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    • 20. 发明申请
    • ANTI-MICROBIAL NITRILE AND ITS PRODUCTION
    • 抗微生物及其生产
    • WO1986006369A1
    • 1986-11-06
    • PCT/EP1986000220
    • 1986-04-16
    • HENKEL KOMMANDITGESELLSCHAFT AUF AKTIENKRAUSE, Horst-JürgenLEINEN, Hans-TheoLEHMANN, Rudolf
    • HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN
    • C07C121/34
    • C07C255/00A01N37/42
    • It is possible to obtain new 2.2-dibromo-3-oxonitriles of formula (I): R - CO - CBr2 - CN, in which R signifies, as applicable, a substitued aliphatic, cycloaliphatic, aromatic or heterocyclic group, excepting a phenyl group substituted with 1 to 3 chlorine atoms, by converting a carboxylic acid ester of formula (II): R - CO - OR', in which R has the signification given for formula (I), and in which R' represents a straight-chained or branched alkyl group with 1 to 4 carbon atoms; the conversion being effected in the presence of a strong base with acetone nitrile; by isolating the 3-oxonitrile produced from the reaction mixture and converting it in a solvent which is inert to bromine and in the presence of a hydrogen bromide acceptor, if necessary accompanied by cooling with bromine, and by isolating the 2.2-dibromo-3-oxonitrile of formula (I) from the reaction mixture.
    • 可以得到式(I)的新的2,2-二溴-3-氧代腈:R-CO-CBr2-CN,其中R表示适用的取代的脂族,脂环族,芳族或杂环基团,除了苯基 通过转化式(II)的羧酸酯:R-CO-OR',其中R具有式(I)给出的含义,其中R'表示直链 或具有1至4个碳原子的支链烷基; 该转化是在有丙酮腈的强碱存在下进行的; 通过分离由反应混合物产生的3-氧杂腈,并将其在对溴惰性的溶剂中并在溴化氢受体存在下,如果需要伴随着用溴冷却,并通过分离2.2-二溴-3- 式(I)的氧腈由反应混合物中得到。