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11. 发明申请

WO2007009094A3 ANTISENSE ANTIBACTERIAL METHOD AND COMPOUND 审中-公开
标题翻译：反义抗菌方法和化合物
公开(公告)号：WO2007009094A3
公开(公告)日：2007-03-01
申请号：PCT/US2006027522
申请日：2006-07-13
申请人： AVI BIOPHARMA INC , GELLER BRUCE L , IVERSEN PATRICK L , TILLEY LUCAS D
发明人： GELLER BRUCE L , IVERSEN PATRICK L , TILLEY LUCAS D
IPC分类号： A61K31/70 , C07H21/02 , C07H21/04 , C12N5/00 , C12Q1/68
CPC分类号： A61K48/00 , C12N15/111 , C12N15/113 , C12N2310/11 , C12N2310/3233 , C12N2310/3513 , C12N2320/50
摘要： An antibacterial antisense conjugate and method of using the same for treating a bacterial infection in a mammalian host are disclosed. The conjugate includes an antisense oligonucleotide conjugated to a carrier peptide that significantly enhances the antibacterial activity of the oligonucleotide. The antisense oligonucleotide contains 10-20 nucleotide bases and has a targeting nucleic acid sequence complementary to a target sequence containing or within 10 bases, in a downstream direction, of the translational start codon of a bacterial mRNA that encodes a bacterial protein essential for bacterial replication, where the compound binds to a target mRNA with a Tm of between 50° to 600C. The carrier peptide is an arginine-rich peptide containing between 6 and 12 amino acids.
摘要翻译：公开了一种抗细菌反义缀合物及其用于治疗哺乳动物宿主细菌感染的方法。缀合物包括与载体肽缀合的反义寡核苷酸，其显着增强寡核苷酸的抗菌活性。反义寡核苷酸含有10-20个核苷酸碱基，并且具有与靶序列互补的靶向核酸序列，该靶序列含有或在10个碱基内，在下游方向，编码细菌蛋白质必需的细菌蛋白质的细菌mRNA的翻译起始密码子其中化合物以50-60℃的Tm结合靶mRNA。载体肽是含有6-12个氨基酸的富含精氨酸的肽。

12. 发明申请

WO2006050414A2 ANTISENSE ANTIVIRAL COMPOUNDS AND METHODS FOR TREATING FILOVIRUS INFECTION 审中-公开
标题翻译：抗真菌化合物和治疗FILOVIRUS感染的方法
公开(公告)号：WO2006050414A2
公开(公告)日：2006-05-11
申请号：PCT/US2005039607
申请日：2005-11-01
申请人： AVI BIOPHARMA INC , STEIN DAVID A , IVERSEN PATRICK L , BAVARI SINA
发明人： STEIN DAVID A , IVERSEN PATRICK L , BAVARI SINA
IPC分类号： A61K48/00
CPC分类号： C12N15/1131 , C12N2310/11 , C12N2310/31 , C12N2310/32 , C12N2310/3513
摘要： The invention provides antisense antiviral compounds and methods of their use and production in inhibition of growth of viruses of the Filoviridae family, and in the treatment of a viral infection. The compounds and methods relate to the treatment of viral infections in mammals including primates by Ebola and Marburg viruses. The antisense antiviral compounds are substantially uncharged morpholino oligonucleotides having: a) a nuclease resistant backbone, b) 15-40 nucleotide bases, and c) a targeting sequence of at least 15 bases in length that hybridizes to a target region selected from the following: i) the AUG start site region of VP35, as exemplified by antisense compounds SEQ ID NO: 21-26, ii) the AUG start site region of VP24, as exemplified by antisense compound SEQ ID NO:34, iii) the region 85 to 65 base pairs upstream of the AUG start site of VP24, as exemplified by SEQ ID NO:39, iv) the AUG start site region of polymerase L, as exemplified by antisense compound SEQ ID NO: 17, and v) combinations of (i), (ii), (iii), and/or (iv).
摘要翻译：本发明提供了反义抗病毒化合物及其在抑制丝状病毒科病毒生长和用于病毒感染治疗中的用途和生产方法。所述化合物和方法涉及哺乳动物中的病毒感染的治疗，包括埃博拉和马尔堡病毒的灵长类动物。反义抗病毒化合物是基本上不带电荷的吗啉代寡核苷酸，其具有：a）核酸酶抗性主链，b）15-40个核苷酸碱基，和c）长度为至少15个碱基的靶向序列与选自以下的靶区域杂交： i）VP35的AUG起始位点区域，如反义化合物SEQ ID NO：21-26所示，ii）VP24的AUG起始位点区域，如反义化合物SEQ ID NO：34所示，iii）区域85至 VP24的AUG起始位点上游65个碱基对，如SEQ ID NO：39所示，iv）聚合酶L的AUG起始位点区域，如反义化合物SEQ ID NO：17所示，v）（i ），（ii），（iii）和/或（iv）。

13. 发明申请

WO0187286A2 ANTISENSE ENZYME INHIBITORS FOR METABOLIC REDIRECTION 审中-公开
标题翻译：抗生素抑制剂代谢重组
公开(公告)号：WO0187286A2
公开(公告)日：2001-11-22
申请号：PCT/US0115857
申请日：2001-05-16
申请人： AVI BIOPHARMA INC , IVERSEN PATRICK L
发明人： IVERSEN PATRICK L
IPC分类号： C12N15/09 , A61K31/167 , A61K31/337 , A61K31/515 , A61K31/565 , A61K31/7048 , A61K38/00 , A61K45/00 , A61K48/00 , A61P3/00 , A61P5/24 , A61P25/20 , A61P29/00 , A61P31/04 , A61P43/00 , C07H21/04 , C12N15/113 , A61K31/00
CPC分类号： C12N15/1137 , A61K31/337 , A61K38/00 , C12N2310/314 , C12N2310/3233 , A61K2300/00
摘要： A method is described for improving the pharmacokinetics of a drug in a subject, by co-administering oligomers, preferably PMO's (phosphorodiamidate morpholino oligonucleotides), antisense to RNAs encoding drug-metabolizing enzymes, particularly p450 enzymes. The oligomers reduce production of the drug-metabolizing enzymes, which extends drug half-life and effectiveness and/or decreases drug toxicity.
摘要翻译：描述了通过共同施用寡核苷酸（优选PMO（磷酸二甲酯吗啉代寡核苷酸））来改善受试者中药物的药代动力学的方法，其与编码药物代谢酶，特别是p450酶的RNA反义。寡聚物减少药物代谢酶的产生，其延长了药物的半衰期和有效性和/或降低了药物毒性。

14. 发明申请

WO2011113015A3 ANTISENSE MODULATION OF NUCLEAR HORMONE RECEPTORS 审中-公开
标题翻译：核激素受体的抗原调节
公开(公告)号：WO2011113015A3
公开(公告)日：2011-10-27
申请号：PCT/US2011028216
申请日：2011-03-11
申请人： AVI BIOPHARMA INC , IVERSEN PATRICK L
发明人： IVERSEN PATRICK L
IPC分类号： C12N15/113 , A61P29/00
CPC分类号： C12N15/1138 , C12N2310/11 , C12N2310/314 , C12N2310/3233 , C12N2310/3513
摘要： Provided are antisense oligonucleotides and other agents that target and modulate nuclear hormone receptors (NHRs) such as the glucocorticoid receptor (GR), compositions that comprise the same, and methods of use thereof.
摘要翻译：提供靶向和调节核激素受体（NHR）的反义寡核苷酸和其它试剂，例如糖皮质激素受体（GR），包含其的组合物及其使用方法。

15. 发明申请

WO2009005793A3 TISSUE SPECIFIC PEPTIDE CONJUGATES AND METHODS 审中-公开
标题翻译：组织特异性结合蛋白和方法
公开(公告)号：WO2009005793A3
公开(公告)日：2009-05-28
申请号：PCT/US2008008168
申请日：2008-06-30
申请人： AVI BIOPHARMA INC , MOULTON HONG M , IVERSEN PATRICK L
发明人： MOULTON HONG M , IVERSEN PATRICK L
IPC分类号： A61K38/00
CPC分类号： C12N15/87 , C07K2319/33 , C12N2810/40
摘要： Cell-penetrating peptides useful for targeting a therapeutic compound to a selected mammalian tissue, methods for their identification, methods of forming conjugate compounds containing such peptides, and conjugates formed thereby are disclosed. The cell-penetrating peptides are 8 to 30 amino acid residues in length and consist of subsequences selected from the group consisting of RXR, RX, RB, and RBR; where R is arginine, B is ß-alanine, and each X is independently -C(O)-(CHR1 )n-NH-, where n is 4-6 and each R1 is independently H or methyl, such that at most two R1,s are methyl. In one embodiment, X is a 6-aminohexanoic acid residue.
摘要翻译：可用于将治疗化合物靶向选定的哺乳动物组织的细胞穿透肽，其鉴定方法，形成含有此类肽的缀合物的方法，以及由此形成的缀合物。细胞穿透肽的长度为8至30个氨基酸残基并由选自RXR，RX，RB和RBR的子序列组成; 其中R是精氨酸，B是β-丙氨酸，每个X独立地是-C（O） - （CHR 1）n -NH-，其中n是4-6，并且每个R 1独立地是H或甲基，使得至多两个 R1，s是甲基。在一个实施方案中，X是6-氨基己酸残基。

16. 发明申请

WO2006047683B1 ANTISENSE ANTIVIRAL COMPOUND AND METHOD FOR TREATING INFLUENZA VIRAL INFECTION 审中-公开
标题翻译：抗真菌化合物和治疗流感病毒感染的方法
公开(公告)号：WO2006047683B1
公开(公告)日：2006-11-09
申请号：PCT/US2005038780
申请日：2005-10-26
申请人： AVI BIOPHARMA INC , STEIN DAVID A , GE QING , CHEN JIANZHU , IVERSEN PATRICK L
发明人： STEIN DAVID A , GE QING , CHEN JIANZHU , IVERSEN PATRICK L
IPC分类号： C07H21/04 , C12N15/113
CPC分类号： C12N15/1131 , C12N2310/3145 , C12N2310/3233 , C12N2310/3513
摘要： The invention provides antisense antiviral compounds and methods of their use and production in inhibition of growth of viruses of the Orthomyxoviridae family and in the treatment of a viral infection. The compounds are particularly useful in the treatment of influenza virus infection in a mammal. The antisense antiviral compounds are substantially uncharged morpholino oligonucleotides having 1) a nuclease resistant backbone, 2) 12-40 nucleotide bases, and 3) a targeting sequence of at least 12 bases in length that hybridizes to a target region selected from the following: a) the 5' or 3' terminal 25 bases of the negative sense viral RNA segment of Influenzavirus A, Influenzavirus B and Influenzavirus C; b) the terminal 25 bases of the 3' terminus of the positive sense cRNA and; and c) the 50 bases surrounding the AUG start codon of an influenza viral mRNA.
摘要翻译：本发明提供反义抗病毒化合物及其在抑制正粘病毒科的病毒生长和用于病毒感染治疗中的用途和生产方法。该化合物特别可用于治疗哺乳动物的流感病毒感染。反义抗病毒化合物是基本上不带电荷的吗啉代寡核苷酸，其具有1）核酸酶抗性主链，2）12-40个核苷酸碱基，和3）长度为至少12个碱基的靶向序列与选自以下的靶区域杂交：）流感病毒A，流感病毒B和流感病毒C的负义病毒RNA片段的5'或3'末端25个碱基; b）正义cRNA的3'末端的末端25个碱基; 和c）围绕流感病毒mRNA的AUG起始密码子的50个碱基。

17. 发明申请

WO2004097017A2 COMPOSITIONS FOR ENHANCING TRANSPORT OF MOLECULES INTO CELLS 审中-公开
标题翻译：用于增强细胞运输到细胞中的组合物
公开(公告)号：WO2004097017A2
公开(公告)日：2004-11-11
申请号：PCT/US2004013660
申请日：2004-04-29
申请人： AVI BIOPHARMA INC , IVERSEN PATRICK L , MOULTON HONG M , NELSON MICHELLE H , KROEKER ANDREW D , STEIN DAVID A
发明人： IVERSEN PATRICK L , MOULTON HONG M , NELSON MICHELLE H , KROEKER ANDREW D , STEIN DAVID A
IPC分类号： A61K47/48 , A61K49/00 , C12N15/113 , C12N15/00
CPC分类号： A61K49/0056 , A61K47/64 , A61K49/0043 , A61K49/0054 , C12N15/113 , C12N15/87 , C12N2310/11 , C12N2310/314 , C12N2310/3233 , C12N2310/3513 , C12N2320/32
摘要： Compositions and methods for enhancing delivery of molecules, e.g. biological agents, into cells are described. The composition is a conjugate of the biological agent, preferably a nucleic acid analog having a substantially uncharged backbone, covalently linked to a peptide transporter moiety as described. Conjugation of the peptide transporter to a substantially uncharged nucleic acid analog, such as a morpholino oligomer, is also shown to enhance binding of the oligomer to its target sequence and enhance antisense activity.
摘要翻译：用于增强分子递送的组合物和方法，例如描述了生物制剂进入细胞。组合物是生物制剂的缀合物，优选具有基本上不带电的主链的核酸类似物，其共价连接到如所述的肽转运蛋白部分。还显示肽转运蛋白与基本上不带电的核酸类似物如吗啉代低聚物的缀合增强寡聚物与其靶序列的结合并增强反义活性。

18. 发明申请

WO2007103529A3 ANTISENSE ANTIVIRAL COMPOUND AND METHOD FOR TREATING ARENAVIRUS INFECTION 审中-公开
标题翻译：抗真菌化合物和治疗ARENAVIRUS感染的方法
公开(公告)号：WO2007103529A3
公开(公告)日：2007-12-13
申请号：PCT/US2007005977
申请日：2007-03-07
申请人： AVI BIOPHARMA INC , NEUMAN BENJAMIN , STEIN DAVID A , BUCHMEIER MICHAEL , IVERSEN PATRICK L
发明人： NEUMAN BENJAMIN , STEIN DAVID A , BUCHMEIER MICHAEL , IVERSEN PATRICK L
IPC分类号： C12Q1/68 , A01N43/04 , A61K31/07 , C07H21/04
CPC分类号： C12N15/1131 , C12N2310/11 , C12N2310/3145 , C12N2310/3233 , C12N2310/3513 , C12N2760/10011
摘要： The invention provides antisense antiviral compounds and methods of their use and production in inhibition of growth of viruses of the Arenaviridae family and in the treatment of a viral infection. The compounds are particularly useful in the treatment of Arenavirus infection in a mammal. The antisense antiviral compounds are substantially uncharged morpholino oligonucleotides have a sequence of 12-40 subunits, including at least 12 subunits having a targeting sequence that is complementary to a region associated with viral RNA sequences within a 19 nucleotide region of the 5'-terminal regions of the viral RNA, viral complementary RNA and/or mRNA identified by SEQ ID NO:1.
摘要翻译：本发明提供了反义抗病毒化合物及其在抑制竞争链球菌科家族病毒生长和用于病毒感染治疗中的用途和生产方法。这些化合物特别可用于治疗哺乳动物中的雷亚病毒感染。反义抗病毒化合物是基本上不带电荷的吗啉代寡核苷酸具有12-40个亚基的序列，包括至少12个亚基，其具有与5'末端区域的19个核苷酸区域内的病毒RNA序列相关的区域互补的靶向序列的病毒RNA，由SEQ ID NO：1鉴定的病毒互补RNA和/或mRNA。

19. 发明申请

WO2005027833A3 COMPOUND AND METHOD FOR TREATING ANDROGEN-INDEPENDENT PROSTATE CANCER 审中-公开
标题翻译：用于治疗独立前列腺癌的化合物和方法
公开(公告)号：WO2005027833A3
公开(公告)日：2006-06-08
申请号：PCT/US2004029810
申请日：2004-09-10
申请人： AVI BIOPHARMA INC , IVERSEN PATRICK L , DEVI GAYATHRI R
发明人： IVERSEN PATRICK L , DEVI GAYATHRI R
IPC分类号： A61K31/7115 , A61K20060101 , A61K48/00 , C07H21/04 , C12N15/113
CPC分类号： C12N15/1138 , C12N2310/11 , C12N2310/3233
摘要： The present invention provides compositions and methods for treating prostate cancer. The composition comprises a morpholino antisense compound having uncharged phosphorus-containing backbone linkages and a base sequence that is complementary to a target region containing at least 12 contiguous bases in a preprocessed or processed human androgen receptor transcript. The method is designed for treating prostate cancer in a subject having a hormone-refractory (androgen-independent) prostate cancer.
摘要翻译：本发明提供了治疗前列腺癌的组合物和方法。该组合物包含具有不带电荷的含磷主链键的吗啉代反义化合物和与在预处理或加工的人类雄激素受体转录物中含有至少12个连续碱基的靶区域互补的碱基序列。该方法设计用于治疗具有激素难治性（雄激素依赖性）前列腺癌的受试者中的前列腺癌。

20. 发明申请

WO2005065268A3 OLIGONUCLEOTIDE COMPOUND AND METHOD FOR TREATING NIDOVIRUS INFECTIONS 审中-公开
标题翻译：寡核苷酸化合物和治疗NIDOVIRUS感染的方法
公开(公告)号：WO2005065268A3
公开(公告)日：2006-01-19
申请号：PCT/US2004043341
申请日：2004-12-23
申请人： AVI BIOPHARMA INC , STEIN DAVID A , BESTWICK RICHARD K , IVERSEN PATRICK L , NEUMAN BENJAMIN , BUCHMEIER MICHAEL
发明人： STEIN DAVID A , BESTWICK RICHARD K , IVERSEN PATRICK L , NEUMAN BENJAMIN , BUCHMEIER MICHAEL
IPC分类号： A61K48/00 , C07F9/6533 , C07H21/02 , C07K14/165 , C12N15/113 , C12Q1/00 , A01N57/00 , A61K31/685
CPC分类号： C07H21/02 , C07K14/005 , C12N15/1131 , C12N2310/11 , C12N2310/3233 , C12N2310/3513 , C12N2770/20022
摘要： A method and oligonucleotide compound for inhibiting replication of a nidovirus in virus-infected animal cells are disclosed. The compound (i) has a nuclease-resistant backbone, (ii) is capable of uptake by the infected cells, (iii) contains between 8-25 nucleotide bases, and (iv) has a sequence capable of disrupting base pairing between the transcriptional regulatory sequences in the 5' leader region of the positive-strand viral genome and negative-strand 3' subgenomic region. In practicing the method, infected cells are exposed to the compound in an amount effective to inhibit viral replication.
摘要翻译：公开了用于抑制病毒感染的动物细胞中的尼非诺病毒复制的方法和寡核苷酸化合物。化合物（i）具有核酸酶抗性主链，（ii）能够被感染细胞吸收，（iii）含有8-25个核苷酸碱基之间，和（iv）具有能够破坏转录之间碱基配对的序列正链病毒基因组和负链3'亚基因组区域的5'前导区域中的调节序列。在实施该方法中，感染的细胞以有效抑制病毒复制的量暴露于化合物。

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