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11. 发明申请

WO0222882A2 TARGET ACTIVATED NUCLEIC ACID BIOSENSOR AND METHODS OF USING SAME 审中-公开
标题翻译：目标活性核酸生物传感器及其使用方法
公开(公告)号：WO0222882A2
公开(公告)日：2002-03-21
申请号：PCT/US0128835
申请日：2001-09-13
申请人： ARCHEMIX CORP , STANTON MARTY , EPSTEIN DAVID , HAMAGUCHI NOBUKO
发明人： STANTON MARTY , EPSTEIN DAVID , HAMAGUCHI NOBUKO
IPC分类号： G01N33/53 , A61K49/00 , C07H21/02 , C07H21/04 , C12M1/00 , C12N9/16 , C12N15/09 , C12Q1/48 , C12Q1/68 , C40B40/06 , C40B60/14 , G01N21/78 , G01N33/58
CPC分类号： C12Q1/6816 , B01J2219/00385 , B01J2219/00479 , B01J2219/00608 , B01J2219/00626 , B01J2219/00637 , B01J2219/00653 , B01J2219/00662 , B01J2219/00691 , B01J2219/00722 , B82Y30/00 , C07H21/02 , C07H21/04 , C12Q1/485 , C12Q1/6825 , C40B40/06 , C40B60/14 , C12Q2565/101 , C12Q2525/179 , C12Q2521/337 , C12Q2521/501
摘要： Methods for engineering a target activated biosensor are provided. Biosensors comprise a plurality of nucleic acid sensor molecules labeled with a first signaling moiety and a second signaling moiety. The nucleic acid sensor molecules recognizes target molecules which do not naturally bind to DNA. Binding of a target molecule to the sensor molecules triggers a change in the proximity of the signaling moieties which leads to a change in the optical properties of the nucleic acid sensor molecules on the biosensor. Reagents and systems for performing the method are also provided. The method is useful in diagnostic applications and drug optimization.
摘要翻译：提供了用于工程化目标活性生物传感器的方法。生物传感器包含用第一信号传导部分和第二信号传导部分标记的多个核酸传感器分子。核酸传感器分子识别不天然结合DNA的靶分子。靶分子与传感器分子的结合触发信号部分的接近度的变化，导致生物传感器上的核酸传感器分子的光学性质的变化。还提供了用于执行该方法的试剂和系统。该方法可用于诊断应用和药物优化。

12. 发明申请

WO2004031360A3 THERAPEUTIC APTAMERS HAVING BINDING SPECIFICITY TO GP41 OF HIV 审中-公开
标题翻译：具有与GP41相关联的特异性的治疗性APTAMERS
公开(公告)号：WO2004031360A3
公开(公告)日：2005-06-16
申请号：PCT/US0331365
申请日：2003-10-02
申请人： ARCHEMIX CORP , EPSTEIN DAVID , BLANCHARD JILL , WILSON CHARLES , DIENER JOHN L
发明人： EPSTEIN DAVID , BLANCHARD JILL , WILSON CHARLES , DIENER JOHN L
IPC分类号： A01N43/04 , A61K39/21 , C07K14/16 , C12N20060101 , C12N15/115 , C12Q1/70 , C12N15/11
CPC分类号： C12N15/115 , C12N2310/16 , C12N2310/317 , C12N2310/351 , C12N2310/51 , C12N2330/31 , C12N2310/322 , C12N2310/3533 , C12N2310/321 , C12N2310/3521
摘要： Materials and methods of use thereof are presented for the treatment or diagnosis of HIV. The materials are aptamers that bind to gp41, CCR5 or other HIV viral targets that are involved in the formation of the gp41 fusion-active intermediate.
摘要翻译：呈现其用于治疗或诊断HIV的材料及其使用方法。这些材料是与gp41，CCR5或其他涉及形成gp41融合活性中间体的HIV病毒靶标结合的适体。

13. 发明申请

WO2004026260A3 PROPHYLACTIC AND THERAPEUTIC HIV APTAMERS 审中-公开
标题翻译：预防性和治疗性HIV接触者
公开(公告)号：WO2004026260A3
公开(公告)日：2004-07-15
申请号：PCT/US0329798
申请日：2003-09-17
申请人： ARCHEMIX CORP , WILSON CHARLES , EPSTEIN DAVID , DIENER JOHN L
发明人： WILSON CHARLES , EPSTEIN DAVID , DIENER JOHN L
IPC分类号： A61K20060101 , A61K31/7088 , A61K39/00 , A61K39/21 , A61K39/42 , A61P31/18 , C07H21/00 , C07H21/02 , C07K14/16 , C07K16/10 , C12N15/115 , C12Q1/68 , C12N5/06
CPC分类号： C12N15/115 , C07K16/1063 , C12N2310/317 , C12N2310/321 , C12N2310/322 , C12N2310/3513 , C12N2310/3521
摘要： Materials and methods of use thereof are presented for the prophylactic treatment of HIV. Therapeutic compositions including regulated aptamer therapeutic compositions with specificity to components of HIV disease are presented with methods of administering these therapeutic compositions as vaccines against HIV infection.
摘要翻译：提出了其用途的材料和方法用于预防性治疗HIV。包括对HIV疾病成分具有特异性的调节适体治疗组合物的治疗组合物提供了施用这些治疗组合物作为针对HIV感染的疫苗的方法。

14. 发明申请

WO2005111238A3 APTAMER-MEDIATED INTRACELLULAR DELIVERY OF THERAPEUTIC OLIGONUCLEOTIDES 审中-公开
标题翻译： APTAMER介导的治疗性寡核苷酸的细胞内递送
公开(公告)号：WO2005111238A3
公开(公告)日：2006-05-26
申请号：PCT/US2005013229
申请日：2005-04-19
申请人： ARCHEMIX CORP , EPSTEIN DAVID , PENDERGRAST SHANNON , KEEFE ANTHONY DOMINIC
发明人： EPSTEIN DAVID , PENDERGRAST SHANNON , KEEFE ANTHONY DOMINIC
IPC分类号： C07H21/04 , C12N15/11 , C12N15/113 , C12Q1/68
CPC分类号： C12N15/111 , C12N15/1135 , C12N15/1137 , C12N15/1138 , C12N2310/14 , C12N2310/16 , C12N2310/315 , C12N2310/317 , C12N2310/322 , C12N2310/332 , C12N2310/3519 , C12N2320/32 , C12Y207/11013
摘要： Materials and methods are provided to modulate, in a controlled manner, the intracellular deliver of therapeutic agents, including therapeutic oligonucleotides using nucleic acid aptamers.
摘要翻译：提供材料和方法以受控的方式调节治疗剂的细胞内递送，包括使用核酸适体的治疗寡核苷酸。

15. 发明申请

WO2007103549A3 COMPLEMENT BINDING APTAMERS AND ANTI-C5 AGENTS USEFUL IN THE TREATMENT OF OCULAR DISORDERS 审中-公开
标题翻译：补充结合APTAMERS和抗C5代谢物治疗眼病
公开(公告)号：WO2007103549A3
公开(公告)日：2007-12-27
申请号：PCT/US2007006020
申请日：2007-03-08
申请人： ARCHEMIX CORP , EPSTEIN DAVID , KURZ JEFF C
发明人： EPSTEIN DAVID , KURZ JEFF C
IPC分类号： A61K48/00 , C12N15/115
CPC分类号： C12N15/115 , A61K9/0048 , A61K31/702 , A61K39/3955 , A61K47/60 , C07K16/22 , C07K2317/24 , C12N2310/16 , C12N2320/32
摘要： Methods of treating complement-mediated ocular disorders by administering agents that inhibit a subject's complement component in an amount sufficient to treat the ocular disorder wherein, in a selected embodiment, said agent is an anti-complement aptamer that, in a preferred embodiment, is an anti-C5 aptamer.
摘要翻译：通过施用抑制受试者的补体成分的剂量来治疗补体介导的眼部疾病的方法，其量足以治疗眼部疾病，其中在选择的实施方案中，所述药剂是反补体适体，在优选实施方案中，其为抗C5适体。

16. 发明申请

WO2006096222A3 NUCLEIC ACID LIGANDS SPECIFIC TO IMMUNOGLOBULIN E AND THEIR USE AS ATOPIC DISEASE THERAPEUTICS 审中-公开
标题翻译：特异性免疫球蛋白E的核酸配体及其作为原发性疾病治疗的用途
公开(公告)号：WO2006096222A3
公开(公告)日：2007-08-23
申请号：PCT/US2005043551
申请日：2005-12-01
申请人： ARCHEMIX CORP , CLOAD SHARON , DIENER JOHN L , EPSTEIN DAVID , WAGNER-WHYTE JESS
发明人： CLOAD SHARON , DIENER JOHN L , EPSTEIN DAVID , WAGNER-WHYTE JESS
IPC分类号： C07H21/04 , A61K31/70 , C12N15/115 , C12Q1/68
CPC分类号： C12N15/115 , C12N2310/16 , C12N2310/315 , C12N2310/317 , C12N2310/321 , C12N2310/331 , C12N2310/336 , C12N2310/351 , C12N2310/3521
摘要： The invention discloses aptamers capable of binding to Immunoglobulin E ("IgE") useful as therapeutics in and diagnostics of atopic disease and/or other diseases or disorders in which IgE has been implicated. The invention further relates to materials and methods for the administration of aptamers capable of binding to IgE.
摘要翻译：本发明公开了能够结合免疫球蛋白E（“IgE”）的适体，其可用作特应性疾病和/或其中涉及IgE的其它疾病或病症的治疗剂和诊断。本发明还涉及用于施用能够结合IgE的适体的材料和方法。

17. 发明申请

WO2006050050A3 CHEMICALLY DEFINED MEDIA COMPOSITIONS 审中-公开
标题翻译：化学定义的媒体组成
公开(公告)号：WO2006050050A3
公开(公告)日：2009-04-16
申请号：PCT/US2005038846
申请日：2005-10-27
申请人： CENTOCOR INC , EPSTEIN DAVID , MONSELL ROGER , HORWITZ JOSEPH , LENK SUSAN , OZTURK SADETTIN , MARSH CHRISTOPHER
发明人： EPSTEIN DAVID , MONSELL ROGER , HORWITZ JOSEPH , LENK SUSAN , OZTURK SADETTIN , MARSH CHRISTOPHER
IPC分类号： C12N5/00
CPC分类号： C12N5/005 , C12N2500/32 , C12N2500/40 , C12N2500/46
摘要： Chemically defined media compositions for the culture of eukaryotic cells are disclosed. The compositions are useful for eukaryotic cell culture in perfusion bioreactors and other vessels.
摘要翻译：公开了用于真核细胞培养的化学上定义的培养基组合物。该组合物可用于灌注生物反应器和其它血管中的真核细胞培养。

18. 发明申请

WO2008097419A3 CREATING AND TRADING BUILDING BLOCK MORTALITY DERIVATIVES TO TRANSFER AND RECEIVE MORTALITY RISK IN A LIQUID MARKET 审中-公开
标题翻译：创建和交易建筑块流动性流动性转移和接收液体市场的风险程度
公开(公告)号：WO2008097419A3
公开(公告)日：2009-01-08
申请号：PCT/US2008000598
申请日：2008-01-17
申请人： JPMORGAN CHASE BANK NA , COUGHLAN GUY D , EPSTEIN DAVID , ONG ALEN SEN KAY , HALL ROBERT JAMES
发明人： COUGHLAN GUY D , EPSTEIN DAVID , ONG ALEN SEN KAY , HALL ROBERT JAMES
IPC分类号： G06Q40/00
CPC分类号： G06Q40/04 , G06Q40/00 , G06Q40/06 , G06Q40/08
摘要： The invention comprises A comprises a system and method for hedging or mitigating mortality exposure risk in a portfolio of mortality-dependent instruments. A mortality risk or longevity risk of the portfolio is calculated or otherwise determined. Then the sensitivity of the portfolio to mortality risk or longevity risk is calculated or otherwise determined, in other words, how much is cost or value of the portfolio affected by a change in mortality rate. To account for that mortality exposure, a selection is made of building block mortality derivatives that include age-based mortality derivatives. The selected plurality of selected plurality of building block mortality derivatives are used to create a hedge against the mortality risk or longevity risk of the portfolio.
摘要翻译：本发明包括A包括用于对照或减轻死亡率依赖器具组合中的死亡率暴露风险的系统和方法。计算或以其他方式确定投资组合的死亡风险或长寿险风险。那么投资组合对死亡率风险或寿命风险的敏感性是计算或以其他方式确定的，换句话说，投资组合的成本或价值受死亡率变化的影响是多少。为了解释死亡率暴露，选择包括基于年龄的死亡率衍生物的构建块死亡率衍生物。所选择的多个选定的多个构建块死亡率衍生物被用于创建投资组合的死亡风险或长寿风险的对冲。

19. 发明申请

WO0127077A3 HYDROXYSULFONYLALKYLENE-, PHOSPHONOALKYLENE- OR DIFLUORO(PHOSPHONONON)METHYL- SUBSTITUTED BENZENE, OR BENZOFURAN DERIVATIVES AS NON-PEPTIDIC CDC25 INHIBITORS 审中-公开
标题翻译：羟基甲基戊烯，磷酸二甲酯或二氟（膦酰）甲基取代的苯甲腈或苯并呋喃衍生物作为非肽性CDC25抑制剂
公开(公告)号：WO0127077A3
公开(公告)日：2002-05-23
申请号：PCT/US0027361
申请日：2000-10-04
申请人： BASF AG , TAYLOR NEIL R , BORHANI DAVID , EPSTEIN DAVID , RUDOLPH JOHANNES , RITTER KURT , FUJIMORI TARO , ROBINSON SIMON , ECKSTEIN JENS , HAUPT ANDREAS , WALKER NIGEL , DIXON RICHARD W , CHOQUETTE DEBORAH , BLANCHARD JILL , KLUGE ARTHUR , PAL KOLLOL , BOCKOVICH NICHOLAS , COME JON , HEDIGER MARK
发明人： TAYLOR NEIL R , BORHANI DAVID , EPSTEIN DAVID , RUDOLPH JOHANNES , RITTER KURT , FUJIMORI TARO , ROBINSON SIMON , ECKSTEIN JENS , HAUPT ANDREAS , WALKER NIGEL , DIXON RICHARD W , CHOQUETTE DEBORAH , BLANCHARD JILL , KLUGE ARTHUR , PAL KOLLOL , BOCKOVICH NICHOLAS , COME JON , HEDIGER MARK
IPC分类号： A61K38/00 , C07C309/24 , C07D307/85 , C07F9/38 , C07K5/02 , C07K5/113 , C12N9/16 , A61K31/185 , A61K31/343 , A61K31/662
CPC分类号： C12N9/16 , A61K38/00 , C07C309/24 , C07D307/85 , C07F9/3882 , C07K5/0205 , C07K5/0207 , C07K5/021 , C07K5/1021 , C07K2299/00
摘要： The present application relates to compounds of the fornula (VII), wherein the substituents R -R , X and Y are as defined in the description and to compounds of formula (VIII) or formula (IX) and when R is in the ortho position to X, R and R are taken together with the atoms to which are each attached to form an aromatic heterocyclic ring. The application further relates to polypeptides which comprise the ligand binding domain of Cdc25, crystalline forms of these polypeptides and the use of these crystalline forms to determine the three dimensional structure of the catalytic domain of Cdc25. The invention also relates to the use of the three dimensional structure of the Cdc25 catalytic domain in methods of designing and/or identifying potential inhibitors of Cdc25 activity, for example, compounds which inhibit the binding of a native substrate to the Cdc25 catalytic domain.
摘要翻译：本申请涉及式（VII）的化合物，其中取代基R 1 -R 5，X和Y如说明书和式（VIII）或式（IX）的化合物所定义，并且当 R 3位于X的邻位，R 3和R 4与各自连接的原子一起形成芳族杂环。本申请还涉及包含Cdc25的配体结合结构域，这些多肽的结晶形式以及这些结晶形式用于确定Cdc25催化结构域的三维结构的多肽。本发明还涉及Cdc25催化结构域的三维结构在设计和/或鉴定Cdc25活性的潜在抑制剂的方法中的用途，例如抑制天然底物与Cdc25催化结构域结合的化合物。

20. 发明申请

WO2005048079A3 MOBILE CONTENT ENGINE WITH ENHANCED FEATURES 审中-公开
标题翻译：具有增强功能的移动内容发动机
公开(公告)号：WO2005048079A3
公开(公告)日：2009-04-09
申请号：PCT/US2004037780
申请日：2004-11-12
申请人： CALIFORNIA INST OF TECHN , EPSTEIN DAVID
发明人： EPSTEIN DAVID
IPC分类号： G06F17/00 , G06F20060101
CPC分类号： G06F17/241 , G06F17/30905
摘要： A special tool (120) for use in manipulating electronic information. Projects are manipulated on the computer, wherein each project may comprise one or more documents that are associated with one another. The contents of the documents can be annotated, in a way which makes that contents look different on viewing (130). The jumping between the different annotations either in the same documents, or in documents associated with the project, is enabled. When the project is closed, the positions of the frames within the project are saved to a single file, which enables that project to be reconstructed on a different computer. In addition, selection of anything within the document allows automatically sending that information to another program.
摘要翻译：用于操纵电子信息的特殊工具（120）。在计算机上操纵项目，其中每个项目可以包括彼此关联的一个或多个文档。可以注释文档的内容，使得内容在查看上看起来不同（130）。在同一文档或与项目相关的文档中的不同注释之间的跳转被启用。当项目关闭时，项目中的框架的位置将保存到单个文件中，从而使项目能够在不同的计算机上进行重建。此外，选择文档中的任何内容可以自动将该信息发送到另一个程序。

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