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11. 发明申请

WO2011030247A1 APPARATUS AND METHOD FOR INFLUENCING AND/OR DETECTING MAGNETIC PARTICLES IN A FIELD OF VIEW 审中-公开
标题翻译：在视场中影响和/或检测磁性颗粒的装置和方法
公开(公告)号：WO2011030247A1
公开(公告)日：2011-03-17
申请号：PCT/IB2010/053684
申请日：2010-08-16
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , RAHMER, Jürgen, Erwin , GLEICH, Bernhard , WEIZENECKER, Jürgen
发明人： RAHMER, Jürgen, Erwin , GLEICH, Bernhard , WEIZENECKER, Jürgen
IPC分类号： A61B5/05
CPC分类号： A61B5/05 , A61B5/0515
摘要： The present invention relates to an apparatus (100) for influencing and/or detecting magnetic particles in a field of view (28), wherein the field of view (28) comprises at least one sub field of interest covering at least a portion of an object of interest containing magnetic particles. The apparatus (100) applying the known principle of Magnetic Particle Imaging (MPI) comprises selection means for generating a magnetic selection field (50) having the known field pattern showing a field free point (FFP), drive means for changing the position in space of the FFP by means of a magnetic drive field, receiving means for acquiring detection signals depending on the magnetization of the magnetic particles within the field of view (28), a control unit (150) for controlling a signal receiving unit (140) comprised in the receiving means for acquiring a set of high resolution detection signals and a set of low resolution detection signals, wherein the set of high resolution detection signals depends on the magnetization of at least one subfield of interest and the set of low resolution detection signals depends on the magnetization of at least one adjacent subfield being arranged adjacent to the at least one subfield of interest, and a reconstruction unit (152) for reconstructing a particle distribution quantity depending on the set of high resolution detection signals and the set of low resolution detection signals. The present invention further relates to a corresponding method as well as to a computer program.
摘要翻译：本发明涉及一种用于在视场（28）中影响和/或检测磁性颗粒的设备（100），其中视场（28）包括至少一个感兴趣的子场，其覆盖至少一部分感兴趣的物体包含磁性颗粒。应用已知的磁性粒子成像原理（MPI）的装置（100）包括选择装置，用于产生具有示出场自由点（FFP）的已知场模式的磁选择场（50），用于改变空间位置的驱动装置通过磁驱动场的FFP的接收装置，用于获取取决于视野内的磁性颗粒的磁化强度的检测信号的接收装置，用于控制信号接收单元（140）的控制单元（150）在用于获取一组高分辨率检测信号和一组低分辨率检测信号的接收装置中，其中该组高分辨率检测信号取决于至少一个感兴趣的子场的磁化，并且该组低分辨率检测信号取决于在与至少一个感兴趣的子场相邻地布置的至少一个相邻子场的磁化上，以及用于重构的重建单元（152）根据高分辨率检测信号和一组低分辨率检测信号来设定粒子分布量。本发明还涉及相应的方法以及计算机程序。

12. 发明申请

WO2008078246A2 ARRANGEMENT AND METHOD FOR INFLUENCING AND/OR DETECTING MAGNETIC PARTICLES IN A REGION OF ACTION 审中-公开
标题翻译：影响和/或检测行动区域中的磁性颗粒的装置和方法
公开(公告)号：WO2008078246A2
公开(公告)日：2008-07-03
申请号：PCT/IB2007/055134
申请日：2007-12-14
申请人： PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , KONINKLIJKE PHILIPS ELECTRONICS N.V. , GLEICH, Bernhard , WEIZENECKER, Jürgen
发明人： GLEICH, Bernhard , WEIZENECKER, Jürgen
IPC分类号： G01N27/00
CPC分类号： A61B5/05 , A61B5/0515 , H01F1/113 , H01F7/021 , H01F7/0294 , H01F7/20 , H01F2027/348
摘要： An arrangement and a method for influencing and/or detecting magnetic particles in a region of action is disclosed, which arrangement comprises: selection means for generating a magnetic selection field having a pattern in space of its magnetic field strength such that a first sub-zone having a low magnetic field strength and a second sub-zone having a higher magnetic field strength are formed in the region of action, drive means for changing the position in space of the two sub-zones in the region of action by means of a magnetic drive field so that the magnetization of the magnetic particles changes locally, wherein the selection means comprise at least one permanent magnet comprising a high resistive permanent magnet material.
摘要翻译：公开了一种用于影响和/或检测作用区域中的磁性颗粒的装置和方法，该装置包括：选择装置，用于产生具有磁场空间中的图案的磁选择场其强度使得在该作用区域中形成具有低磁场强度的第一子区域和具有较高磁场强度的第二子区域;驱动装置，用于改变在该区域中的两个子区域的空间位置通过磁场驱动作用区域，使得磁性粒子的磁化局部地改变，其中选择装置包括至少一个包含高电阻永磁材料的永磁体。

13. 发明申请

WO2008078244A2 ARRANGEMENT AND METHOD FOR INFLUENCING AND/OR DETECTING MAGNETIC PARTICLES IN A REGION OF ACTION 审中-公开
标题翻译：在行动区域影响和/或检测磁性颗粒的布置方法
公开(公告)号：WO2008078244A2
公开(公告)日：2008-07-03
申请号：PCT/IB2007/055131
申请日：2007-12-14
申请人： PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , KONINKLIJKE PHILIPS ELECTRONICS N.V. , GLEICH, Bernhard , WEIZENECKER, Jürgen
发明人： GLEICH, Bernhard , WEIZENECKER, Jürgen
IPC分类号： A61B5/00 , G01R33/00 , G01N27/00
CPC分类号： A61B5/05 , A61B5/0515
摘要： An arrangement for influencing and/or detecting magnetic particles, a method for calibrating such an arrangement and a method for influencing and/or detecting magnetic particles in a region of action is disclosed, which arrangement comprises selection means for generating a magnetic selection field having a pattern in space of its magnetic field strength such that a first sub-zone having a low magnetic field strength and a second sub-zone having a higher magnetic field strength are formed in the region of action, drive means for changing the position in space of the two sub-zones in the region of action by means of a magnetic drive field so that the magnetization of the magnetic particles changes locally, the arrangement comprising a drive signal chain, receiving means for acquiring detection signals, which detection signals depend on the magnetization in the region of action, which magnetization is influenced by the change in the position in space of the first and second sub-zone, the arrangement comprising a detection signal chain, wherein the arrangement comprises a compensation controller providing a compensation signal to the drive signal chain and/or to the detection signal chain by means of a coupling means.
摘要翻译：公开了一种用于影响和/或检测磁性颗粒的装置，用于校准这种布置的方法以及用于影响和/或检测磁性颗粒在作用区域中的方法，该装置包括选择装置，用于产生具有使得具有低磁场强度的第一子区域和具有较高磁场强度的第二子区域的磁场强度的空间图案形成在作用区域中，用于改变空间位置的驱动装置通过磁驱动场在动作区域中的两个子区域，使得磁性颗粒的磁化在局部变化，该装置包括驱动信号链，用于获取检测信号的接收装置，该检测信号取决于磁化在作用区域中，哪个磁化受到第一和第二子区域的空间位置的变化的影响包括检测信号链的装置，其中所述装置包括补偿控制器，该补偿控制器通过耦合装置向驱动信号链和/或检测信号链提供补偿信号。

14. 发明申请

WO2008078242A2 ARRANGEMENT AND METHOD FOR INFLUENCING AND/OR DETECTING MAGNETIC PARTICLES IN A REGION OF ACTION 审中-公开
标题翻译：在行动区域影响和/或检测磁性颗粒的布置方法
公开(公告)号：WO2008078242A2
公开(公告)日：2008-07-03
申请号：PCT/IB2007/055126
申请日：2007-12-14
申请人： PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , KONINKLIJKE PHILIPS ELECTRONICS N.V. , GLEICH, Bernhard , WEIZENECKER, Jürgen , KANZENBACH, Jürgen
发明人： GLEICH, Bernhard , WEIZENECKER, Jürgen , KANZENBACH, Jürgen
IPC分类号： A61B5/00 , H01B7/00 , A61B5/05
CPC分类号： A61B5/05 , A61B5/0515 , H01B7/30
摘要： An arrangement and a method for influencing and/or detecting magnetic particles in a region of action is disclosed, which arrangement comprises: - selection means for generating a magnetic selection field having a pattern in space of its magnetic field strength such that a first sub-zone having a low magnetic field strength 5 and a second sub-zone having a higher magnetic field strength are formed in the region of action, - drive means for changing the position in space of the two sub-zones in the region of action by means of a magnetic drive field so that the magnetization of the magnetic particles changes locally, 10 - receiving means for acquiring signals, which signals depend on the magnetization in the region of action, which magnetization is influenced by the change in the position in space of the first and second sub-zone, wherein the selection means and/or the drive means and/or the receiving means comprises at least partially a litz wire/stranded wire. 15
摘要翻译：公开了一种用于影响和/或检测动作区域中的磁性颗粒的装置和方法，该装置包括： - 选择装置，用于产生具有其磁场强度空间中的图案的磁选区，在动作区域形成具有低磁场强度5的区域和具有较高磁场强度的第二子区域， - 驱动装置，用于改变作用区域中的两个子区域的空间位置的磁驱动场，使得磁性颗粒的磁化在局部变化，10-用于获取信号的接收装置，这些信号取决于作用区域中的磁化强度，该磁化受到位于空间中的位置的变化的影响第一和第二子区域，其中选择装置和/或驱动装置和/或接收装置至少部分地包括绞合线/绞线。 15

15. 发明申请

WO2007000351A1 COMPOSITIONS CONTAINING MAGNETIC IRON OXIDE PARTICLES AND USE OF SAID COMPOSITIONS IN MAGNETIC PARTICLE IMAGING 审中-公开
标题翻译：含有磁性氧化物颗粒的组合物和在磁性颗粒成像中使用合成组合物
公开(公告)号：WO2007000351A1
公开(公告)日：2007-01-04
申请号：PCT/EP2006/006320
申请日：2006-06-29
申请人： SCHERING AG , KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , BRIEL, Andreas , GLEICH, Bernhard , WEIZENECKER, Jürgen , ROHRER, Martin , WEINMANN, Hanns-Joachim , PIETSCH, Hubertus , LAWACZECK, Rüdiger , ROTHE, Matthias , THOMSEN, Jens
发明人： BRIEL, Andreas , GLEICH, Bernhard , WEIZENECKER, Jürgen , ROHRER, Martin , WEINMANN, Hanns-Joachim , PIETSCH, Hubertus , LAWACZECK, Rüdiger , ROTHE, Matthias , THOMSEN, Jens
IPC分类号： A61K49/18
CPC分类号： A61B5/418 , A61B5/0515 , A61B5/411 , A61B5/415 , A61B5/416 , A61K49/1836 , A61K49/1863 , A61K49/1866 , A61K49/1875 , B82Y5/00
摘要： The present invention relates to complexes which contain polycrystalline magnetic iron oxide particles in a pharmaceutically acceptable shell, and to the use of these compositions in magnetic particle imaging (MPI). Particular preference is given to the use of these compositions in examining the gastrointestinal tract, the vascular system of the heart and cranial components, in the diagnosis of arteriosclerosis, infarctions, and tumors and metastases, for example of the lymphatic system.
摘要翻译：本发明涉及在药学上可接受的壳中含有多晶磁性氧化铁颗粒的复合物，以及这些组合物在磁性颗粒成像（MPI）中的用途。特别优选使用这些组合物来检查胃肠道，心脏和颅脑部分的血管系统，诊断动脉硬化，梗死以及肿瘤和转移灶，例如淋巴系统。

16. 发明申请

WO2003062846A3 COIL SYSTEM FOR AN MR APPARATUS AND AN MR APPARATUS PROVIDED WITH SUCH A COIL SYSTEM 审中-公开
公开(公告)号：WO2003062846A3
公开(公告)日：2003-07-31
申请号：PCT/IB2003/000086
申请日：2003-01-15
申请人： PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , KONINKLIJKE PHILIPS ELECTRONICS N.V. , SCHULZ, Volkmar , GLEICH, Bernhard , WEIZENECKER, Jürgen
发明人： SCHULZ, Volkmar , GLEICH, Bernhard , WEIZENECKER, Jürgen
IPC分类号： G01R33/385
摘要： A coil system (210) for an apparatus operating in conformity with the spin resonance or magnetic resonance (MR) method encloses an examination space (217) which extends along an axis (218) and is intended to receive a patient (215). It includes an inner RF coil (219), an inner sub-coil (213') which externally encloses the RF coil (219) and projects beyond the RF coil (219) in the axial direction at both sides, and an active shield (212) which externally encloses the inner sub-coil (213') and constitutes a gradient coil arrangement in conjunction with the inner sub-coil (213'). For specified gradients, the energy required for the gradient coil arrangement (213', 212) in such a coil system is reduced in that the volume occupied by the inner sub-coil (213') is extended in the axial direction by way of regions extending beyond the RF coil (219) in the direction of the axis (218). It is an essential aspect that generally three gradient coils are accommodated in the volume enclosed by the gradient coil arrangement (213', 212). This layered arrangement produces three mutually perpendicular gradient fields as usual. However, it is not necessary to calculate these fields to be such that they extend perpendicularly to one another. All three coil arrangements per se require a smaller energy component in comparison with the normal case.

17. 发明申请

WO2008099331A1 ARRANGEMENT FOR MAGNETIC PARTICLE IMAGING, METHOD FOR INFLUENCING AND/OR DETECTING MAGNETIC PARTICLES AND MAGNETIC PARTICLE 审中-公开
标题翻译：用于磁粒成像的装置，用于影响和/或检测磁性颗粒和磁性颗粒的方法
公开(公告)号：WO2008099331A1
公开(公告)日：2008-08-21
申请号：PCT/IB2008/050490
申请日：2008-02-11
申请人： PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , KONINKLIJKE PHILIPS ELECTRONICS N.V. , WEIZENECKER, Jürgen , GLEICH, Bernhard , NEGLE, Hans , LUNDING, Arne
发明人： WEIZENECKER, Jürgen , GLEICH, Bernhard , NEGLE, Hans , LUNDING, Arne
IPC分类号： A61B5/05 , A61K49/18
CPC分类号： A61B5/05 , A61B5/0515
摘要： An arrangement for magnetic particle imaging and a method for influencing and/or detecting magnetic particles in a region of action is disclosed, which arrangement comprises: magnetic particles in a region of action, the magnetic particles being influenceable and/or detectable, selection means for generating a magnetic selection field having a pattern in space of its magnetic field strength such that a first sub-zone having a low magnetic field strength and a second sub-zone having a higher magnetic field strengthare formed in the region of action, drive means for changing the position in space of the two sub-zones in the region of action by means of a magnetic drive field so that the magnetization of the magnetic particles changes locally, wherein each magneticparticle comprises a non-magnetic substrate with a layer of stainless steel.
摘要翻译：公开了用于磁性颗粒成像的装置和用于影响和/或检测动作区域中的磁性颗粒的方法，该装置包括：磁性颗粒在作用区域中，磁性颗粒是可影响的和/或可检测的，选择装置产生具有其磁场强度空间中的图案的磁选择场，使得具有低磁场强度的第一子区和具有较高磁场强度的第二子区形成在动作区域中，驱动装置通过磁驱动场来改变动作区域中的两个子区域的空间位置，使得磁性颗粒的磁化局部变化，其中每个磁性颗粒包括具有不锈钢层的非磁性基板。

18. 发明申请

WO2008078275A2 METHOD AND ARRANGEMENT FOR INFLUENCING AND/OR DETECTING MAGNETIC PARTICLES IN A REGION OF ACTION 审中-公开
标题翻译：影响和/或检测某区域磁性颗粒的方法和装置
公开(公告)号：WO2008078275A2
公开(公告)日：2008-07-03
申请号：PCT/IB2007/055177
申请日：2007-12-17
申请人： PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , KONINKLIJKE PHILIPS ELECTRONICS N.V. , GLEICH, Bernhard , WEIZENECKER, Jürgen
发明人： GLEICH, Bernhard , WEIZENECKER, Jürgen
IPC分类号： A61B5/05 , G01N27/00
CPC分类号： A61B5/05 , A61B5/0515
摘要： A method and an arrangement for influencing and/or detecting magnetic particles in a region of action is disclosed, which method comprises the steps of: - generating a magnetic selection field having a pattern in space of its magnetic field strength such that a first sub-zone having a low magnetic field strength and a second sub-zone having a higher magnetic field strength are formed in the region of action - changing the position in space of the two sub-zones in the region of action by means of a magnetic drive field so that the magnetization of the magnetic particles change locally, - acquiring signals, which signals depend on the magnetization in the region of action, which magnetization is influenced by the change in the position in space of the first and second sub-zone, wherein a magnetic drive vector of the magnetic drive field is rotated in at least one rotation plane.
摘要翻译：公开了一种用于影响和/或检测作用区域中的磁性颗粒的方法和装置，该方法包括以下步骤： - 生成具有磁场空间中的图案的磁选择场场强度，使得在作用区域中形成具有低磁场强度的第一子区域和具有较高磁场强度的第二子区域 - 改变在区域中的两个子区域的空间位置借助磁场驱动磁性粒子的磁化，使得磁性粒子的磁化局部地改变， - 获取信号，该信号取决于作用区域中的磁化，该磁化受到第一空间中的位置变化和第二分区，其中磁驱动场的磁驱动矢量在至少一个旋转平面内旋转。

19. 发明申请

WO2008078272A2 ARRANGEMENT AND METHOD FOR INFLUENCING AND/OR DETECTING MAGNETIC PARTICLES IN A REGION OF ACTION 审中-公开
标题翻译：在行动区域影响和/或检测磁性颗粒的布置和方法
公开(公告)号：WO2008078272A2
公开(公告)日：2008-07-03
申请号：PCT/IB2007/055174
申请日：2007-12-17
申请人： PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , KONINKLIJKE PHILIPS ELECTRONICS N.V. , GLEICH, Bernhard , WEIZENECKER, Jürgen
发明人： GLEICH, Bernhard , WEIZENECKER, Jürgen
IPC分类号： A61B5/05
CPC分类号： A61B5/05 , A61B5/0515
摘要： An arrangement for influencing and/or detecting magnetic particles, a method for adjusting such an arrangement and a method for influencing and/or detecting magnetic particles in a region of action is disclosed, which arrangement comprises selection means for generating a magnetic selection field having a pattern in space of its magnetic field strength such that a first sub-zone having a low magnetic field strength and a second sub-zone having a higher magnetic field strength are formed in the region of action, drive means for changing the position in space of the two sub-zones in the region of action by means of a magnetic drive field so that the magnetization of the magnetic particles changes locally, receiving means for acquiring signals, which signals depend on the magnetization in the region of action, which magnetization is influenced by the change in the position in space of the first and second sub-zone, wherein the receiving means comprises a first compensation means and a second compensation means the first and second compensation means comprising each a compensation coil.
摘要翻译：公开了一种用于影响和/或检测磁性颗粒的装置，一种用于调整这种布置的方法和用于影响和/或检测磁性颗粒在作用区域中的方法，该装置包括选择装置，用于产生具有在其磁场强度的空间中形成具有低磁场强度的第一子区和具有较高磁场强度的第二子区，该驱动装置用于改变空间中的位置通过磁驱动场在动作区域中的两个子区域，使得磁性颗粒的磁化在局部变化，用于获取信号的接收装置，这些信号取决于作用区域中的磁化，该磁化受到影响通过第一和第二子区域的空间位置的变化，其中接收装置包括第一补偿装置和第二补偿装置补偿补偿是指包括每个补偿线圈的第一和第二补偿装置。

20. 发明申请

WO2007000350A1 COMPOSITIONS CONTAINING MAGNETIC IRON OXIDE PARTICLES, AND USE OF SAID COMPOSITIONS IN MAGNETIC PARTICLE IMAGING 审中-公开
标题翻译：含有磁性氧化物颗粒的组合物，以及在磁颗粒成像中使用上述组合物
公开(公告)号：WO2007000350A1
公开(公告)日：2007-01-04
申请号：PCT/EP2006/006319
申请日：2006-06-29
申请人： SCHERING AG , KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , BRIEL, Andreas , GLEICH, Bernhard , WEIZENECKER, Jürgen , ROHRER, Martin , WEINMANN, Hanns-Joachim , PIETSCH, Hubertus , LAWACZECK, Rüdiger , ROTHE, Matthias , THOMSEN, Jens
发明人： BRIEL, Andreas , GLEICH, Bernhard , WEIZENECKER, Jürgen , ROHRER, Martin , WEINMANN, Hanns-Joachim , PIETSCH, Hubertus , LAWACZECK, Rüdiger , ROTHE, Matthias , THOMSEN, Jens
IPC分类号： A61K49/18
CPC分类号： A61B5/418 , A61B5/0515 , A61B5/411 , A61B5/415 , A61B5/416 , A61K49/1836 , A61K49/1863 , A61K49/1866 , A61K49/1875 , B82Y5/00
摘要： The present invention relates to complexes which contain magnetic iron oxide particles in a pharmaceutically acceptable shell, said particles having a diameter of 20 nm to 1 µm with an overall particle diameter/core diameter ratio of less than 6, and to the use of these complexes in magnetic particle imaging (MPI). Particular preference is given to the use of these compositions in examining the gastrointestinal tract, the vascular system of the heart and cranial components, in the diagnosis of arteriosclerosis, infarctions, and tumors and metastases, for example of the lymphatic system.
摘要翻译：本发明涉及在药学上可接受的壳中含有磁性氧化铁颗粒的复合物，所述颗粒的直径为20nm至1μm，总体颗粒直径/芯直径比小于6，并且使用这些配合物在磁粉成像（MPI）中。特别优选使用这些组合物来检查胃肠道，心脏和颅脑部分的血管系统，诊断动脉硬化，梗死以及肿瘤和转移灶，例如淋巴系统。

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