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11. 发明申请

WO2009025512A2 SYSTEM AND METHOD FOR ESTIMATING LONG TERM CHARACTERISTICS OF BATTERY 审中-公开
标题翻译：用于估计电池长期特性的系统和方法
公开(公告)号：WO2009025512A2
公开(公告)日：2009-02-26
申请号：PCT/KR2008/004883
申请日：2008-08-21
申请人： LG CHEM, LTD. , SONG, Hyun-Kon , CHO, Jeong-Ju , CHOO, Yeon-Uk , SON, Mi-Young , LEE, Ho-Chun
发明人： SONG, Hyun-Kon , CHO, Jeong-Ju , CHOO, Yeon-Uk , SON, Mi-Young , LEE, Ho-Chun
IPC分类号： G01R31/36
CPC分类号： G01R31/3651 , G06N7/00
摘要： A system for estimating long term characteristics of a battery includes a learning data input unit for receiving initial characteristic learning data and long term characteristic learning data of a battery to be a learning object; a measurement data input unit for receiving initial characteristic measurement data of a battery to be an object for estimation of long term characteristics; and an artificial neural network operation unit for receiving the initial characteristic learning data and the long term characteristic learning data from the learning data input unit to allow learning of an artificial neural network, receiving the initial characteristic measurement data from the measurement data input unit and applying the learned artificial neural network thereto, and thus calculating long term characteristic estimation data from the initial characteristic measurement data of the battery and outputting the long term characteristic estimation data.
摘要翻译：一种用于估计电池的长期特性的系统包括用于接收作为学习对象的电池的初始特征学习数据和长期特征学习数据的学习数据输入单元; 测量数据输入单元，用于接收作为用于估计长期特性的对象的电池的初始特性测量数据; 以及人工神经网络操作单元，用于从学习数据输入单元接收初始特征学习数据和长期特征学习数据，以允许学习人造神经网络，从测量数据输入单元接收初始特征测量数据并应用从而从电池的初始特性测量数据计算长期特征估计数据并输出长期特征估计数据。

12. 发明申请

WO2006075808A1 PHARMACEUTICAL COMPOSITION COMPRISING A P25/CDK5 INHIBITOR FOR PREVENTING OR TREATING A NEURODEGENERATIVE DISEASE 审中-公开
标题翻译：包含P25 / CDK5抑制剂的药物组合物，用于预防或治疗神经病变疾病
公开(公告)号：WO2006075808A1
公开(公告)日：2006-07-20
申请号：PCT/KR2005/000098
申请日：2005-01-12
申请人： INJE UNIVERSITY , CHUNG, Sul-Hee , HA, Ilho , SON, Mi-Young , LEE, Hye-Won
发明人： CHUNG, Sul-Hee , HA, Ilho , SON, Mi-Young , LEE, Hye-Won
IPC分类号： A61K31/381 , A61P25/28
CPC分类号： A61K31/381
摘要： A pharmaceutical composition for preventing or treating a neurodegenerative disease comprises a compound inhibiting a P25/CDK (cycline-dependent kinase 5) complex as an active ingredient. Also disclosed is a method for screening a compound capable of preventing or treating a neurodegenerative disease, which comprises the steps of a) reacting a candidate compound with a P25/CDK5 complex and beta-site APP (amyloid precursor protein)-cleaving enzyme 1 (BACEl) or treating a mammalian cell expressing P25 with the candidate compound, and measuring BACE l phosphorylation; and b) comparing the measured BACEl phosphorylation with that of a control group employing no candidate compound, and identifying a compound reducing BACEl phosphorylation compared to the control group. The compound inhibiting the P25/CDK5 complex may be useful for preventing or treating a neurodegenerative disease including Alzheimer's disease because it inhibits BACEl phosphorylation and reduces the secretion of β-amyloid and the hyperphosphorylation of Tau.
摘要翻译：用于预防或治疗神经变性疾病的药物组合物包括抑制P25 / CDK（cycline-dependent kinase 5）复合物作为活性成分的化合物。还公开了一种筛选能够预防或治疗神经变性疾病的化合物的方法，其包括以下步骤：a）使候选化合物与P25 / CDK5复合体和β-位点APP（淀粉样蛋白前体蛋白）切割酶1（ BACE1）或用候选化合物处理表达P25的哺乳动物细胞，并测量BACE1磷酸化; 和b）比较测定的BACE1磷酸化与不使用候选化合物的对照组的BACE1磷酸化，并且与对照组相比，鉴定减少BACE1磷酸化的化合物。抑制P25 / CDK5复合物的化合物可用于预防或治疗包括阿尔茨海默病在内的神经变性疾病，因为它抑制BACE1磷酸化并降低β-淀粉样蛋白的分泌和Tau的过度磷酸化。

13. 发明申请

WO2010147395A2 MEDIUM COMPOSITION COMPRISING NEUROPEPTIDE Y FOR THE GENERATION, MAINTENANCE, PROLOGNED UNDIFFERENTIATED GROWTH OF PLURIPOTENT STEM CELLS AND METHOD OF CULTURING PLURIPOTENT STEM CELL USING THE SAME 审中-公开
标题翻译：包含神经元Y的中间组合物用于产生，维持，生物化学抑制的PLUIPOTETE STEM细胞的不成熟生长以及使用其培养PLUIPOTETI干细胞的方法
公开(公告)号：WO2010147395A2
公开(公告)日：2010-12-23
申请号：PCT/KR2010003891
申请日：2010-06-16
申请人： KOREA RES INST OF BIOSCIENCE , CHO YEE SOOK , SON MI-YOUNG
发明人： CHO YEE SOOK , SON MI-YOUNG
IPC分类号： C12N5/071 , C12N5/02 , C12N5/0735
CPC分类号： C12N5/0606 , C12N5/0696 , C12N2500/90 , C12N2501/115 , C12N2501/15 , C12N2501/835
摘要： The present invention relates to a medium composition comprising neuropeptide Y, effective for proliferation and maintenance of undifferentiated pluripotent stem cells, and a method for culturing undifferentiated pluripotent stem cells using the same. The present invention improves the culture conditions for undifferentiated pluripotent stem cells, and ultimately, the present invention can be effectively used for the development of large-scale culture systems, thereby acquiring clinically applicable pluripotent stem cells. Further, the present invention relates to a dedifferentiation medium composition comprising neuropeptide Y (NPY), and a method for inducing dedifferentiation(or reprogramming) using the same. The present invention improves the culture conditions for dedifferentiation and contributes to develop technology of producing clinically applicable induced pluripotent stem cells, thereby being used for the development of stem cell therapy.
摘要翻译：本发明涉及包含对未分化多能干细胞的增殖和维持有效的神经肽Y的培养基组合物，以及使用该组合物培养未分化多能干细胞的方法。本发明改善了未分化多能干细胞的培养条件，最终本发明可有效地用于大规模培养系统的开发，从而获得临床适用的多能干细胞。此外，本发明涉及包含神经肽Y（NPY）的去分化培养基组合物和使用其的诱导去分化（或重编程）的方法。本发明改善去分化的培养条件，有助于开发临床应用的诱导多能干细胞的生产技术，从而用于干细胞治疗的发展。

14. 发明申请

WO2009088174A2 NON-AQUEOUS ELECTROLYTE SOLUTION FOR LITHIUM SECONDARY BATTERY AND LITHIUM SECONDARY BATTERY CONTAINING THE SAME 审中-公开
标题翻译：用于锂二次电池的非水电解质溶液和含有它的锂二次电池
公开(公告)号：WO2009088174A2
公开(公告)日：2009-07-16
申请号：PCT/KR2008/007850
申请日：2008-12-31
申请人： LG CHEM, LTD. , KIM, Soo-Jin , CHO, Jeong-Ju , SON, Mi-Young , YOON, Su-Jin
发明人： KIM, Soo-Jin , CHO, Jeong-Ju , SON, Mi-Young , YOON, Su-Jin
IPC分类号： H01M10/40
CPC分类号： H01M10/0567 , H01M10/0525 , H01M10/4235
摘要： A non-aqueous electrolyte solution for a lithium secondary battery includes a lithium salt and an organic solvent. The non-aqueous electrolyte solution includes 0.5 to 5 weight% of vinylethylene carbonate and 0.1 to 5 weight% of 1,3-divinyltetramethyldisiloxane simul¬ taneously, based on the total weight of the non-aqueous electrolyte solution. 1,3-divinyltetramethyldisiloxane may significantly solve side effect of battery swelling without deteriorating effects such as improvement of performance deterioration and life cycle according to the addition of vinylethylene carbonate.
摘要翻译：锂二次电池用非水电解液包括锂盐和有机溶剂。基于非水电解质溶液的总重量，非水电解质溶液包括0.5-5重量％的碳酸乙烯基碳酸亚乙酯和0.1至5重量％的1,3-二乙烯基四甲基二硅氧烷。 1,3-二乙烯基四甲基二硅氧烷可以显着地解决电池膨胀的副作用，而不会降低根据加入乙烯基碳酸亚乙酯的性能劣化和寿命周期改善的效果。

15. 发明申请

WO2009035288A2 SYSTEM AND METHOD FOR ESTIMATING LONG TERM CHARACTERISTICS OF BATTERY 审中-公开
标题翻译：用于估计电池长期特性的系统和方法
公开(公告)号：WO2009035288A2
公开(公告)日：2009-03-19
申请号：PCT/KR2008/005403
申请日：2008-09-12
申请人： LG CHEM, LTD. , SONG, Hyun-Kon , CHO, Jeong-Ju , CHOO, Yeon-Uk , SON, Mi-Young , LEE, Ho-Chun
发明人： SONG, Hyun-Kon , CHO, Jeong-Ju , CHOO, Yeon-Uk , SON, Mi-Young , LEE, Ho-Chun
IPC分类号： H01M10/48
CPC分类号： H01M10/482 , G01R31/3651 , G01R31/3679 , H01M10/48
摘要： A system includes a learning data input unit for receiving initial and long term characteristic learning data of a battery to be a learning object; a measurement data input unit for receiving initial characteristic measurement data of a battery to be an object for long term characteristic estimation; an artificial neural network operation unit for converting the learning data into first and second data structures, allowing an artificial neural network to learn the learning data based on each data structure, converting the measurement data into first and second data structures, and individually applying the learned artificial neural network corresponding to each data structure to calculate and output long term characteristic estimation data based on each data structure; and a long term characteristic evaluation unit for calculating an error of the estimation data of each data structure and determining reliability of the estimation data depending on error.
摘要翻译：一种系统，包括用于接收作为学习对象的电池的初始和长期特征学习数据的学习数据输入单元; 测量数据输入单元，用于接收作为长期特性估计对象的电池的初始特性测量数据; 一种用于将学习数据转换为第一和第二数据结构的人造神经网络操作单元，允许人造神经网络基于每个数据结构学习学习数据，将测量数据转换为第一和第二数据结构，以及单独应用所学习的对应于每个数据结构的人工神经网络，基于每个数据结构计算和输出长期特征估计数据; 以及长期特征评估单元，用于计算每个数据结构的估计数据的误差，并根据误差确定估计数据的可靠性。

16. 发明申请

WO2010147395A3 MEDIUM COMPOSITION COMPRISING NEUROPEPTIDE Y FOR THE GENERATION, MAINTENANCE, PROLOGNED UNDIFFERENTIATED GROWTH OF PLURIPOTENT STEM CELLS AND METHOD OF CULTURING PLURIPOTENT STEM CELL USING THE SAME 审中-公开
公开(公告)号：WO2010147395A3
公开(公告)日：2010-12-23
申请号：PCT/KR2010/003891
申请日：2010-06-16
申请人： KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY , CHO, Yee Sook , SON, Mi-Young
发明人： CHO, Yee Sook , SON, Mi-Young
IPC分类号： C12N5/071 , C12N5/0735 , C12N5/02
摘要： The present invention relates to a medium composition comprising neuropeptide Y, effective for proliferation and maintenance of undifferentiated pluripotent stem cells, and a method for culturing undifferentiated pluripotent stem cells using the same. The present invention improves the culture conditions for undifferentiated pluripotent stem cells, and ultimately, the present invention can be effectively used for the development of large-scale culture systems, thereby acquiring clinically applicable pluripotent stem cells. Further, the present invention relates to a dedifferentiation medium composition comprising neuropeptide Y (NPY), and a method for inducing dedifferentiation(or reprogramming) using the same. The present invention improves the culture conditions for dedifferentiation and contributes to develop technology of producing clinically applicable induced pluripotent stem cells, thereby being used for the development of stem cell therapy.

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