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11. 发明申请

WO2008008463A3 METHODS AND COMPOSITIONS FOR DETECTING AND QUANTIFYING SAPPß 审中-公开
标题翻译：用于检测和量化SAPPß的方法和组合物
公开(公告)号：WO2008008463A3
公开(公告)日：2008-10-09
申请号：PCT/US2007015938
申请日：2007-07-13
申请人： UNIV COLUMBIA , KIM TAE-WAN , HWANG JEREMY C
发明人： KIM TAE-WAN , HWANG JEREMY C
IPC分类号： A61K49/00 , A61K38/00 , A61K39/395 , C07K5/00 , C12N15/63
CPC分类号： G01N33/6896 , C07K16/18 , C07K2317/34 , G01N33/5058 , G01N2333/4709 , G01N2333/96425
摘要： The present invention provides methods (assays) for detecting and/or quantifying sAPPß, a secreted ß-secretase (BACE1) cleavage fragment of the ß-amyloid precursor protein (APP), in a biological sample. One such method includes contacting a biological sample with a first antibody that selectively binds to a BACE1 cleavage site on sAPPß and detecting the presence of the antibody. Also provided are compositions, including antibodies that selectively bind to the BACE1 cleavage site of sAPPß. Kits containing such compositions are also provided. Methods of diagnosing a neurodegenerative disease, such as AD, using the methods and compositions of the present invention are further provided. Methods for identifying BACE1 modulators, candidate compounds that are BACE1 modulators, and methods for treating, preventing or ameliorating neurodegenerative disease, such as AD, using such compounds or pharmaceutical compositions containing such compounds are also provided.
摘要翻译：本发明提供了用于检测和/或定量生物样品中的β-淀粉样前体蛋白（APP）的分泌型β-分泌酶（BACE1）切割片段sAPPß的方法（测定法）。一种这样的方法包括使生物样品与选择性结合sAPPβ上的BACE1切割位点并检测抗体存在的第一抗体接触。还提供了组合物，包括选择性结合sAPPβ的BACE1切割位点的抗体。还提供了含有这种组合物的试剂盒。进一步提供了使用本发明的方法和组合物诊断神经退行性疾病例如AD的方法。还提供了鉴定BACE1调节剂，BACE1调节剂的候选化合物和使用这些化合物或含有这些化合物的药物组合物治疗，预防或改善神经变性疾病如AD的方法。

12. 发明申请

WO2008064244A9 PHOSPHOINOSITIDE MODULATION FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES 审中-公开
标题翻译：用于治疗神经病变性疾病的磷酸盐调节
公开(公告)号：WO2008064244A9
公开(公告)日：2008-08-21
申请号：PCT/US2007085274
申请日：2007-11-20
申请人： UNIV COLUMBIA , KIM TAE-WAN , DIPAOLO GILBERT , KANG MIN SUK , BERMAN DIEGO , MCINTIRE LAURA BETH JOHNSON
发明人： KIM TAE-WAN , DIPAOLO GILBERT , KANG MIN SUK , BERMAN DIEGO , MCINTIRE LAURA BETH JOHNSON
IPC分类号： A61K31/663
CPC分类号： A61K31/663
摘要： The present invention relates to the use of agents that inhibit the toxic effects of amyloid oligomers by increasing intracellular levels of phosphoinositol 4- phosphate (PI(4)P, or "PIP") and/or phosphotidylinositol 4,5-biphosphate (PI(4,5)P2 or "PIP2"), the use of such agents for the treatment of neurodegenerative diseases, methods of treating neurodegenerative diseases by administration of agents which alter lipid metabolism, and methods of identifying agents which alter the association of presenilins with ?-secretase and lipid rafts.
摘要翻译：本发明涉及通过增加细胞内水平的磷酸肌醇4-磷酸（PI（4）P或“PIP”）和/或磷脂酰肌醇4,5-二磷酸（PI（4）P））抑制淀粉样寡聚物的毒性作用的药剂的用途， 4,5）P2或“PIP2”），使用这些药物治疗神经变性疾病，通过施用改变脂质代谢的药物来治疗神经变性疾病的方法，以及鉴定改变前列素的关联的药剂的方法分泌酶和脂筏。

13. 发明申请

WO9847917A2 A PURIFIED 20 kDa PRESENILIN 2 C-TERMINAL FRAGMENT AND METHODS OF SCREENING FOR COMPOUNDS THAT INHIBIT PROTEOLYSIS OF PRESENILIN 2 审中-公开
标题翻译：一种纯化的20kDa PRESENILIN 2 C端子片段和筛选化合物的方法，该化合物抑制PRESENILIN 2的分解
公开(公告)号：WO9847917A2
公开(公告)日：1998-10-29
申请号：PCT/US9808260
申请日：1998-04-24
申请人： TANZI RUDOLPH E , KIM TAE WAN
发明人： TANZI RUDOLPH E , KIM TAE-WAN
IPC分类号： A01K67/027 , A61K38/00 , A61P25/28 , C07K14/47 , C07K16/18 , C12N5/10 , C12N15/02 , C12N15/09 , G01N33/15 , G01N33/50 , G01N33/53 , C07K14/00
CPC分类号： C07K14/4711 , A01K2217/05 , A61K38/00 , Y10S435/975
摘要： The present invention relates, in general, to presenilin 2 proteolytic fragments. In particular, the present invention relates to a purified 20 kDa presenilin 2 C-terminal fragment (PS2-CTF); purified nucleic acid molecules coding for the 20 kDa PS2-CTF protein; cells containing the nucleic acid molecules; non-human organisms containing the nucleic acid molecule; antibodies having specific binding affinity to the 20 kDa PS2-CTF; hybridomas containing the antibodies; methods of detecting 20 kDa PS2-CTF in a sample; diagnostic kits; methods for screening compounds that inhibit proteolytic processing of presenilin 2 in a cell, isolated compounds that inhibit proteolytic processing of presenilin 2 in a cell, and a method of inhibiting apoptotic cell death by preventing proteolytic cleavage of presenilin 2 at a cleavage site which generates a 20 kDa C-terminal fragment.
摘要翻译：本发明一般涉及早老素2蛋白水解片段。特别地，本发明涉及纯化的20kDa早老素2 C-末端片段（PS2-CTF）; 编码20kDa PS2-CTF蛋白质的纯化核酸分子; 含有核酸分子的细胞; 含有核酸分子的非人体生物体; 对20kDa PS2-CTF具有特异性结合亲和力的抗体; 含有抗体的杂交瘤; 检测样品中20kDa PS2-CTF的方法; 诊断试剂盒用于筛选抑制细胞中早老素2的蛋白水解加工的化合物的方法，抑制细胞中早老素2的蛋白水解加工的分离的化合物，以及通过在切割位点处阻止早老素2的蛋白水解切割来抑制凋亡细胞死亡的方法， 20 kDa C末端片段。

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