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11. 发明申请

WO2005044802A2 TETRAHYDRO-QUINOLINYLUREA DERIVATIVES 审中-公开
标题翻译：四氢喹啉衍生物
公开(公告)号：WO2005044802A2
公开(公告)日：2005-05-19
申请号：PCT/EP2004/012051
申请日：2004-10-26
申请人： BAYER HEALTHCARE AG , BOUCHON, Axel , DIEDRICHS, Nicole , HERMANN, Achim , LUSTIG, Klemens , MEIER, Heinrich , PERNERSTORFER, Josef , REISSMÜLLER, Elke , MOGI, Muneto , FUJISHIMA, Hiroshi , TAJIMI, Masaomi , YAMAMOTO, Noriyuki
发明人： BOUCHON, Axel , DIEDRICHS, Nicole , HERMANN, Achim , LUSTIG, Klemens , MEIER, Heinrich , PERNERSTORFER, Josef , REISSMÜLLER, Elke , MOGI, Muneto , FUJISHIMA, Hiroshi , TAJIMI, Masaomi , YAMAMOTO, Noriyuki
IPC分类号： C07D215/00
CPC分类号： C07D215/38
摘要： This invention relates to tetrahydro-quinolinylurea derivatives and salts thereof which are useful as active ingredients of pharmaceutical preparations. The tetrahydro-quinolinylurea derivative of the present invention has vanilloid receptor (VR1) antagonistic activity, and can be used for the prophylaxis and treatment of diseases associated with VR1 activity, in particular for the treatment of urological diseases or disorders, such as detrusor overactivity (overactive bladder), urinary incontinence, neurogenic detrusor oeractivity (detrusor hyperflexia), idiopathic detrusor overactivity (detrusor instability), benign prostatic hyperplasia, and lower urinary tract symptoms; chronic pain, neuropathic pain, postoperative pain, rheumatoid arthritic pain, neuralgia, neuropathies, algesia, nerve injury, ischaemia, neurodegeneration, stroke, and inflammatory disorders such as asthma and chronic obstructive pulmonary (or airways) disease (COPD).
摘要翻译：本发明涉及可用作药物制剂活性成分的四氢 - 喹啉基脲衍生物及其盐。本发明的四氢 - 喹啉基脲衍生物具有香草素受体（VR1）拮抗活性，可用于预防和治疗与VR1活性有关的疾病，特别是用于治疗泌尿系统疾病或障碍，例如逼尿肌过度活动膀胱过度活动），尿失禁，神经源性逼尿肌反应性（逼尿肌hyperflexia），特发性逼尿肌过度活动（逼尿肌不稳定），良性前列腺增生和下尿路症状; 慢性疼痛，神经性疼痛，术后疼痛，类风湿性关节炎疼痛，神经痛，神经病，痛觉，神经损伤，局部缺血，神经变性，中风和炎性疾病如哮喘和慢性阻塞性肺（或气道）疾病（COPD）。

12. 发明申请

WO2004072020A1 HYDROXY-TETRAHYDRO-NAPHTHALENYLUREA DERIVATIVES 审中-公开
标题翻译：羟基四氢萘基萘衍生物
公开(公告)号：WO2004072020A1
公开(公告)日：2004-08-26
申请号：PCT/EP2004/001055
申请日：2004-02-05
申请人： BAYER HEALTHCARE AG , YURA, Takeshi , MOGI, Muneto , FUJISHIMA, Hiroshi , URBAHNS, Klaus , MASUDA, Tsutomu , TSUKIMI, Yasuhiro , TAJIMI, Masaomi , YAMAMOTO, Noriyuki , YOSHIDA, Nagahiro , MORIWAKI, Toshiya
发明人： YURA, Takeshi , MOGI, Muneto , FUJISHIMA, Hiroshi , URBAHNS, Klaus , MASUDA, Tsutomu , TSUKIMI, Yasuhiro , TAJIMI, Masaomi , YAMAMOTO, Noriyuki , YOSHIDA, Nagahiro , MORIWAKI, Toshiya
IPC分类号： C07C275/32
CPC分类号： C07D295/096 , C07C275/32 , C07C2602/10
摘要： This invention relates to hydroxy-tetrahydro-naphthalenylurea derivatives and salts thereof which are useful as active ingredients of pharmaceutical preparations. The hydroxy-tetrahydro-naphthalenylurea derivatives of the present invention have an excellent activity as VRl antagonist and are useful for the prophylaxis and treatment of diseases associated with VRl activity, in particular for the treatment of urinary incontinence, urge urinary incontinence, overactive bladder, chronic pain, neuropathic pain, postoperative pain, rheumatoid arthritic pain, neuralgia, neuropathies, algesia, nerve injury, ischaemia, neurodegeneration, stroke, inflammatory disorders, asthma and COPD.
摘要翻译：本发明涉及可用作药物制剂活性成分的羟基 - 四氢 - 萘基脲衍生物及其盐。本发明的羟基 - 四氢 - 萘基脲衍生物作为VR1拮抗剂具有优异的活性，可用于预防和治疗与VR1活性有关的疾病，特别是用于治疗尿失禁，敦促尿失禁，膀胱过度活动症，慢性疼痛，神经性疼痛，术后疼痛，类风湿性关节炎疼痛，神经痛，神经病，痛觉，神经损伤，局部缺血，神经变性，中风，炎症性疾病，哮喘和COPD。

13. 发明申请

WO2003106403A1 CARBOXAMIDES DERIVATIVES 审中-公开
标题翻译：碳氧化物衍生物
公开(公告)号：WO2003106403A1
公开(公告)日：2003-12-24
申请号：PCT/EP2003/006168
申请日：2003-06-12
申请人： BAYER HEALTHCARE AG , SHIMAZAKI, Makoto , SAKURAI, Osamu , HIRAI, Kanako , URBAHNS, Klaus , YAMAMOTO, Noriyuki , YOSHIKAWA, Satoru , UMEDA, Masaomi , TAJIMI, Masaomi
发明人： SHIMAZAKI, Makoto , SAKURAI, Osamu , HIRAI, Kanako , URBAHNS, Klaus , YAMAMOTO, Noriyuki , YOSHIKAWA, Satoru , UMEDA, Masaomi , TAJIMI, Masaomi
IPC分类号： C07C235/34
CPC分类号： C07C235/34
摘要： The present invention relates to carboxamides which are useful as an active ingredient of pharmaceutical preparations. The carboxamides of the present invention have IP receptor antagonistic activity, and can be used for the prophylaxis and treatment of diseases associated with IP receptor antagonistic activity.Such diseases include urological diseases or disorder as follows: bladder outlet obstruction, overactive bladder, urinary incontinence, detrusor hyper-reflexia, detrusor instability, reduced bladder capacity, frequency of micturition, urge incontinence, stress incontinence, bladder hyperreactivity, benighn prostatic hypertrophy (BPH), prostatitis, urinary frequency, nocturia, urinary urgency, pelvic hypersensitivity, urethritis, pelvic pain syndrome, prostatodynia, cystitis, or idiophatic bladder hypersensitivity.The compounds of the present invention are also useful for treatment of pain including, but not limited to inflammatory pain, neuropathic pain, acute pain, chronic pain, dental pain, premenstrual pain, visceral pain, headaches, and the like; hypotension;hemophilia and hemorrhage; and inflammation, since the diseases are alleviated by treatment with an IP receptor antagonist.
摘要翻译：本发明涉及可用作药物制剂活性成分的羧酰胺。本发明的甲酰胺具有IP受体拮抗活性，可用于预防和治疗与IP受体拮抗作用相关的疾病。这些疾病包括泌尿系统疾病或病症如下：膀胱出口阻塞，膀胱过度活动症，尿失禁，逼尿肌反射反射，逼尿肌不稳定，膀胱容量减少，排尿频率，急迫性尿失禁，压力性尿失禁，膀胱反应过度，前列腺肥大（BPH），前列腺炎，尿频，夜尿症，尿急，盆腔超敏反应，尿道炎，盆腔疼痛综合征，前列腺痛，膀胱炎或自发性膀胱过敏症。本发明的化合物还可用于治疗疼痛，包括但不限于炎症性疼痛，神经性疼痛，急性疼痛，慢性疼痛，牙痛，经前痛，内脏痛，头痛等; 低血压;血友病和出血; 和炎症，因为通过用IP受体拮抗剂治疗来减轻疾病。

14. 发明申请

WO2004028440A2 USE OF VANILLOID RECEPTOR ANTAGONISTS FOR THE TREATMENT OF UROLOGICAL DISORDER 审中-公开
标题翻译：使用VANILLOID受体拮抗剂治疗尿毒症
公开(公告)号：WO2004028440A2
公开(公告)日：2004-04-08
申请号：PCT/EP2003/010111
申请日：2003-09-11
申请人： BAYER HEALTHCARE AG , SHIROO, Masahiro , YURA, Takeshi , YAMAMOTO, Noriyuki , TAJIMI, Masomi , TSUKIMI, Yasuhiro
发明人： SHIROO, Masahiro , YURA, Takeshi , YAMAMOTO, Noriyuki , TAJIMI, Masomi , TSUKIMI, Yasuhiro
IPC分类号： A61K
CPC分类号： A61K31/17
摘要： The present invention relates to methods for treating urological disorders. More particularly, this invention concerns the use of a vanilloid receptor (VR1) antagonist for the prophylaxis and treatment of urinary incontinence and overactive bladder.
摘要翻译：本发明涉及治疗泌尿系疾病的方法。更具体地，本发明涉及用于预防和治疗尿失禁和膀胱过度活动症的香草素受体（VR1）拮抗剂的用途。

15. 发明申请

WO2005103018A1 UREA DERIVATIVES AS ANTAGONISTS OF THE VANILLOID RECEPTOR (VR1) 审中-公开
标题翻译：尿素衍生物作为VANILLOID受体（VR1）的拮抗剂
公开(公告)号：WO2005103018A1
公开(公告)日：2005-11-03
申请号：PCT/EP2005/003632
申请日：2005-04-07
申请人： BAYER HEALTHCARE AG , FUJISHIMA, Hiroshi , MOGI, Muneto , YUASA, Hiroaki , TAIJIMI, Masaomi , YAMAMOTO, Noriyuki , HAYASHI, Fumihiko , TSUKIMI, Yasuhiro , GUPTA, Jang
发明人： FUJISHIMA, Hiroshi , MOGI, Muneto , YUASA, Hiroaki , TAIJIMI, Masaomi , YAMAMOTO, Noriyuki , HAYASHI, Fumihiko , TSUKIMI, Yasuhiro , GUPTA, Jang
IPC分类号： C07D265/36
CPC分类号： C07D265/36 , C07D215/227
摘要： This invention relates to urea derivatives according to general formula I and salts thereof which are useful as active ingredients of pharmaceutical preparations. The urea derivatives of the present invention have an excellent activity as VR1 antagonists and are useful for the prophylaxis and treatment of diseases associated with VR1 activity, in particular for the treatment of urological disorder or disease, such as detrusor overactivity (overactive bladder), urinary incontinence, neurogenic detrusor oeractivity (detrusor hyperflexia), idiopathic detrusor overactivity (detrusor instability), benign prostatic hyperplasia, and lower urinary tract symptoms; chronic pain, neuropathic pain, postoperative pain, rheumatoid arthritic pain, neuralgia, neuropathies, algesia, nerve injury, ischaemia, neurodegeneration, stroke; and respiratory diseases and inflammatory disorders such as asthma, chronic obstructive pulmonary (or airways) disease (COPD), common cold, cough, sneeze, bronchitis including acute and chronic bronchitis, bronchiolitis, rhinitis, allergic rhinitis, vasomotor rhinitis, mucositis, sinusitis, allergy, disorders associated with exogenous irritants such as tobacco smoke, smog, high levels of atmospheric SO2 and noxious gases in the workplace, and airways hyperreactivity, milk product intolerance, Loffler's pneumonia, emphysema, cystic fibrosis, bronchiectasis, pulmonary fibrosis, pneumoconiosis, collagen vascular disease, granulomatous disease, laryngitis, pharyngitis, pneumonia, pleuritis, persistent asthma and chronic asthmatic bronchitis. Formula I Wherein n represents 0, 1, 2, 3, or 4; X represents O, CH 2 , S, or N(R 10 ), Wherein R 10 respresents hydrogen or C 1-6 alkyl
摘要翻译：本发明涉及可用作药物制剂活性成分的通式Ⅰ的脲衍生物及其盐。本发明的尿素衍生物作为VR1拮抗剂具有优异的活性，并且可用于预防和治疗与VR1活性有关的疾病，特别是用于治疗泌尿系统疾病或疾病，例如逼尿肌过度活动症（膀胱过度活动症），尿失禁，神经源性逼尿肌反应性（逼尿肌hyperflexia），特发性逼尿肌过度活动（逼尿肌不稳定），良性前列腺增生和下尿路症状; 慢性疼痛，神经性疼痛，术后疼痛，类风湿关节炎疼痛，神经痛，神经病，痛觉，神经损伤，局部缺血，神经退行性卒中; 呼吸系统疾病和哮喘，慢性阻塞性肺（或气道）疾病（COPD），感冒，咳嗽，打喷嚏，支气管炎，包括急性和慢性支气管炎，细支气管炎，鼻炎，过敏性鼻炎，血管舒缩性鼻炎，粘膜炎，鼻窦炎，过敏，与外来刺激物如烟草烟雾，烟雾，工作场所大气中二氧化硫和有毒气体高度相关的疾病，气道高反应性，乳制品不耐受，霍夫勒氏肺炎，肺气肿，囊性纤维化，支气管扩张，肺纤维化，肺尘埃沉着病，胶原蛋白血管疾病，肉芽肿病，喉炎，咽炎，肺炎，胸膜炎，持续性哮喘和慢性哮喘性支气管炎。其中n表示0,1,2,3或4; X表示O，CH 2，S或N（R 10），其中R 10表示氢或C 1-6烷基

16. 发明申请

WO2013018325A1 INFORMATION PROCESSING APPARATUS, INFORMATION PROCESSING METHOD, AND COMPUTER PROGRAM PRODUCT 审中-公开
标题翻译：信息处理设备，信息处理方法和计算机程序产品
公开(公告)号：WO2013018325A1
公开(公告)日：2013-02-07
申请号：PCT/JP2012/004746
申请日：2012-07-25
申请人： SONY CORPORATION , TAKAMURA, Seiichi , YAMAMOTO, Noriyuki , OHTANI, Shinya , ASANO, Yasuharu
发明人： TAKAMURA, Seiichi , YAMAMOTO, Noriyuki , OHTANI, Shinya , ASANO, Yasuharu
IPC分类号： G06F13/00
CPC分类号： G06T11/206 , G06F13/00 , G06Q10/10 , G06Q30/0201 , G06Q50/01
摘要： An information processing apparatus, method and computer program product cooperate to provide graphical trends of posts regarding a posting subject and additional information. The apparatus includes a collector that collects posts regarding a posting subject that proceeds over time. A counting unit is included that counts a number of collected posts for each of different classes of posts. A display controller causes graphs to be displayed along a time-axis illustrating time-wise trends in the posts for each class together with additional information. The additional information is information that includes at least one of posts at respective times and information regarding the posting subject.
摘要翻译：信息处理设备，方法和计算机程序产品协作以提供关于发布主题和附加信息的帖子的图形趋势。该装置包括收集器，用于收集关于随时间推移的过帐主题的帖子。包括一个计数单位，用于计算每个不同类别职位的收集职位数。显示控制器使得沿着时间轴显示图表，示出了每个类的帖子中的时间趋势以及附加信息。附加信息是包括在相应时间的至少一个帖子和关于发布主题的信息的信息。

17. 发明申请

WO2013005817A1 METHOD FOR PREPARING A FATTY ACID DERIVATIVE 审中-公开
标题翻译：制备脂肪酸衍生物的方法
公开(公告)号：WO2013005817A1
公开(公告)日：2013-01-10
申请号：PCT/JP2012/067253
申请日：2012-06-29
申请人： R-TECH UENO, LTD. , SUCAMPO AG , MATSUKAWA, Tatsuya , YAMAMOTO, Noriyuki , UENO, Ryuji , KOTAJIMA, Hiroyuki , FUKUYA, Shunsuke , HANDA, Michiharu , SAKATA, Katsuya
发明人： MATSUKAWA, Tatsuya , YAMAMOTO, Noriyuki , UENO, Ryuji , KOTAJIMA, Hiroyuki , FUKUYA, Shunsuke , HANDA, Michiharu , SAKATA, Katsuya
IPC分类号： C07D309/12
CPC分类号： C07D307/30 , Y02P20/55
摘要： Disclosed is a method for manufacturing a fatty acid derivative represented by formula (I): which comprises the step of, reacting a compound of formula (II): with a co-oxidizer under the presence of an azaadamantane-N-oxyl derivative. According to the method, the desired fatty acid derivative can be synthesized without special equipment, by using an easy-available inexpensive co-oxidizer and generation of the undesired by-product is suppressed.
摘要翻译：公开了一种制备由式（I）表示的脂肪酸衍生物的方法：其包括使式（II）化合物与共氧化剂在氮杂金刚烷-N-氧基衍生物存在下反应的步骤。根据该方法，可以通过使用易于获得的廉价的辅助氧化剂而无需特殊设备即可合成所需的脂肪酸衍生物，并抑制不希望的副产物的产生。

18. 发明申请

WO2005056544A1 2- ( (2, 3-DIHYDROXYPROPYL) AMINOMETHYL) CHROMANE DERIVATIVES FOR USE AS BETA-3 ADRENORECEPTOR AGONISTS IN THE TREATMENT OF UROLOGICAL AND INFLAMMATORY DISORDERS 审中-公开
标题翻译： 2-（（2,3-二羟基丙基）氨基甲基）丙酮衍生物用作治疗尿毒症和炎症性疾病的β-3腺苷二磷酸腺苷激酶
公开(公告)号：WO2005056544A1
公开(公告)日：2005-06-23
申请号：PCT/EP2004/013677
申请日：2004-12-02
申请人： BAYER HEALTHCARE AG , BOYER, Stephen, J. , HASHIMOTO, Kentaro , RÖLLE, Thomas , SANDNER, Peter , STELTE-LUDWIG, Beatrix , TINEL, Hanna , HENNINGER, Kerstin , CONCEPCION, Arnel , SAKURAI, Osamu , HIRAI, Kanako , INOUE, Tadashi , MOCHIZUKI, Yuki , NUNAMI, Noriko , TAIJIMI, Masaomi , YAMAMOTO, Noriyuki , TSUKIMI, Yasuhiro
发明人： BOYER, Stephen, J. , HASHIMOTO, Kentaro , RÖLLE, Thomas , SANDNER, Peter , STELTE-LUDWIG, Beatrix , TINEL, Hanna , HENNINGER, Kerstin , CONCEPCION, Arnel , SAKURAI, Osamu , HIRAI, Kanako , INOUE, Tadashi , MOCHIZUKI, Yuki , NUNAMI, Noriko , TAIJIMI, Masaomi , YAMAMOTO, Noriyuki , TSUKIMI, Yasuhiro
IPC分类号： C07D311/58
CPC分类号： C07D311/58 , C07D405/12
摘要： This invention relates to chroman derivatives of formula (I) and salts thereof which are useful as active ingredients of pharmaceutical preparations. The chroman derivatives of the present invention have an excellent activity as BETA 3 antagonists and are useful for the prophylaxis and treatment of diseases associated with BETA 3 activity, in particular for the treatment of urological disorder or disease, such as detrusor overactivity (overactive bladder), urinary incontinence, neurogenic detrusor overactivity (detrusor hyperflexia), idiopathic detrusor overactivity (detrusor instability), benign prostatic hyperplasia, and lower urinary tract symptoms; and inflammatory disorders, such as asthma and COPD.
摘要翻译：本发明涉及可用作药物制剂活性成分的式（I）的苯并二氢吡喃衍生物及其盐。本发明的苯并二氢吡喃衍生物作为BETA 3拮抗剂具有优异的活性，可用于预防和治疗与BETA 3活性相关的疾病，特别是用于治疗泌尿系统疾病或疾病，如逼尿肌过度活动（膀胱过度活动症），尿失禁，神经源性逼尿肌过度活动（逼尿肌hyperflexia），特发性逼尿肌过度活动（逼尿肌不稳定），良性前列腺增生和下尿路症状; 和炎症性疾病，如哮喘和COPD。

19. 发明申请

WO2013005819A1 METHOD FOR PREPARING A FATTY ACID DERIVATIVE 审中-公开
标题翻译：制备脂肪酸衍生物的方法
公开(公告)号：WO2013005819A1
公开(公告)日：2013-01-10
申请号：PCT/JP2012/067257
申请日：2012-06-29
申请人： R-TECH UENO, LTD. , MATSUKAWA, Tatsuya , YAMAMOTO, Noriyuki
发明人： MATSUKAWA, Tatsuya , YAMAMOTO, Noriyuki
IPC分类号： C07F7/08
CPC分类号： C07D317/30 , C07C405/00 , C07C2601/08 , C07F7/1856
摘要： Disclosed is a method for manufacturing a fatty acid derivative represented by formula (I): which comprises the step of, reacting a compound of formula (II): with a co-oxidizer under the presence of an azaadamantane-N-oxyl derivative. According to the method, the desired fatty acid derivative can be synthesized by using an easy-available inexpensive co-oxidizer without special equipment, and generation of the undesired by-product is suppressed.
摘要翻译：公开了一种制备由式（I）表示的脂肪酸衍生物的方法：其包括使式（II）化合物与辅助氧化剂在氮杂金刚烷-N-氧基衍生物存在下反应的步骤。根据该方法，可以通过使用易于使用的廉价的辅助氧化剂而不需要特殊的设备来合成所需的脂肪酸衍生物，并且抑制不需要的副产物的产生。

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