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11. 发明申请

WO1995020405A1 ORAL MAGNETIC PARTICLE FORMULATION 审中-公开
标题翻译：口服磁性颗粒配方
公开(公告)号：WO1995020405A1
公开(公告)日：1995-08-03
申请号：PCT/GB1995000175
申请日：1995-01-30
申请人： NYCOMED IMAGING AS , COCKBAIN, Julian , GORMAN, William, George , CARROLL, Fred, Andrew , OSTRANDER, Kevin, Darryl , HUNKE, William
发明人： NYCOMED IMAGING AS , COCKBAIN, Julian
IPC分类号： A61K49/00
CPC分类号： A61K49/1851
摘要： There is provided a substantially hydrated, low viscosity carrier for dispersing magnetically responsive particles. Contrast media for nuclear magnetic imaging of the gastrointestinal system are also provided for oral or rectal administration. A method of generating a magnetic resonance image using the composition of the invention is also described.
摘要翻译：提供了用于分散磁响应性颗粒的基本上水合的低粘度载体。还提供口服或直肠给药的胃肠系统核磁成像对照培养基。还描述了使用本发明的组合物产生磁共振图像的方法。

12. 发明申请

WO1995002831A1 METHODS AND COMPOSITIONS FOR IMAGE CONTRAST ENHANCING 审中-公开
标题翻译：图像对比增强的方法和组合
公开(公告)号：WO1995002831A1
公开(公告)日：1995-01-26
申请号：PCT/GB1994001500
申请日：1994-07-11
申请人： COCKBAIN, Julian, Roderick, Michaelson , NYCOMED IMAGING AS , ERICCSON, Anders , FAHLVIK, Anne, Kjersti , HEMMINGSSON, Anders , WIKSTROM, Mats , OKSENDAL, Audun , BACH-GANSMO, Tore
发明人： COCKBAIN, Julian, Roderick, Michaelson , NYCOMED IMAGING AS
IPC分类号： G01R33/28
CPC分类号： G01R33/5601 , A61K49/06 , Y10S514/836
摘要： This invention relates to improvements in and relating to magnetic resonance imaging of the human or non-human body, in particular to a method in which positive and negative contrast agents are administered to enhance image contrast.
摘要翻译：本发明涉及人体或非人体的磁共振成像的改进和涉及，特别涉及其中施用正和负造影剂以增强图像对比度的方法。

13. 发明申请

WO1999039748A1 TARGETING IMMUNOREAGENTS USEFUL IN THERAPEUTIC AND DIAGNOSTIC COMPOSITIONS AND METHODS 审中-公开
标题翻译：有针对性的治疗和诊断组合物和方法中的免疫缺陷病
公开(公告)号：WO1999039748A1
公开(公告)日：1999-08-12
申请号：PCT/GB1999000396
申请日：1999-02-08
申请人： NYCOMED IMAGING AS , MATTHEWS, Derek, Peter
发明人： NYCOMED IMAGING AS , MATTHEWS, Derek, Peter , SNOW, Robert, A. , DELECKI, Daniel, J. , SHAH, Chandra , BLACK, Christopher , WOLFE, Henry
IPC分类号： A61K51/10
CPC分类号： A61K49/14 , A61K49/085 , A61K51/0482 , A61K51/088 , A61K51/1093
摘要： A targeting immunoreagent comprising a metal ion, a residue of a complexing agent and an immunoreactive group linked to said complNxing agent having structure (I), wherein each R and R1 is independently selected from hydrogen, alkyl, alkoxy, hydroxyalkyl, alkoxyalkyl, hydroxyalkyloxy, alkoxyalkyloxy, alkylthio, alkylthioalkyl, alkylthioalkyloxy, hydroxyalkylthio, hydroxyalkylthioalkyl, hydroxyalkylthioalkyloxy, N,N--dialkylamino, N-(hydroxyalkyl)-N-alkylamino, N,N--bis(hydroyalkyl)amino, N,N-dialkylaminoalkyl, N--(hydroxyalkyl)-N-alkylaminoalkyl, N-N-bis(hydroxyalkyloaminoalkyl), alkylformamido, formamidoalkyl, aryl, alkylaryl, alkoxyaryl, hydroxyalkylaryl, alkoxyalkylaryl, hydroxyalkyloxyaryl, alkoxyalkyloxyaryl, alkylthioaryl, hydroxyalkylthioaryl, hydroxyalkylthioalkylaryl, hydroxyalkylthioalkyloxyaryl, aralkyl, aralkyloxy, alkoxyaralkyl, alkoxyaralkyloxy, aryloxy, alkylarylaxy, alkoxyaryloxy, and heterocyclyl; each Q is independently selected from hydrogen, alkyl, hydroxyl, carboxyl, carboxyalkyl, hydroxyalkyl, alkylthioalkyl, sulfhydryl, thioalkyl, alkoxy, alkylthio, alkylamino, aminoalkyl, aminoalkylaminoalkyl, hydroxy-alkylaminoalkyl, hydroxylaminoalkyl, hydroxamido, formamidoalkyl, alkylformamido, aryl, including substituted aryl, aryloxy, heterocyclyl, carbonyliminodiacetic acid, methyle eiminodiacetic acid, methylenethioethylene-iminodiacetic acid, carboxyalkylthioalkyl, a residue of ethylenediaminetetraascetic acid (EDTA), a residue of diethylenetriaminepentaacetic acid (DTPA), hydrazinylidenediacetic acid, and a salt of any of the foregoing acids; each Z is independently selected from a heteroatom with a valence of two, a heteroatom with a valence of three, an alkylene group, an alkylene group bonded to a heteroatom having a valence of two, and an alkylene group bonded to a heteroatom having a valence of three; each X is independently selected from nitrogen and a residue of an alkylene group; each W is independently selected from hydrogen and a substituent that comprises a protein reactive group; each L' is independently selected from a chemical bond and an intra-ring linking group; each L is independently selected from a residue of an alkylene group and an extra-ring linking group; n is 1, 2, 3 or 4; and each p is independently 0, 1, 2, 3 or 4; provided that only one W is a protein reactive group; the L bonded to the W that is a protein reactive group contains 1, 2, or 3 carbon atoms and connects X to a heteroatom capable of participating in the chelation of a metal ion; and when X is a nitrogen and a heteroatom of Z is bonded to X, the heteroatom of Z is also nitrogen; and the immunoreactive group is an ST receptor binding moiety.
摘要翻译：一种靶向免疫反应剂，其包含金属离子，络合剂的残基和与具有结构（I）的所述补偿剂连接的免疫反应性基团，其中每个R和R 1独立地选自氢，烷基，烷氧基，羟基烷基，烷氧基烷基，羟基烷氧基，烷氧基烷氧基，烷硫基烷基，烷硫基烷基，烷硫基烷氧基，羟烷基硫代，羟烷基硫代烷基，羟烷基硫代烷氧基，N，N-二烷基氨基，N-（羟烷基）-N-烷基氨基，N，N-二（烷基）氨基，N， - （羟基烷基）-N-烷基氨基烷基，NN-双（羟基烷基氨基烷基），烷基酰氨基，甲酰氨基烷基，芳基，烷基芳基，烷氧基芳基，羟基烷基芳基，烷氧基烷基芳基，羟基烷氧基芳基，烷氧基烷氧基芳基，烷硫基芳基，羟烷基硫代芳基，羟基烷基硫代烷基芳基，羟烷基硫代烷氧基芳基，芳烷基，芳烷氧基，烷氧基烷基，烷氧基烷氧基，芳氧基，烷基芳基，烷氧基氧基和杂环基; 每个Q独立地选自氢，烷基，羟基，羧基，羧基烷基，羟基烷基，烷硫基烷基，巯基，硫代烷基，烷氧基，烷硫基，烷基氨基，氨基烷基，氨基烷基氨基烷基，羟基 - 烷基氨基烷基，羟基氨基烷基，羟基酰氨基，甲酰氨基烷基，烷基酰氨基，芳基，芳氧基，杂环基，羰基亚氨基二乙酸，甲基亚氨基二乙酸，亚甲基亚乙基 - 亚氨基二乙酸，羧基烷基硫代烷基，乙二胺四乙酸（EDTA）的残基，二亚乙基三胺五乙酸（DTPA）的残基，亚肼基二乙酸和任何上述酸 ; 每个Z独立地选自二价的杂原子，二价的杂原子，三价的杂原子，亚烷基，与二价的杂原子键合的亚烷基，以及与具有化合价的杂原子键合的亚烷基的三每个X独立地选自氮和亚烷基的残基; 每个W独立地选自氢和包含蛋白质反应性基团的取代基; 每个L'独立地选自化学键和环内连接基团; 每个L独立地选自亚烷基和环外连接基团的残基; n为1,2,3或4; 并且每个p独立地为0,1,2,3或4; 条件是只有一个W是蛋白质反应性基团; 与蛋白质反应性基团的W键合的L含有1,2或3个碳原子，并将X连接到能够参与金属离子螯合的杂原子; 当X是氮并且Z的杂原子与X键合时，Z的杂原子也是氮; 并且免疫反应性基团是ST受体结合部分。

14. 发明申请

WO1998023296A1 PROCESS FOR THE PRODUCTION OF IODINATED ORGANIC X-RAY CONTRAST AGENTS 审中-公开
标题翻译：生产有机X射线对比剂的方法
公开(公告)号：WO1998023296A1
公开(公告)日：1998-06-04
申请号：PCT/GB1997003205
申请日：1997-11-21
申请人： NYCOMED IMAGING AS , COCKBAIN, Julian , MALTHE-SORENSSEN, Dick , SCHELVER HYNI, Anne, Cathrine , AABYE, Arne , BJORSVIK, Hans, René , BREKKE, Geir , SJOGREN, Carl, Einar
发明人： NYCOMED IMAGING AS , COCKBAIN, Julian
IPC分类号： A61K49/04
CPC分类号： A61K49/0433
摘要： The present invention provides a process for the production of an organic iodinated X-ray contrast agent, characterized in that process control comprises vibrational (e.g. infrared, Raman or preferably near-infrared) spectroscopic monitoring of the reaction mixture in at least one of the process steps, preferably one of the final reaction steps.
摘要翻译：本发明提供了一种生产有机碘化X射线造影剂的方法，其特征在于，所述方法控制包括在所述方法中的至少一个中对所述反应混合物的振动（例如红外，拉曼或优选近红外）光谱监测步骤，优选最后一个反应步骤。

15. 发明申请

WO1998023295A1 METHOD OF IMAGING 审中-公开
标题翻译：成像方法
公开(公告)号：WO1998023295A1
公开(公告)日：1998-06-04
申请号：PCT/GB1997003204
申请日：1997-11-21
申请人： NYCOMED IMAGING AS , COCKBAIN, Julian , McINTIRE, Gregory, Lynn , LADD, David, Lee , BACON, Edward, Richard , TONER, John, Luke , NA, George, Chao
发明人： NYCOMED IMAGING AS , COCKBAIN, Julian
IPC分类号： A61K49/00
CPC分类号： A61K49/0054 , A61K49/0433 , A61K49/128
摘要： The invention provides a method for contrast enhanced imaging of at least part of the lymphatic system of a human or animal body which comprises administering a diagnostically effective contrast agent to said body and generating a contrast enhanced image of at least part of the lymphatic system of said body, characterised in that said agent is a water-soluble polymeric material having a molecular weight of at least 1kD and is administered indirectly but parenterally.
摘要翻译：本发明提供了一种用于对人或动物体的至少部分淋巴系统进行造影增强成像的方法，其包括向所述身体施用诊断有效的造影剂并产生所述淋巴系统的至少一部分的对比度增强图像其特征在于，所述试剂是分子量至少为1kD的水溶性聚合物材料，并间接或非肠道给药。

16. 发明申请

WO1997049409A1 CHELATING AGENTS AND THEIR METAL CHELATES FOR TREATING FREE RADICALS INDUCED CONDITIONS 审中-公开
标题翻译：调理剂及其金属螯合剂用于治疗自由放射诱导条件
公开(公告)号：WO1997049409A1
公开(公告)日：1997-12-31
申请号：PCT/GB1997001722
申请日：1997-06-24
申请人： NYCOMED IMAGING AS , KARLSSON, Jan, Olof, Gustav , JYNGE, Per , TOWART, Robertson
发明人： NYCOMED IMAGING AS
IPC分类号： A61K31/675
CPC分类号： A61K33/32 , A61K31/198 , A61K31/28 , A61K31/4415 , A61K31/444 , A61K31/675 , Y10S514/836 , A61K2300/00
摘要： The invention provides the use of a compound of formula (I) or a metal chelate or salt thereof in the manufacture of a therapeutic agent for use in the treatment or prophylaxis of conditions resulting from the presence of free radicals in the human or non-human animal body (wherein in formula (I): each R independently represents hydrogen or -CH2COR ; R represents hydroxy, optionally hydroxylated alkoxy, amino or alkylamido; each R independently represents a group XYR ; X represents a bond, or a C1-3 alkylene or oxoalkylene group optionally substituted by a group R ; Y represents a bond, an oxygen atom or a group NR ; R is a hydrogen atom, a group COOR , an alkyl, alkenyl, cycloalkyl, aryl or aralkyl group optionally substituted by one or more groups selected from COOR , CONR 2, NR 2, OR , =NR , =O, OP(O) (OR )R and OSO3M; R is hydroxy, an optionally hydroxylated, optionally alkoxylated alkyl or aminoalkyl group; R is a hydrogen atom or an optionally hydroxylated, optionally alkoxylated alkyl group; M is a hydrogen atom or one equivalent of a physiologically tolerable cation; R represents a C1-8 alkylene group, a 1,2-cycloalkylene group, or a 1,2-arylene group; and each R independently represents hydrogen or C1-3 alkyl). Such compounds are particularly effective in relieving symptoms associated with reperfusion of ischemic tissue and in treating or preventing radiation-induced injury.
摘要翻译：本发明提供式（I）化合物或其金属螯合物或其盐在制备治疗剂中的用途，所述治疗剂用于治疗或预防由人或非人的自由基存在引起的病症动物体（其中在式（I）中：每个R 1独立地表示氢或-CH 2 COR 5; R 5表示羟基，任选羟基化的烷氧基，氨基或烷基酰氨基;每个R 2独立地表示基团XYR X表示键，或任选被基团R 7取代的C 1-3亚烷基或氧代亚烷基; Y表示键，氧原子或基团NR 6; R 6为氢原子，COOR 8基团，任选被一个或多个选自COOR 8，CONR 8，NR 8或OR 8的基团取代的烷基，烯基，环烷基，芳基或芳烷基，= NR 8，= O，OP（O）（OR 8）R 7和OSO 3 M; R 7是羟基，任选羟基化，任选烷氧基化的烷基或氨基烷基; R 8，是一个氢原子或一个选择烷基羟基化，任选烷氧基化烷基; M是氢原子或1当量的生理上可耐受的阳离子; R 3表示碳原子数1〜8的亚烷基，1,2-亚环烷基或1,2-亚芳基。并且每个R 4独立地表示氢或C 1-3烷基）。这些化合物在缓解与缺血组织的再灌注相关的症状以及治疗或预防辐射诱发的损伤方面特别有效。

17. 发明申请

WO1995021631A1 IMPROVEMENTS IN OR RELATING TO CONTRAST AGENTS 审中-公开
标题翻译：改进或与对比剂相关
公开(公告)号：WO1995021631A1
公开(公告)日：1995-08-17
申请号：PCT/GB1995000316
申请日：1995-02-15
申请人： NYCOMED IMAGING AS , HOLMES, Michael, John , HOLMES, Michael, John , DUGSTAD, Harald , FOSS, Per, Antonius , KLAVENESS, Jo , RONGVED, Pål , SKURTVEIT, Roald , SOLBERG, Jan , AUKRUST, Inger, Reidun, Fjeldskaar
发明人： NYCOMED IMAGING AS , HOLMES, Michael, John , HOLMES, Michael, John
IPC分类号： A61K49/00
CPC分类号： A61K49/223
摘要： Microparticulate contrast agents comprising gas or a gas precursor encapsulated by a non-polymeric and non-polymerisable wall-forming material are readily characterisable materials exhibiting surprising structural integrity and stability.
摘要翻译：包含由非聚合和不可聚合的壁形成材料包封的气体或气体前体的微颗粒造影剂是显示令人惊奇的结构完整性和稳定性的易于表征的材料。

18. 发明申请

WO1994006477A1 IMPROVEMENTS IN OR RELATING TO CONTRAST AGENTS 审中-公开
标题翻译：改进或与对比剂相关
公开(公告)号：WO1994006477A1
公开(公告)日：1994-03-31
申请号：PCT/GB1993001861
申请日：1993-09-03
申请人： HOLMES, Michael, John , NYCOMED IMAGING AS , KLAVENESS, Jo , RONGVED, Pål , JOHANSEN, John, Henrik , FOSS, Per, Antonius , HOGSET, Anders , HVOSLEF, Anne, Marie
发明人： HOLMES, Michael, John , NYCOMED IMAGING AS
IPC分类号： A61K49/00
CPC分类号： A61K49/1821 , A61K49/18 , A61K49/223
摘要： Proteinaceous gas- or gas precursor-containing microbubble contrast agents, e.g. for use in ultrasound and/or MR imaging, in which the protein matrix is crosslinked by reaction with a bifunctional aldehyde (e.g. a dialdehyde such as glutaraldehyde or an (alpha),(beta)-unsaturated aldehyde such as acrolein) in an aqueous medium at substantially neutral pH exhibit improved (in vivo) and storage stabilities, particularly if the matrix is also reacted with a Schiff's base reducing agent such as a borohydride. Modification of the size distribution of such crosslinked proteinaceous gas-containing contrast agents, e.g. to reduce the mean size of the microbubbles, further enhances their stability and permits preparation of novel contrast agents having a particularly narrow microbubble size distribution.
摘要翻译：含蛋白质气体或气体前体的微泡造影剂，例如用于超声和/或MR成像，其中蛋白质基质通过与水性介质中的双官能醛（例如二醛如戊二醛或（α），（β-）不饱和醛如丙烯醛反应）反应而交联在基本上中性的pH下表现出改善的（体内）和储存稳定性，特别是如果基质也与席夫碱还原剂如硼氢化钠反应。这种交联的蛋白质含气体造影剂的尺寸分布的改变，例如为了减少微泡的平均尺寸，进一步提高了它们的稳定性并且允许制备具有特别窄的微泡尺寸分布的新型造影剂。

19. 发明申请

WO1993021960A1 NHR CONTRAST AGENTS 审中-公开
标题翻译： NHR对比剂
公开(公告)号：WO1993021960A1
公开(公告)日：1993-11-11
申请号：PCT/GB1993000843
申请日：1993-04-22
申请人： COCKBAIN, Julian , NYCOMED IMAGING AS , KLAVENESS, Jo , BERG, Arne
发明人： COCKBAIN, Julian , NYCOMED IMAGING AS
IPC分类号： A61K49/00
CPC分类号： A61K49/06
摘要： The invention provides parenterally administrable, liver-specific MR imaging contrast media comprising Mn(II) chelates of N,N'-EDTA bisamides.
摘要翻译：本发明提供包含N，N'-EDTA双酰胺的Mn（II）螯合物的肠胃外可施用的肝特异性MR成像造影剂。

20. 发明申请

WO1993013809A1 IMPROVEMENTS IN CONTRAST AGENTS, CONSISTING OF GALACTOSE PARTICLES 审中-公开
标题翻译：对比剂的改进，包括胶质糖颗粒
公开(公告)号：WO1993013809A1
公开(公告)日：1993-07-22
申请号：PCT/EP1993000028
申请日：1993-01-08
申请人： HOLMES, Michael, John , NYCOMED IMAGING AS , KLAVENESS, Jo , RONGVED, Pål , STUBBERUD, Lars
发明人： HOLMES, Michael, John , NYCOMED IMAGING AS
IPC分类号： A61K49/00
CPC分类号： A61K49/1818 , A61K49/1821 , A61K49/223 , A61K49/226
摘要： Contrast agents comprising water-soluble microbubble-generating carbohydrate microparticles in admixture with at least 10 % w/w relative to the overall composition of a non-surface active material which is less water-soluble than the carbohydrate exhibit useful levels of contrast efficiency and/or stability and may be used in diagnostic applications such as ultrasound and MR imaging.
摘要翻译：包含水溶性微泡生成碳水化合物微粒的造影剂相对于非碳酸钙水溶性较低的非表面活性物质的总体组合物与至少10％w / w的混合物表现出有用的对比度效率水平和/ 或稳定性，并可用于诸如超声和MR成像的诊断应用中。

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