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11. 发明申请

WO02074156A8 COMPOSITIONS AND METHODS FOR THE THERAPY AND DIAGNOSIS OF COLON CANCER 审中-公开
标题翻译：用于治疗和诊断结肠癌的组合物和方法
公开(公告)号：WO02074156A8
公开(公告)日：2005-03-17
申请号：PCT/US0202870
申请日：2002-02-01
申请人： CORIXA CORP , JIANG YUQIU , CHENAULT RUTH A , XU JIANGCHUN , INDIRIAS CAROL YOSEPH , LODES MICHAEL J , SECRIST HEATHER , CARTER DARRICK , FANGER GARY R , SMITH CAROLE L , DURHAM MARGARITA , STOLK JOHN A
发明人： JIANG YUQIU , CHENAULT RUTH A , XU JIANGCHUN , INDIRIAS CAROL YOSEPH , LODES MICHAEL J , SECRIST HEATHER , CARTER DARRICK , FANGER GARY R , SMITH CAROLE L , DURHAM MARGARITA , STOLK JOHN A
IPC分类号： A61K38/00 , A61P31/00 , C07K14/47 , C12N15/12 , C07H21/04 , C12N15/00 , C12N15/63 , C12Q1/68
CPC分类号： C07K14/47 , A61K38/00
摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly colon cancer, are disclosed. Illustrative compositions comprise one or more colon tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly colon cancer.
摘要翻译：公开了用于治疗和诊断癌症，特别是结肠癌的组合物和方法。示例性组合物包含一种或多种结肠肿瘤多肽，其免疫原性部分，编码该多肽的多核苷酸，表达此类多肽的抗原呈递细胞，以及表达该多肽的细胞特异的T细胞。所公开的组合物可用于例如疾病，特别是结肠癌的诊断，预防和/或治疗。

12. 发明申请

WO2005051990A3 POLYNUCLEOTIDES OVEREXPRESSED IN BREAST CANCER CELLS, COMPOSITIONS AND METHODS FOR THE THERAPY AND DIAGNOSIS OF BREAST CANCER 审中-公开
标题翻译：在乳腺癌细胞中超表达的多核苷酸，用于治疗和诊断乳腺癌的组合物和方法
公开(公告)号：WO2005051990A3
公开(公告)日：2005-08-04
申请号：PCT/US2004038649
申请日：2004-11-18
申请人： CORIXA CORP , DILLON DAVIN C , JIANG YUQIU
发明人： DILLON DAVIN C , JIANG YUQIU
IPC分类号： A61K38/00 , A61K39/00 , C07K14/47 , C12N9/02 , G01N33/574 , G01N33/68
CPC分类号： C07K14/47 , A61K38/00 , A61K39/00 , A61K2039/5154 , A61K2039/5156 , A61K2039/5158 , C07K14/4748 , C07K16/3015 , C07K2319/00 , G01N33/505 , G01N33/574 , G01N33/57415 , G01N33/6878 , G01N2500/00
摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly breast cancer, are disclosed. Illustrative compositions comprise one or more breast tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly breast cancer.
摘要翻译：公开了用于治疗和诊断癌症，特别是乳腺癌的组合物和方法。示例性组合物包含一种或多种乳腺肿瘤多肽，其免疫原性部分，编码该多肽的多核苷酸，表达此类多肽的抗原呈递细胞，以及对表达该多肽的细胞特异的T细胞。所公开的组合物可用于例如疾病，特别是乳腺癌的诊断，预防和/或治疗。

13. 发明申请

WO0196388A3 COMPOSITIONS AND METHODS FOR THE THERAPY AND DIAGNOSIS OF COLON CANCER 审中-公开
标题翻译：用于治疗和诊断结肠癌的组合物和方法
公开(公告)号：WO0196388A3
公开(公告)日：2002-10-03
申请号：PCT/US0118557
申请日：2001-06-08
申请人： CORIXA CORP , JIANG YUQIU , HARLOCKER SUSAN L , SECRIST HEATHER
发明人： JIANG YUQIU , HARLOCKER SUSAN L , SECRIST HEATHER
IPC分类号： G01N33/53 , A61K31/7088 , A61K35/12 , A61K38/00 , A61K39/00 , A61K39/39 , A61K48/00 , A61P35/00 , A61P37/04 , A61P43/00 , C07K14/47 , C07K16/30 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/06 , C12N5/10 , C12N15/09 , C12Q1/68 , G01N33/566 , G01N33/574 , C07K14/82 , C12N15/12 , C12N15/62
CPC分类号： C07K14/4748 , A61K38/00 , A61K39/00 , A61K2039/505 , C07K2319/00 , C12Q1/6886 , C12Q2600/158
摘要： Compositions and methods for the therapy and diagnosis of cancer, such as colon cancer, are disclosed. Compositions may comprise one or more colon tumor proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a colon tumor protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as colon cancer. Diagnostic methods based on detecting a colon tumor protein, or mRNA encoding such a protein, in a sample are also provided.
摘要翻译：公开了用于治疗和诊断癌症的组合物和方法，例如结肠癌。组合物可以包含一种或多种结肠肿瘤蛋白，其免疫原性部分或编码这些部分的多核苷酸。或者，治疗组合物可以包含表达结肠肿瘤蛋白的抗原呈递细胞，或表达这种蛋白质的细胞特异的T细胞。这样的组合物可以用于例如预防和治疗诸如结肠癌的疾病。还提供了在样品中检测结肠肿瘤蛋白或编码这种蛋白的mRNA的诊断方法。

14. 发明申请

WO0196388A8 COMPOSITIONS AND METHODS FOR THE THERAPY AND DIAGNOSIS OF COLON CANCER 审中-公开
公开(公告)号：WO0196388A8
公开(公告)日：2002-03-21
申请号：PCT/US0118557
申请日：2001-06-08
申请人： CORIXA CORP , JIANG YUQIU , HARLOCKER SUSAN L , SECRIST HEATHER
发明人： JIANG YUQIU , HARLOCKER SUSAN L , SECRIST HEATHER
IPC分类号： G01N33/53 , A61K31/7088 , A61K35/12 , A61K38/00 , A61K39/00 , A61K39/39 , A61K48/00 , A61P35/00 , A61P37/04 , A61P43/00 , C07K14/47 , C07K16/30 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/06 , C12N5/10 , C12N15/09 , C12Q1/68 , G01N33/566 , G01N33/574
CPC分类号： C07K14/4748 , A61K38/00 , A61K39/00 , A61K2039/505 , C07K2319/00 , C12Q1/6886 , C12Q2600/158
摘要： Compositions and methods for the therapy and diagnosis of cancer, such as colon cancer, are disclosed. Compositions may comprise one or more colon tumor proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a colon tumor protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as colon cancer. Diagnostic methods based on detecting a colon tumor protein, or mRNA encoding such a protein, in a sample are also provided.

15. 发明申请

WO02060317A2 COMPOSITIONS AND METHODS FOR THE THERAPY AND DIAGNOSIS OF PANCREATIC CANCER 审中-公开
标题翻译：胰腺癌的治疗和诊断的组合物和方法
公开(公告)号：WO02060317A2
公开(公告)日：2002-08-08
申请号：PCT/US0202781
申请日：2002-01-30
申请人： CORIXA CORP , BENSON DARIN R , KALOS MICHAEL D , LODES MICHAEL J , PERSING DAVID H , HEPLER WILLIAM T , JIANG YUQIU
发明人： BENSON DARIN R , KALOS MICHAEL D , LODES MICHAEL J , PERSING DAVID H , HEPLER WILLIAM T , JIANG YUQIU
IPC分类号： A61K38/00 , C07K14/47 , C12N1/21 , A61B
CPC分类号： C07K14/47 , A61K38/00
摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly pancreatic cancer, are disclosed. Illustrative compositions comprise one or more pancreatic tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly pancreatic cancer.
摘要翻译：披露了用于治疗和诊断癌症，特别是胰腺癌的组合物和方法。说明性组合物包含一种或多种胰腺肿瘤多肽，其免疫原性部分，编码此类多肽的多核苷酸，表达此类多肽的抗原呈递细胞和对表达此类多肽的细胞具有特异性的T细胞。所公开的组合物可用于例如诊断，预防和/或治疗疾病，特别是胰腺癌。

16. 发明申请

WO0212332A2 COMPOSITIONS AND METHODS FOR THE THERAPY AND DIAGNOSIS OF COLON CANCER 审中-公开
标题翻译：用于结肠癌的治疗和诊断的组合物和方法
公开(公告)号：WO0212332A2
公开(公告)日：2002-02-14
申请号：PCT/US0141625
申请日：2001-08-07
申请人： CORIXA CORP , HEPLER WILLIAM T , JIANG YUQIU , PYLE RUTH A , XU JIANGCHUN
发明人： HEPLER WILLIAM T , JIANG YUQIU , PYLE RUTH A , XU JIANGCHUN
IPC分类号： C07K14/47 , C12N15/12
CPC分类号： C07K14/4748
摘要： Compositions and methods for the therapy and diagnosis of cancer, such as colon cancer, are disclosed. Compositions may comprise one or more colon tumor proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a colon tumor protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as colon cancer. Diagnostic methods based on detecting a colon tumor protein, or mRNA encoding such a protein, in a sample are also provided.
摘要翻译：披露了用于治疗和诊断癌症的组合物和方法，例如结肠癌。组合物可以包含一种或多种结肠肿瘤蛋白，其免疫原性部分或编码这些部分的多核苷酸。或者，治疗组合物可包含表达结肠肿瘤蛋白的抗原呈递细胞或对表达此类蛋白的细胞特异的T细胞。例如，这种组合物可用于预防和治疗诸如结肠癌等疾病。还提供了基于检测样品中的结肠肿瘤蛋白质或编码这种蛋白质的mRNA的诊断方法。

17. 发明申请

WO0196390A3 COMPOSITIONS AND METHODS FOR THE THERAPY AND DIAGNOSIS OF COLON CANCER 审中-公开
公开(公告)号：WO0196390A3
公开(公告)日：2002-12-27
申请号：PCT/US0118577
申请日：2001-06-08
申请人： CORIXA CORP , JIANG YUQIU , HEPLER WILLIAM T , CLAPPER JONATHAN D , WANG AIJUN , SECRIST HEATHER
发明人： JIANG YUQIU , HEPLER WILLIAM T , CLAPPER JONATHAN D , WANG AIJUN , SECRIST HEATHER
IPC分类号： C12N15/09 , A61K35/12 , A61K38/00 , A61K45/00 , A61P35/00 , C07K14/47 , C07K14/705 , C07K16/18 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/06 , C12N5/10 , C12N15/12 , C12Q1/68 , A61K31/7088 , A61K35/14 , A61K38/17 , A61K39/395 , C12N15/62 , G01N33/68
CPC分类号： C07K14/70575 , A61K38/00
摘要： Compositions and methods for the therapy and diagnosis of cancer, such as colon cancer, are disclosed. Compositions may comprise one or more colon tumor proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a colon tumor protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as colon cancer. Diagnostic methods based on detecting a colon tumor protein, or mRNA encoding such a protein, in a sample are also provided.

18. 发明申请

WO0241763A3 COMPOSITIONS AND METHODS FOR THE THERAPY AND DIAGNOSIS OF COLON CANCER 审中-公开
标题翻译：用于治疗和诊断结肠癌的组合物和方法
公开(公告)号：WO0241763A3
公开(公告)日：2003-10-02
申请号：PCT/US0150718
申请日：2001-10-18
申请人： CORIXA CORP , JIANG YUQIU
发明人： JIANG YUQIU
IPC分类号： A61K38/00 , A61K39/00 , C07K14/47 , C07H21/02 , A01N43/04 , C07H21/04 , C12N5/00 , C12N15/00 , C12N15/63
CPC分类号： C07K14/4748 , A61K38/00 , A61K39/00 , A61K39/0011 , A61K2039/515 , C07K2319/00
摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly colon cancer, are disclosed. Illustrative compositions comprise one or more colon tumor polypeptides, immunogenic portions thereof, polynuleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositiosn are usefel, for example, in the diagnosis, prevention and/or treatment of diseases, particularly colon cancer.
摘要翻译：公开了用于治疗和诊断癌症，特别是结肠癌的组合物和方法。说明性组合物包含一种或多种结肠肿瘤多肽，其免疫原性部分，编码这种多肽的多核苷酸，表达此类多肽的抗原呈递细胞，以及表达该多肽的细胞特异的T细胞。所公开的组合物例如用于疾病，特别是结肠癌的诊断，预防和/或治疗中。

19. 发明申请

WO2006108135A9 LASER MICRODISSECTION AND MICROARRAY ANALYSIS OF BREAST TUMORS REVEAL ESTROGEN RECEPTOR RELATED GENES AND PATHWAYS 审中-公开
标题翻译：乳腺肿瘤的激光微观分析和微观分析相关基因和途径
公开(公告)号：WO2006108135A9
公开(公告)日：2009-10-15
申请号：PCT/US2006013004
申请日：2006-04-03
申请人： VERIDEX LLC , WANG YIXIN , YU JACK , JIANG YUQIU , YANG FEI , LEHNHARDT SUSAN
发明人： WANG YIXIN , YU JACK , JIANG YUQIU , YANG FEI
IPC分类号： A61K38/00
CPC分类号： C12Q1/6806 , C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/154 , C12Q2600/158

20. 发明申请

WO2006108135A8 LASER MICRODISSECTION AND MICROARRAY ANALYSIS OF BREAST TUMORS REVEAL ESTROGEN RECEPTOR RELATED GENES AND PATHWAYS 审中-公开
标题翻译：乳腺肿瘤的激光微观分析和微观分析相关基因和途径
公开(公告)号：WO2006108135A8
公开(公告)日：2007-11-15
申请号：PCT/US2006013004
申请日：2006-04-03
申请人： VERIDEX LLC , LEHNHARDT SUSAN , YU JACK , JIANG YUQIU , YANG FEI , WANG YIXIN
发明人： YU JACK , JIANG YUQIU , YANG FEI , WANG YIXIN
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6806 , C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/154 , C12Q2600/158
摘要： About 70% to 80% of breast cancers express estrogen receptor-a (ERa), and estrogens play important roles in the development and growth of hormone-dependent tumors. Together with lymph node metastasis, tumor size and histological grade, ER status is considered one of the prognostic factors in breast cancer, and an indicator for hormonal treatment. 147 genes and 112 genes with significant P- value and having significant differential expression between ER+ and ER- tumors were identified from the LCM data set and bulk tissue data set, respectively. 61 genes were found to be common in both data sets, while 85 genes were unique to the LCM data set and 51 genes were present only in the bulk tumor data set. Pathway analysis with the 85 genes using Gene Ontology suggested that genes involved in endocytosis, ceramide generation, Ras/ERK/Ark cascade, and JAT- STAT pathway may play roles related to ER. The gene profiling with LCM-captured tumpr cells provides a unique approach to characterize and study epithelial tumor cells and to gain an insight into signaling pathways associated with ER.
摘要翻译：大约70％至80％的乳腺癌表达雌激素受体-a（ERα），雌激素在激素依赖性肿瘤的发育和生长中起重要作用。与淋巴结转移，肿瘤大小和组织学分级一起，ER状态被认为是乳腺癌的预后因素之一，也是激素治疗的指标。分别从LCM数据集和体组织数据集中分别鉴定了147个基因和112个具有显着P值且具有ER +和ER-肿瘤差异表达的基因。发现61个基因在两个数据集中都是常见的，而85个基因是LCM数据集所独有的，51个基因仅存在于肿瘤数据集中。使用Gene Ontology的85个基因的途径分析表明，参与内吞作用，神经酰胺生成，Ras / ERK / Ark级联和JAT-STAT通路的基因可能发挥与ER相关的作用。用LCM捕获的Tumpr细胞进行基因分析提供了一种独特的方法来表征和研究上皮肿瘤细胞，并获得与ER相关的信号传导途径的洞察。

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