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11. 发明申请

WO2021252339A1 SUBSTITUTED PURINE-2,6-DIONE COMPOUNDS AS KRAS INHIBITORS 审中-公开
公开(公告)号：WO2021252339A1
公开(公告)日：2021-12-16
申请号：PCT/US2021/036135
申请日：2021-06-07
申请人： ACCUTAR BIOTECHNOLOGY, INC.
发明人： FAN, Jie , QIAN, Yimin , HE, Wei , LIU, Ke , HUANG, Pin
IPC分类号： C07D487/14 , A61K31/519 , A61P35/00
摘要： The present disclosure relates to novel compounds that inhibits KRAS G12C, pharmaceutical compositions containing such compounds, and their use in prevention and treatment of cancer and related diseases and conditions.

12. 发明申请

WO2021118629A1 NOVEL CHROMAN DERIVATIVES HAVING ESTROGEN RECEPTOR DEGRADATION ACTIVITY AND USES THEREOF 审中-公开
公开(公告)号：WO2021118629A1
公开(公告)日：2021-06-17
申请号：PCT/US2020/027895
申请日：2020-04-13
申请人： ACCUTAR BIOTECHNOLOGY INC.
发明人： FAN, Jie , QIAN, Yimin , HE, Wei , LIU, Ke
IPC分类号： A61K31/352 , A61K31/353 , A61K31/4035 , C07D209/46 , C07D311/00 , C07D311/20
摘要： The present disclosure relates to novel compounds, pharmaceutical compositions containing such compounds, and their use in prevention and treatment of cancer and related diseases and conditions.

13. 发明申请

WO2021061642A1 NOVEL UREAS HAVING ANDROGEN RECEPTOR DEGRADATION ACTIVITY AND USES THEREOF 审中-公开
公开(公告)号：WO2021061642A1
公开(公告)日：2021-04-01
申请号：PCT/US2020/051997
申请日：2020-09-22
申请人： ACCUTAR BIOTECHNOLOGY INC.
发明人： FAN, Jie , QIAN, Yimin , HE, Wei , LIU, Ke
IPC分类号： A61K31/445 , A61K31/454 , C07D401/04
摘要： The present disclosure relates to novel compounds, pharmaceutical compositions containing such compounds, and their use in prevention and treatment of cancer and related diseases and conditions. In some embodiments, the compounds disclosed herein exhibit androgen receptor degradation activity.

14. 发明申请

WO2020106933A1 NOVEL COMPOUNDS HAVING ESTROGEN RECEPTOR ALPHA DEGRADATION ACTIVITY AND USES THEREOF 审中-公开
公开(公告)号：WO2020106933A1
公开(公告)日：2020-05-28
申请号：PCT/US2019/062564
申请日：2019-11-21
申请人： ACCUTAR BIOTECHNOLOGY INC.
发明人： FAN, Jie , LIU, Ke , ZHANG, Hui , HE, Wei
IPC分类号： A61K31/015 , C07C217/64
摘要： The present disclosure relates to novel compounds having estrogen receptor alpha degradation activity, pharmaceutical compositions containing such compounds, and their use in prevention and treatment of cancer and related diseases and conditions.

15. 发明申请

WO2017196963A1 COMPUTATIONAL METHOD FOR CLASSIFYING AND PREDICTING PROTEIN SIDE CHAIN CONFORMATIONS 审中-公开
标题翻译：蛋白质侧链结构分类与预测的计算方法
公开(公告)号：WO2017196963A1
公开(公告)日：2017-11-16
申请号：PCT/US2017/031934
申请日：2017-05-10
申请人： ACCUTAR BIOTECHNOLOGY INC.
发明人： FAN, Jie , LIU, Ke
IPC分类号： C07K1/00 , G06F17/50 , G06F19/10 , G06F19/16 , G06F19/22
摘要： Computational methods for classifying and predicting protein side chain conformations utilizing a data driven scoring function are disclosed. According to some embodiments, the methods may include obtaining structure data representing a plurality of conformations of a compound. The methods may also include determining structural differences among the conformations. The methods may also include classifying, based on the structural differences, the conformations into one or more clusters. The methods may also include determining representative conformations of the clusters, wherein an average structural difference between a representative conformation of a cluster and conformations in the cluster is below a predetermined threshold. The method may further include determining the representative conformations as poses of the compound.
摘要翻译：公开了利用数据驱动评分函数对蛋白质侧链构象进行分类和预测的计算方法。根据一些实施例，所述方法可以包括获得表示化合物的多个构象的结构数据。该方法还可以包括确定构象之间的结构差异。该方法还可以包括基于结构差异将构象分类为一个或多个聚类。该方法还可以包括确定簇的代表性构象，其中簇的代表性构象与簇中构象之间的平均结构差异低于预定阈值。该方法可以进一步包括将代表性构象确定为化合物的姿势。

16. 发明申请

WO2023081094A1 NOVEL SPIROCYCLIC COMPOUNDS AS KLHDC2 LIGANDS 审中-公开
公开(公告)号：WO2023081094A1
公开(公告)日：2023-05-11
申请号：PCT/US2022/048403
申请日：2022-10-31
申请人： UNIVERSITY OF WASHINGTON , ACCUTAR BIOTECHNOLOGY INC.
发明人： ZHENG, Ning , RUSNAC, Domnita, Valeria , FAN, Jie , QIAN, Yimin , LIU, Ke
IPC分类号： A61K31/33 , A61K31/395 , A61K31/438 , A61K31/55
摘要： Spirocyclic compounds that are KLHDC2 ligands and methods for inhibiting the enzymatic activity of KLHDC2 using the ligands.

17. 发明申请

WO2021216770A1 SUBSTITUTED TETRAHYDROQUINAZOLINE COMPOUNDS AS KRAS INHIBITORS 审中-公开
公开(公告)号：WO2021216770A1
公开(公告)日：2021-10-28
申请号：PCT/US2021/028478
申请日：2021-04-21
申请人： ACCUTAR BIOTECHNOLOGY INC.
发明人： QIAN, Yimin , LUO, Robert Zhiyong , HE, Wei , LIU, Ke , SU, Jie , HUANG, Pin , FAN, Jie
IPC分类号： C07D401/14 , C07D403/14 , C07D413/14 , A61K31/517 , A61K31/5377 , A61K31/538 , A61P35/00
摘要： The present disclosure relates to novel compounds that inhibits KRAS G12C, pharmaceutical compositions containing such compounds, and their use in prevention and treatment of cancer and related diseases and conditions.

18. 发明申请

WO2021163281A1 ANTISENSE OLIGONUCLEOTIDES AND THEIR USE FOR TREATING PENDRED SYNDROME 审中-公开
公开(公告)号：WO2021163281A1
公开(公告)日：2021-08-19
申请号：PCT/US2021/017595
申请日：2021-02-11
申请人： ACCUTAR BIOTECHNOLOGY INC.
发明人： HUA, Yimin
IPC分类号： A61K31/7088 , C12N15/113
摘要： The present disclosure relates to the field of medicine. In particular, it relates to novel antisense oligonucleotides that prevent or reduce exon 8 skipping in the SLC26A4 gene during pre-mRNA splicing, and their use in the treatment of Pendred Syndrome.

19. 发明申请

WO2021061644A1 NOVEL SUBSTITUTED QUINOLINE-8-CARBONITRILE DERIVATIVES WITH ANDROGEN RECEPTOR DEGRADATION ACTIVITY AND USES THEREOF 审中-公开
公开(公告)号：WO2021061644A1
公开(公告)日：2021-04-01
申请号：PCT/US2020/051999
申请日：2020-09-22
申请人： ACCUTAR BIOTECHNOLOGY INC.
发明人： FAN, Jie , QIAN, Yimin , HE, Wei , LIU, Ke
IPC分类号： A61K31/445 , A61K31/454 , C07D401/04
摘要： The present disclosure relates to novel compounds, pharmaceutical compositions containing such compounds, and their use in prevention and treatment of cancer and related diseases and conditions. In some embodiments, the compounds disclosed herein exhibit androgen receptor degradation activity.

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