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11. 发明申请

WO2013087699A1 ANTIBODIES AGAINST HUMAN CSF-1R AND USES THEREOF 审中-公开
标题翻译：抗人CSF-1R的抗体及其用途
公开(公告)号：WO2013087699A1
公开(公告)日：2013-06-20
申请号：PCT/EP2012/075241
申请日：2012-12-12
申请人： F. HOFFMANN-LA ROCHE AG , FERTIG, Georg , FIDLER, Alexander , KALUZA, Klaus , RIES, Carola , SEEBER, Stefan , THOMAS, Marlene
发明人： FERTIG, Georg , FIDLER, Alexander , KALUZA, Klaus , RIES, Carola , SEEBER, Stefan , THOMAS, Marlene
IPC分类号： C07K16/28
CPC分类号： C07K16/2866 , C07K2317/33 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to antibodies against human CSF-1R (CSF-1R antibody), methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
摘要翻译：本发明涉及针对人CSF-1R（CSF-1R抗体）的抗体，其制备方法，含有所述抗体的药物组合物及其用途。

12. 发明申请

WO2009053038A2 COMBINATION THERAPY OF A TYPE II ANTI-CD20 ANTIBODY WITH A PROTEASOME INHIBITOR 审中-公开
标题翻译： II型抗CD20抗体与蛋白酶抑制剂的组合治疗
公开(公告)号：WO2009053038A2
公开(公告)日：2009-04-30
申请号：PCT/EP2008/008919
申请日：2008-10-22
申请人： F. HOFFMANN-LA ROCHE AG , GLYCART BIOTECHNOLOGY AG , FERTIG, Georg , FRIESS, Thomas , KLEIN, Christian , UMANA, Pablo
发明人： FERTIG, Georg , FRIESS, Thomas , KLEIN, Christian , UMANA, Pablo
IPC分类号： A61P35/00 , A61K39/395 , A61K31/00
CPC分类号： A61K39/39558 , A61K31/69 , A61K47/00 , A61K2039/505 , C07K16/2887 , C07K2317/24 , C07K2317/41 , A61K2300/00
摘要： The present invention is directed to the use an type II anti-CD20 antibody for the manufacture of a medicament for the treatment of cancer, especially of CD20 expressing cancers in combination with a proteasome inhibitor.
摘要翻译：本发明涉及II型抗CD20抗体在制备用于治疗癌症，特别是与蛋白酶体抑制剂组合的CD20表达癌症的药物中的用途。

13. 发明申请

WO2004087693A1 OXIME DERIVATIVES AND THEIR USE AS PHARMACEUTICALLY ACTIVE AGENTS 审中-公开
标题翻译： OXIME衍生物及其作为药物活性剂的用途
公开(公告)号：WO2004087693A1
公开(公告)日：2004-10-14
申请号：PCT/EP2004/003498
申请日：2004-04-02
申请人： F. HOFFMANN-LA ROCHE AG , FERTIG, Georg , HERTING, Frank , KUBBIES, Manfred , LIMBERG, Anja , REIFF, Ulrike , WEIDNER, Michael
发明人： FERTIG, Georg , HERTING, Frank , KUBBIES, Manfred , LIMBERG, Anja , REIFF, Ulrike , WEIDNER, Michael
IPC分类号： C07D409/12
CPC分类号： A61K31/38 , A61K31/44 , C07D333/38 , C07D409/12
摘要： Objects of the present invention are the compounds of formula I, their pharmaceutically acceptable salts as well as their enantiomeric forms, diastereoisomers and racemates; the preparation of the above-mentioned compounds, medicaments containing them and their manufacture, as well as the use of the above-mentioned compounds as inhibitors of histone deacetylase ( HDAC ) and therefore in the control or prevention of illnesses and disorders as mentioned above, or in the manufacture of corresponding medicaments.
摘要翻译：本发明的目的是式I化合物，其药学上可接受的盐以及它们的对映体形式，非对映异构体和外消旋体; 上述化合物的制备，含有它们的药物及其制造，以及上述化合物作为组蛋白脱乙酰酶（HDAC）的抑制剂的用途，因此用于控制或预防上述疾病和病症，或制造相应的药物。

14. 发明申请

WO2004052838A1 ARYLENE-CARBOXYLIC ACID (2-AMINO-PHENYL)-AMIDE DERIVATIVES AS PHARMACEUTICAL AGENTS 审中-公开
标题翻译：作为药物代谢物的亚甲基 - 羧酸（2-氨基苯基）酰胺衍生物
公开(公告)号：WO2004052838A1
公开(公告)日：2004-06-24
申请号：PCT/EP2003/013941
申请日：2003-12-09
申请人： F. HOFFMANN-LA ROCHE AG
发明人： FERTIG, Georg , HERTING, Frank , KOERNER, Matthias , KUBBIES, Manfred , LIMBERG, Anja , REIFF, Ulrike , WEIDNER, Michael
IPC分类号： C07C233/77
CPC分类号： C07D213/82 , C07C237/42 , C07C275/24 , C07C2601/02 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07D333/38
摘要： The present invention describes compounds of general formula (I), a process for their manufacture, medicaments containing them and their manufacture as well as the use of these compounds as pharmaceutical agents. The compounds according to this invention show antiproliferative and differentiation- inducing activity, which results in inhibition of tumor cell proliferation, induction of apoptosis and inhibition of invasion.
摘要翻译：本发明描述了通式（I）的化合物，其制备方法，含有它们的药物及其制备以及这些化合物作为药剂的用途。根据本发明的化合物显示抗增殖和分化诱导活性，其导致抑制肿瘤细胞增殖，诱导凋亡和抑制侵袭。

15. 发明申请

WO2017055404A1 BISPECIFIC ANTIBODIES SPECIFIC FOR PD1 AND TIM3 审中-公开
标题翻译： PD1和TIM3的特异性抗体
公开(公告)号：WO2017055404A1
公开(公告)日：2017-04-06
申请号：PCT/EP2016/073192
申请日：2016-09-29
申请人： F. HOFFMANN-LA ROCHE AG , HOFFMANN-LA ROCHE INC.
发明人： CODARRI-DEAK, Laura , FERTIG, Georg , FISCHER, Jens , KLEIN, Christian , LEVITSKI, Viktor , LIFKE, Valeria , PERRO, Mario , REGULA, Joerg Thomas , SCHLOTHAUER, Tilman , SEEBER, Stefan , UMAÑA, Pablo , WUENSCHE, Ildiko , ZWICK, Adrian
IPC分类号： C07K16/28
CPC分类号： C07K16/2818 , A61K2039/505 , C07K16/2803 , C07K2317/24 , C07K2317/31 , C07K2317/41 , C07K2317/51 , C07K2317/515 , C07K2317/52 , C07K2317/55 , C07K2317/56 , C07K2317/66 , C07K2317/71 , C07K2317/76 , C07K2317/77 , C07K2317/92
摘要： The invention relates to bispecific antibodies comprising a first antigen-binding site that specifically binds to PD1 and a second antigen-binding site that specifically binds to TIM3, in particular to bispecific antibodies, wherein the bispecific antibody binds to TIM3 with a lower binding affinity when compared to the binding to PD1. The invention further relates to methods of producing these molecules and to methods of using the same.
摘要翻译：本发明涉及双特异性抗体，其包含特异性结合PD1的第一抗原结合位点和特异性结合TIM3的第二抗原结合位点，特别是双特异性抗体，其中双特异性抗体以较低的结合亲和力结合TIM3，与PD1的结合相比。本发明还涉及生产这些分子的方法及其使用方法。

16. 发明申请

WO2004069803A2 NEW MONO-ACYLATED O-PHENYLENDIAMINES DERIVATIVES 审中-公开
标题翻译：新单酚O-邻苯二甲酸衍生物
公开(公告)号：WO2004069803A2
公开(公告)日：2004-08-19
申请号：PCT/EP2004/001044
申请日：2004-02-05
申请人： F. HOFFMANN-LA ROCHE AG
发明人： FERTIG, Georg , HERTING, Frank , KUBBIES, Manfred , LIMBERG, Anja , REIFF, Ulrike , WEIDNER, Michael
IPC分类号： C07D213/90
CPC分类号： C07D213/82 , C07C233/80 , C07C2601/02 , C07D333/38
摘要： Objects of the present invention are new mono-acylated o-phenylendiamines derivatives of formula (A) wherein Ar is thiophen-2,5-diyl, pyridine-2,5-diyl, pyridine-5,2-diyl, pyridine-2,6-diyl, pyridine-2,4-diyl or 1,4-phenylene, R 1 , R 2 independently from each other represent hydrogen, C 1-12 -alkyl, C 2-12 -alkenyl, C 2-12 -alkynyl, C 3-12 -cycloalkyl, the alkyl, alkenyl, alkynyl and cycloalkyl groups being optionally mono or multiple substituted by hydroxy, halogen, C 3-12 -cycloalkyl, alkoxy, alkylsulfanyl, acyloxy, alkoxycarbonyl, acyl, C 1-6 -alkyl-NH-C(O)-, C 1-6 -alkyl-C(O)NH- or -NR 3 R 4 , or alternatively R 1 is hydrogen, and R 2 is hydroxyl, alkoxy, C 2- C 12 -alkenyloxy or phenoxy, which phenoxy group is optionally substituted with methyl, methoxy, halogen, nitro, cyano, trifluoromethyl, ethenyl or -C(O)-O-CH 3 , provided that if R 2 is hydroxy, Ar is not thiophen-2,5-diyl; and R 3 and R 4 independently from each other represent hydrogen or C 1 - 6 -alkyl, or wherein R 3 and R 4 together with the nitrogen-atom to which they are attached form a ring, which ring is monosubstituted by oxo and which ring may contain a further heteroatom, and pharmaceutically acceptable salts thereof, as well as processes for the manufacturing of these compounds, pharmaceutical compositions containing such compounds and their use in the manufacture of drugs for the treatment of diseases such as cancer.
摘要翻译：本发明的目的是式（A）的新的单酰化邻苯基苯胺衍生物，其中Ar是噻吩-2,5-二基，吡啶-2,5-二基，吡啶-5,2-二基，吡啶-2， 6-二基，吡啶-2,4-二基或1,4-亚苯基，R 1，R 2彼此独立地表示氢，C 1-12 - 烷基，C 2-12 - 烯基，C 2-12 - 炔基，C 3-12 - 环烷基，烷基，烯基，炔基和环烷基任选被羟基，卤素，C 3-12 - 环烷基，烷氧基，烷基硫烷基，酰氧基，烷氧基羰基，酰基，C 1-6 - NH-C（O） - ，C 1-6 - 烷基-C（O）NH-或-NR 3 R 4，或者R 1是氢，R 2是羟基，烷氧基， C 2 -C 12 - 烯氧基或苯氧基，该苯氧基任选被甲基，甲氧基，卤素，硝基，氰基，三氟甲基，乙烯基或-C（O）-O-CH 3取代，条件是如果R 2是羟基，则Ar 不是噻吩-2,5-二基; R 3和R 4彼此独立地表示氢或C 1-6 - 烷基，或其中R 3和R 4与它们所连接的氮原子一起形成环，其中环被氧基单取代，并且该环可以含有另外的杂原子及其药学上可接受的盐，以及制备这些化合物的方法，含有这些化合物的药物组合物及其在制备用于治疗疾病的药物中的用途作为癌症。

17. 发明申请

WO2019154890A1 ANTIBODIES BINDING TO GPRC5D 审中-公开
公开(公告)号：WO2019154890A1
公开(公告)日：2019-08-15
申请号：PCT/EP2019/052962
申请日：2019-02-07
申请人： F. HOFFMANN-LA ROCHE AG , HOFFMANN-LA ROCHE INC.
发明人： FERTIG, Georg , KLEIN, Christian , LORENZ, Stefan , XU, Wei , BERNASCONI, Marie-Luise , BUJOTZEK, Alexander
IPC分类号： C07K16/28 , A61K39/00 , A61P35/00
摘要： The present invention generally relates to antibodies that bind to GPRC5D, including bispecific antigen binding molecules e.g. for activating T cells. In addition, the present invention relates to polynucleotides encoding such antibodies, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the antibodies, and to methods of using them in the treatment of disease.

18. 发明申请

WO2003087026A1 2-(2,6-DICHLOROPHENYL)-DIARYLIMIDAZOLES 审中-公开
标题翻译： 2-（2,6-二氯苯基）-DIARYLIMIDAZOLES
公开(公告)号：WO2003087026A1
公开(公告)日：2003-10-23
申请号：PCT/EP2003/003969
申请日：2003-04-16
申请人： F. HOFFMANN-LA ROCHE AG
发明人： BRANDT, Michael , FERTIG, Georg , KRELL, Hans-Willi , VON HIRSCHHEYDT, Thomas , VOSS, Edgar
IPC分类号： C07C47/55
CPC分类号： C07D403/04 , C07C45/511 , C07C45/673 , C07C45/71 , C07C47/565 , C07C47/575 , C07C69/708 , C07C303/28 , C07C315/02 , C07C319/14 , C07D405/14 , C07F7/1852 , C07F9/65583 , C07C317/24 , C07C323/22 , C07C323/52 , C07C323/62 , C07C309/66 , C07C309/73
摘要： Compounds of the general formula (I) are valuable therapeutics for the treatment of cancer and cancer related diseases.
摘要翻译：通式（I）的化合物是用于治疗癌症和癌症相关疾病的有价值的治疗剂。

19. 发明申请

WO2021018925A1 ANTIBODIES BINDING TO GPRC5D 审中-公开
公开(公告)号：WO2021018925A1
公开(公告)日：2021-02-04
申请号：PCT/EP2020/071325
申请日：2020-07-29
申请人： F. HOFFMANN-LA ROCHE AG , HOFFMANN-LA ROCHE INC.
发明人： BERNASCONI, Marie-Luise , FERTIG, Georg , KLEIN, Christian , LORENZ, Stefan , XU, Wei
IPC分类号： C07K16/28
摘要： -176- Abstract The present invention generally relates to antibodies that bind to GPRC5D, including bispecific antigen binding molecules e.g. for activating T cells. In addition, the present invention relates to polynucleotides encoding such antibodies, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the antibodies, and to 5 methods of using them in the treatment of disease.

20. 发明申请

WO2021018859A2 ANTIBODIES BINDING TO GPRC5D 审中-公开
公开(公告)号：WO2021018859A2
公开(公告)日：2021-02-04
申请号：PCT/EP2020/071182
申请日：2020-07-28
申请人： F. HOFFMANN-LA ROCHE AG , HOFFMANN-LA ROCHE INC.
发明人： BUJOTZEK, Alexander , CHRISTOPEIT, Tony , FAUTI, Tanja , FERTIG, Georg , HAEGEL, Hélène Cécile , KLEIN, Christian , KRAFT, Thomas , LORENZ, Stefan , MAYOUX, Maud Léa , SCHNEIDER, Anneliese
IPC分类号： A61P35/00 , A61P35/02 , C07K16/28 , A61K2039/505 , C07K16/2809 , C07K16/2866 , C07K16/42 , C07K16/4283 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/524 , C07K2317/526 , C07K2317/55 , C07K2317/64 , C07K2317/66 , C07K2317/71 , C07K2317/75 , C07K2317/77 , C07K2317/90 , C07K2317/92 , C07K2319/03 , C07K2319/33
摘要： The present invention generally relates to antibodies that bind to GPRC5D, including bispecific antigen binding molecules e.g. for activating T cells. In addition, the present invention relates to polynucleotides encoding such antibodies, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the antibodies, and to methods of using them in the treatment of disease.

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