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    • 12. 发明申请
    • SEMICONDUCTOR DEVICE FOR DETECTING FLUORESCENT PARTICLES
    • 用于检测荧光颗粒的半导体器件
    • WO2015177373A1
    • 2015-11-26
    • PCT/EP2015/061479
    • 2015-05-22
    • IMEC VZW
    • VAN DORPE, PolLAGAE, LiesbetPEUMANS, PeterSTASSEN, AndimHELIN, PhilippeDU BOIS, BertSEVERI, Simone
    • G01N21/64
    • G01N21/6428G01N21/6454G01N21/648G01N21/7703G01N2201/0873
    • The invention provides an integrated semiconductor device (100) for detecting fluorescent tags, comprising a first layer (101) comprising a detector element (107), a second layer (102) located on top of the first layer (101) and comprising a rejection filter, a third layer (103) located on top of the second layer (102) and being fabricated from a dielectric material, a fourth layer (104) located on top of the third layer (103) and comprising an optical waveguide, and furthermore a fifth layer located on top of the fourth layer comprising a microfluidic channel (106). The optical waveguide is configured and positioned such that the micro-fluidic channel (106) is illuminated with an evanescent tail of excitation light guided by the optical waveguide. The rejection filter is positioned such that fluorescence from activated fluorescent tags present on top of the fourth layer (104) is filtered before falling onto the detector element (107). The rejection filter is configured to reject the wavelength range of the excitation light and configured to transmit the wavelength range of fluorescence from the activated fluorescent tags towards the detector element (107).
    • 本发明提供了一种用于检测荧光标签的集成半导体器件(100),包括:第一层(101),包括检测器元件(107),位于第一层(101)顶部的第二层(102) 过滤器,位于第二层(102)的顶部并由电介质材料制成的第三层(103),位于第三层(103)的顶部上并包括光波导的第四层(104),此外 位于第四层顶部的第五层包括微流体通道(106)。 光波导被配置和定位成使得微流体通道(106)被由光波导引导的激发光的渐逝尾部照亮。 排斥滤光器被定位成使得存在于第四层(104)的顶部上的来自活化荧光标签的荧光在落到检测器元件(107)之前被过滤。 拒绝滤波器被配置为拒绝激发光的波长范围并且被配置为将荧光的波长范围从激活的荧光标签朝向检测器元件(107)传输。
    • 15. 发明申请
    • TIME, SPACE DIGITALLY RESOLVED QUANTIFICATION OF LUMINESCENT TARGETS
    • 时间空间数字化解决目标的数量
    • WO2017001262A1
    • 2017-01-05
    • PCT/EP2016/064441
    • 2016-06-22
    • IMEC VZW
    • PEUMANS, PeterLAGAE, LiesbetVAN ROY, WillemSTAKENBORG, TimVAN DORPE, Pol
    • G01N21/64
    • G01N21/6408G01N21/6456G01N21/648
    • A sensor device (100) for quantifying luminescent targets. The device comprises a light source (111) for exciting the targets, thus generating luminescence signals, and a detector (120) for detecting these signals of the targets in a cell (310), resulting in a detected signal comprising a desired signal and a background signal. The detector (120) has a spatial cell resolution and/or a time resolution that is so high that only a limited number of targets will be present in the cell when measuring at low concentration and/or that only a limited number of targets add to the cell in between two measurements. A change in the number of targets in the cell can be observed in the detected signal. The device comprises a processor (140) configured to distinguish the desired and the background signal, and to combine the detected signals of the different cells and/or moments in time, to quantify the targets.
    • 一种用于量化发光靶的传感器装置(100)。 该装置包括用于激发目标的光源(111),从而产生发光信号,以及用于检测单元(310)中的目标的这些信号的检测器(120),从而产生包括期望信号和 背景信号。 检测器(120)具有如此之高的空间单元分辨率和/或时间分辨率,以便在以低浓度测量时只有有限数量的目标将存在于单元格中,和/或仅有限数量的目标添加到 两个测量之间的单元格。 在检测到的信号中可以观察到单元格中的目标数量的变化。 该设备包括被配置为区分期望和背景信号并且将检测到的不同小区和/或时刻的信号组合在一起以量化目标的处理器(140)。
    • 16. 发明申请
    • MODULATION OF LUMINESCENT DYES
    • 发光染料的调制
    • WO2017001536A1
    • 2017-01-05
    • PCT/EP2016/065232
    • 2016-06-30
    • IMEC VZW
    • PEUMANS, PeterLAGAE, LiesbetVAN ROY, WillemSTAKENBORG, TimVAN DORPE, Pol
    • G01N21/17G01N21/64
    • G01N21/1717G01N21/645G01N21/648G01N2021/1731
    • A sensor device (100) for quantifying luminescent targets comprises a light source (111), a detector (120), a modulator (130), and a processor (140). The light source (111) is adapted for exciting the luminescent target. The detector (120) is adapted for detecting the luminescence of the luminescent target resulting in a measured signal which comprises a desired signal originating from the luminescent target and a background signal. The modulator (130) is adapted for modulating a physical parameter resulting in a modulation of the desired signal which is different from the modulation of the background signal. The processor (140) is configured to correlate the modulation of the physical parameter with the modulation of the desired signal and/or the modulation of the background signal.
    • 用于量化发光靶的传感器装置(100)包括光源(111),检测器(120),调制器​​(130)和处理器(140)。 光源(111)适于激发发光靶。 检测器(120)适于检测发光目标的发光,从而产生包含源自发光目标的期望信号和背景信号的测量信号。 调制器(130)适于调制产生与背景信号的调制不同的期望信号的调制的物理参数。 处理器(140)被配置为将物理参数的调制与期望信号的调制和/或背景信号的调制相关联。