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    • 11. 发明申请
    • METHODS AND ARTICLES FOR REMOTE MAGNETICALLY INDUCED TREATMENT OF CANCER AND OTHER DISEASES, AND METHOD FOR OPERATING SUCH ARTICLE
    • 用于远程磁性诱导治疗癌症及其他疾病的方法和文章及其操作方法
    • WO2005065282A2
    • 2005-07-21
    • PCT/US2004/043459
    • 2004-12-23
    • THE REGENTS OF THE UNIVERSITY OF CALIFORNIAJIN, SunghoPISANIC, Thomas
    • JIN, SunghoPISANIC, Thomas
    • A61K41/00A61K47/48A61N2/02A61N2/06
    • A61N2/06A61K41/0028A61K41/0052A61K47/6923A61K47/6929A61N2/02
    • This invention describes unique treatment methods and innovative articles that can be placed in a human or animal body to enable controlled destruction of diseased tissue. The methods include destruction of diseased cells and tissues by magnetically controlled motion and an externally controllable drug delivery process with a capability to start and stop the drug delivery at any time, for any duration. This invention provides two approaches to diseased cell destruction, (1) magneto-mechanical disturbance of cell structure ( e.g. cancer cells) for cell lysis and (2) magnetically activated drug release at local regions ( e.g. tumors) from a magnetic-particle-containing drug reservoir. The invention also provides combinations of both the above treatments for dual therapy. It further combines one or both of the treatments with magnetic hyperthermia for multifunctional cell destruction therapy. The approaches can be combined with magnetic MRI for monitoring the accuracy of placement as well as for following up the cancer destruction progress and appropriate reprogramming of the magneto-mechanical therapy and remote-controlled drug release.
    • 本发明描述了可以放置在人体或动物体内的独特的治疗方法和创新的制品,以实现病变组织的受控破坏。 所述方法包括通过磁力控制的运动破坏患病细胞和组织,以及外部可控的药物递送过程,其能够在任何时间内随时开始和停止药物递送。 本发明提供了两种病变细胞破坏的方法,(1)用于细胞裂解的细胞结构(例如癌细胞)的磁机械扰动和(2)来自含磁粉的局部区域(例如肿瘤)的磁性活化药物释放 药库 本发明还提供了用于双重治疗的上述两种治疗的组合。 它进一步结合了一种或两种治疗与磁疗热疗用于多功能细胞破坏治疗。 这些方法可以与磁性MRI结合,用于监测放置的准确性,以及跟踪癌症破坏进展和磁力机械治疗和远程控制药物释放的适当重新编程。
    • 12. 发明申请
    • IMPROVED MICROSCALE VACUUM TUBE DEVICE AND METHOD FOR MAKING SAME
    • 改进的微孔真空管装置及其制造方法
    • WO2004045267A2
    • 2004-06-03
    • PCT/US2003/026571
    • 2003-08-23
    • THE REGENTS OF THE UNIVERSITY OF CALIFORNIAJIN, Sungho
    • JIN, Sungho
    • H01J1/46H01J1/62H01J3/02H01J9/00H01J9/02H01J21/10H01L21/00
    • H01J3/021H01J9/025H01J21/10Y10S977/939
    • The invention comprises a method of fabricating a vacuum microtube device comprising the steps of forming a cathode layer comprising an array of electron emitters, forming a gate layer comprising an array of openings for passing electrons from the electron emitters, and forming an anode layer for receiving electrons from the emitters. The cathode gate layer and the anode layer are vertically aligned and bonded together with intervening spacers on a silicon substrate so that electrons from respective emitters pass through respective gate openings to the anode. The use of substrate area is highly efficient and electrode spacing can be precisely controlled. An optional electron multiplying structure providing secondary electron emission material can be disposed between the gate layer and the anode in the path of emitted electrons.
    • 本发明包括一种制造真空微管装置的方法,包括以下步骤:形成包括电子发射体阵列的阴极层,形成包含用于使来自电子发射体的电子的开口阵列的栅极层,以及形成用于接收的阳极层 来自发射体的电子。 阴极栅极层和阳极层与硅衬底上的中间间隔物垂直对准并结合在一起,使得来自各个发射体的电子通过相应的栅极开口到达阳极。 衬底面积的使用是高效的,电极间距可以精确控制。 提供二次电子发射材料的可选的电子倍增结构可以在发射电子的路径中设置在栅极层和阳极之间。