiplexed bead-based immunoassays to profile protease activity. This platform technology integrates protease activity measurements with total protein quantification techniques. It represents a significant improvement over existing detection techniques by allowing for multiplexed, sensitive active protease measurements in complex biological samples. Exemplary multiplexed detections are realized in a single assay using a minute sample amount (e.g., 5 µl) for active recombinant MMP-1, -2, -3, -7, 9, and 12 and those same MMPs in cell culture supernatant, menstrual fluid effluent, and peritoneal aspirates. This multiplexed platform achieves high level of sensitivities equal to or better than existing leading single-plex detection strategies. It also allows for high throughput screening to identify inhibitors of proteases in complex, donor-derived samples.

14. 发明申请

WO2017106566A1 COMBINATION OF A JAK INHIBITOR AND AN MMP9 BINDING PROTEIN FOR TREATING INFLAMMATORY DISORDERS 审中-公开
标题翻译： JAK抑制剂与MMP9结合蛋白联合治疗炎性疾病
公开(公告)号：WO2017106566A1
公开(公告)日：2017-06-22
申请号：PCT/US2016/067036
申请日：2016-12-15
申请人： GILEAD SCIENCES, INC.
发明人： KIM, Sunhwa , SMITH, Victoria
IPC分类号： C07K16/40 , A61K39/395 , A61P37/06
CPC分类号： C07K16/40 , A61K31/541 , A61K39/3955 , A61K2300/00 , C07K2317/34 , C12Y304/24035
摘要： Provided herein are methods and pharmaceutical compositions for the treatment of inflammatory disorders comprising filgotinib and a matrix metalloproteinase-9 (MMP9) binding protein.
摘要翻译：本文提供了用于治疗炎性病症的方法和药物组合物，其包含屈他替尼和基质金属蛋白酶-9（MMP9）结合蛋白。

15. 发明申请

WO2011109767A2 GELATINASE INHIBITORS AND PRODRUGS 审中-公开
标题翻译： GELATINASE抑制剂和PRODRUGS
公开(公告)号：WO2011109767A2
公开(公告)日：2011-09-09
申请号：PCT/US2011/027282
申请日：2011-03-04
申请人： UNIVERSITY OF NOTRE DAME DU LAC , CHANG, Mayland , MOBASHERY, Shahriar , LEE, Mijoon
发明人： CHANG, Mayland , MOBASHERY, Shahriar , LEE, Mijoon
CPC分类号： A61K31/38 , A61K38/482 , A61K38/4886 , A61K38/49 , C07D331/02 , C07D409/12 , C12Y304/21 , C12Y304/21068 , C12Y304/21073 , C12Y304/24007 , C12Y304/24017 , C12Y304/24023 , C12Y304/24035
摘要： The invention provides compounds, compositions, and methods for the treatment of diseases, disorders, or conditions that are modulated by matrix metalloproteinases (MMPs). The disease, disorder, or condition can include, for example, stroke, neurological disorders, or ophthalmological disorders. The treatment can include administering a compound or composition described herein, thereby providing a prodrug compound that metabolizes to an active MMP inhibitor in vivo. The MMP inhibition can be selective inhibition, for example, selective inhibition of MMP-2, MMP-9, and/or MMP-14. Thus, the invention provides non-mutagenic prodrug compounds of the formulas described herein that result in the inhibition of MMPs upon in vivo administration.
摘要翻译：本发明提供了用于治疗由基质金属蛋白酶（MMP）调节的疾病，病症或病症的化合物，组合物和方法。疾病，障碍或病症可包括例如中风，神经障碍或眼科疾病。治疗可以包括施用本文所述的化合物或组合物，从而提供在体内代谢为活性MMP抑制剂的前药化合物。 MMP抑制可以是选择性抑制，例如MMP-2，MMP-9和/或MMP-14的选择性抑制。因此，本发明提供本文所述式的非诱变前药化合物，其在体内施用时导致MMPs的抑制。

16. 发明申请

WO2010062057A3 COMPOSITION FOR PROMOTING IMPLANTATION OF EMBRYO OR PREGNANCY 审中-公开
标题翻译：促进胚胎植入或妊娠的组合物
公开(公告)号：WO2010062057A3
公开(公告)日：2010-08-19
申请号：PCT/KR2009006419
申请日：2009-11-03
申请人： BENEBIOSIS CO LTD , KIM CHEORL HO , KANG SEUNG WOO
发明人： KIM CHEORL HO , KANG SEUNG WOO
IPC分类号： A61K38/46 , A61P15/00
CPC分类号： A61K38/4886 , C12Y304/24035
摘要： The present invention relates to a composition for promoting implantation of an embryo or pregnancy of an animal, containing MMP-9(metalloproteinase-9) as active ingredients. The composition of the present invention significantly increases an embryo implantation rate, or remarkably increases a pregnancy rate. As proved in the following embodiment, the composition of the present invention leads to a 25% increase in pregnancy rate and embryo implantation rate.
摘要翻译：本发明涉及用于促进植入胚胎或动物妊娠的组合物，其含有作为活性成分的MMP-9（金属蛋白酶-9）。本发明的组合物显着增加胚胎着床率，或显着提高妊娠率。如在下面的实施方案中证明的，本发明的组合物导致妊娠率和胚胎着床率增加25％。

17. 发明申请

WO2009022328A3 REGULATORS OF MMP-9 AND USES THEROF 审中-公开
标题翻译： MMP-9的调节因子及其用途
公开(公告)号：WO2009022328A3
公开(公告)日：2010-03-04
申请号：PCT/IL2008001082
申请日：2008-08-07
申请人： YEDA RES & DEV , SAGI IRIT , ROSENBLUM GABRIEL
发明人： SAGI IRIT , ROSENBLUM GABRIEL
IPC分类号： A61K38/17
CPC分类号： C07K16/40 , A61K38/005 , A61K39/3955 , C07K2299/00 , C12N9/6491 , C12Q1/37 , C12Y304/24035 , G01N33/573 , G01N2333/96494 , G01N2500/04 , G01N2500/20
摘要： A method of regulating an activity of metalloproteinase 9 (MMP-9) is disclosed. The method comprises contacting the MMP-9 with an agent which specifically interacts with an OG domain of the MMP-9. Molecules capable of specifically interacting with the OG domain, methods of identifying same, pharmaceutical compositions comprising same and uses thereof are also disclosed.
摘要翻译：公开了一种调节金属蛋白酶9（MMP-9）活性的方法。该方法包括使MMP-9与与MMP-9的OG结构域特异性相互作用的试剂接触。还可以公开能够与OG结构域特异性相互作用的分子，鉴定其的方法，包含其的药物组合物及其用途。

18. 发明申请

WO2009022328A2 REGULATORS OF MMP-9 AND USES THEROF 审中-公开
标题翻译： MMP-9的调节因子及其用途
公开(公告)号：WO2009022328A2
公开(公告)日：2009-02-19
申请号：PCT/IL2008/001082
申请日：2008-08-07
申请人： YEDA RESEARCH AND DEVELOPMENT CO. LTD. , SAGI, Irit , ROSENBLUM, Gabriel
发明人： SAGI, Irit , ROSENBLUM, Gabriel
IPC分类号： A61K39/395 , A61K31/47
CPC分类号： C07K16/40 , A61K38/005 , A61K39/3955 , C07K2299/00 , C12N9/6491 , C12Q1/37 , C12Y304/24035 , G01N33/573 , G01N2333/96494 , G01N2500/04 , G01N2500/20
摘要： A method of regulating an activity of metalloproteinase 9 (MMP-9) is disclosed. The method comprises contacting the MMP-9 with an agent which specifically interacts with an OG domain of the MMP-9. Molecules capable of specifically interacting with the OG domain, methods of identifying same, pharmaceutical compositions comprising same and uses thereof are also disclosed.
摘要翻译：公开了一种调节金属蛋白酶9（MMP-9）活性的方法。该方法包括使MMP-9与与MMP-9的OG结构域特异性相互作用的试剂接触。还可以公开能够与OG结构域特异性相互作用的分子，鉴定其的方法，包含其的药物组合物及其用途。

19. 发明申请

WO2015101637A3 APTAMERS INHIBITING THE ENZYMATIC ACTIVITY OF THE MMP-9 PROTEIN 审中-公开
标题翻译： APTAMERS抑制MMP-9蛋白的酶活性
公开(公告)号：WO2015101637A3
公开(公告)日：2015-08-27
申请号：PCT/EP2014079471
申请日：2014-12-30
申请人： LVMH RECH , INST NAT SANTE RECH MED
发明人： DAUSSE ERIC , TOULME JEAN-JACQUES , CAUCHARD JEAN HUBERT , KURFURST ROBIN , SCHNEBERT SYLVIANNE
IPC分类号： C12N15/115
CPC分类号： C12N15/115 , A61K8/606 , A61K2800/782 , A61Q17/04 , A61Q19/00 , A61Q19/02 , A61Q19/08 , A61Q19/10 , C12N15/1048 , C12N2310/16 , C12N2320/30 , C12N2320/51 , C12Y304/24035
摘要： The invention relates to an aptamer that has a G-quadruplex structure and is able to inhibit the enzymatic activity of the MMP-9 protein, as well as to the dermatological and cosmetic uses thereof.
摘要翻译：本发明涉及具有G-四联体结构并且能够抑制MMP-9蛋白质的酶活性的适体以及其皮肤病学和化妆用途。

20. 发明申请

WO2014165780A3 MATRIX METALLOPROTEINASES AND USES THEREOF 审中-公开
标题翻译： MATRIX金属及其用途
公开(公告)号：WO2014165780A3
公开(公告)日：2014-12-18
申请号：PCT/US2014033009
申请日：2014-04-04
申请人： ZYLBERBERG CLAUDIA , FIELDS GREGG B
发明人： ZYLBERBERG CLAUDIA , FIELDS GREGG B
IPC分类号： A61K38/08 , A61K38/16 , C12N9/50 , C12N9/64
CPC分类号： C12N9/6491 , A61K38/4886 , C12N9/6416 , C12Y304/24 , C12Y304/24007 , C12Y304/24017 , C12Y304/24024 , C12Y304/24034 , C12Y304/24035 , C12Y304/24065
摘要： Matrix metalloproteinases (MMPs) compositions, inactive forms of MMPs (e.g. proMMPs), fragments, mutants, variants or combinations thereof. A pharmaceutical composition comprises one or more of the above in a pharmaceutical carrier. A composition comprises at least one of: a matrix metalloproteinase (MMP), an inactive MMP or a proenzyme (proMMP) thereof, wherein the matrix metalloproteinase (MMPs), inactive MMPs or proMMPs thereof, comprise: MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-11, MMP-12, MMP-13.MMP-14, MMP-15, MMP-16, MMP-17, MMP-18, MMP-19, MMP-20, MMP-21, MMP-23A, MMP-23B, MMP-24, MMP-25, MMP-26, MMP-27, MMP-28, active fragments, mutants, variants or any combinations thereof. The uses include isolation of cells, in particular stem cells, from tissues, dissociation of tissues, proteins and treatment of a variety of conditions.
摘要翻译：基质金属蛋白酶（MMPs）组合物，MMPs的无活性形式（例如proMMP），片段，突变体，变体或其组合。药物组合物在药物载体中包含上述一种或多种。组合物包含以下中的至少一种：基质金属蛋白酶（MMP），非活性MMP或其酶原（proMMP），其中所述基质金属蛋白酶（MMP），其无活性的MMP或其proMMP包含：MMP-1，MMP-2， MMP-3，MMP-7，MMP-8，MMP-9，MMP-10，MMP-11，MMP-12，MMP-13MMP-14，MMP-15，MMP-16， 18，MMP-19，MMP-20，MMP-21，MMP-23A，MMP-23B，MMP-24，MMP-25，MMP-26，MMP-27，MMP-28，活性片段，突变体，其组合。用途包括从组织中分离细胞，特别是干细胞，分解组织，蛋白质以及各种条件的治疗。

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