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11. 发明申请

WO2006034456A3 COMPOSITIONS AND METHODS FOR DETECTING AND TREATING TUMORS 审中-公开
公开(公告)号：WO2006034456A3
公开(公告)日：2006-03-30
申请号：PCT/US2005/034179
申请日：2005-09-23
申请人： VASGENE THERAPEUTICS, INC. , REDDY, Ramachandra , GILL, Parkash
发明人： REDDY, Ramachandra , GILL, Parkash
IPC分类号： C12Q1/68
摘要： In certain embodiments, this present disclosure provides compositions and methods for detecting EphB4 gene amplification in test cells. In certain embodiments, the present disclosure provides methods and compositions for evaluating tumor (cancer) status and prognosis in a subject having or suspected of having a tumor.

12. 发明申请

WO2007028110A2 METHODS FOR USING AND IDENTIFYING MODULATORS OF DELTA-LIKE 4 审中-公开
标题翻译：使用和识别类似DELTA的调制器的方法4
公开(公告)号：WO2007028110A2
公开(公告)日：2007-03-08
申请号：PCT/US2006/034391
申请日：2006-09-01
申请人： VASGENE THERAPEUTICS, INC. , GILL, Parkash , DUARTE, Antonio , JIANG, Weidong
发明人： GILL, Parkash , DUARTE, Antonio , JIANG, Weidong
CPC分类号： A61K38/1709 , G01N33/5064
摘要： In certain embodiments, this present invention provides methods of identifying and using agonists and antagonists of Delta-like 4 (D114) signaling.
摘要翻译：在某些实施方案中，本发明提供了鉴定和使用δ样4（Dll4）信号传导的激动剂和拮抗剂的方法。

13. 发明申请

WO2008156642A1 NON-IMMUNOGLOBULIN ANTIGEN BINDING SCAFFOLDS FOR INHIBITING ANGIOGENESIS AND TUMOR GROWTH 审中-公开
标题翻译：用于抑制血管生成和肿瘤生长的非免疫抑制蛋白抗原结合蛋白
公开(公告)号：WO2008156642A1
公开(公告)日：2008-12-24
申请号：PCT/US2008/007347
申请日：2008-06-12
申请人： VASGENE THERAPEUTICS, INC. , GILL, Parkash
发明人： GILL, Parkash
IPC分类号： A61K39/395 , A61P35/00 , C07K16/28
CPC分类号： C07K16/2866
摘要： In certain embodiments, this present application provides polypeptide, or nucleotide non-immunoglobulin antigen binding scaffold compositions, and methods for inhibiting Ephrin B2 or EphB4 activity. In other embodiments, the present application provides methods and compositions for treating cancer or for treating angiogenesis-associated diseases.
摘要翻译：在某些实施方案中，本申请提供了多肽或核苷酸非免疫球蛋白抗原结合支架组合物以及用于抑制Ephrin B2或EphB4活性的方法。在其它实施方案中，本申请提供了用于治疗癌症或用于治疗血管生成相关疾病的方法和组合物。

14. 发明申请

WO2014153056A3 CANCER TREATMENT USING ANTIBODIES THAT BING CELL SURFACE GRP78 审中-公开
标题翻译：使用抗体治疗癌细胞表面GRP78
公开(公告)号：WO2014153056A3
公开(公告)日：2014-09-25
申请号：PCT/US2014/028868
申请日：2014-03-14
申请人： GILL, Parkash , LIU, Ren
发明人： GILL, Parkash , LIU, Ren
IPC分类号： C07K16/00 , C12P21/08 , A61K39/395 , A61K39/00
摘要： This application provides, inter alia, antibodies or antigen-binding fragments thereof, targeting cell surface GRP78 expressed on tumor cells, tumor endothelial cells, and tumor initiating cancer cells. These anti-GRP78 antibodies, or antigen-binding fragments thereof, have a high affinity for GRP78 and are less immunogenic compared to their unmodified parent antibodies in a given species, e.g., a human, and function to inhibit GRP78. Importantly, these isolated novel antibodies and antigen-binding fragments thereof, attenuate PI3K signaling and promote apoptosis in tumor cells, while leaving normal cells unaffected. The antibodies and antigen-binding fragments are useful for UPR- targeted cancer therapeutic treatments.
摘要翻译：本申请尤其提供了靶向在肿瘤细胞，肿瘤内皮细胞和肿瘤起始癌细胞上表达的细胞表面GRP78的抗体或其抗原结合片段。这些抗GRP78抗体或其抗原结合片段对GRP78具有高亲和力，并且与其在给定物种（例如人）中的未修饰亲本抗体相比免疫原性较低，并具有抑制GRP78的功能。重要的是，这些分离的新型抗体及其抗原结合片段减弱PI3K信号传导并促进肿瘤细胞凋亡，同时使正常细胞不受影响。抗体和抗原结合片段可用于UPR靶向癌症治疗性治疗。

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