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11. 发明申请

WO2002076970A3 TOCOPHEROL SUCCINATE DERIVATIVES AND COMPOSITIONS 审中-公开
公开(公告)号：WO2002076970A3
公开(公告)日：2002-10-03
申请号：PCT/US2002/011264
申请日：2002-03-21
申请人： SONUS PHARMACEUTICALS, INC. , LAMBERT, Karel, J. , LAL, Manjari , NIENSTEDT, Andrew, M.
发明人： LAMBERT, Karel, J. , LAL, Manjari , NIENSTEDT, Andrew, M.
IPC分类号： C07D311/76
摘要： Tocopherol succinic acid derivatives including tocopherol succinic acid esters and tocopherol succinic acid amides are described. Compositions that include the tocopherol succinic acid derivatives are also provided.

12. 发明申请

WO2002076937A2 AMINOBENZOPYRAN DERIVATIVES AND COMPOSITIONS 审中-公开
标题翻译：氨基苯并吡喃衍生物和组合物
公开(公告)号：WO2002076937A2
公开(公告)日：2002-10-03
申请号：PCT/US2002/011265
申请日：2002-03-21
申请人： SONUS PHARMACEUTICALS, INC. , LAMBERT, Karel, J. , LAL, Manjari
发明人： LAMBERT, Karel, J. , LAL, Manjari
IPC分类号： C07D
CPC分类号： C07D311/74
摘要： Benzopyran derivatives including aminobenzopyran derivatives are described. Compositions that include the aminobenzopyran derivatives are also provided.
摘要翻译：描述了包括氨基苯并吡喃衍生物的苯并吡喃衍生物。还提供了包括氨基苯并吡喃衍生物的组合物。

13. 发明申请

WO1996040282A3 NUCLEATION AND ACTIVATION TECHNIQUES FOR USE IN ULTRASOUND IMAGING 审中-公开
公开(公告)号：WO1996040282A3
公开(公告)日：1996-12-19
申请号：PCT/US1996009108
申请日：1996-06-06
申请人： SONUS PHARMACEUTICALS, INC.
发明人： SONUS PHARMACEUTICALS, INC. , QUAY, Steven, C. , KESSLER, Dean, R. , ROY, Ronald, A. , WORAH, Dilip
IPC分类号： A61K49/00

14. 发明申请

WO1994016739A1 PHASE SHIFT COLLOIDS AS ULTRASOUND CONTRAST AGENTS 审中-公开
标题翻译：相移胶囊作为超声对比剂
公开(公告)号：WO1994016739A1
公开(公告)日：1994-08-04
申请号：PCT/US1994000422
申请日：1994-01-19
申请人： SONUS PHARMACEUTICALS, INC. , QUAY, Steven, C.
发明人： SONUS PHARMACEUTICALS, INC.
IPC分类号： A61K49/00
CPC分类号： A61K49/226 , A61K49/223
摘要： Agents for enhancing the contrast in a diagnostic ultrasound procedure comprise colloidal dispersions of the liquid-in-liquid type, i.e., emulsions or microemulsions, in which the dispersed liquid phase is a liquid having a boiling point below the temperature of the animal to be imaged and which therefore undergoes a phase change from a dispersed liquid to a highly echogenic dispersed gaseous foam or kugelschaum following administration to the animal. The liquid state of the dispersed phase allows one to manufacture extremely stable, pharmaceutically acceptable emulsions with particle sizes typically below 1000 nm. The gaseous state at body temperature yields highly echogenic microbubbles, typically below 10,000 nm in diameter, which are effective as ultrasound contrast agents. Intravenous, intraarterial, oral, intraperitoneal, and intrauterine dosage forms, methods of administration, and imaging techniques are described.
摘要翻译：用于增强诊断超声程序中的对比度的试剂包括液体 - 液体类型的胶体分散体，即乳液或微乳液，其中分散液相是沸点低于待成像动物温度的液体因此，在施用于动物后，其从分散的液体经历相变到高回声分散的气态泡沫或密封胶。分散相的液体状态允许制造粒度通常低于1000nm的非常稳定的药学上可接受的乳液。在体温下的气态产生高度回声的微泡，通常在直径小于10,000nm的范围内，其作为超声造影剂是有效的。描述静脉内，动脉内，口服，腹膜内和子宫内剂型，给药方法和成像技术。

15. 发明申请

WO1998003205A3 ENHANCED ULTRASOUND CONTRAST IMAGING USING INHALED GASES 审中-公开
公开(公告)号：WO1998003205A3
公开(公告)日：1998-01-29
申请号：PCT/US1997012354
申请日：1997-07-16
申请人： SONUS PHARMACEUTICALS, INC.
发明人： SONUS PHARMACEUTICALS, INC. , QUAY, Steven, C.
IPC分类号： A61K49/00

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