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11. 发明申请

WO2005030969A1 METHOD FOR MASS PRODUCTION OF HUMAN FOLLICLE STIMULATING HORMONE 审中-公开
标题翻译：人类激素刺激大鼠生产方法
公开(公告)号：WO2005030969A1
公开(公告)日：2005-04-07
申请号：PCT/KR2004/002474
申请日：2004-09-24
申请人： PROGEN CO., LTD. , YANG, Se Hwan , SUNG, Young Chul , NA, Kyu-Heum , LEE, Sung Hee , KIM, Won Bae
发明人： YANG, Se Hwan , SUNG, Young Chul , NA, Kyu-Heum , LEE, Sung Hee , KIM, Won Bae
IPC分类号： C12N15/85
CPC分类号： A61K38/44 , A61K38/00 , A61K48/00 , C07K14/59 , C12N15/85 , C12N2840/203 , C12Y105/01003
摘要： The present invention relates to a method for mass-production of human follicle stimulating hormone, more precisely, to an expression vector containing human follicle stimulating hormone gene, a transformant transfected with the expression vector and a method for mass-production of human follicle stimulating hormone by using the same. Human follicle stimulating hormone can be produced largely by using an expression vector and a transformant of the present invention. Therefore the expression vector and the transformant of the present invention can be effectively used for the treatment of infertility.
摘要翻译：本发明涉及一种批量生产人卵泡刺激素的方法，更确切地说，涉及含有人促卵泡激素基因的表达载体，用表达载体转染的转化体和大量生产人卵泡刺激素的方法通过使用相同。可以通过使用本发明的表达载体和转化体大量产生人类促卵泡激素。因此，本发明的表达载体和转化体可以有效地用于治疗不育症。

12. 发明申请

WO2004067020A1 DNA VACCINE COMPOSITION WITH ENHANCED IMMUNOGENICITY 审中-公开
标题翻译：具有增强免疫原性的DNA疫苗组合物
公开(公告)号：WO2004067020A1
公开(公告)日：2004-08-12
申请号：PCT/KR2004/000177
申请日：2004-01-30
申请人： POHANG UNIVERSITY OF SCIENCE AND TECHNOLOGY , GENEXINE CO., LTD. , PARK, Ki-Seok , PARK, Su-Hyung , YANG, Se-Hwan , LEE, Chang-Geun , CHOI, So-Young , RYU, Sung-Ho , KIM, Youn-Dong , SUNG, Young-Chul
发明人： PARK, Ki-Seok , PARK, Su-Hyung , YANG, Se-Hwan , LEE, Chang-Geun , CHOI, So-Young , RYU, Sung-Ho , KIM, Youn-Dong , SUNG, Young-Chul
IPC分类号： A61K38/00
CPC分类号： C07K14/005 , A61K39/39 , A61K2039/53 , A61K2039/55516 , C12N2740/16022 , C12N2760/16022
摘要： Disclosed is a vaccine composition that includes a peptide adjuvant, and a DNA vaccine encoding an immunogenic protein. Also, the present invention discloses a method of enhancing immune responses, which is based on the administration of the vaccine composition.
摘要翻译：公开了包含肽佐剂和编码免疫原性蛋白质的DNA疫苗的疫苗组合物。此外，本发明公开了一种增强免疫应答的方法，其基于疫苗组合物的施用。

13. 发明申请

WO2011043584A3 HIGHLY PATHOGENIC AVIAN INFLUENZA VIRUS PROTEIN VACCINE DERIVED FROM TRANSGENIC PLANTS, AND METHOD FOR PREPARING SAME 审中-公开
标题翻译：来自转基因植物的高致病性禽流感病毒蛋白疫苗及其制备方法
公开(公告)号：WO2011043584A3
公开(公告)日：2011-10-20
申请号：PCT/KR2010006821
申请日：2010-10-06
申请人： HELIX CO LTD , HWANG IN HWAN , SOHN EUN JU , KWON EUN HYE , NA YUN JEONG , JEON EUN HYUN , IM SE JIN , PARK KI SEOK , SUNG YOUNG CHUL
发明人： HWANG IN HWAN , SOHN EUN JU , KWON EUN HYE , NA YUN JEONG , JEON EUN HYUN , IM SE JIN , PARK KI SEOK , SUNG YOUNG CHUL
IPC分类号： A01H1/00 , A61K39/12 , C12N15/40 , C12N15/82
CPC分类号： A61K39/145 , A61K39/12 , C12N15/8258 , C12N2760/16134
摘要： The present invention relates to a method for producing transgenic plants, which involves producing hemagglutinin proteins of the H5N1 virus in a highly efficient manner using a plant transformation recombinant vector, wherein said vector can express, in a highly efficient manner, hemagglutinin proteins of the H5N1 virus which is the highly pathogenic avian influenza virus, and can transport proteins expressed in plants to the endoplasmic reticulum and enable the retention of the proteins in the endoplasmic reticulum so as to accomplish glycosylation which is necessarily required for antigen activity. The present invention also relates to a method for the mass production of hemagglutinin proteins of the antigenic H5N1 virus from the transgenic plants, and to a vaccine composition for the avian influenza virus comprising the transgenic plants or the hemagglutinin proteins produced from the plants. The method for producing hemagglutinin proteins of the H5N1 virus using transgenic plants according to the present invention enables the mass production of hemagglutinin proteins at a low cost. The plant transformation recombinant vector used in the present invention has a cellulose-binding domain inserted therein to separate proteins expressed in plants in a quick and easy manner. In addition, transgenic plants according to the present invention can be taken in the form of feed additives or the like, and therefore can be used as edible vaccines. Further, antigenic hemagglutinin proteins produced by the method induce immune response when administered to an animal model, and therefore can be used not only as protein vaccines for the H5N1 avian influenza virus, but also as diagnostic reagents for avian influenza virus infection.
摘要翻译：本发明涉及生产转基因植物的方法，其包括使用植物转化重组载体以高效方式产生H5N1病毒的血凝素蛋白，其中所述载体可以高效方式表达H5N1的血凝素蛋白病毒是高致病性禽流感病毒，并且可以将植物中表达的蛋白质转运到内质网并使蛋白质滞留在内质网中，从而完成抗原活性所必需的糖基化。本发明还涉及从转基因植物大量生产抗原性H5N1病毒的血凝素蛋白质的方法，以及包含由该植物产生的转基因植物或血凝素蛋白质的用于禽流感病毒的疫苗组合物。使用根据本发明的转基因植物生产H5N1病毒的血凝素蛋白质的方法能够以低成本大量生产血凝素蛋白质。用于本发明的植物转化重组载体具有插入其中的纤维素结合结构域，以快速且容易的方式分离在植物中表达的蛋白质。另外，根据本发明的转基因植物可以以饲料添加剂等的形式摄取，因此可以用作可食用疫苗。此外，由该方法产生的抗原性血凝素蛋白当施用于动物模型时诱导免疫反应，因此不仅可以用作H5N1禽流感病毒的蛋白质疫苗，而且可以用作禽流感病毒感染的诊断试剂。

14. 发明申请

WO2009104831A1 USE OF MUTANT HIV-1 PROTEASE OR SIV PROTEASE AS AN ADJUVANT 审中-公开
标题翻译：使用突变型HIV-1蛋白酶或SIV蛋白酶作为辅助剂
公开(公告)号：WO2009104831A1
公开(公告)日：2009-08-27
申请号：PCT/KR2008/001067
申请日：2008-02-22
申请人： POSTECH FOUNDATION , SUNG, Young Chul , JIN, Dong Bin , KIM, Kwang Soon
发明人： SUNG, Young Chul , JIN, Dong Bin , KIM, Kwang Soon
IPC分类号： A61K39/39 , A61P31/18
CPC分类号： A61K39/39 , A61K2039/53 , A61K2039/55516
摘要： The present invention relates to a mutant HIV-1 (Human immunodeficiency virus-1) protease capable of effectively enhancing cell-mediated immune responses to DNA vaccination, and use of a nucleic acid encoding the same as a vaccine adjuvant. The mutant HIV-1 protease according to the present invention has inactivated or attenuated proteolytic activity, while retaining chaperone-like activity. When the mutant HIV-1 protease is used together with a DNA vaccine against the HIV-1 envelope protein or the HPV antigen (E6 or E7), cell-mediated immune responses can be effectively enhanced for the prevention or treatment of AIDS or cervical cancer.
摘要翻译：本发明涉及能够有效增强细胞介导的针对DNA接种的免疫应答的突变型HIV-1（人类免疫缺陷病毒-1）蛋白酶，以及使用其编码与疫苗佐剂相同的核酸。根据本发明的突变型HIV-1蛋白酶具有灭活或减弱的蛋白水解活性，同时保留伴侣样活性。当突变HIV-1蛋白酶与针对HIV-1包膜蛋白或HPV抗原（E6或E7）的DNA疫苗一起使用时，可以有效增强细胞介导的免疫应答，以预防或治疗艾滋病或宫颈癌。

15. 发明申请

WO2009038310A1 POLYMER SUBSTRATE FOR FLEXIBLE DISPLAY HAVING ENHANCED FLEXIBILITY 审中-公开
标题翻译：具有增强柔性的柔性显示器的聚合物基板
公开(公告)号：WO2009038310A1
公开(公告)日：2009-03-26
申请号：PCT/KR2008/005378
申请日：2008-09-11
申请人： KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY , YOON, Choon Sup , SUNG, Young Chul , CHO, Dong Ho , JEON, Duk Young
发明人： YOON, Choon Sup , SUNG, Young Chul , CHO, Dong Ho , JEON, Duk Young
IPC分类号： G02F1/1335
CPC分类号： G02F1/133305 , G02F1/167 , Y10T428/24074 , Y10T428/24917 , Y10T428/31507 , Y10T428/31678 , Y10T428/31681
摘要： Disclosed herein is a polymer substrate for a flexible display, comprising a reticular superelastic alloy structure and/or an annular superelastic alloy structure therein. The polymer substrate has an improved flexibility because the superelastic alloy structure is embedded therein.
摘要翻译：本文公开了一种用于柔性显示器的聚合物基底，其中包括网状超弹性合金结构和/或其中的环形超弹性合金结构。聚合物基材由于超弹性合金结构嵌入其中而具有改进的柔性。

16. 发明申请

WO2007102690A1 VECTOR INCLUDING THE CODON-OPTIMIZED DNA CASSETTE FOR PRODUCING SECRETORY RECOMBINANT DODECAMER TRAIL 审中-公开
标题翻译：包含用于生产秘密重组剂DODECAMER TRAIL的CODON优化的DNA盒的载体
公开(公告)号：WO2007102690A1
公开(公告)日：2007-09-13
申请号：PCT/KR2007/001099
申请日：2007-03-06
申请人： POSTECH FOUNDATION , LEE, Ok Hee , SUNG, Young Chul , YOUN, Je-In , PARK, Sang Hoon
发明人： SUNG, Young Chul , YOUN, Je-In , PARK, Sang Hoon
IPC分类号： C12N15/09 , C12N15/10 , C12N15/64
CPC分类号： C07K14/70575
摘要： Disclosed are a novel codon-optimized DNA cassette for secretory recombinant dodecamer TRAIL, in which three different nucleotide sequences respectively encoding a secretion signal sequence, a dodecamer-forming domain, and TRAIL are linked sequentially, and a vector carrying the same. Also, the present invention is directed to a secretory recombinant TRAIL protein produced using the vector, and an adenovirus, anchoring the vector therein, capable of producing the secretory recombinant dodecamer TRAIL protein. The TRAIL protein or the adenovirus can be prepared into anticancer preparations.
摘要翻译：公开了一种用于分泌重组十二聚体TRAIL的新型密码子优化的DNA盒，其中分别编码分泌信号序列，十二烷基化形成结构域和TRAIL的三个不同核苷酸序列依次连接，并携带携带其的载体。此外，本发明涉及使用载体产生的分泌型重组TRAIL蛋白质，以及能够产生分泌型重组十二聚体TRAIL蛋白质的腺病毒锚定载体。 TRAIL蛋白或腺病毒可以制备成抗癌剂。

17. 发明申请

WO1996030513A1 APOPTOSIS REGULATING GENE 审中-公开
标题翻译：疫苗调控基因
公开(公告)号：WO1996030513A1
公开(公告)日：1996-10-03
申请号：PCT/KR1996000040
申请日：1996-03-25
申请人： KOREA GREEN CROSS CORPORATION , POSTECH FOUNDATION , SHIN, Hee, Sup , SUNG, Young, Chul , HONG, Seok, Il , CHOI, Sun, Sim , YUN, Jin, Won , CHOI, Eun, Kyoung , PARK, In, Chul
发明人： KOREA GREEN CROSS CORPORATION , POSTECH FOUNDATION
IPC分类号： C12N15/12
CPC分类号： C07K14/82 , A01K2217/05 , A61K38/00
摘要： A new Bcl-2 related gene "Bfl-1", a polypeptide encoded by said gene, and a plasmid and a transformant comprising said gene are disclosed. The gene can be used to detect cancer.
摘要翻译：公开了一种新的Bcl-2相关基因“Bfl-1”，由所述基因编码的多肽，以及包含所述基因的质粒和转化体。该基因可用于检测癌症。

18. 发明申请

WO2011040738A3 INTRACELLULAR VIRAL VECTOR DELIVERY METHOD EMPLOYING IRON ION/VIRAL VECTOR COMPOSITE 审中-公开
标题翻译：使用铁离子/病毒载体复合材料的细胞内载体递送方法
公开(公告)号：WO2011040738A3
公开(公告)日：2011-10-13
申请号：PCT/KR2010006577
申请日：2010-09-28
申请人： POSTECH ACAD IND FOUND , BIOD CO LTD , SUNG YOUNG CHUL , PARK SANG HOON , PARK KI SEOK
发明人： SUNG YOUNG CHUL , PARK SANG HOON , PARK KI SEOK
IPC分类号： C12N15/83 , C12N5/10 , C12N15/87
CPC分类号： C12N15/86 , C12N15/00 , C12N15/63 , C12N15/861 , C12N15/863 , C12N15/8636 , C12N15/864 , C12N15/867 , C12N2710/10343 , C12N2710/10345 , C12N2810/10
摘要： The present invention relates to an intracellular viral vector delivery method employing an iron ion/viral vector composite. The iron ion/viral vector composite according to the present invention is not dependent on the expression of CAR and so improves the efficiency of delivery of viral vectors and gene expression in cells of diverse types, and has an outstanding virus-neutralizing antibody escape performance, exhibits little cytotoxicity and is outstandingly stable even when subjected to iron ion processing at low concentration, and hence can be used to advantage in recombinant viral vaccine compositions.
摘要翻译：本发明涉及使用铁离子/病毒载体复合物的细胞内病毒载体递送方法。根据本发明的铁离子/病毒载体复合物不依赖于CAR的表达，因此提高病毒载体的传递效率和在不同类型的细胞中的基因表达，并且具有优异的病毒中和抗体逃逸性能，表现出很小的细胞毒性，即使在低浓度下进行铁离子处理也显着稳定，因此可用于重组病毒疫苗组合物中。

19. 发明申请

WO2011043584A2 HIGHLY PATHOGENIC AVIAN INFLUENZA VIRUS PROTEIN VACCINE DERIVED FROM TRANSGENIC PLANTS, AND METHOD FOR PREPARING SAME 审中-公开
标题翻译：从致敏植物衍生的高致病性AVIAN流感病毒蛋白疫苗及其制备方法
公开(公告)号：WO2011043584A2
公开(公告)日：2011-04-14
申请号：PCT/KR2010006821
申请日：2010-10-06
申请人： HELIX CO LTD , HWANG IN HWAN , SOHN EUN JU , KWON EUN HYE , NA YUN JEONG , JEON EUN HYUN , IM SE JIN , PARK KI SEOK , SUNG YOUNG CHUL
发明人： HWANG IN HWAN , SOHN EUN JU , KWON EUN HYE , NA YUN JEONG , JEON EUN HYUN , IM SE JIN , PARK KI SEOK , SUNG YOUNG CHUL
IPC分类号： A01H1/00 , A61K39/12 , C12N15/40 , C12N15/82
CPC分类号： A61K39/145 , A61K39/12 , C12N15/8258 , C12N2760/16134
摘要： The present invention relates to a method for producing transgenic plants, which involves producing hemagglutinin proteins of the H5N1 virus in a highly efficient manner using a plant transformation recombinant vector, wherein said vector can express, in a highly efficient manner, hemagglutinin proteins of the H5N1 virus which is the highly pathogenic avian influenza virus, and can transport proteins expressed in plants to the endoplasmic reticulum and enable the retention of the proteins in the endoplasmic reticulum so as to accomplish glycosylation which is necessarily required for antigen activity. The present invention also relates to a method for the mass production of hemagglutinin proteins of the antigenic H5N1 virus from the transgenic plants, and to a vaccine composition for the avian influenza virus comprising the transgenic plants or the hemagglutinin proteins produced from the plants. The method for producing hemagglutinin proteins of the H5N1 virus using transgenic plants according to the present invention enables the mass production of hemagglutinin proteins at a low cost. The plant transformation recombinant vector used in the present invention has a cellulose-binding domain inserted therein to separate proteins expressed in plants in a quick and easy manner. In addition, transgenic plants according to the present invention can be taken in the form of feed additives or the like, and therefore can be used as edible vaccines. Further, antigenic hemagglutinin proteins produced by the method induce immune response when administered to an animal model, and therefore can be used not only as protein vaccines for the H5N1 avian influenza virus, but also as diagnostic reagents for avian influenza virus infection.
摘要翻译：本发明涉及一种生产转基因植物的方法，其涉及使用植物转化重组载体以高效的方式生产H5N1病毒的血凝素蛋白，其中所述载体能以高效的方式表达H5N1的血凝素蛋白病毒是高致病性禽流感病毒，并且可以将在植物中表达的蛋白质转运到内质网，并使蛋白质保留在内质网中，从而完成抗原活性必需的糖基化。本发明还涉及从转基因植物大批量生产抗原性H5N1病毒的血细胞凝集素蛋白质的方法，以及包含转基因植物或由植物产生的血凝素蛋白质的禽流感病毒疫苗组合物。使用根据本发明的转基因植物生产H5N1病毒血凝素蛋白的方法能够以低成本大规模生产血凝素蛋白。用于本发明的植物转化重组载体具有插入其中的纤维素结合结构域，以快速和容易的方式分离在植物中表达的蛋白质。此外，根据本发明的转基因植物可以以饲料添加剂等的形式获取，因此可以用作可食用疫苗。此外，通过该方法产生的抗原性血凝素蛋白质在施用于动物模型时诱导免疫应答，因此不仅可以用作H5N1禽流感病毒的蛋白疫苗，而且可用作禽流感病毒感染的诊断试剂。

20. 发明申请

WO2010098613A9 TM7SF3 COMPOSITION FOR DIAGNOSING LIVER CANCER, DIAGNOSTIC KIT CONTAINING ANTI-TM7SF3 ANTIBODIES, AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING LIVER CANCER 审中-公开
标题翻译：用于诊断肝癌的TM7SF3组合物，含有抗TM7SF3抗体的诊断试剂盒和用于预防或治疗肝癌的药物组合物
公开(公告)号：WO2010098613A9
公开(公告)日：2011-03-03
申请号：PCT/KR2010001222
申请日：2010-02-26
申请人： POSTECH ACAD IND FOUND , SUNG YOUNG CHUL , YANG SE HWAN , CHOI SO YOUNG , LEE JI YEUNG , KIM SAE WON
发明人： SUNG YOUNG CHUL , YANG SE HWAN , CHOI SO YOUNG , LEE JI YEUNG , KIM SAE WON
IPC分类号： G01N33/574 , A61K39/395 , A61P35/00 , G01N33/53
CPC分类号： G01N33/57438 , C07K16/303
摘要： The present invention relates to a composition for diagnosing liver cancer containing TM7SF3 as an active ingredient, a kit for diagnosing liver cancer with anti-TM7SF3 antibodies as reagent, and a pharmaceutical composition for preventing or treating liver cancer containing the anti-TM7SF3 antibodies as an active ingredient. The TM7SF3 protein is rarely expressed in liver tissue of a healthy person, but is specifically over-expressed in malignant hepatic tissue of liver cancer patients. As diagnosis or prognosis of liver cancer is thus predictable, the TM7SF protein can be used as a marker for diagnosing liver cancer. In addition, the anti-TM7SE3 antibodies of the present invention specifically bind with an extracellular domain of the TTM7SF3, and respond to this particular liver cell line. Therefore, the anti-TM7SE3 antibodies selectively induce apoptosis of only cancer cells caused by IM7SF3 over-expression, and can thus be used in preventing or treating liver cancer.
摘要翻译：本发明涉及用于诊断含有TM7SF3作为活性成分的肝癌的组合物，用抗TM7SF3抗体作为试剂诊断肝癌的试剂盒，以及用于预防或治疗含有抗TM7SF3抗体的肝癌的药物组合物有效成分。 TM7SF3蛋白很少在健康人的肝组织中表达，但在肝癌患者的恶性肝组织中特异性地过表达。由于肝癌的诊断或预后因此可预测，TM7SF蛋白可用作诊断肝癌的标志物。此外，本发明的抗TM7SE3抗体与TTM7SF3的细胞外结构域特异性结合，并对该特定肝细胞系作出反应。因此，抗TM7SE3抗体选择性诱导仅由IM7SF3过度表达引起的癌细胞的凋亡，因此可用于预防或治疗肝癌。

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