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11. 发明申请

WO0244354A3 MOLECULES OF THE CARD-RELATED PROTEIN FAMILY AND USES THEREOF 审中-公开
标题翻译：相关蛋白家族的分子及其用途
公开(公告)号：WO0244354A3
公开(公告)日：2002-12-12
申请号：PCT/US0144894
申请日：2001-11-29
申请人： MILLENIUM PHARMACEUTICALS INC , BERTIN JOHN
发明人： BERTIN JOHN
IPC分类号： C07K14/47 , C07K16/18 , C12N5/10 , G01N33/50 , G01N33/53
CPC分类号： C07K14/4702
摘要： CARD-5 polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to CARD-5 proteins, and the invention further provides CARD-5 fusion proteins, antigenic peptides and anti-CARD 5 antibodies. The invention also provides CARD-5 nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals in which a CARD-5 gene has been introduced or disrupted. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译：公开了CARD-5多肽，蛋白质和核酸分子。除了CARD-5蛋白质，本发明还提供CARD-5融合蛋白，抗原肽和抗CARD 5抗体。本发明还提供了CARD-5核酸分子，含有本发明的核酸分子的重组表达载体，已经引入了表达载体的宿主细胞和其中引入了CARD-5基因的非人转基因动物，或破坏。还提供利用本发明组合物的诊断，筛选和治疗方法。

12. 发明申请

WO0183753A3 MOLECULES OF THE NBS/LRR PROTEIN FAMILY AND USES THEREOF 审中-公开
标题翻译： NBS / LRR蛋白家族的分子及其用途
公开(公告)号：WO0183753A3
公开(公告)日：2002-05-23
申请号：PCT/US0114283
申请日：2001-05-03
申请人： MILLENNIUM PHARM INC , BERTIN JOHN
发明人： BERTIN JOHN
IPC分类号： C07K14/47 , C12N15/12 , C07K16/18 , C12N15/10 , C12N15/62 , C12Q1/68 , G01N33/53
CPC分类号： C07K14/47 , C07K2319/00
摘要： Novel NBS-2, NBS-3, NBS-4, and NBS-5 polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated NBS-2, NBS-3, NBS-4, and NBS-5 proteins, the invention further provides NBS-2, NBS-3, NBS-4, and NBS-5 fusion proteins, antigenic peptides and anti-NBS-2, anti-NBS-3, anti-NBS-4, and anti-NBS-5 antibodies. The invention also provides NBS-2, NBS-3, NBS-4, and NBS-5 nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals in which a NBS-2, NBS-3, NBS-4, or NBS-5 gene has been introduced or disrupted. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译：公开了新型NBS-2，NBS-3，NBS-4和NBS-5多肽，蛋白质和核酸分子。除了分离的NBS-2，NBS-3，NBS-4和NBS-5蛋白外，本发明还提供NBS-2，NBS-3，NBS-4和NBS-5融合蛋白，抗原肽和抗 - NBS-2，抗NBS-3，抗NBS-4和抗NBS-5抗体。本发明还提供了NBS-2，NBS-3，NBS-4和NBS-5核酸分子，含有本发明的核酸分子的重组表达载体，已经引入了表达载体的非宿主细胞 NBS-2，NBS-3，NBS-4或NBS-5基因已被引入或破坏的转基因动物。还提供利用本发明组合物的诊断，筛选和治疗方法。

13. 发明申请

WO0140468A3 MOLECULES OF THE CARD-RELATED PROTEIN FAMILY AND USES THEREOF 审中-公开
标题翻译：相关蛋白家族的分子及其用途
公开(公告)号：WO0140468A3
公开(公告)日：2002-01-17
申请号：PCT/US0032716
申请日：2000-12-01
申请人： MILLENNIUM PHARM INC , BERTIN JOHN
发明人： BERTIN JOHN
IPC分类号： C07K14/47 , C12N15/12 , C07K16/18 , C12Q1/68 , G01N33/53 , G01N33/68
CPC分类号： C07K14/4747
摘要： Novel CARD-9, CARD-10, or CARD-11 polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated CARD-9, CARD-10, or CARD-11 proteins, the invention further provides CARD-9, CARD-10, or CARD-11, fusion proteins, antigenic peptides and anti-CARD-9, CARD-10, or CARD-11 antibodies. The invention also provides CARD-9, CARD-10, or CARD-11 nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals in which a CARD-9, CARD-10, or CARD-11 gene has been introduced or disrupted. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译：公开了新型CARD-9，CARD-10或CARD-11多肽，蛋白质和核酸分子。除了分离的CARD-9，CARD-10或CARD-11蛋白，本发明还提供CARD-9，CARD-10或CARD-11，融合蛋白，抗原肽和抗CARD-9 CARD-10 或CARD-11抗体。本发明还提供CARD-9，CARD-10或CARD-11核酸分子，含有本发明的核酸分子的重组表达载体，已经引入了表达载体的宿主细胞和非人转基因动物，其中 CARD-9，CARD-10或CARD-11基因已被引入或破坏。还提供利用本发明组合物的诊断，筛选和治疗方法。

14. 发明申请

WO0130971A3 NOVEL MOLECULES AND THE CARD-RELATED PROTEIN FAMILY AND USES THEREOF 审中-公开
标题翻译：新型分子和与卡片相关的蛋白家族及其用途
公开(公告)号：WO0130971A3
公开(公告)日：2002-01-10
申请号：PCT/US0029643
申请日：2000-10-26
申请人： MILLENNIUM PHARM INC , BERTIN JOHN , ROBISON KEITH E
发明人： BERTIN JOHN , ROBISON KEITH E
IPC分类号： A61K38/00 , C07K14/47 , C07K7/08 , C07K16/18 , C12N1/00 , C12N5/00 , C12N5/06 , C12N15/12 , C12P21/02 , C12Q1/37 , C12Q1/68 , G01N33/53 , G01N33/566 , G01N33/68
CPC分类号： C07K14/4702 , A61K38/00
摘要： Novel CARD-12 polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated CARD-12 proteins, the invention further provides CARD-12, fusion proteins, antigenic peptides and anti-CARD-12 antibodies. The invention also provides CARD-12 nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals in which a CARD-12 gene has been introduced or disrupted. Diagnostic, screening and therapeutic methods utilizing compositions of the inventions are also provided.
摘要翻译：公开了新型CARD-12多肽，蛋白质和核酸分子。除了分离的CARD-12蛋白之外，本发明还提供CARD-12，融合蛋白，抗原肽和抗CARD-12抗体。本发明还提供CARD-12核酸分子，含有本发明的核酸分子的重组表达载体，已经引入了表达载体的宿主细胞和其中引入了CARD-12基因的非人转基因动物，或破坏。还提供利用本发明组合物的诊断，筛选和治疗方法。

15. 发明申请

WO0100826A3 NOVEL MOLECULES OF THE CARD-RELATED PROTEIN FAMILY AND USES THEREOF 审中-公开
标题翻译：相关蛋白家族的新分子及其用途
公开(公告)号：WO0100826A3
公开(公告)日：2001-11-29
申请号：PCT/US0017691
申请日：2000-06-28
申请人： MILLENNIUM PHARM INC , BERTIN JOHN
发明人： BERTIN JOHN
IPC分类号： C07K14/47 , C12N15/12 , C12Q1/68 , C07K16/18 , C12N5/10 , G01N33/50 , G01N33/53
CPC分类号： C12Q1/6897 , C07K14/4702
摘要： Novel CARD-3, CARD-4L, CARD-4S, CARD-4Y, CARD-4Z, CARD-5, and CARD-6 polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated CARD-3, CARD-4L, CARD-4S, CARD-4Y, CARD-4Z, CARD-5, and CARD-6 proteins, and the invention further provides CARD-3, CARD-4L, CARD-4S, CARD-4Y, CARD-4Z, CARD-5, and CARD-6 fusion proteins, antigenic peptides and anti-CARDS-3, anti-CARD-4L and anti-CARD-4S, anti-CARD-4Y, anti-CARD-4Z, anti-CARDS-5, and anti-CARD-6 antibodies. The invention also provides CARD-3, CARD-4L, CARD-4S, CARD-4Y, CARD-4Z, CARD-5, and CARD-6 nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals in which a CARD-3, CARD-4L, CARD-4S, CARD-4Y, CARD-4Z, CARD-5, and CARD-6 gene has been introduced or disrupted. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译：公开了新型CARD-3，CARD-4L，CARD-4S，CARD-4Y，CARD-4Z，CARD-5和CARD-6多肽，蛋白质和核酸分子。除了分离的CARD-3，CARD-4L，CARD-4S，CARD-4Y，CARD-4Z，CARD-5和CARD-6蛋白外，本发明还提供CARD-3，CARD-4L，CARD-4S CARD-4Y，CARD-4Z，CARD-5和CARD-6融合蛋白，抗原肽和抗CARDS-3，抗CARD-4L和抗CARD-4S，抗CARD-4Y，抗CARD -4Z，抗CARDS-5和抗CARD-6抗体。本发明还提供CARD-3，CARD-4L，CARD-4S，CARD-4Y，CARD-4Z，CARD-5和CARD-6核酸分子，含有本发明核酸分子的重组表达载体，宿主细胞其中引入了表达载体和已经引入了CARD-3，CARD-4L，CARD-4S，CARD-4Y，CARD-4Z，CARD-5和CARD-6基因的非人转基因动物，或破坏。还提供利用本发明组合物的诊断，筛选和治疗方法。

16. 发明申请

WO9940102A9 NOVEL MOLECULES OF THE CARD-RELATED PROTEIN FAMILY AND USES THEREOF 审中-公开
标题翻译：相关蛋白家族的新分子及其用途
公开(公告)号：WO9940102A9
公开(公告)日：2001-09-20
申请号：PCT/US9902544
申请日：1999-02-05
申请人： MILLENNIUM PHARM INC , BERTIN JOHN
发明人： BERTIN JOHN
IPC分类号： G01N33/50 , C07K14/47 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12P21/02 , C12Q1/02 , C12Q1/68 , G01N33/15 , C07H21/02 , C07H21/04 , C07K5/00 , C12N15/11
CPC分类号： C12Q1/6897 , C07K14/4702
摘要： Novel CARD-3, CARD-4L, CARD-4S, CARD-4Y, CARD-4Z, and murine CARD-4L polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated CARD-3, CARD-4L, CARD-4S, CARD-4Y, CARD-4Z, and murine CARD-4L proteins, and the invention further provides CARD-3, CARD-4L, CARD-4S, CARD-4Y, CARD-4Z, and murine CARD-4L fusion proteins, antigenic peptides and anti-CARD-3, anti-CARD-4L and anti-CARD-4S, anti-CARD-4Y, anti-CARD-4Z, and anti-murine CARD-4L antibodies. The invention also provides CARD-3, CARD-4L, CARD-4S, CARD-4Y, CARD-4Z, and murine CARD-4L nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals in which a CARD-3, CARD-4L, CARD-4S, CARD-4Y, CARD-4Z, and murine CARD-4L gene has been introduced or disrupted. The invention further provides CARD-3 and CARD-4 target proteins that bind to CARD-3 or CARD-4 and allelic variants of human CARD-4. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译：公开了新型CARD-3，CARD-4L，CARD-4S，CARD-4Y，CARD-4Z和鼠CARD-4L多肽，蛋白质和核酸分子。除了分离的CARD-3，CARD-4L，CARD-4S，CARD-4Y，CARD-4Z和鼠CARD-4L蛋白之外，本发明还提供CARD-3，CARD-4L，CARD-4S，CARD- 4Y，CARD-4Z和鼠CARD-4L融合蛋白，抗原肽和抗CARD-3，抗CARD-4L和抗CARD-4S，抗CARD-4Y，抗CARD-4Z和抗 - 鼠CARD-4L抗体。本发明还提供CARD-3，CARD-4L，CARD-4S，CARD-4Y，CARD-4Z和鼠CARD-4L核酸分子，含有本发明的核酸分子的重组表达载体，已经引入了表达载体，其中引入或破坏CARD-3，CARD-4L，CARD-4S，CARD-4Y，CARD-4Z和鼠CARD-4L基因的非人转基因动物。本发明还提供结合CARD-3或CARD-4的CARD-3和CARD-4靶蛋白以及人CARD-4的等位基因变体。还提供利用本发明组合物的诊断，筛选和治疗方法。

17. 发明申请

WO0159065A2 NOVEL MOLECULES OF THE CARD-RELATED PROTEIN FAMILY AND USES THEREOF 审中-公开
标题翻译：相关蛋白家族的新分子及其用途
公开(公告)号：WO0159065A2
公开(公告)日：2001-08-16
申请号：PCT/US0102087
申请日：2001-01-22
申请人： MILLENNIUM PHARM INC , BERTIN JOHN
发明人： BERTIN JOHN
IPC分类号： A61K38/00 , C07K14/47 , C12N
CPC分类号： C07K14/4747 , A61K38/00
摘要： Novel CARD-14 polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated CARD-14 proteins, the invention further provides CARD-14 fusion proteins, antigenic peptides and anti-CARD-14 antibodies. The invention also provides CARD-14 nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals in which a CARD-14 gene has been introduced or disrupted. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译：公开了新的CARD-14多肽，蛋白质和核酸分子。除了分离的CARD-14蛋白之外，本发明还提供CARD-14融合蛋白，抗原肽和抗CARD-14抗体。本发明还提供CARD-14核酸分子，含有本发明的核酸分子的重组表达载体，已经引入了表达载体的宿主细胞和其中引入了CARD-14基因的非人转基因动物，或破坏。还提供利用本发明组合物的诊断，筛选和治疗方法。

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