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11. 发明申请

WO2009016202A3 DESATURASES AND METHODS FOR PRODUCING POLYUNSATURATED FATTY ACIDS IN TRANSGENIC ORGANISMS 审中-公开
标题翻译：去饱和酶和过程在转基因生物生产多不饱和脂肪酸
公开(公告)号：WO2009016202A3
公开(公告)日：2009-06-18
申请号：PCT/EP2008059999
申请日：2008-07-30
申请人： BASF PLANT SCIENCE GMBH , BAUER JOERG , SENGER TORALF
发明人： BAUER JOERG , SENGER TORALF
IPC分类号： C12Q1/68 , C12N15/82
CPC分类号： C12N15/8247 , C12N9/0083
摘要： The invention relates to polynucleotides from Helobdella robusta, Laccaria bicolor, Lottia gigantea, Microcoleus chthonoplastes, Monosiga brevicollis, Mycosphaerella fijiensis, Mycospaerella graminicola, Naegleria gruben, Nectria haematococca, Nematostella vectensis, Phycomyces blakesleeanus, Trichoderma resii, Physcomitrella patens, Postia placenta, Selaginella moellendorffii and Microdochium nivale that code desaturases and that can be used for the recombinant production of polyunsaturated fatty acids. The invention also relates to the vectors, host cells and transgenic non-human organisms that contain said inventive polynucleotides, and also the polypeptides coded by said polynucleotides. The invention further relates to antibodies against the inventive polypeptides. Finally, the invention relates to production methods for the polyunsaturated fatty acids and for oil, lipid and fatty acid compositions and to the use thereof as medicments, cosmetics, food, animal food, preferably fish food or food supplements.
摘要翻译：本发明涉及Helobdella罗布斯塔，双色蜡蘑，Lottia巨，Microcoleus chthonoplastes，Monosiga brevicollis，斐济球腔菌，Mycospaerella蛛，福氏耐格里坑，Nectria haematococca，Nematostella vectensis，须霉属blakesleeanus，木霉属resii，小立碗藓，Postia胎盘，江南卷柏的多核苷酸和微结节nivale编码去饱和酶和可用于重组生产多不饱和脂肪酸。此外，本发明涉及载体，宿主细胞和包含本发明的转基因非人生物的多核苷酸，以及由所述多核苷酸的多肽编码的蛋白质。本发明还涉及抗体与本发明的多肽。最后，本发明涉及一种制造方法，所述多不饱和脂肪酸和油，脂类和脂肪酸组合物和它们作为药物，化妆品，食品，饲料，优选鱼饲料或食品补充剂。

12. 发明申请

WO2005083093A3 METHOD FOR PRODUCING POLYUNSATURATED FATTY ACIDS IN TRANSGENIC PLANTS 审中-公开
标题翻译： PROCESS转基因植物中多产多不饱和脂肪酸
公开(公告)号：WO2005083093A3
公开(公告)日：2006-02-16
申请号：PCT/EP2005001863
申请日：2005-02-23
申请人： BASF PLANT SCIENCE GMBH , CIRPUS PETRA , BAUER JOERG , QIU XIAO , WU GUOHAI , DATLA NAGAMANI
发明人： CIRPUS PETRA , BAUER JOERG , QIU XIAO , WU GUOHAI , DATLA NAGAMANI
IPC分类号： C11B1/02 , C12N9/02 , C12N9/10 , A01K67/027
CPC分类号： C12N15/82 , C12N15/8247
摘要： The invention relates to a method for producing polyunsaturated fatty acids in seeds of transgenic plants. According to said method, nucleic acids, coding for polypeptides with a ?-3-desaturase, ?-12-desaturase, ?-6-desaturase, ?-6-elongase, ?-5-desaturase, ?-5-elongase and/or ?-4-desaturase activity, preferably for polypeptides with a ?-6-desaturase, ?-6-elongase and ?-5-desaturase activity, are introduced into the organism. The nucleic acid sequences are represented by SEQ ID NO: 11, SEQ ID NO: 27, SEQ ID NO: 193, SEQ ID NO: 197, SEQ ID NO: 199 and SEQ ID NO: 201. Advantageously, said nucleic acid sequences can be expressed in the organism optionally together with other nucleic acid sequences that code for polypeptides of the biosynthesis of the fatty acid or lipid metabolism. Nucleic acid sequences coding for a ?-6-desaturase, ?-5-desaturase, ?-4-desaturase, ?-1 2-desaturase and/or ?-6-elongase activity are especially advantageous. Advantageously, said desaturases and elongases originate from thalassiosira, euglena or ostreococcus. The invention also relates to a method for producing oils and/or triacylglycerides with an increased content of long-chain polyunsaturated fatty acids. In a preferred embodiment, the invention also relates to a method for producing arachidonic acid, eicosapentaenic acid or docosahexaenic acid, and to a method for producing triglycerides with an increased content of unsaturated fatty acids, especially arachidonic acid, eicosapentaenoic acid and/or docosahexaenoic acid, in transgenic plants, preferably in seeds of the transgenic plants. The invention further relates to the production of a transgenic plant with an increased content of polyunsaturated fatty acids, especially arachidonic acid, eicosapentaenoic acid and/or docosahexaenoic acid, based on the expression of the elongases and desaturases used in the inventive method. The invention also relates to recombinant nucleic acids molecules containing, together or individually, nucleic acid sequences coding for the polypeptides with a ?-6-desaturase, ?-6-elongase, ?-5-desaturase and ?-5-elongase activity, and transgenic plants containing said recombinant nucleic acid molecules. Another part of the invention relates to oils, lipids and/or fatty acids produced according to the inventive method, and to the use thereof. Furthermore, the invention relates to unsaturated fatty acids and triglycerides with an increased content of unsaturated fatty acids, and to the use of the same.
摘要翻译：本发明涉及一种用于生产由核酸的转基因植物的种子中的多不饱和脂肪酸的方法被引入到生物体中，其与β-3去饱和酶，？-12-去饱和酶，？-6去饱和酶编码多肽，？-6-延伸,? -5去饱和酶，？-5-延伸酶和/或Δ4-去饱和酶优选的多肽具有？-6去饱和酶，？-6延伸酶和？-5- 脱氢酶活性。的核酸序列示于SEQ ID NO：11，SEQ ID NO：27，SEQ ID NO：193，SEQ ID NO：197，SEQ ID NO：199和SEQ ID NO：所示第二百○一序列有利地，这些核酸序列可以在生物体中，任选地与编码所述脂肪酸或脂质的生物合成的多肽的另外的核酸序列表达。特别有利的是编码一个？-6去饱和酶中，α-1 2去饱和酶-6-延伸-5去饱和酶，？4去饱和酶，？和/或核酸序列？有利的是，这些去饱和酶和延伸酶海链藻，裸藻或Ostreococcus。此外，本发明涉及用于生产油和/或三酰基甘油酯与长链多不饱和脂肪酸的升高的内容的处理。本发明中的优选实施例还涉及一种用于生产花生四烯酸，二十碳五烯酸或二十二碳六酸和用于生产甘油三酯的与不饱和脂肪酸含量增加的处理，特别是花生四烯酸，二十碳五烯酸和/或二十碳六烯酸的，有利的是在转基因植物中的转基因的种子植物。本发明涉及生产具有多不饱和脂肪酸，特别是花生四烯酸，二十碳五烯酸和/或二十碳六烯酸，含量增加的转基因植物由于延伸酶的表达和在本发明的去饱和酶处理中使用。本发明还涉及含有核酸序列，其的重组核酸分子编码的多肽具有？-6去饱和酶，？-6-延伸,? -5去饱和酶和β-5-延伸酶，联合或单独，以及含有上述的重组核酸分子的转基因植物。本发明的另一部分涉及通过本发明和它们的使用过程中产生的油，脂质和/或脂肪酸。本发明还涉及到的不饱和脂肪酸和甘油三酯具有不饱和脂肪酸的含量增加及其用途。

13. 发明申请

WO2010000708A3 PROMOTERS FROM BRASSICA NAPUS FOR SEED SPECIFIC GENE EXPRESSION 审中-公开
公开(公告)号：WO2010000708A3
公开(公告)日：2010-04-22
申请号：PCT/EP2009058138
申请日：2009-06-30
申请人： BASF PLANT SCIENCE GMBH , BAUER JOERG , SENGER TORALF
发明人： BAUER JOERG , SENGER TORALF
IPC分类号： C12N15/82 , A01H5/00 , C07K14/415
CPC分类号： C12N15/8234
摘要： The present invention is concerned with means and methods for allowing tissue specific and, in particular, seed specific expression of genes. The present invention, accordingly, relates to a polynucleotide comprising an expression control sequence which allows seed specific expression of a nucleic acid of interest being operatively linked thereto. Moreover, the present invention contemplates vectors, host cells, non-human transgenic organisms comprising the aforementioned polynucleotide as well as methods and uses of such a polynucleotide.

14. 发明申请

WO2009077478A3 PROMOTERS FROM BRASSICA NAPUS FOR SEED SPECIFIC GENE EXPRESSION 审中-公开
标题翻译：来自芸苔属植物的用于种子特异性基因表达的启动子
公开(公告)号：WO2009077478A3
公开(公告)日：2009-12-10
申请号：PCT/EP2008067492
申请日：2008-12-15
申请人： BASF PLANT SCIENCE GMBH , BIORIGINAL FOOD & SCIENCE CORP , BAUER JOERG , WETJEN TOM , QIU YIAO , WU GUOHAI
发明人： BAUER JOERG , WETJEN TOM , QIU YIAO , WU GUOHAI
IPC分类号： C12N15/82
CPC分类号： C12N15/8234
摘要： The present invention is concerned with means and methods for allowing tissue specific and, in particular, seed specific expression of genes. The present invention, accordingly, relates to a polynucleotide comprising an expression control sequence which allows seed specific expression of a nucleic acid of interest being operatively linked thereto. Moreover, the present invention contemplates vectors, host cells, non-human transgenic organisms comprising the aforementioned polynucleotide as well as methods and uses of such a polynucleotide.
摘要翻译：本发明涉及用于使组织特异性，特别是基因的种子特异性表达的手段和方法。因此，本发明涉及包含表达控制序列的多核苷酸，所述表达控制序列允许目的核酸的种子特异性表达与其可操作地连接。此外，本发明考虑包含上述多核苷酸的载体，宿主细胞，非人转基因生物以及这种多核苷酸的方法和用途。

15. 发明申请

WO2007118751A3 METHOD FOR MODIFYING THE ATP/ADP RATIO IN CELLS 审中-公开
标题翻译：改变细胞中ATP-ADP比率的方法
公开(公告)号：WO2007118751A3
公开(公告)日：2007-12-21
申请号：PCT/EP2007052655
申请日：2007-03-20
申请人： MAX PLANCK INST FUER MOLEKULAR , ZANK THORSTEN , OSWALD OLIVER , BAUER JOERG , VIGEOLAS HELENE , GEIGENBERGER PETER , STITT MARK
发明人： ZANK THORSTEN , OSWALD OLIVER , BAUER JOERG , VIGEOLAS HELENE , GEIGENBERGER PETER , STITT MARK
IPC分类号： C12N15/82 , C07K14/415
CPC分类号： C12N15/8247 , C07K14/805
摘要： The invention relates to a method for modifying the ATP/ADP ratio in a cell, tissue, organ, microorganism or plant by modifying the hemoprotein activity in the cell. The invention also relates to the use of said method.
摘要翻译：本发明涉及通过改变细胞中的血红蛋白活性及其用途来改变细胞，组织，器官，微生物或植物中ATP / ADP比例的方法。

16. 发明申请

WO2006008099A3 METHOD FOR INCREASING THE CONTENT OF POLYUNSATURATED LONG-CHAINED FATTY ACIDS IN TRANSGENIC ORGANISMS 审中-公开
标题翻译：方法用于增加转基因生物多不饱和长链脂肪酸的含量
公开(公告)号：WO2006008099A3
公开(公告)日：2007-03-15
申请号：PCT/EP2005007754
申请日：2005-07-15
申请人： BASF PLANT SCIENCE GMBH , CIRPUS PETRA , BAUER JOERG , QIU XIAO , VRINTEN PATRICIA
发明人： CIRPUS PETRA , BAUER JOERG , QIU XIAO , VRINTEN PATRICIA
IPC分类号： C12N15/82 , A01H5/00 , C12N9/04 , C12N9/20 , C12N9/88 , C12N15/53 , C12N15/55 , C12N15/60
CPC分类号： C12N9/0006 , C12N9/20 , C12N9/88 , C12N15/8247
摘要： The invention relates to a method for increasing the content of polyunsaturated long-chained fatty acids in an organism, by introducing nucleic acid coding for polypeptides and/or proteins having phopholipase, ketoacyl-CoA-reductase and/or dehydratase activity into the organisms. Advantageously, said enzymes stem from ostreococcus or thraustochytrium. The invention also relates to nucleic acid sequences, nucleic acid structures, vectors and organisms containing the inventive nucleic acid sequences, vectors containing the nucleic acid sequences and/or the nucleic acid structures, and transgenic organisms containing the above-mentioned nucleic acid sequences, nucleic acid structures and/or vectors. Advantageously, said above-mentioned nucleic acid frequencies, nucleic acid structures and vectors can optionally be expressed in the organism along with additional nucleic acid sequences coding for the polypeptides and/or proteins of fatty acids or lipid metabolism biosynthesis. Another advantage of the nucleic acid sequences of the fatty acids or lipid metabolism is that they are coded for ?-9 elongase, ?-8-desaturase, a ?-5-desaturase, ?-4-desaturase, ?-12-desaturase, ?-5-elongase and/or ?-6-elongase activity. Said desaturases and elongases stem from organisms such as thalassiosira, euglena, isochrysis, physcomitrella, thraustochytrium, borago, phytophthora, crypthecodinium, oncorhynchus, primula, xenopus, ciona, arabidopsis, mortierella, caenorhabditis, phaeodactylum, ceratodon or ostreococcus. The invention further relates to oils, lipids, and/or fatty acids that are produced according the inventive method, and to the use thereof, in addition to the inventive unsaturated fatty acids and triglycerides having an increased content of unsaturated fatty acids and to the use thereof.
摘要翻译：本发明涉及一种用于被引入到生物体中，在增加的核酸的生物体的多不饱和长链脂肪酸含量，其编码具有Phopholipase-，脂酰CoA还原酶和/或脱水酶活性的多肽或蛋白质编码。有利的是，这些酶是从Ostreococcus或破囊壶菌。本发明还涉及包含本发明核酸序列的核酸序列，核酸构建体，载体，和生物体，包含含有上述Nukleinsäuersequenzen，核酸构建体和/或载体的核酸序列和/或核酸构建体，和转基因生物体的载体。有利地，这些上述核酸序列，Nukleainsäurekonstrukte，载体可在生物体与编码多肽或所述脂肪酸或脂质的生物合成的蛋白质的进一步的核酸序列表达，任选一起。所述脂肪酸或脂质的特别有利的核酸序列所必需的一个？-9延长酶？-8-去饱和酶，？-5去饱和酶，？4去饱和酶，？-12-去饱和酶，？-5 编码-Elongase-和/或ω-6延伸酶活性。有利地，这些去饱和酶和从生物体如海链，眼虫，等鞭金藻，小立碗，破囊壶菌属，琉璃苣，疫霉，隐甲藻属，大马哈鱼，报春花，非洲爪蟾，玻璃海鞘，拟南芥，被孢霉属，秀丽隐杆线虫，褐指藻属，角齿或Ostreococcus衍生延伸酶。本发明的另一部分涉及通过本发明和它们的使用过程中产生的油，脂质和/或脂肪酸。本发明还涉及到的不饱和脂肪酸和甘油三酯具有不饱和脂肪酸的含量增加及其用途。

17. 发明申请

WO2009130291A3 PLANT SEED OIL 审中-公开
标题翻译：植物种子油
公开(公告)号：WO2009130291A3
公开(公告)日：2010-05-06
申请号：PCT/EP2009054916
申请日：2009-04-23
申请人： BASF PLANT SCIENCE GMBH , REIN DIETRICH , SENGER TORALF , BAUER JOERG
发明人： REIN DIETRICH , SENGER TORALF , BAUER JOERG
IPC分类号： A23D9/00 , A23L1/30 , C12N15/82
CPC分类号： A23D9/00 , A23K20/158 , A23K50/80 , A23L33/115 , A23L33/40 , A23V2002/00 , C12N15/8247 , A23V2250/1872 , A23V2250/1874 , A23V2250/187 , A23V2250/1862 , A23V2250/188 , A23V2250/1886
摘要： The invention relates to a plant seed oil, comprising arachidonic acid with a content of approximately 7 to 26 percent by weight in the total fatty acid content, the ratio of the weight percentages of arachidonic acid to gamma-linolenic acid being approximately 1:1 to approximately 5:1 and the ratio of the weight percentages of arachidonic acid to dihomo-gamma-linolenic acid being approximately 1:1 to approximately 5:1. The invention further relates to methods for producing said plant seed oil and to formulations and uses of said plant seed oil. The invention specifically makes available food items and baby food containing said plant seed oil.
摘要翻译：本发明涉及一种植物种子油总重量的脂肪酸含量，其包含花生四烯酸在约7含量至约26％，其中重量百分数花生四烯酸到γ-亚麻酸的比例为约1：1至约5：1和花生四烯酸的重量百分比的比率到二高-γ-亚麻酸是约1：1至约5：1。本发明还涉及一种用于生产所述植物的种子油以及制剂和植物种子油的用途的方法。特别地，本发明还提供了含有所提到的植物种子油的食品和婴儿食品。

18. 发明申请

WO2008043849A3 PLANTS WITH INCREASED YIELD 审中-公开
标题翻译：植物增加
公开(公告)号：WO2008043849A3
公开(公告)日：2008-09-04
申请号：PCT/EP2007060912
申请日：2007-10-12
申请人： BASF PLANT SCIENCE GMBH , MAX PLANCK INST FUER MOLEKULAR , ZANK THORSTEN , OSWALD OLIVER , BAUER JOERG , ZRENNER RITA MARIA , KOSLOWSKY SILKE
发明人： ZANK THORSTEN , OSWALD OLIVER , BAUER JOERG , ZRENNER RITA MARIA , KOSLOWSKY SILKE
IPC分类号： C12N15/82 , A01H5/10 , C12N9/12
CPC分类号： C12N15/8247 , C12N9/1235 , C12N15/8261 , Y02A40/146
摘要： This invention relates generally to plant cells and/or plants with increased yield as compared to a corresponding non-transformed wild type plant cell by increasing or generating one or more activities of polypeptides associated with the intermediate phosphoribosylpyrophosphate (PRPP) in plants. In particular, this invention relates to plant cells and/or plants with increased yield as compared to a corresponding non- transformed wild type plant cell by increasing or generating one or more activities of phosphoribosyl pyrophosphate synthases (PRPP synthetase, PRS) The invention also deals with methods of producing and screening for and breeding such plant cells and/or plants.
摘要翻译：与相应的未转化的野生型植物细胞相比，通过增加或产生与植物中的中间磷酸核糖基焦磷酸（PRPP）相关的多肽的一种或多种活性，本发明一般涉及具有增加的产量的植物细胞和/或植物。特别地，本发明涉及通过增加或产生磷酸核糖焦磷酸合酶（PRPP合成酶，PRS）的一种或多种活性而与相应的未转化的野生型植物细胞相比具有增加的产量的植物细胞和/或植物。本发明还涉及使用生产和筛选和繁殖这种植物细胞和/或植物的方法。

19. 发明申请

WO2008040787A3 PROCESSES FOR PRODUCING POLYUNSATURATED FATTY ACIDS IN TRANSGENIC ORGANISMS 审中-公开
标题翻译：在转基因生物体中生产多种不饱和脂肪酸的方法
公开(公告)号：WO2008040787A3
公开(公告)日：2008-06-12
申请号：PCT/EP2007060554
申请日：2007-10-04
申请人： BASF PLANT SCIENCE GMBH , BAUER JOERG , WETJEN TOM
发明人： BAUER JOERG , WETJEN TOM
IPC分类号： C12N9/02 , C12N15/82
CPC分类号： C12N9/0071 , A23D9/00 , A23D9/02 , A23K20/158 , A23K50/80 , A23L33/105 , A23L33/115 , A23V2002/00 , A61K38/00 , C12N9/0083 , C12N9/1029 , C12N9/93 , C12N15/8247 , C12P7/6427 , C12P7/6472 , C12Y114/19001 , C12Y602/01003 , Y02P20/52
摘要： The present invention relates to polynucleotides from Ostreococcus lucimarinus which encode desaturases and elongases, and can be used for the recombinant production of polyunsaturated fatty acids. In addition, the invention relates to vectors, host cells and transgenic non-human organisms which contain the polynucleotides, and also the polypeptides encoded by the polynucleotides. Finally, the invention also relates to production processes for the polyunsaturated fatty acids and for oil, lipid and fatty acid compositions.
摘要翻译：本发明涉及来自Ostreococcus lucimarinus的编码去饱和酶和延伸酶的多核苷酸，并且可用于多不饱和脂肪酸的重组生产。此外，本发明涉及包含多核苷酸的载体，宿主细胞和转基因非人生物体，以及由多核苷酸编码的多肽。最后，本发明还涉及多不饱和脂肪酸和油脂，脂肪酸组合物的生产方法。

20. 发明申请

WO2008022963A2 ISOLATION AND CHARACTERIZATION OF A NOVEL PYTHIUM OMEGA 3 DESATURASE WITH SPECIFICITY TO ALL OMEGA 6 FATTY ACIDS LONGER THAN 18 CARBON CHAINS 审中-公开
标题翻译：一个新的磷酸三钙脱硫剂的分离和表征对所有欧米茄6脂肪酸长18个碳链具有特异性
公开(公告)号：WO2008022963A2
公开(公告)日：2008-02-28
申请号：PCT/EP2007058528
申请日：2007-08-16
申请人： BASF PLANT SCIENCE GMBH , BIORIGINAL FOOD & SCIENCE CORP , BAUER JOERG , WU GUOHAI , QIU XIAO
发明人： BAUER JOERG , WU GUOHAI , QIU XIAO
IPC分类号： C12N9/02 , A01K67/027 , C07K14/37 , C07K16/14 , C07K16/40 , C12N5/10 , C12N15/53 , C12N15/63 , C12N15/81 , C12N15/82 , C12P7/64
CPC分类号： C12P7/6472 , A61K8/64 , A61K8/922 , A61K31/202 , A61K2800/10 , A61Q19/00 , C12N9/0006 , C12N9/0083 , C12N9/0093 , C12N15/52 , C12P7/6427 , C12P7/6436
摘要： The present invention relates to a polynucleotide encoding an omega 3 (?-3) desaturase from Pythium irregulare with specificity to long chain polyunsaturated omega 6 (?- 6) fatty acids as well as a vector containing said polynucleotide, and a host cell containing the vector or the polynucleotide. Moreover, the present invention pertains to a polypeptide encoded by the said polynucleotide, antibodies against the polypeptide as well as a method for the manufacture of the polypeptide. Further, encompassed by the present invention are transgenic non-human organisms. Finally, the present invention relates to methods for the manufacture of compounds and oil- fatty acid- or lipid- containing compositions.
摘要翻译：本发明涉及编码具有对长链多不饱和ω-6（α-6）脂肪酸的特异性的不锈钢的ω3（α-3）去饱和酶的多核苷酸，以及含有所述多核苷酸的载体和含有载体或多核苷酸。此外，本发明涉及由所述多核苷酸编码的多肽，针对多肽的抗体以及制备多肽的方法。此外，本发明包括转基因非人生物体。最后，本发明涉及制备化合物和含油脂肪酸或脂质的组合物的方法。

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