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11. 发明申请

WO2004069795A3 DIAGNOSIS AND TREATMENT OF CHRONIC TISSUE DAMAGE 审中-公开
标题翻译：诊断和治疗慢性组织损伤
公开(公告)号：WO2004069795A3
公开(公告)日：2007-08-09
申请号：PCT/US2004002881
申请日：2004-02-02
申请人： PFIZER PROD INC , OXFORD GLYCOSCIENCES UK LTD , BUTT RICHARD , RUMPEL KLAUS , WILLIAMS-JONES BRYN I , HERATH HERATH MUDIYANSELAGE AT , ROHLFF CHRISTIAN , BRUCE JAMES A , PATEL THAKORBHAI P
发明人： BUTT RICHARD , RUMPEL KLAUS , WILLIAMS-JONES BRYN I , HERATH HERATH MUDIYANSELAGE AT , ROHLFF CHRISTIAN , BRUCE JAMES A , PATEL THAKORBHAI P
IPC分类号： G01N33/573 , A61K31/01 , A61K31/135 , A61K31/38 , A61K38/00 , C07D20060101 , G01N33/574 , G01N33/68
CPC分类号： G01N33/6881 , A61K38/2006 , G01N2500/00 , G01N2800/20
摘要： This invention relates to use of proteins associated with chronic tissue damage, e.g., chronic dermal ulcers. The proteins identified are useful for clinical screening, diagnosis, prognosis, therapy, and prophylaxis, as well as for drug screening and drug development.
摘要翻译：本发明涉及与慢性组织损伤相关的蛋白质的使用，例如慢性皮肤溃疡。鉴定的蛋白质可用于临床筛选，诊断，预后，治疗和预防以及药物筛选和药物开发。

12. 发明申请

WO0175454A3 DIAGNOSIS AND TREATMENT OF ALZHEIMER'S DISEASE 审中-公开
标题翻译：诊断和治疗阿尔茨海默病
公开(公告)号：WO0175454A3
公开(公告)日：2003-05-08
申请号：PCT/US0110908
申请日：2001-04-03
申请人： OXFORD GLYCOSCIENCES UK LTD , PFIZER , DURHAM KATHRYN L , FRIEDMAN DAVID L , HERATH HERATH MUDIYANSELAGE AT , KIMMEL LIDA H , PAREKH RAJESH BHIKHU , POTTER DAVID M , ROHLFF CHRISTIAN , SILBER B MICHAEL , STIGER THOMAS R , SUNDERLAND P TREY , TOWNSEND ROBERT REID , WHITE FROST , WILLIAMS STEPHEN A
发明人： DURHAM KATHRYN L , FRIEDMAN DAVID L , HERATH HERATH MUDIYANSELAGE AT , KIMMEL LIDA H , PAREKH RAJESH BHIKHU , POTTER DAVID M , ROHLFF CHRISTIAN , SILBER B MICHAEL , STIGER THOMAS R , SUNDERLAND P TREY , TOWNSEND ROBERT REID , WHITE FROST , WILLIAMS STEPHEN A
IPC分类号： G01N27/62 , A61K31/7088 , A61K39/395 , A61K48/00 , A61P25/28 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/00 , C12N15/09 , C12P21/08 , C12Q1/02 , C12Q1/68 , G01N27/447 , G01N33/15 , G01N33/53 , G01N33/68 , G01N37/00 , C07K14/47 , G01N33/561
CPC分类号： G01N33/6896 , G01N2800/2821
摘要： The present invention provides methods and compositions for screening, diagnosis and prognosis of Alzheimer's disease, for monitoring the effectiveness of Alzheimer's disease treatment, and for drug development. Alzheimer's Disease-Associated Features (AFs), detectable by two-dimensional electrophoresis of cerebrospinal fluid, serum or plasma are described. The invention further provides Alzheimer's Disease-Associated Protein Isoforms (APIs) detectable in cerebrospinal fluid, serum or plasma, preparations comprising isolated APIs, antibodies immunospecific for APIs, pharmaceutical compositions, diagnostic and therapeutic methods, and kits comprising or based on the same.
摘要翻译：本发明提供了用于阿尔茨海默病筛选，诊断和预后的方法和组合物，用于监测阿尔茨海默病治疗的有效性和药物开发。描述了通过脑脊液，血清或血浆的二维电泳可检测的阿尔茨海默氏病相关特征（AF）。本发明还提供在脑脊液，血清或血浆中可检测的阿尔茨海默氏病相关蛋白质异构体（API），包含分离的API的制剂，针对API免疫特异性的抗体，药物组合物，诊断和治疗方法，以及包含或基于其的试剂盒。

13. 发明申请

WO02059604A8 PROTEINS, GENES AND THEIR USE FOR DIAGNOSIS AND TREATMENT OF MULTIPLE SCLEROSIS 审中-公开
标题翻译：蛋白质，基因及其用于诊断和治疗多发性硬化症的用途
公开(公告)号：WO02059604A8
公开(公告)日：2002-11-21
申请号：PCT/GB0200330
申请日：2002-01-25
申请人： OXFORD GLYCOSCIENCES UK LTD , HERATH HERATH MUDIYANSELAGE AT , PAREKH RAJESH BHIKHU , ROHLFF CHRISTIAN
发明人： HERATH HERATH MUDIYANSELAGE AT , PAREKH RAJESH BHIKHU , ROHLFF CHRISTIAN
IPC分类号： G01N33/53 , A61K31/7088 , A61K38/00 , A61K39/395 , A61K48/00 , A61P25/00 , C07K14/47 , C07K16/18 , C07K16/46 , C12N15/09 , C12P21/08 , C12Q1/02 , C12Q1/68 , G01N33/15 , G01N33/483 , G01N33/50 , G01N33/566 , G01N33/68 , G01N33/564 , A61K39/00
CPC分类号： C07K14/4713 , A61K38/00 , C07K2319/00 , G01N33/6803 , G01N33/6896 , G01N2800/285 , G01N2800/52
摘要： The present invention provides methods and compositions for screening, diagnosis and prognosis of Multiple Sclerosis, for monitoring the effectiveness of Multiple Sclerosis treatment, identifying patients most likely to respond to a particular therapeutic treatment and for drug development. Multiple Sclerosis-Associated Features (MSFs), detectable by two-dimensional electrophoresis of body fluid e.g. cerebrospinal fluid are described. The invention further provides Multiple Sclerosis-Associated Protein Isoforms (MSPIs) detectable in body fluid e.g. cerebrospinal fluid, preparations comprising isolated MSPIs, antibodies immunospecific for MSPIs, and kits comprising the aforesaid.
摘要翻译：本发明提供用于多发性硬化症的筛选，诊断和预后的方法和组合物，用于监测多发性硬化症治疗的有效性，鉴定最可能对特定治疗和药物开发作出反应的患者。多发性硬化相关特征（MSF）可通过体液的二维电泳检测。描述脑脊液。本发明进一步提供在体液中可检测的多发性硬化症相关蛋白质异构体（MSPI），例如。脑脊液，包含分离的MSPI的制剂，针对MSPI的免疫特异性抗体，以及包含上述的试剂盒。

14. 发明申请

WO2008104804A3 PROTEINS 审中-公开
标题翻译：蛋白质
公开(公告)号：WO2008104804A3
公开(公告)日：2009-03-26
申请号：PCT/GB2008050125
申请日：2008-02-26
申请人： OXFORD GENOME SCIENCES UK LTD , ROHLFF CHRISTIAN , STAMPS ALASDAIR
发明人： ROHLFF CHRISTIAN , STAMPS ALASDAIR
IPC分类号： C07K14/705 , G01N33/574 , G01N33/68
CPC分类号： A61K39/39558 , C07K14/705 , C07K16/3023 , C07K16/303 , C07K16/3038 , C07K16/3046 , C07K16/3061 , C07K16/3069 , C07K2317/734 , C12Q1/6886 , G01N33/57407 , G01N33/57419 , G01N33/57423 , G01N33/57426 , G01N33/57438 , G01N33/57449 , Y10T436/143333
摘要： The present invention relates to the identification of membrane proteins associated with B-cell non-Hodgkin's lymphoma, breast cancer, cervical cancer, colorectal cancer, gastric cancer, glioblastoma, hepatocellular carcinoma, lung cancer, lymphoid leukaemia (particularly acute T- cell leukaemia and chronic lymphocytic leukaemia), melanoma, neuroblastoma, osteosarcoma, ovarian cancer, pancreatic cancer, prostate cancer, renal cell cancer and retinoblastoma which have utility as markers and for treatment of said cancers and which also form biological targets against which antibodies such as therapeutic antibodies (or other affinity reagents) or other pharmaceutical agents can be made.
摘要翻译：本发明涉及与B细胞非霍奇金淋巴瘤，乳腺癌，子宫颈癌，结肠直肠癌，胃癌，成胶质细胞瘤，肝细胞癌，肺癌，淋巴白血病（特别是急性T细胞白血病和慢性淋巴细胞白血病），黑素瘤，神经母细胞瘤，骨肉瘤，卵巢癌，胰腺癌，前列腺癌，肾细胞癌和视网膜母细胞瘤，其可用作标记物和用于治疗所述癌症，并且还形成抗体如治疗性抗体或其他亲和试剂）或其它药剂。

15. 发明申请

WO2008026008A8 PROTEIN 审中-公开
标题翻译：蛋白
公开(公告)号：WO2008026008A8
公开(公告)日：2008-05-08
申请号：PCT/GB2007050513
申请日：2007-08-29
申请人： OXFORD GENOME SCIENCES UK LTD , ROHLFF CHRISTIAN
发明人： ROHLFF CHRISTIAN
IPC分类号： G01N33/574 , G01N33/68
CPC分类号： G01N33/57419 , G01N2500/04
摘要： The present invention provides methods and compositions for screening, diagnosis and prognosis of colorectal cancer, for monitoring the effectiveness of colorectal cancer treatment, and for drug development.
摘要翻译：本发明提供了用于筛查，诊断和预测结直肠癌，用于监测结肠直肠癌治疗的有效性和用于药物开发的方法和组合物。

16. 发明申请

WO2007015113A3 NEW PROTEIN ISOFORMS OF THE PIF-FAMILY AND USES THEREOF 审中-公开
标题翻译： PIF家族的新蛋白质蛋白质及其用途
公开(公告)号：WO2007015113A3
公开(公告)日：2007-12-27
申请号：PCT/GB2006050232
申请日：2006-08-04
申请人： OXFORD GENOME SCIENCES UK LTD , ROHLFF CHRISTIAN
发明人： ROHLFF CHRISTIAN
IPC分类号： G01N33/50
CPC分类号： G01N33/6896
摘要： A method for screening for or diagnosis or prognosis of a neurological disorder associated with de-regulated glutamate signalling in a subject, for determining the stage or severity of such a neurological disorder in a subject, for identifying a subject at risk of developing such a neurological disorder, or for monitoring the effect of therapy administered to a subject having such a neurological disorder, said method comprising: (a) analyzing a test sample of body fluid or tissue from the subject said sample comprising at least one Protein Isoform selected from the following Protein Isoform Families: PIF-1, PIF-2, and PIF-3 in a detectable amount; and (b) comparing the abundance of said Protein Isoform(s) in the test sample or the abundance of said Protein Isoform(s) relative to another Protein Isoform with the abundance or relative abundance of said Protein Isoform(s) in a test sample from one or more persons free from neurological disorder, or with a previously determined reference range for that Protein Isoform in subjects free from neurological disorder, wherein a diagnosis of or a positive result in screening for or a prognosis of a more advanced condition of said neurological disorder is indicated by (i) decreased abundance or relative abundance of PIF-1 and/or (ii) increased abundance or relative abundance of PIF-2 and/or (iii) decreased abundance or relative abundance of PIF-3.
摘要翻译：用于筛选或诊断或预测与受试者中解除调节的谷氨酸信号传导相关的神经障碍的方法，用于确定受试者中这种神经障碍的阶段或严重程度，用于鉴定发生这种神经系统风险的受试者或用于监测施用于具有这种神经障碍的受试者的疗效的影响，所述方法包括：（a）分析来自受试者的体液或组织的测试样品，所述样品包含至少一种选自以下的蛋白质异构体蛋白质异构体家族：可检测量的PIF-1，PIF-2和PIF-3; 和（b）比较测试样品中所述蛋白质异构体的丰度或所述蛋白质异构体相对于另一蛋白质异构体的丰度与所述蛋白质同种型的丰度或相对丰度在测试样品来自一个或多个没有神经障碍的人，或者在没有神经障碍的受试者中具有预先确定的该蛋白质同种型的参考范围，其中诊断或阳性导致所述神经系统的更晚期状况的筛选或预后（i）PIF-1的丰度或相对丰度降低和/或（ii）增加的PIF-2的丰度或相对丰度和/或（iii）PIF-3的丰度或相对丰度降低。

17. 发明申请

WO2004034062A3 USE OF CAP-1 FOR THE THERAPY OF ASTHMA 审中-公开
标题翻译：使用CAP-1治疗哮喘
公开(公告)号：WO2004034062A3
公开(公告)日：2004-06-03
申请号：PCT/GB0304341
申请日：2003-10-08
申请人： OXFORD GLYCOSCIENCES UK LTD , BAYER HEALTHCARE AG , BACON KEVIN BRUCE , HERATH HERATH MUDIYANSELAGE AT , LIU NINGSHU , REINEMER PETER , ROHLFF CHRISTIAN
发明人： BACON KEVIN BRUCE , HERATH HERATH MUDIYANSELAGE AT , LIU NINGSHU , REINEMER PETER , ROHLFF CHRISTIAN
IPC分类号： G01N33/50 , G01N33/68
CPC分类号： G01N33/5091 , G01N33/5008 , G01N33/5023 , G01N33/5047 , G01N33/6884 , G01N33/6893 , G01N2500/00 , G01N2800/122 , G01N2800/52
摘要： Methods for the treatment of inflammatory diseases including respiratory diseases, such as asthma and asthma related conditions, comprising regulation of the polypeptide (Adenylyl Cyclase-Associated Protein 1/CAP-1), agents which modulate the expression or activity of the polypeptide, methods for the identification of such agents and the use of CAP-1 in the diagnosis of inflammatory diseases including respiratory diseases such as asthma and asthma related conditions.
摘要翻译：包括调节多肽（腺苷酸环化相关蛋白1 / CAP-1），调节多肽表达或活性的试剂，治疗炎性疾病包括呼吸疾病如哮喘和哮喘相关病症的方法，用于这些药物的鉴定和CAP-1在诊断包括呼吸系统疾病如哮喘和哮喘相关疾病在内的炎症疾病中的应用。

18. 发明申请

WO0163293A3 DIAGNOSIS AND TREATMENT OF SCHIZOPHRENIA 审中-公开
标题翻译： SCHIZOPHRENIA的诊断和治疗
公开(公告)号：WO0163293A3
公开(公告)日：2002-04-11
申请号：PCT/GB0100783
申请日：2001-02-23
申请人： OXFORD GLYCOSCIENCES UK LTD , HERATH HERATH MUDIYANSELAGE AT , PAREKH RAJESH BHIKHU , ROHLFF CHRISTIAN
发明人： HERATH HERATH MUDIYANSELAGE AT , PAREKH RAJESH BHIKHU , ROHLFF CHRISTIAN
IPC分类号： A61K38/00 , A61P25/18 , C07K14/47 , C07K14/705 , G01N33/68 , C07K16/18
CPC分类号： C07K14/705 , A61K38/00 , C07K14/47 , G01N2500/00 , G01N2800/302
摘要： The present invention provides methods and compositions for screening, diagnosis and prognosis of Schizophrenia, for monitoring the effectiveness of Schizophrenia treatment, identifying patients most likely to respond to a particular therapeutic treatment and for drug development. Schizophrenia-Associated Features (SFs), detectable by two-dimensional electrophoresis of cerebrospinal fluid, serum or plasma are described. The invention further provides Schizophrenia-Associated Protein Isoforms (SPIs) detectable in cerebrospinal fluid, serum or plasma, preparations comprising SPIs, antibodies immunospecific for SPIs, and kits comprising the aforesaid.
摘要翻译：本发明提供用于精神分裂症筛查，诊断和预后的方法和组合物，用于监测精神分裂症治疗的有效性，鉴定最可能对特定治疗和药物开发作出反应的患者。描述了通过脑脊液，血清或血浆的二维电泳可检测的精神分裂症相关特征（SF）。本发明还提供在脑脊液，血清或血浆中可检测的精神分裂症相关蛋白异构体（SPI），包含SPI的制剂，对SPIs免疫特异性的抗体，以及包含上述的试剂盒。

19. 发明申请

WO2008104803A3 PROTEINS 审中-公开
标题翻译：蛋白质
公开(公告)号：WO2008104803A3
公开(公告)日：2009-01-15
申请号：PCT/GB2008050124
申请日：2008-02-25
申请人： OXFORD GENOME SCIENCES UK LTD , STAMPS ALASDAIR , ROHLFF CHRISTIAN
发明人： ROHLFF CHRISTIAN
IPC分类号： G01N33/574 , C07K14/705 , G01N33/68
CPC分类号： A61K39/39558 , C07K14/705 , C07K16/3023 , C07K16/303 , C07K16/3038 , C07K16/3046 , C07K16/3061 , C07K16/3069 , C07K2317/734 , C12Q1/6886 , G01N33/57407 , G01N33/57419 , G01N33/57423 , G01N33/57426 , G01N33/57438 , G01N33/57449 , Y10T436/143333
摘要： The present invention provides methods and compositions for treatment, prevention, diagnosis and monitoring of colorectal cancer, kidney cancer, lung cancer and/orpancreatic cancer in particular relating to a polypeptide OGTA066.
摘要翻译：本发明提供了用于治疗，预防，诊断和监测结直肠癌，肾癌，肺癌和/或胰腺癌的方法和组合物，特别是涉及多肽OGTA066。

20. 发明申请

WO2008104805A3 PROTEINS 审中-公开
标题翻译：蛋白质
公开(公告)号：WO2008104805A3
公开(公告)日：2008-11-20
申请号：PCT/GB2008050126
申请日：2008-02-25
申请人： OXFORD GENOME SCIENCES UK LTD , ROHLFF CHRISTIAN , STAMPS ALASDAIR
发明人： ROHLFF CHRISTIAN , STAMPS ALASDAIR
IPC分类号： C07K14/435 , C07K16/18
CPC分类号： C07K14/705 , A61K38/00
摘要： The present invention provides new polypeptides. Said polypeptides are of use in the screening, diagnosis and prognosis of B-cell non-Hodgkin's lymphoma, breast cancer, colorectal cancer, gastric cancer, hepatocellular carcinoma, lung cancer, lymphoid leukaemia (particularly acute T-cell leukaemia), melanoma, osteosarcoma, ovarian cancer, pancreatic cancer, prostate cancer and renal cell cancer, in monitoring the effectiveness of B-cell non-Hodgkin s lymphoma, breast cancer, colorectal cancer, gastric cancer, hepatocellular carcinoma, lung cancer, lymphoid leukaemia (particularly acute T-cell leukaemia), melanoma, osteosarcoma, ovarian cancer, pancreatic cancer, prostate cancer and renal cell cancer treatment, and in drug development. Also provided are antibodies (and other affinity reagents such as Affibodies) which interact with or modulate the expression or activity of the polypeptides.
摘要翻译：本发明提供了新的多肽。所述多肽可用于B细胞非霍奇金淋巴瘤，乳腺癌，结肠直肠癌，胃癌，肝细胞癌，肺癌，淋巴白血病（特别是急性T细胞白血病），黑素瘤，骨肉瘤的筛选，诊断和预后，卵巢癌，胰腺癌，前列腺癌和肾细胞癌，用于监测B细胞非霍奇金淋巴瘤，乳腺癌，结肠直肠癌，胃癌，肝细胞癌，肺癌，淋巴样白血病（特别是急性T- 细胞白血病），黑素瘤，骨肉瘤，卵巢癌，胰腺癌，前列腺癌和肾细胞癌治疗，以及药物开发。还提供了与多肽的表达或活性相互作用或调节多肽的抗体（和其它亲和试剂如亲体）。

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