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    • 15. 发明申请
    • PEROXIDE CROSS-LINKING OF POLYMERIC MATERIALS IN THE PRESENCE OF ANTIOXIDANTS
    • 在抗氧化剂存在下聚合物材料的过氧化物交联
    • WO2013151960A2
    • 2013-10-10
    • PCT/US2013/034887
    • 2013-04-02
    • THE GENERAL HOSPITAL CORPORATIONMURATOGLU, Orhun, K.ORAL, Ebru
    • MURATOGLU, Orhun, K.ORAL, Ebru
    • B22C1/00
    • C08K5/14A61L2/081A61L2/087A61L31/048A61L31/143B65B55/16B65B55/18C08F220/00C08F255/00C08F291/18C08G59/00C08J3/247C08J2323/06C08K5/1345C08K5/1545C08K5/159C08L23/06
    • Methods of chemically cross-linking antioxidant-stabilized polymeric material are provided. In one example embodiment, peroxide cross-linking can be used to improve wear resistance and the addition of antioxidant can be used to improve oxidation resistance of ultra-high molecular weight polyethylene. A balance between the amounts of peroxide(s) and antioxidant(s) in the polymeric material can ensure that enough cross-linking is achieved for wear reduction and that enough antioxidant is incorporated for improved long-term oxidative stability. In one example embodiment, peroxide(s) can be diffused into a consolidated polymeric material for cross-linking. In another embodiment, polymeric material is consolidated with a vinyl silane, an antioxidant, and a free radical initiator, and the consolidated polymeric material is contacted with water thereby forming an oxidation resistant, cross-linked polymeric material. Such materials can be used in orthopedic applications such as bearing surfaces in total joint implants, including total hips, total knees, total shoulders, and other total joints.
    • 提供了化学交联抗氧化剂稳定的聚合物材料的方法。 在一个示例性实施方式中,可以使用过氧化物交联来提高耐磨性,并且可以使用抗氧化剂的添加来改善超高分子量聚乙烯的抗氧化性。 在聚合物材料中过氧化物和抗氧化剂的量之间的平衡可以确保实现足够的交联以减少磨损并且引入足够的抗氧化剂以改善长期氧化稳定性。 在一个示例性实施例中,过氧化物可以扩散到固结的聚合物材料中用于交联。 在另一个实施方案中,聚合物材料与乙烯基硅烷,抗氧化剂和自由基引发剂固结,并且固结的聚合物材料与水接触,从而形成抗氧化的交联聚合物材料。 这种材料可用于骨科应用,例如全关节植入物的支承表面,包括总髋关节,全膝关节,全肩关节和其他全关节。